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Oral Corticosteroid Therapy in Lumbar Radiculopathy: Evidence From Randomized Controlled Trials.

Oral corticosteroids are frequently prescribed for lumbar radicular pain, despite uncertainty regarding their clinical benefit. Electronic d … tion. An active-comparator trial reported lower pain scores with oral corticosteroids compared with pregabalin or gabapentin, although interpretation was limited by methodological concerns. Quality-of-life outcomes were inconsistent, rates of surgery did not differ between groups, and oral corticosteroids were associated with more frequent short-term adverse …

Comparative Efficacy of Pulsed Radiofrequency-Based and Related Interventions for Postherpetic Neuralgia: A Network Meta-Analysis of Randomized Controlled Trials.

OBJECTIVE: This study aimed to assess the effectiveness of 12 interventions for postherpetic neuralgia (PHN) through direct and indirect com … 92.9%), Mental Health (MH, SUCRA: 100.0%), vitality (VT, SUCRA: 100.0%) scale scores, and reducing pregabalin dosage (SUCRA: 90.5%, MD=-387.08, 95% CI=-540.05,-234.10). CONCLUSION: SCS is the optimal intervention for pain relief in PHN, while PRF+drug effectively improves quality of life and reduces medication burden. These findings provide evidence-based …

A Toothache That Was a Stroke: Acute Right Parietal Infarction Presenting As Isolated Left-Sided Odontogenic-Like Pain.

Pain as a presenting symptom of acute ischemic stroke is uncommon and may delay diagnosis when typical focal neurological deficits are absen … cortical ischemic lesion. The patient was treated with aspirin for secondary stroke prevention, and pregabalin was prescribed for the symptomatic management of presumed central neuropathic pain. The odontogenic-like pain improved substantially during follow-up. This case demonstrates that acute parietal ischemic stroke may present as isolated contralateral t …

Менделианская случайность не охватывает потенциальные лекарственные средства, которые могут быть восстановлены при нейропсихических расстройствах.

СТРУКТУРА: Растущая распространенность нейропсихиатрических расстройств становится серьезной проблемой в области здравоохранения. Традиционные фармакотерапии сталкиваются с ограничениями, в результате чего лекарственные средства становятся ценной стратегией. Вместе с тем для этих условий используются весьма ограниченные подходы к отбору данных с высокой производительностью. МЕТОДЫ: В этом исследовании используются данные о воздействии, полученные из лаборатории Biobank Neal (N = 361,141) и конечных данных из базы данных FinnGen (N = приблизительно 410,000) использовать результаты анализа менде

Совпадение в аннотации оригинала
BACKGROUND: The growing prevalence of neuropsychiatric disorders is becoming a major health challenge. Traditional pharmacotherapies face li … even medications with negative causal associations with neuropsychiatric disorders were identified. Pregabalin, bumetanide, and prednisolone were associated with reduced anxiety (beta = -7.28, p = 4.00e-03; beta = -2.24, p = 6.00e-03; beta = -1.74, p = 2.84e-03). Vitamin B1 preparations showed an inverse association with dementia (beta = -2.47, p = 1.51e-03) …

Update on Treating Painful Diabetic Peripheral Neuropathy: A Review of Current US Guidelines with a Focus on the Most Recently Approved Management Options.

Painful diabetic peripheral neuropathy (DPN) is a highly prevalent and disabling complication of diabetes that is often misdiagnosed and undertreated. The management of painful DPN involves treating its underlying cause via lifestyle modifications and intensive glucose control, targeting its pathogenesis, and providing symptomatic pain relief, thereby improving patient function and health-related quality of life. Four pharmacologic options are currently approved by the US Food and Drug Administration (FDA) to treat painful DPN. These include three oral medications (duloxetine, pregabalin, and …

Priapism associated with anti-seizure medications: a pharmacovigilance study and a review of published cases.

BACKGROUND: Recently, case reports of priapism associated with the use of some anti-seizure medications began to emerge in the literature. W … lished cases of priapism associated with these drugs. We also found published cases of priapism for pregabalin and phenytoin in the literature and FAERS, and at least one reported adverse event of priapism in FAERS for clonazepam, lacosamide, ethosuximide, oxcarbazepine, and vigabatrin in which they were considered primary suspect. CONCLUSIONS: Our study id …

Trigeminal root demyelination is sufficient to induce trigeminal neuralgia-like facial pain in adult rodents.

BACKGROUND: Current etiology-centered management guidelines have not brought about satisfactory outcomes for trigeminal neuralgia patients. … e and motivational behavioral proxies to assess facial pain. More importantly, carbamazepine versus pregabalin treatment and chemical silencing of primary nociceptive afferents were used to ascertain the resemblance of facial pain in rodent models to trigeminal neuralgia in patients. RESULTS: Chemically or viral genetically induced demyelination in trigemin …

Nortriptyline for neuropathic pain in adults.

BACKGROUND: Antidepressants are widely used to treat chronic neuropathic pain (pain due to nerve damage), usually in doses below those at wh … nt. Effective medicines with much greater supportive evidence are available, such as duloxetine and pregabalin.

Evaluation of mixture modeling with count data using NONMEM.

Mixture modeling within the context of pharmacokinetic (PK)/pharmacodynamic (PD) mixed effects modeling is a useful tool to explore a popula … dosing design for the simulation was based on a trial with the investigational anti-epileptic drug pregabalin. Four hundred and forty seven subjects received pregabalin as add on therapy for partial seizures, each with a baseline seizure count and up to three subsequent seizure counts. For the mixtures, the two subpopulations were simulated to differ in the …

Bilateral nervus intermedius neuralgia with neurovascular contact: a case report highlighting hypertension and eczema as potential precipitating factors.

BACKGROUND: Nervus intermedius neuralgia (NIN) is a rare craniofacial pain syndrome. Bilateral involvement is extremely uncommon, and the pa … s of bilateral NIN was established according to ICHD-3 criteria. The patient responded favorably to pregabalin combined with strict blood pressure control. At three-month follow-up, her stabbing pain had essentially resolved (VAS: 0-1/10). CONCLUSION: This first case of bilateral NIN with radiologically confirmed bilateral neurovascular contact supports neu …

Comparative analysis of percutaneous endoscopic lumbar discectomy and microdiscectomy: Outcomes in lumbar disc herniation treatment with post-operative use of analgesics and NSAIDs.

BACKGROUND: Percutaneous endoscopic lumbar discectomy (PELD) and microdiscectomy (MD) are both minimally invasive for lumbar disc herniation … e or the incidence of postoperative complications between the two groups (all P>0.05). CONCLUSION: Pregabalin and celecoxib administered after PELD/MD were effective and safe for LDH patients. PELD achieved better short-term outcomes, with no significant difference during 1-year follow-up.

Hyperacusis-inducing drug candidates.

Hyperacusis is a troubling loudness hypersensitivity disorder occasionally involving pain around ear and face. The neural origins of hyperac … cs, (8) corticosteroid/glucocorticoid (e.g., prednisolone), (9) anticonvulsant-GABA analogue (e.g., pregabalin) and (10) anticonvulsants (e.g., topiramate). Approximately 70% of hyperacusis cases were females, possibly due to a reporting bias. The most prevalent comorbidities were headache, photophobia, nausea, fatigue, dizziness, anxiety, insomnia, tinnitus …

Spinal α2δ-1 induces GluA3 degradation to regulate assembly of calcium-permeable AMPA receptors and pain hypersensitivity.

The increased prevalence of GluA2-lacking, Ca2+-permeable AMPA receptors (CP-AMPARs) at spinal cord sensory synapses amplifies nociceptive t … - but not α2δ-2 or α2δ-3 - diminished GluA3 AMPAR currents and protein levels, an effect blocked by pregabalin, an α2δ-1 C-terminus peptide, or proteasome inhibition. Both nerve injury and α2δ-1 overexpression reduced protein levels of GluA3 and GluA2/GluA3 heteromers in the spinal cord. Furthermore, α2δ-1 coexpression or nerve injury increased GluA3 ubiquit …

Drugs and Nutrients in Epilepsy: Vitamin B6 and the Ketogenic Diet.

Certain foods and specific drugs have been linked to epilepsy in the literature. Here, we query PubMed citations for the co-occurrence of epilepsy with foods and drugs, using a list of 217,776 molecules from the HMDB. Notably, the top associations with epilepsy include approved drugs and drug families, diagnostic markers, inducers, and vitamins. Drugs include fosphenytoin (40%), topiramate (37%), valproic acid (34%), hydantoin (20%), phenytoin (31%), carbamazepine (33%), carbamazepine-10,11-epoxide (40%), trimethadione (31%), gabapentin (14%), pregabalin (11%), flunarizine (7%), fenfluramine (…

Pharmacologic pitfalls in heart failure: A guide to drugs that may cause or exacerbate heart failure. A European Journal of Heart Failure expert consensus document.

Heart failure (HF) exerts a global health burden, often complicated by polypharmacy due to the frequent coexistence of cardiovascular and no … rs, centrally acting sympatholytics), neurological and psychiatric medications (e.g. carbamazepine, pregabalin, lithium), and selected anaesthetic and anticancer agents such as anthracyclines and vascular endothelial growth factor inhibitors. Each section addresses clinical scenarios where these medications may be contraindicated or require close monitoring. …

In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments.

Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, non-restorative sleep, and cognitive impairmen … ic management remains multidisciplinary, combining pharmacological interventions (e.g., duloxetine, pregabalin, milnacipran) with non-pharmacological strategies such as graded aerobic exercise and cognitive behavioral therapy. Emerging approaches include drug repurposing to target neuroinflammation, mitochondrial dysfunction, and nociceptive pathways. Despit …

Rare case of schwannomatosis presenting with cauda equina syndrome: a case report.

BACKGROUND: Schwannomatosis is a rare disorder characterized by multiple schwannomas without vestibular schwannomas or other features of neu … yndrome symptoms. Symptomatic cutaneous schwannomas were excised. Neuropathic pain was managed with pregabalin and NSAIDs. At 6-month follow-up, she showed improved lower limb strength, resolution of incontinence, and no significant tumor regrowth. CONCLUSION: This case highlights schwannomatosis presenting with cauda equina syndrome, emphasizing the import …

Neurogenic Rosacea Treatment: A Literature Review.

Rosacea is a chronic skin disorder involving central facial erythema secondary to vascular instability and cutaneous inflammation. Rosacea i … ons including vascular (eg, beta blockers), psychiatric (eg, diazepam, duloxetine), neurologic (eg, pregabalin, sumatriptan), and antibiotic agents (eg, rifaximin), were often cited to have better outcomes, but this finding was highly variable between patients. There were isolated reports of effective management with onabotulinumtoxinA intradermal injections …

Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study.

Tapentadol (TAP) and oxycodone/naloxone (OXN) potentially offer an improved opioid tolerability. However, real-world studies in chronic non- … controls. Here, OXN achieved the greatest pain relief under a 28% higher MEDD, 8-13% higher use of pregabalin and duloxetine, and 23% more prescription change due to pain, compared to TAP. Whilst, TAP yielded a better tolerability due the lower number of 4 [0-6] AEs/patient, in front of OXN. Furthermore, OXN COMT-AA homozygotes evidenced higher rates of ery …