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Листерия моноцитогены и ауреат ауреуса Staphylococus у пациента с множественной миеломой: отчет по делу.

ВВЕДЕНИЕ: Listeria monocitogenes представляет собой грозный патоген, который представляет собой значительную угрозу для иммунокомпромизации и может вызвать редкие нетипичные формы заболевания, особенно осложненные при кондиционировании Staphylococcus aureus. КАСЕ: Мы представляем случай пациента с моноцитогенесом менингоэнцефалитом, эндокардитом, сепсисом и С. ауреусом остеомиелитом, высветив сложность лечения распространяемой полимикробной инфекции. A 64-year-old Женщина с множественной миеломой лечится химиотерапией с температурой, изменившимся психическим состоянием, тошнотой и диареей в от

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… S.aureus susceptible to oxacillin, cefoxitin, erythromycin, ciprofloxacine, clindamycin, tetracycline, trimethoprim/sulfamethoxazole; resistant to penicillin. Susceptibility report done according to EUCAST standardised disk diffusion method. …

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… Classes Specific Agents Drug-induced: antibiotics Incidence > 50 cases reported Methicillin, rifampin, ciprofloxacin Incidence < 30 cases reported Acyclovir, amoxicillin, ampicillin, atazanivir, carbenicillin, cefazolin, cefaclor, cefamandole, cefotaxime, cefotetan, cefoperazone, cefoxitin, ceftriaxone … Classes | Specific Agents Drug-induced: antibiotics | Incidence > 50 cases reported Methicillin, rifampin, ciprofloxacin Incidence < 30 cases reported Acyclovir, amoxicillin, ampicillin, atazanivir, carbenicillin, cefazolin, cefaclor, cefamandole, cefotaxime, cefotetan, cefoperazone, cefoxitin, ceftriaxone …

Infectious Diseases

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… Inpatients ( doxycycline 100 mg PO q12h and cefoxitin 2 g IV q6h × 14 days, or clindamycin 900 mg IV q8h and gentamicin 1.5 mg/kg IV q8h × 14 days) http://www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/index-eng.php Soft Tissue Infections NEJM 2007 357:4; IDSA Guidelines 2014 Differential Diagnosis … Cefoxitin 1–2 g IV q6–8 h | Bactericidal, cell wall synthesis inhibition and lysis | +++ | +++ | ++ | | Yes (interval) Cefotaxime 1–2 g IV q6–8 h | | +++ | +++ | | | Yes (interval) Ceftriaxone 1–2 g IV q24h | | +++ | +++ | | | No Ceftazidime 1 g IV q8–12 h | | +++ | +++Pseudo | | | Yes (interval …

Abstracts cont.

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… Methicillin resistance was determined by the cefoxitin disk diameter, as recommended by the NCCLS. …

Is Camphor the Future in Supporting Therapy for Skin Infections?

The aim of this review is to present the potential application of camphor-a bicyclic monoterpene ketone-in the prevention of skin infections. Skin diseases represent a heterogeneous group of disorders characterized by prolonged symptoms that significantly diminish the quality of life. They affect the dermis, the epidermis, and even subcutaneous tissue. They very often have a bacterial or fungal background. Therapy for dermatological skin disorders is difficult and long-term. Therefore, it is important to find a compound, preferably of natural origin, that (i) prevents the initiation of this in

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… AKN—amikacin; AMC—amoxicillin/clavulanate; AMP—ampicillin; AMX—amoxicillin; CFX—cefoxitin; CHL—chloramphenicol; CIP—cyprofloxacine; CPL—colistin; GM—gentamycin; NAL—nalidixic acid; OTC—oxytetracycline; PCN—penicillin; STR—streptomycin; TET—tetracycline; ND—not defined. … Moreover, synergistic properties of the combination of EOs with cefoxitin against staph were indicated [ 24 ]. The synergistic interaction was also detected in the case of Croton tetradenius EO with meropenem and ciprofloxacin against S. aureus [ 116 ]. …

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

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… Moreover, evidence supports that cefoxitin eliminates enterotoxigenic Bacteroides fragilis , mitigating IL-17a-mediated tumor development [ 174 , 175 ]. …

Нетуберкулезные микобактерные инфекции в Центре комплексного рака Национального института рака во Флориде.

Нетуберкулезная микобактерия (НТМ) - это экологические организмы, которые становятся оппортунистическими патогенами в некоторых популяциях. Показатель распространенности НТМ возрос во всем мире, что, вероятно, объясняется расширением диагностических тестов и наличием демографических исследований. Нынешняя литература по онкологическим пациентам минимальна и представляет собой уникальную область исследований. Здесь мы представляем эпидемиологию и лечение случаев заражения НТМ в созданном Национальным институтом раковых заболеваний Центре комплексного лечения раковых заболеваний. Мы провели ретро

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… In vitro activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against Mycobacterium abscessus . Antimicrob Agents Chemother 2024; 68:e0017424. 25. de Souza Barbosa F, Capra Pezzi L, Tsao M, et al. …

Risk Factors of Death in Bloodstream Infections Caused by AmpC β-Lactamase-Producing Enterobacterales in Patients with Neoplasia.

PurposeThe infections caused by ESCPM Enterobacterales (Enterobacter spp., Serratia spp., Citrobacter spp., Providencia spp. and Morganella spp.) have limited therapeutic options. Patients with neoplastic diseases are particularly vulnerable to bloodstream infections (BSIs).ObjectiveTo analyze determinant factors of death in patients with neoplasia complicated with BSI caused by ESCPM Enterobacterales.Patients and methodsA cohort study of patients aged 18 years or older with neoplasia and BSI due to ESCPM group was conducted at the Cancer Hospital I of the National Cancer Institute, Brazil, fr

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… The resistance to cefoxitin is considered a phenotypic marker of the presence of chromosomal AmpC. Statistical Analysis Proportions and median values were reported for categorical and continuous variables, respectively. …

Infectious Diseases

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… Inpatients ( doxycycline 100 mg PO q12 h and cefoxitin 2 g IV q6 h ×14 days, or clindamycin 900 mg IV q8h and gentamicin 1.5 mg/kg IV q8h ×14 days) Soft Tissue Infections NEJM 2004 350:9; NEJM 2007 357:4; CID 2005 41:10 Differential Diagnosis DISCRETE, LOCALIZED CUTANEOUS INFECTIONS — superficial … Cefoxitin 1–2 g IV q6–8 h | Bactericidal, cell wall synthesis inhibition and lysis | +++ | +++ | ++ | | Yes (interval) Cefotaxime 1–2 g IV q6–8 h | | +++ | +++ | | | Yes (interval) Ceftriaxone 1–2 g IV q24h | | +++ | +++ | | | No Ceftazidime 1 g IV q8–12 h | | +++ | +++Pseudo | | | Yes (interval …

Естественные и синтетические АМП из Латинской Америки по всему спектру технологий и приложений в области разнообразия.

Биоразнообразие в Латинской Америке примерно 60% в целом по миру, подпитывая научные исследования в области природных продуктов, весьма значимой области открытия наркотиков по сей день. Это сопровождается увеличением числа антимикробных пептидов (АМП), полученных из натуральных продуктов в регионе, которые за последнее десятилетие были переработаны путем модификации, усовершенствования и уточнения их физико-химических свойств и антимикробной эффективности с использованием подходов, которые варьируются от изучения рациональной конструкции и соотношения структуры-активности (САР) до методов иску

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… Notably, litvan ALF-G35–54 demonstrated the broadest and most potent antibacterial activity (2.5–40 μM), inhibiting the growth of most tested bacterial strains, including clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) 16003 (cefoxitin-resistant) and 17022 (resistant to cefoxitin …

ECC-4 Abstracts

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… Drugs tested were: amoxicillin (AMX), AMX+clavulanic acid (AMC), ticarcillin (TC) TC+clavulanic acid (TCC), cefoxitin (FOX), cefotetan (CTT), imipenem (IMP), clindamycin (CM) and metronidazole (MOL). …

Pharmacomicrobiomics in Anticancer Therapies: Why the Gut Microbiota Should Be Pointed Out.

Anticancer treatments have shown a variable therapeutic outcome that may be partly attributable to the activity of the gut microbiota on the pathology and/or therapies. In recent years, microbiota-drug interactions have been extensively investigated, but most of the underlying molecular mechanisms still remain unclear. In this review, we discuss the relationship between the gut microbiota and some of the most commonly used drugs in oncological diseases. Different strategies for manipulating the gut microbiota layout (i.e., prebiotics, probiotics, antibiotics, and fecal microbiota transplantati

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… Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides Fragilis Using Cefoxitin Treatment J. Infect. Dis. 2016 214 122 129 10.1093/infdis/jiw069 26908749 PMC4907405 97. Ramirez J. Guarner F. Bustos Fernandez L. Maruy A. Sdepanian V.L. Cohen H. …

Drug Repurposing of Selected Antibiotics: An Emerging Approach in Cancer Drug Discovery.

Drug repurposing is a method of investigating new therapeutic applications for previously approved medications. This repurposing approach to "old" medications is now highly efficient, simple to arrange, and cost-effective and poses little risk of failure in treating a variety of disorders, including cancer. Drug repurposing for cancer therapy is currently a key topic of study. It is a way of exploring recent therapeutic applications for already-existing drugs. Theoretically, the repurposing strategy has various advantages over the recognized challenges of creating new molecular entities, inclu

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… . | ( 34 ) (b) Cefazolin (c) Cephalexin (d) Cefaclor (e) Cefotetan (f) Cefoxitin (g) Cefprozil (h) Cefuroxime (i) Cefotaxime (j) Ceftazidime (k) Cefdinir (l) Ceftriaxone (m) Cefpodoxime (n) Cefoperazone (o) Cefixime (p) Cefepime 13. | Chloramphenicol | (a) Chloromycetin | Chloramphenicol inhibits protein …

Potential drug development and therapeutic approaches for clinical intervention in COVID-19.

While the vaccination is now available to many countries and will slowly dissipate to others, effective therapeutics for COVID-19 is still illusive. The SARS-CoV-2 pandemic has posed an unprecedented challenge to researchers, scientists, and clinicians and affected the wellbeing of millions of people worldwide. Since the beginning of the pandemic, a multitude of existing anti-viral, antibiotic, antimalarial, and anticancer drugs have been tested, and some have shown potency in the treatment and management of COVID-19, albeit others failed to leave any positive impact and a few also became cont

Pathology Competencies in Medical Education and Educational Cases: Update 2023.

Pathology is a core component of medical school curricula because understanding the pathogenesis of the disease is foundational both for diagnostic efficiency and optimal use of ancillary resources in patient care. The Pathology Competencies for Medical Education (PCME) were developed as a national resource of expectations of pathology knowledge for medical students. The PCME are composed of three competencies: disease mechanisms and processes, organ system pathology, and diagnostic pathology and therapeutic pathology. The learning goals and learning objectives of the PCME that were first publ

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TB AND OTHER CHEST INFECTIONS

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Emergency Care

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Proceedings of Réanimation 2020, the French Intensive Care Society International Congress.

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… of patients receiving antibiotics n = 435 n = 386 < 0.0001 Antibiotics administrated Amoxicillin 29 (6.7%) 67 (17.6%) < 0.0001 Amoxicillin/ clavulanic acid 122 (88.0%) 69 (17.9%) < 0.0001 Piperacillin/tazobactam 169 (38.9%) 18 (4.7%) < 0.0001 Cefotaxime/Ceftriaxone (C3G) 196 (45.1%) 162 (42%) 0.37 Cefoxitin … = 435 | n = 386 | < 0.0001 Antibiotics administrated | | | Amoxicillin | 29 (6.7%) | 67 (17.6%) | < 0.0001 Amoxicillin/ clavulanic acid | 122 (88.0%) | 69 (17.9%) | < 0.0001 Piperacillin/tazobactam | 169 (38.9%) | 18 (4.7%) | < 0.0001 Cefotaxime/Ceftriaxone (C3G) | 196 (45.1%) | 162 (42%) | 0.37 Cefoxitin …

Abstracts from the 8th Drug Hypersensitivity Meeting (DHM)

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