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Safety and efficacy of rituximab in refractory noninfectious uveitis and scleritis.

PURPOSE: To investigate the safety and efficacy of rituximab in patients with refractory noninfectious uveitis and scleritis. METHODS: A retrospective review of 24 patients (47 eyes) treated with rituximab for refractory noninfectious uveitis and scleritis in the period between January 2018 and December 2024. The diagnosis of these patients included chronic recurrent uveitis associated with Vogt-Koyanagi-Harada disease (n = 16), idiopathic granulomatous uveitis (n = 3), multiple sclerosis-associated uveitis (n = 2), progressive subretinal fibrosis (n = 1) and scleritis (n = 2). The primary ou…

Оценка функционального состояния пациентов с множественным склерозом на основе потенциала воспаления их рациона питания.

Множественный склероз (MS) является хроническим, подстрекательским и демиелинизирующим заболеванием центральной нервной системы, которое в основном затрагивает молодых людей, особенно женщин, и связано с постепенной инвалидностью и широким спектром симптомов, подрывающих функциональность и качество жизни. Недавние исследования показывают, что питание, особенно его подстрекательский потенциал, может повлиять на клинический ход болезни. Мы предполагаем, что пациенты, потребляющие провоспалительное питание, будут иметь более низкие функциональные результаты, чем пациенты, страдающие от воспаления

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system that predominantly affects young adults, particularly women, and is associated with progressive disability and a wide range of symptoms that impair functionality and quality of life. Recent research suggests that diet, especially its inflam…

Паллиативная потребность в уходе и качество жизни, вызванное психологическими расстройствами, связанными с нейронологическими заболеваниями.

КОНТЕКСТ: Пациенты с прогрессивными неврологическими заболеваниями (ПНД) сталкиваются с продолжительным и изменяющимся ходом болезни, характеризующимся растущей инвалидностью и целым рядом немоторных симптомов. Однако последствия немоторных симптомов и неудовлетворенных потребностей в уходе остаются недостаточно изученными. Паллиативные потребности в уходе возникают в связи с многогранными страданиями, связанными с PND, которые охватывают не только физическую боль, но и психологические, социальные и духовные страдания. Несмотря на рекомендации о раннем паллиативном уходе за НДП в целях преодол

Совпадение в аннотации оригинала
CONTEXT: Patients with progressive neurologic diseases (PNDs) face a prolonged and fluctuating course of illness marked by increasing disabi … life among patients with PNDs. METHODS: A total of 210 patients with PNDs (Parkinson's disease or multiple sclerosis) were recruited using convenience sampling from regional neurology outpatient clinics and patient support groups in Hong Kong. Participants responded to Palliative Care Outcome Scale (POS), Hospital Anxiety and Depression Scale (HADS), and EQ-5D-5L …

Safety and efficacy of extended versus standard interval dosing of natalizumab in multiple sclerosis patients: a systematic review and meta-analysis.

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory, immune-mediated disease affecting the central nervous system. Natalizumab, an FDA-approved monoclonal antibody for MS, has been explored for its off-label extended interval dosing (EID), suggesting a potential reduction in the risk of progressive multifocal leukoencephalopathy (PML) compared to standard interval dosing (SID). Our objective was to assess the efficacy and safety of EID in comparison to SID for natalizumab treatment in patients with MS. METHODS: We searched PubMed, Embase, WOS, Scopus, Ovid, Science Direct, Clinical …

Fibrotic Response in Pericite Cultural после воздействия склерозовой серы.

ВВЕДЕНИЕ: Множественный склероз (МС) представляет собой хроническое аутоиммунное и демиелинизирующее заболевание центральной нервной системы (ЦНС), приводящее к постепенной потере функции. Помимо инфильтрации периферийных иммунных клеток в CNS после нейроинфламмации, аккумуляция внеклеточной матрицы (ECM) элементов, генерируемых клетками мозгового барьера, в расширенных перивашкулярных пространствах способствует патофизиологии. В этом исследовании мы стремились разработать внутреннюю модель MS для исследования фиброза, вызванного серой или цереброспиновой жидкостью (CSF) пациентов MS, и оценит

Совпадение в аннотации оригинала
INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune and demyelinating disease of central nervous system (CNS) leading to progressive function loss. Besides infiltration of peripheral immune cells into CNS subsequent to neuroinflammation, the accumulation of extracellular matrix (ECM) elements, produced by brain barrier cells, in the enlarged periva…

Management and long-term outcomes of patients with chronic inflammatory diseases experiencing ST-segment elevation myocardial infarction: The SCALIM registry.

BACKGROUND: Patients with chronic inflammatory diseases (CIDs) are at increased risk of cardiovascular events. However, the prognostic impac … ce of CID (including inflammatory bowel diseases, rheumatic conditions, inflammatory skin diseases, multiple sclerosis, vasculitis and autoimmune diseases) was identified. The primary outcome was all-cause death. Secondary outcomes were cardiovascular death, myocardial infarction, ischaemic stroke, peripheral vascular events and rehospitalization for cardiovascular …

Rituximab for the treatment of multiple sclerosis: a review.

In the last decades, evidence suggesting the direct or indirect involvement of B cells on multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on the efficacy and safety of B-cell-depleting therapies from several studies has suggested the addition of these drugs as treatment options to the current armamentarium of disease modifying therapies (DMTs) for MS. Particularly, rituximab (RTX), a chimeric monoclonal antibody directed at CD20 positive B lymphocytes resulting in cell-mediated apoptosis, has been demonstrated to reduce inflammatory activity, incidence of rel…

Headaches in multiple sclerosis patients might imply an inflammatorial process.

Recent studies on Multiple Sclerosis (MS) pathology mention the involvement of "tertiary B cell follicles" in MS pathogenesis. This inflammatory process, which occurs with interindividually great variance, might be a link between MS pathology and headaches. The aim of this study was to detect the prevalence of headaches and of subtypes of headaches (migraine, cluster, tension-type headache [TTH]) in an unselected MS collective and to compile possibly influencing factors. Unselected MS patients (n = 180) with and without headache were examined by a semi-structured interview using a questionnair…

Alemtuzumab therapy for multiple sclerosis.

Alemtuzumab is a humanized monoclonal antibody that is administered daily for 5 days, and then no further therapy is required for 12 months. It causes rapid and prolonged lymphocyte depletion; the consequent homeostatic reconstitution leads to a radically reformed lymphocyte pool with a relative increase in regulatory T cells and expansion of autoreactive T cells. Although previously licensed for the treatment of B-cell chronic lymphocytic leukemia, it is now been considered for licensing in the treatment of multiple sclerosis (MS). From a disappointing experience with alemtuzumab in progressi…

Pre-existing T- and B-cell defects in one progressive multifocal leukoencephalopathy patient.

Progressive multifocal leukoencephalopathy (PML) usually occurs in patients with severe immunosuppression, hematological malignancies, chronic inflammatory conditions or receiving organ transplant. Recently, PML has also been observed in patients treated with monoclonal antibodies. By taking advantage of the availability of samples from a multiple sclerosis (MS) patient treated with natalizumab, the antibody anti-α4 integrin, who developed PML and was monitored starting before therapy initiation, we investigated the fate of T and B lymphocytes in the onset of PML. Real-time PCR was used to mea…

[MULTIPLE SCLEROSIS THERAPY - 2019].

Multiple sclerosis (MS) is a chronic inflammatory-demyelinating and neurodegenerative disease of the central nervous system (CNS) of a putative autoimmune origin. The disease is characterized pathologically by scattered areas of peri-vascular mononuclear cell infiltrates, demyelination with various degrees of remyelination, axonal loss and gliosis that form multiple plaques throughout the brain and spinal cord, and clinically by a variety of neurological signs and symptoms disseminated in time and space. A better understanding of the immune pathogenesis of MS has led to the development of a va…

Quantification of Leukocyte Trafficking in a Mouse Model of Multiple Sclerosis through In Vivo Imaging.

PURPOSE: Optic neuritis occurring in multiple sclerosis (MS) is a disease characterized by chronic inflammation and demyelination in the optic nerve. Although it has been well appreciated that leukocyte infiltration into the optic nerve is an early event during the course of the disease, there has been no study on visualizing and quantifying leukocyte trafficking in the retina during the progression of MS. METHODS: In this study, we generated green fluorescent protein (GFP)+ bone marrow chimeric mice, in which GFP-labeled leukocytes facilitate the visualization of their trafficking in the ret…

Septin multimer autoantibodies in severe motor neuropathy mimicking lower motor neuron disease.

Severe neuropathies with predominant involvement of motor fibres can resemble lower motor neuron disease (LMND) phenotypes. Given the fatal … neuropathy n = 30, other inflammatory neuropathies n = 10), amyotrophic lateral sclerosis (n = 50), multiple sclerosis (n = 50) and healthy controls (n = 50) was negative for septin multimer autoantibodies. Histopathological analysis of skin and the sural nerve including electron microscopy was performed in one seropositive patient, and autoantibody binding was char …

Неврологические последствия гипергликемии: сообщение о редком представлении о синдроме осмотической демиелинации.

Синдром осмотического обезвоживания (ОРД) представляет собой редкое, но потенциально опасное для жизни неврологическое расстройство. Она характеризуется невоспалительным обезвоживанием, которое, как правило, вызвано внезапными сменами сыворотки. Однако появляющиеся данные свидетельствуют о том, что резкие осмотические изменения, вызванные сильной гипергликемией, даже при отсутствии натриевого дисбаланса, могут также приводить к образованию ОРВ. ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: А 57-year-old мужского пола с плохо управляемым типом 2 Больной диабет и хроническое употребление алкоголя сопровождаются период

Совпадение в аннотации оригинала
BACKGROUND: : Osmotic demyelination syndrome (ODS) is a rare but potentially life-threatening neurological disorder. It is characterized by … OSIS: : Radiological differentials considered included acute disseminated encephalomyelitis (ADEM), multiple sclerosis (MS), ischemic infarction, vasculitis, and brainstem glioma. However, the symmetric pontine involvement without enhancement or mass effect, along with the clinical context of hyperosmolar hyperglycemia, favored a diagnosis of ODS. MANAGEMENT AND OU …

Predicting Quality of Life in Relapsing-Remitting Multiple Sclerosis: Clinical Burden Meets Emotional Balance in Early Disease.

BACKGROUND/OBJECTIVES: Relapsing-remitting multiple sclerosis (RRMS) is a chronic neurological disease that significantly impacts health-related quality of life (HRQoL). This study aimed to analyze the evolution of HRQoL in individuals with RRMS, identify associated factors, and determine predictive variables. METHODS: A prospective observational study was conducted with 35 participants diagnosed with RRMS at the Lucus Augusti University Hospital between January 2023 and March 2025. HRQoL was assessed using the MSQOL-54 questionnaire at baseline, 3 months, and 6 months. Data were analyzed usi…

Последствия тренировок для некоторых цитокиновых профилей пациентов с множественным склерозом: систематический обзор и метаанализ выборочных контролируемых испытаний.

Множественный склероз (MS) является хроническим, постепенным аутоиммунным расстройством центральной нервной системы, где воспаление играет ключевую роль в ее патофизиологии. В качестве эффективной нефармакологической стратегии управления НР была предложена учебная подготовка. Однако из-за непоследовательных выводов, сделанных в ходе предыдущих исследований, этот систематический обзор и метаанализ были направлены на всеобъемлющую оценку воздействия долгосрочных упражнений на цитокиновый профиль у пациентов с НР. МЕТОДЫ: До 27 июня 2025 года были проведены обыски шести электронных баз данных (Pu

Совпадение в аннотации оригинала
BACKGROUND: Multiple Sclerosis (MS) is a chronic, progressive autoimmune disorder of the central nervous system, where inflammation plays a pivotal role in its pathophysiology. Exercise training has been proposed as an effective non-pharmacological strategy for managing MS. However, due to inconsistent findings in previous studies, this systematic review and…

Efficacy and safety of pulsed electromagnetic field therapy for fatigue in patients with multiple sclerosis: A systematic review and meta-analysis.

INTRODUCTION: Multiple sclerosis (MS) is a chronic, progressive neurological disorder characterized by inflammation, demyelination, and neurodegeneration of the central nervous system. Globally, it affects approximately 2.8 million people, often leading to significant disability and impaired quality of life. Fatigue is among the most common and debilitating symptoms of MS, profoundly impacting daily functioning. Pulsed Electromagnetic Field (PEMF) therapy has recently gained attention as a promising non-invasive intervention. This study aimed to synthesize evidence from randomized controlled t…

Olig2+ single-colony-derived cranial bone-marrow mesenchymal stem cells achieve improved regeneration in a cuprizone-induced demyelination mouse model.

Oligodendrocytes are the myelinating cells of the central nervous system. Brain injury and neurodegenerative disease often lead to oligodendrocyte death and subsequent demyelination-related pathological changes, resulting in neurological defects and cognitive impairment (Spaas et al., 2021; Zhang J et al., 2022). Multiple sclerosis (MS) is a major demyelinating disease of the central nervous system. The pathology of MS is characterized by the loss of myelin, oligodendrocytes, and axons in the brain, brain stem, and spinal cord, as well as by white matter lesions (Lassmann et al., 2007). Unfort…

The Early Initiation Advantages of Physical Therapy in Multiple Sclerosis-A Pilot Study.

(1) Background: Multiple sclerosis (MS), a chronic progressive neurological disorder which affects the central nervous system (CNS), can result in disorders of all the functions controlled by the CNS: motor, sensory, cognitive and emotional. Physical therapy (PT), conducted through proprioceptive neuromuscular facilitation (PNF) techniques, can be customized to the individual patient's needs and has the potential to improve the patient's evolution. This study aims to establish if PT based on PNF techniques has a beneficial role in MS treatment. (2) Methods: We performed a prospective study on …

The association between multiple sclerosis and migraine: A meta-analysis.

BACKGROUND: Multiple sclerosis (MS) is a chronic progressive condition marked by the deterioration of myelin and impairment of neurological function. The global prevalence of MS is approximately 2.2 million. Migraines are common in MS patients, with inconclusive data on their relationship. Our systematic review aimed to assess the prevalence and odds of migraine in pwMS and investigate the potential factors that may influence these associations. METHOD: Through an extensive search and meticulous study selection, we identified pertinent literature investigating the occurrence and odds of migra…