Результаты поиска

Monkeypox during COVID-19 era in Africa: Current challenges and recommendations.

In May 2022, monkeypox virus (MPXV) outbreak was confirmed amid the coronavirus disease 2019 (COVID-19) pandemic in many parts of the world including Africa. This is the largest outbreak since monkeypox (MPX) was first detected in humans in 1970. The MPX outbreak in Africa is an added burden to the fragile healthcare systems that are already overburdened with several reoccurring epidemics. Although several efforts are in place to effectively contained the outbreak. Several measures such as improved surveillance and diagnostic are necessary to contain the spread of the disease in Africa. This c…

Monkeypox Mysteries of the New Outbreak in Non-Endemic Areas.

Monkeypox virus (MPXV) was declared by the World Health Organization (WHO) in mid-2022 to be a public health emergency of international concern, following its spread around the world after circulating in Western and Central Africa. This new outbreak is concentrated in men who have sex with men (MSM). Moreover, beyond the epidemiological change, compared with endemic countries, differences in clinical features and many other aspects have also been detected. These and other characteristics are unusual and still unclear. Based on the available data, the authors try to help to clarify some of the …

Ectromelia virus: the causative agent of mousepox.

Ectromelia virus (ECTV) is an orthopoxvirus whose natural host is the mouse; it is related closely to Variola virus, the causative agent of smallpox, and Monkeypox virus, the cause of an emerging zoonosis. The recent sequencing of its genome, along with an effective animal model, makes ECTV an attractive model for the study of poxvirus pathogenesis, antiviral and vaccine testing and viral immune and inflammatory responses. This review discusses the pathogenesis of mousepox, modulation of the immune response by the virus and the cytokine and cellular components of the skin and systemic immune s…

The Generation and Characterization of Monoclonal Antibodies against the MPXV A29L Protein.

Mpox (formerly known as monkeypox) is a zoonotic disease caused by monkeypox virus (MPXV), a DNA virus belonging to the Orthopoxvirus genus, in the Poxviridae family. The disease constitutes a moderate risk to public health at the global level. The MPXV A29L protein plays a crucial role in coordinating virion assembly and facilitating important virus-host interactions. This study focused on the expression, purification, and recombinant protein synthesis of the A29L protein of MPXV using prokaryotic systems. Using hybridoma technology, we successfully generated the monoclonal antibodies (mAbs) …

Подозреваемый случай заражения неонатальной обезьянопоксой при участии окулиста.

Mpox (первоначально известный как обезьянопоксский вирус Clade IIb) разрушил не эндемический мир в 2022 году с дерматологическими и системными проявлениями. Быстрое распространение этого вируса пролило свет на дефицит информации о вирусе, о котором впервые сообщалось в 1958 году. Мы представляем первый, вероятно, неонатальный случай mpox с окулярным участием. Офтальмологи могут быть первыми, кто диагностирует мпокс или входит в состав междисциплинарной группы, необходимой для надлежащей работы и лечения, с тем чтобы предотвратить последствия для неонатального населения на протяжении всей жизни

Совпадение в аннотации оригинала
Mpox (initially reported as monkeypox virus Clade IIb) ravaged the non-endemic world in 2022 with dermatological and systemic manifestations. The rapid propagation of this virus shed light on the scarcity of information for a virus that was first reported in 1958. We present the first probable neonatal case of mpox with ocular involvement. Ophthalmologists m…

Оценка диагностических результатов коммерческого молекулярного анализа для выявления предполагаемых случаев обезьянопокс в Шри-Ланке.

Основная цель настоящего исследования состояла в том, чтобы сопоставить диагностические характеристики коммерческого вируса Modlar Modkeypox (MPXV) qPCR (TIB Molbiol, Германия) с результатами анализа невариольского ортопокса/монкейпокса в режиме реального времени (ICMR-NIV, Pune) для выявления случаев заболевания (MPXV) в Институте медицинских исследований (MRI) в Шри-Ланке. Кроме того, были проанализированы клинические и социально-демографические данные о предполагаемых/подтвержденных случаях, полученные в МРТ для проверки MPXV.МЕТОДЫ: Диагностические характеристики коммерческого MIx Modular

Совпадение в аннотации оригинала
BACKGROUND: The main objective of the present study was to compare the diagnostic performance of the commercial LightMix Modular Monkeypox Virus (MPXV) qPCR (TIB Molbiol, Germany) assay with the in-house nonvariola orthopox/monkeypox generic real-time PCR assay (ICMR-NIV, Pune) for the screening of (MPXV) cases at Medical Research Institute (MRI) in Sri Lank…

Risk assessment of human monkeypox infections: A systematic review and meta-analysis.

BACKGROUND: Human monkeypox is a zoonotic disease with increasing global prevalence. Although several studies have identified its potential risk factors, findings remain inconsistent, highlighting the need for a systematic evaluation. OBJECTIVES: To systematically investigate risk factors associated with human monkeypox infections using meta-analysis. MATERIAL AND METHODS: A comprehensive search of PubMed, Scopus, Web of Science, Embase, and The Cochrane Library databases was conducted on all records up to February 19, 2024. Eligible studies assessing risk factors for monkeypox were included

Capsule network approach for monkeypox (CAPSMON) detection and subclassification in medical imaging system.

In response to the pressing need for the detection of Monkeypox caused by the Monkeypox virus (MPXV), this study introduces the Enhanced Spatial-Awareness Capsule Network (ESACN), a Capsule Network architecture designed for the precise multi-class classification of dermatological images. Addressing the shortcomings of traditional Machine Learning and Deep Learning models, our ESACN model utilizes the dynamic routing and spatial hierarchy capabilities of CapsNets to differentiate complex patterns such as those seen in monkeypox, chickenpox, measles, and normal skin presentations. CapsNets' inhe…

Monkeypox (Mpox) requires continued surveillance, vaccines, therapeutics and mitigating strategies.

The widespread outbreak of the monkeypox virus (MPXV) recognized in 2022 poses new challenges for public healthcare systems worldwide. With more than 86,000 people infected, there is concern that MPXV may become endemic outside of its original geographical area leading to repeated human spillover infections or continue to be spread person-to-person. Fortunately, classical public health measures (e.g., isolation, contact tracing and quarantine) and vaccination have blunted the spread of the virus, but cases are continuing to be reported in 28 countries in March 2023. We describe here the vaccin…

Monkeypox Outbreak 2023 in Chengdu, China: an Observational Study.

Monkeypox is a zoonotic viral disease caused by monkeypox virus infection, which is endemic to Africa. Since May 2022, the disease has rapidly spread worldwide, and imported cases have been sporadically confirmed in China. Given these circumstances, data on confirmed cases were collected consecutively in Chengdu, Southwest China, to investigate their clinical and epidemiological characteristics. In this study, 28 male patients were confirmed to have monkeypox infection, with 26 men who had sex with men. Typical lesions included papules, pustular papules, vesicles, scabs, and ulcers. The most c…

Discovering conserved epitopes of Monkeypox: Novel immunoinformatic and machine learning approaches.

The Monkeypox virus, an Orthopoxvirus with zoonotic origins, has been responsible for a growing number of human infections reminiscent of smallpox since May 2022, as reported by the World Health Organization. As of now, there are no established medical treatments for managing Monkeypox infections. In this study, we used machine learning to select conserved epitopes. Proteins were determined using Reverse Vaccinology and Gene Ontology subcellular localization, and their epitopes were predicted. NextClade was used to calculate the number of mutations in each amino acid position using 2433 Monkey…

The Global Human Monkeypox Outbreak and Management: A Comprehensive Literature Review.

Monkeypox (MPX) belongs to the genus Orthopoxvirus (OPV), family Poxviridae, and sub-family Chordopoxvirinae. Human monkeypox (HMPX) is a viral zoonotic illness caused by the monkeypox virus (MPXV). Several non-endemic countries have confirmed MPX cases across the globe. Therefore, consider an outbreak to be a global health emergency. MPXV transmits from animals to humans via infected animals, and there is currently human-to-human transmission, notably among guys who have sexual relations with males. Healthcare interventions are required to stop outbreaks. These include strict isolation and ca…

A method for serological differentation of closely related poxviruses.

A two-step gel precipitation reaction with antiserum to vaccinia virus, based on sequential addition of two test viruses was elaborated for differentiation of closely related orthopoxviruses. The appearance of an additional precipitation line indicated differences in the antigenic structure of the viruses compared. Differences in the antigenic structure of vaccinia, variola and monkey pox viruses as well as the antigenic identity with cow pox virus of poxviruses isolated from carnivora, elephants and okapi were established.

Monkeypox: a review of the 2022 outbreak.

INTRODUCTION: In May 2022, the World Health Organisation declared a multi-country monkeypox outbreak in non-endemic countries following cases reported from 12 member states that were not endemic for monkeypox virus. SOURCES OF DATA: Pubmed search. AREAS OF AGREEMENT: The virology, epidemiology, transmission, incubation and aspects of infection control are described. Clinical features of previous and current outbreaks are described, with growing observations that the current outbreak presents with clinical features distinct from previous outbreaks. AREAS OF CONTROVERSY: There are variations …

How can imported monkeypox break the borders? A rapid systematic review.

BACKGROUND: Monkeypox was designated as an emerging illness in 2018 by the World Health Organization Research and Development Blueprint, necessitating expedited research, development, and public health action. In this review, we aim to shed the light on the imported cases of monkeypox in attempt to prevent the further spread of the disease. Methodology An electronic search in the relevant database (Web of Science, PubMed Medline, PubMed Central, Google scholar, and Embase) was conducted to identify eligible articles. In addition to searching the grey literature, manual searching was carried ou

A Prolonged Case of Severe Mpox as an Opportunistic Infection in Advanced AIDS.

The case report discusses a 29-year-old male with advanced HIV who experienced one of the longest, confirmed cases of monkeypox (mpox) infec … ailure. Despite repeated treatments, including brincidofovir, the patient remained PCR-positive for monkeypox virus (MPXV) with low cycle threshold (Ct) values, indicating active infection. The case underscores the severity of mpox in immunocompromised individuals, particularly those with advanced HIV, and highlights the challenges in managing such cases. The pat …