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High prevalence of fecal carriage of Extended-spectrum beta-lactamase and carbapenemase-producing Enterobacteriaceae among food handlers at the University of Gondar, Northwest Ethiopia.

BACKGROUND: Fecal carriage of extended-spectrum beta-lactamase and Carbapenemase-producing Enterobacteriaceae is a potential risk for the tr … me, and ceftriaxone (100% each). In contrast, a low resistance level was recorded for Meropenem and cefoxitin. The overall Multi-drug resistant Enterobacteriaceae (MDR) was 147 (42.3%). Antibiotics usage in the last 3 months and drinking unpasteurized milk were associated with the carriage of the Extended-spectrum beta-lactamase-Producing Enterobacteriaceae …

Antimicrobial resistance profile of extended-spectrum beta-lactamases, adenosine-monophosphate-cyclic, and carbapenemase-producing Gram-negative bacteria isolated from domestic animals.

BACKGROUND AND AIM: The production of beta-lactamase enzymes, such as extended-spectrum beta-lactamase (ESBL), adenosine-monophosphate-cycli … ial isolates showed high levels of resistance against clindamycin, penicillin, imipenem, polymyxin, cefoxitin, gentamycin, cefotaxime, ceftazidime, cephalothin, ceftriaxone, ciprofloxacin, trimethoprim/sulfamethoxazole, chloramphenicol, and tetracycline. The best effectiveness rates were observed for cefepime, streptomycin, amoxicillin-clavulanate, aztreona …

[Laboratory and clinical studies of cefmetazole in serious infection by Staphylococcus (author's transl)].

Cefmetazole (CMZ) is an antibiotic agent belonging to the cephamycin group, which is resistant to beta-lactamase and has a broad antibacterial spectrum covering from Gram-negative to -positive organisms. Although this agent has been proved to have an antibacterial activity against Staphylococcus spp., it has not been used for treatment of the infections caused by the organism. Thus, 62 strains of S. aureus isolated clinically were compared for their sensitivity to CMZ, cefoxitin (CFX), cefuroxime (CXM), cefazolin (CEZ), and ampicillin (ABPC). In addition, 5 children suffering from septicemia d…

Prevalence and characterisation of carbapenemase encoding genes in multidrug-resistant Gram-negative bacilli.

BACKGROUND: Emerging worldwide in the past decade, there has been a significant increase in multidrug-resistant bacteria from serious nosoco … hat were resistant to beta-lactam drugs, including carbapenems, third-generation cephalosporines or cefoxitin, were selected for phenotyping using Carba plus disc system assay for detection of carbapenemase-producing isolates. These isolates were further confirmed by molecular detection. PCR was used for the detection carbapenem-resistant genes (OXA-48, IMP …

Colonization of methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci and its associated factors in cancer patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

BACKGROUND: Cancer patients are predisposed to methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci colonization … r vancomycin determined via E-test strips. To detect methicillin-resistant Staphylococcus aureus, a cefoxitin disk was used. Inducible clindamycin resistance in Staphylococcus aureus was determined by the D test. Epi-info version 7 and SPSS version 27 were used for data entry and data analysis, respectively. The Pearson Chi-Square test was initially used to …

Prevalence and characterization of Staphylococcus aureus isolates from subclinical bovine mastitis in southern Xinjiang, China.

Staphylococcus aureus is one of the major pathogens causing mastitis in dairy herds. The colonization of dairy cows and subsequent contamina … 0.0, 18.5, 12.3, 10.8, 9.2, 6.2, 4.6, 4.6, and 1.5%, respectively. All isolates were susceptible to cefoxitin, sulfamethoxazole-trimethoprim, and vancomycin. Isolates from farm A showed a significantly higher resistance rate to tetracycline (16.9%) than those from farm B (1.5%). The most frequently detected virulence factors were hla (96.9%, 63/65) and hlb …

[Investigation of Virulence Genes and Carbapenem Resistance Genes in Hypervirulent and Classical Isolates of Klebsiella pneumoniae Isolated from Various Clinical Specimens].

Klebsiella pneumoniae is a global pathogen that can cause hospital-acquired and community-acquired infections and is known for its resistanc … iotic susceptibility between hvKp and cKp isolates; ceftriaxone, cefuroxime, ceftazidime, amikacin, cefoxitin, ertapenem, cefuroxime axetil were found to be more sensitive in hvKp isolates. Ciprofloxacin and trimethoprim sulfamethoxazole were found to be more sensitive in hvKp isolates than cKp isolates, and the difference was statistically significant (p<0 …

Risk factors associated with preoperative fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae in liver transplant recipients.

OBJECTIVE: The aim of the study was to identify risk factors associated with pre-transplant fecal carriage of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in liver transplant recipients. PATIENTS AND METHODS: Over a 3-year period (January 2009-December 2011), 317 patients who underwent liver transplantation were screened preoperatively for fecal carriage of ESBL-producing Enterobacteriaceae. Risk factors for fecal carriage were investigated by univariate analysis and stepwise logistic regression. RESULTS: Of the 317 patients screened, 50 (15.7%) harbored an ESBL-producin

Nasopharyngeal carriage, antimicrobial susceptibility patterns, and associated factors of Gram-positive bacteria among children attending the outpatient department at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.

BACKGROUND: Gram-positive bacteria residing in the nasopharynx can lead to severe illnesses in children, such as otitis media, pneumonia, an … onducted using clindamycin and erythromycin discs to detect inducible clindamycin resistance, while cefoxitin disc tests were utilized to ascertain methicillin resistance. Data entry was executed using Epi-Data version 4.6, and subsequent analysis was performed utilizing SPSS version 25. Bivariable and multivariable logistic regression analyses were employe …

Epidemiological profile and antimicrobial resistance trends of Staphylococcus aureus in Chinese pediatric intensive care units from 2016 to 2022: a multi-center retrospective study.

OBJECTIVE: This study aimed to analyze the profiles and evolution of Staphylococcus aureus in the pediatric intensive care units (PICUs) of … st, to erythromycin was as high as 51.8% at least, to benzocillin was as high as 38.0% at least, to cefoxitin was as high as 35.5% at least, and to clindamycin was as high as 32.7% at least. All the strains of MRSA were sensitive to vancomycin, linezolid, quinupristin/dalfopristin, and tigecycline. Of these 234 strains of MRSA, 179 (76.5%) were resistant to …

Антимикробный спектр деятельности и механизм действий линейных альфа-гелипических Пептидов, вдохновляемых креветочными антилиполисахаридами.

Креветочные антилипополизакхаридные факторы (АФО) образуют многофункциональное и разнообразное семейство противомикробных защитных пептидов (АМП), состоящих из seven Члены (группы А-G), которые различаются по своей первичной структуре и биохимическим свойствам. Это амфипатические пептиды с two Сохраненные остатки цистейна стабилизируют центральный β-волокн, который, как считается, является основным районом их биологической деятельности. В этом исследовании мы синтезировали three Линейные (без цистейна) пептиды, основанные на аминокислотной последовательности центральных β-волокн недавно иденти

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… Notably, Litvan ALF-G 35–54 was active against the clinical methicillin-resistant S. aureus (MRSA) isolates 16003 (resistant to cefoxitin) and 17022 (resistant to cefoxitin, ciprofloxacin, clindamycin, erythromycin, gentamicin, rifampicin, and trimethoprim-sulfamethoxazole). … Remarkably, Litvan ALF-G 35–54 was active against two MRSA isolates: 16003 (resistant to cefoxitin) and 17022 (resistant to cefoxitin, ciprofloxacin, clindamycin, erythromycin, gentamicin, rifampicin, and trimethoprim-sulfamethoxazole). …

A Case Series of Elizabethkingia meningosepticum Bacteremia in the Cancer Population.

Elizabethkingia meningosepticum (E. meningosepticum) is a ubiquitous microorganism previously known as Chryseobacterium meningosepticum. It is emerging as a pathogen responsible for bacteremia in the immunocompromised population, particularly in cancer patients and those with a history of prolonged hospital stay and frequent instrumentations. A retrospective chart review of all cases over 10 years at the Moffitt Cancer Center showed a total of three patients with E. meningosepticum infection. The first patient (history of multiple myeloma) underwent endoscopy complicated by aspiration pneumoni

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… Antibiotics were changed to ciprofloxacin, cefoxitin, minocycline, and metronidazole for broad-spectrum coverage until the susceptible organism was identified. Following the identification of E. meningosepticum , antibiotic coverage was deescalated to align with susceptibility results. … Elizabethkingia meningosepticum in Case 3 R: resistant; I: intermediate; MDIL: minimum dilutional inhibitory level; MINT: minimum inhibitory concentration interpretation Antibiotic | MDIL | MINT Ampicillin | ≥32 | R Ampicillin/Sulbactam | ≥​​​​​​​32 | R Cefazolin | ≥​​​​​​​64 | R Cefepime | 32 | R Cefoxitin …

Bacterial profile and antimicrobial susceptibility patterns in cancer patients.

BACKGROUND: Bloodstream infections have been the leading complications in cancer patients because they are at high risk for antibiotic-resis … tazobactam (72.3%), and ceftazidime (73.5%) were effective against for Gram-negative isolates while cefoxitin (81.2%) and penicillin (70.5%) were effective for Gram-positive isolates. Additionally, most Gram-negative and Gram-positive bacterial isolates were sensitive for gentamycin (75.9%). Multidrug resistance was seen among 17.1% bacterial isolates, and …

Clinical study of extrapulmonary head and neck tuberculosis in an urban setting.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a common inflammatory disorder that strongly impacts patients' quality of life. CRSwNP is still a challenge for ENT specialists due to its unknown pathogenesis, difficult control and frequent relapse. We tested the hypothesis that a new standardised therapeutic approach based on individual clinical-cytological grading (CCG), may improve control of the disease and prevent the needing for surgery. We analysed 204 patients suffering from bilateral CRSwNP, 145 patients of whom regularly assumed therapy, respecting the planned check-up, and were

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… Antibiotic prophylaxis Administration of iv cefoxitin (2 g if body weight > 50 kg; 1 g if body weight < 50 kg) and clindamycin (600 mg) 0-30 minutes before surgery, to be repeated every 3 hours for cefoxitin and every 6 hours for clindamycin. 6. …

[Analysis of epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with perineal and/or hip burns].

Objective: To explore the epidemiological characteristics and risk factors of catheter-associated urinary tract infections in patients with … triaxone, and levofloxacin were higher than 70.0%, the resistance rates of Klebsiella pneumoniae to cefoxitin, cefoperazone/sulbactam, cefepime, meropenem, imipenem, and piperacillin/tazobactam ranged from 56.3% to 68.8%, and the resistance rates of Klebsiella pneumoniae to ceftazidime and tigecycline were lower than 50.0%. The resistance rates of Enterococ …

Investigation of methicillin, beta lactam, carbapenem, and multidrug resistant bacteria from blood cultures of septicemia suspected patients in Northwest Ethiopia.

The presence of microorganisms in the bloodstream can result in severe, potentially life-threatening conditions, which are a significant cau … . Resistance to methicillin, extended-spectrum beta-lactams, and carbapenems was determined via the cefoxitin disc test, combined-disk diffusion method, and modified carbapenem inactivation method, respectively. The data were entered into Epi-Data version 4.6 and analysed via SPSS version 25. Binary logistic regression analyses were employed to identify fac …

[Risk factors and etiological analysis of ventilator-associated pneumonia: three year's cases analysis of intensive care unit in county hospital].

OBJECTIVE: To investigate the risk factors of ventilator-associated pneumonia (VAP) and the distribution and drug resistance of pathogens in … acillin (PIP), piperacillin tazobactam (TZP) and TOB. Acinetobacter baumannii was 100% sensitive to cefoxitin (FOX), cefuroxime (CXM) and POT. Staphylococcus aureus was 100% sensitive to gentamicin (GEN), furantoin (NIT), rifampicin (RIF), vancomycin (VAN) and teicoplanin (TEC), while the drug resistance to clindamycin (CLI) and penicillin (PEN) was high (b …

[Analysis of the pathogenic characteristics of 162 severely burned patients with bloodstream infection].

OBJECTIVE: To analyze the distribution and drug resistance of pathogen isolated from severely burned patients with bloodstream infection, so … while its drug resistance rates to amoxicillin/clavulanic acid, piperacillin/tazobactam, cefepime, cefoxitin, amikacin, levofloxacin were 35.3%-47.1%, and those to the other antibiotics were 50.0%-100.0%. (3) Drug resistance rates of methicillin-resistant Staphylococcus aureus (MRSA) to most of the antibiotics were higher than those of the methicillin-sens …

Сепсис, вызванный Clostridium Perfringens у женщины пожилого возраста, больной раком груди: доклад по делу.

ЦЕЛЬ: Сообщить о редком случае заболевания раком груди, у которого септический шок и множественные повреждения органов. В нем анализируются клинические характеристики, патогенные факторы и прогноз, связанные с смешанной инфекцией, вызванной Clostridium perfringens и Escherichia coli, в целях обеспечения основы для раннего выявления и вмешательства аналогичных клинических случаев. МЕТОДЫ: Был проведен ретроспективный анализ клинических данных 75-year-old Женщина, больная раком груди, которая также страдала гипертонией и диабетом. Были резюмированы клинические проявления, результаты этиологическ

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… Clostridium Perfringens by E-Test Method Antifungal Drugs MIC (μg/mL) Result MEM 0.012 S PEN 0.064 S CRO 0.5 S MFX 0.125 S TZP 0.125 S CXT 1 S AMC 0.064 S AMP 0.064 S MNZ 32 R CLI 8 R Abbreviations : MEM, Meropenem; PEN, Penicillin; CRO, Ceftriaxone; MFX, Moxifloxacin; TZP, Piperacillin/Tazobactam; CXT, Cefoxitin … Table 3 Results of Antifungal Sensitivity Test of Clostridium Perfringens by E-Test Method Abbreviations : MEM, Meropenem; PEN, Penicillin; CRO, Ceftriaxone; MFX, Moxifloxacin; TZP, Piperacillin/Tazobactam; CXT, Cefoxitin; AMC, Amoxicillin Clavulanate; AMP, Ampicillin; MNZ, Metronidazole; CLI, Clidamycin …

Клиническое представление лептоспироза: ретроспективное исследование 34 Пациенты поступили в одно учебное заведение во Франции.

Лептоспироз имеет весьма изменчивое клиническое представление, которое может быть связано с различными заражающими сероварами, факторами хост-компьютеров или их комбинацией. Это исследование проводилось ретроспективно 34 Число пациентов с серологическим подтвержденным лептоспирозом, принятых в течение отчетного периода 1992-2002. Наиболее частыми симптомами при поступлении в школу были лихорадка (см.100%), головная боль75%), миальгии55%), артхальгии45%) и рвотой (т.е.39%). Применяемые лабораторные исследования включали в себя лимфопенцию (см.85%), тромбоцитопенсия75%), повышенные ферменты пече

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… On the other hand, there were no significant differences between PU and PSU for cefoxitin (96% each), amoxicillin/clavulanate (84 vs 73%), nitrofurantoin (96 vs 92%) and ciprofloxacin (CIP, 100 vs 96%). … AmpC hyperproduction phenotype was defined as co-resistance to ampicillin, cephalotin, cefoxitin, and amoxicillin-clavulanic acid, in the absence (NCCLS guidelines) of extended spectrum beta-lactamase expression. …