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The impact of spring wheat species and sowing density on soil biochemical properties, content of secondary plant metabolites and the presence of Oulema ssp.

The physical and chemical properties of the soil are important factors influencing the yield of crops. One of the agrotechnical factors infl … (CAT), dehydrogenases (DEH), peroxidases (PER); (ii) plant analysis: total phenolic compounds (TP), chlorogenic acid (CA), antioxidant capacity (FRAP); (iii) entomological analysis of the number of insects-Oulema spp. adults and larvae. Performing analyzes in such a wide (interdisciplinary) scope will allow for a comprehensive understanding of the soil-plant-insec …

Ageratina adenophora (Spreng.) King & H. Rob. Standardized leaf extract as an antidiabetic agent for type 2 diabetes: An in vitro and in vivo evaluation.

Type 2 diabetes has become one of the major health concerns of the 21st century, marked by hyperglycemia or glycosuria, and is associated with the development of several secondary health complications. Due to the fact that chemically synthesized drugs lead to several inevitable side effects, new antidiabetic medications from plants have gained substantial attention. Thus, the current study aims to evaluate the antidiabetic capacity of the Ageratina adenophora hydroalcoholic (AAHY) extract in streptozotocin-nicotinamide (STZ-NA)-induced diabetic Wistar albino rats. The rats were segregated rand

Phytochemical Analysis, Antioxidant Potential and Antibacterial Activities of Different Anatomical Parts of Hypericum cordifolium Choisy.

The genus Hypericum comprises a large number of species. The flower, leaf, stem, and root of the Hypericum species are widely used in tradit … ce of 11 compounds and the leaf extract showed the presence of 8 compounds. Both extracts contained chlorogenic acid and mangiferin. Hyperoside and quercetin were present only in the flower extract. In the TLC-DPPH. assay, almost all of the flower extracts and 5 compounds of the leaf extract showed radical scavenging potential. Estimation of phenolics and flavonoi …

Intestinal metabolism and absorption mechanism of multi-components in Gaultheria leucocarpa var. yunnanensis - An assessment using in situ and in vitro models, comparing gut segments in pathological with physiological conditions.

ETHNOPHARMACOLOGICAL RELEVANCE: Dianbaizhu (Gaultheria leucocarpa var. yunnanensis) as a Chinese folk medicine exerts significant treatment … um, ileum, and colon), 7 key components in ARF, including MATG-B, (+)-catechin, MSTG-A, Gaultherin, chlorogenic acid, quercetin, and kaempferol were quantitatively analyzed by a high-performance liquid chromatography (HPLC). Secondly, combining the physiological and pathological rats, the in situ single-pass intestinal perfusion and in vitro everted gut sacs of ra …

Spectrum-effect relationship and network pharmacology reveal key anti-rheumatoid arthritis and attenuated toxicity components of processed curculigo rhizome.

ETHNOPHARMACOLOGICAL RELEVANCE: Curculigo rhizome (CR), a traditional Chinese medicine (TCM), has been used for centuries to treat rheumatic … ar docking predicted favorable binding affinities between active components (orcinol gentiobioside, chlorogenic acid) and core targets. Mechanistically, preliminary evidence indicated that both RCR and WCR suppressed the mRNA expression of glycolytic enzymes (HK2, PKM2, PFKFB3, GLUT-1), suggesting that inhibition of glycolytic reprogramming in inflammatory cells m …

RETRACTED: Spirulina Unleashed: A Pancreatic Symphony to Restore Glycemic Balance and Improve Hyperlipidemia and Antioxidant Properties by Transcriptional Modulation of Genes in a Rat Model.

Hyperlipidemia is the root cause of numerous chronic conditions, leading to high mortality rates around the globe. Spirulina (Arthrospira pl … esearch findings, spirulina powder has certain noteworthy features. It had the greatest quantity of chlorogenic acid (4052.90 µg/g) among seven phenolics and two flavonoid compounds obtained by HPLC-UV analysis. Furthermore, the proximate analysis demonstrated that spirulina is high in protein (16.45 ± 0.8%) and has a significant energy yield of 269.51 K-calories …

Ameliorative effects of Wikstroemia trichotoma 95% EtOH extract on a mouse model of DNCB-induced atopic dermatitis.

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Wikstroemia has been extensively utilized in traditional Chinese medicine (TCM) for the management … H3 cells. Chemical profile analysis of WTE confirmed the presence of three phenolic compounds, viz. chlorogenic acid, miconioside B, and matteucinol-7-O-β-apiofuranosyl (1 → 6)-β-glucopyranoside. CONCLUSIONS: WTE ameliorates AD symptoms by modulating in the skin barrier and immune system dysfunction. This suggests that W. trichotoma extract may offer therapeutic …

Trichilia silvatica extracts modulate the oxinflammatory response: an in vitro analysis.

ETHNOPHARMACOLOGICAL RELEVANCE: Plants belonging to the Meliaceae family, such as Trichilia silvatica C. DC., known as catiguá-branco, have attracted considerable interest in phytochemical research due to their diverse and significant secondary metabolites. Trichilia silvatica has traditionally been employed in Brazilian medicine to treat inflammatory disorders. Moreover, studies have reported its antioxidant and antimicrobial properties, highlighting its potential therapeutic applications. AIM OF THE STUDY: This study aimed to evaluate the potential of Trichilia silvatica leaf and stem extra

Integrated plasma pharmacochemistry and network pharmacology to explore the mechanism of Gerberae Piloselloidis Herba in treatment of allergic asthma.

ETHNOPHARMACOLOGICAL RELEVANCE: Gerberae Piloselloidis Herba (GPH), a commonly used traditional medicine in China, is derived from Gerbera p … r verified using Western blot analysis. RESULTS: Eleven chemical constituents (such as arbutin, neochlorogenic acid, chlorogenic acid, etc.) were identified through the analysis of plasma samples, on which basis a total of 142 genes intersecting GPH and allergic asthma were collected by network pharmacology. After performing enrichment analysis of these genes in …

Study on the activity and mechanism of herbal formula anti-infection powder (AIP) against influenza-virus-induced pneumonia through genetic susceptibility genes.

ETHNOPHARMACOLOGICAL RELEVANCE: Anti-infection powder (AIP), a patented Chinese herbal formulation, is used traditionally in the treatment o … AV infection with IC50 values of 65.49 μg/mL. The anti-IAV activity of AIP was mainly determined by chlorogenic acid, forsythiarin, puerarin, paeoniflorin and prim-o-glucosylcimigin. Moreover, AIP inhibited the neuraminidase activity and the M gene expression in vitro. In vivo, oral administration of AIP significantly reduced viral load and improved lung tissue le …

Multiomics and experimental validation reveal theophylline's mechanism targeting IL1A/ACTB/TLR4 and identify synergistic drugs in hepatocellular carcinoma.

This study aimed to investigate the mechanism by which theophylline influences hepatocellular carcinoma (HCC) through the regulation of core … ns demonstrated that theophylline could stably bind to these core targets. Multiple drugs including chlorogenic acid (PubChem CID: 1794427), losartan (PubChem CID: 3961), and estrone sulfate (PubChem CID: 3001028), were found to potentially exhibit synergistic effects with theophylline. The expression of core targets was significantly associated with clinical stag …

[Screening of pharmacodynamic substances for modified-zengshengping in blocking the progression of oral squamous cell carcinoma based on salivary metabolomics].

Objective: To identify the active ingredients of modified-Zengshengping (ZSP-M) that inhibit the progression of oral squamous cell carcinoma … 6 in negative ion mode. Through computer-aided virtual screening, maackiain (MA), scutellarin (SC), chlorogenic acid (CGA), and vitexin-2-O-rhamnoside (VOR) were identified as potential key pharmacodynamic substances with strong binding potential to target proteins. In vitro experimental results showed that all four key pharmacodynamic substances could inhibit the …

Metabolomic and chemometric analyses of St. John's wort and related Asian Hypericum species linked to bioactivity.

ETHNOPHARMACOLOGICAL RELEVANCE: Plants in the genus Hypericum (Hypericaceae), include more than 500 species worldwide, and many are valued f … nd H. perforatum showed the highest anti-inflammatory activity, with pseudohypericin, quercetin and chlorogenic acid being observed at higher concentrations. Hypericum perforatum and H. erectum showed anti-plasmodial activity, with higher hyperforin and xanthones in these species that may account for the anti-plasmodial activity. CONCLUSIONS: This study character …

Mechanism of Sangqi Qingxuan Liquid in Alleviating Vascular Endothelial Injury in Hypertension Focuses on β-Catenin.

OBJECTIVE: To explore the main components and potential mechanisms of Sangqi Qingxuan Liquid in the treatment of arterial vascular endotheli … nt/ β -catenin signaling pathway. RESULTS: The main SQQX components were betaine, buddleoside, and chlorogenic acid, in descending order. Network pharmacology analysis screened 12 pathways associated with the hypertensive vascular endothelium. The results showed that 1 µ mol/L for 12 h was the optimal condition for Ang II to induce AVECs injury, and 2.47 mg/mL SQ …

Spectrum-effect relationship study to reveal the pharmacodynamic substances in Flos Puerariae-Semen Hoveniae medicine pair for the treatment of alcohol-induced liver damage.

ETHNOPHARMACOLOGICAL RELEVANCE: Alcoholic liver disease (ALD) is the most serious and irreversible liver damage associated with alcohol cons … o-AKT and phospho-mTOR. Also, the results of the spectrum-effect relationship study showed that P1 (chlorogenic acid), P3 (daidzin), P4 (6″-O-xylosyl-glycitin), P5 (glycitin), P6 (unknown), P7 (unknown), P9 (unknown), P10 (6″-O-xylosyl-tectoridin), P12 (tectoridin) and P23 (unknown) can be considered as the main components of the medicine pair in the treatment of …

Shenqi Yanshen Decoction protects against renal and bone injury in chronic kidney disease-mineral and bone disorder with potential involvement of Wnt5a/RhoA/Pkn3 signaling.

ETHNOPHARMACOLOGICAL RELEVANCE: Shenqi Yanshen Decoction (SQYSD) is a traditional Chinese herbal formula that is used for treating chronic k … fied in SQYSD, and 12 representative constituents were quantified; among them, icariin, epimedin B, chlorogenic acid, and epimedin A were abundant components. In CKD-MBD mice, SQYSD improved body weight, decreased the levels of serum creatinine and blood urea nitrogen, corrected calcium-phosphate imbalance, and attenuated renal inflammatory infiltration, fibrosis, …

Небиториальное воздействие сафронных соединений на множественный склероз: молекулярная стыковка и динамика, повышение свойств с помощью золотых наночастиц и оценка антиоксидантных, антибактериальных, цитотоксичных свойств.

Уникальные свойства наночастиц, такие, как их небольшой размер и способность пересечь мозговой барьер, делают их хорошо пригодными для целевой доставки наркотиков в центральную нервную систему. Текущие исследования направлены на разработку новаторских методов лечения наночастиц от неврологического расстройства; множественного склероза (МС). В исследовании было подтверждено, что зеленый синтез является оптимальным методом производства экологически безопасных соединений. Наночастицы характеризовались инфракрасной спектроскопией Фурье (FT-IR), диффузией рентгеновского порошка (XRD) и микроскопией

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… Fig. 19 MD analysis of (blue) TNF, (green) Chlorogenic acid, (red) HTCC, and (yellow) Gallic acid. H-Bond of (blue) TNF, (green) Chlorogenic acid, (red) HTCC, and (yellow) Gallic acid. … H-bond of (blue) LMP-1, (green) Chlorogenic acid, (red) EGCG, and (yellow) Isoquercetin. Free energy landscape with minima for A, B) EBNA-1 C, D) Chlorogenic acid E, F) EGCG and G, H) Isoquercetin. …

Exploiting autophagy-targeting natural compounds for potential antimicrobial actions.

Natural products are biologically active compounds used for therapeutic interventions for various diseases, particularly infections. Autopha … : calcium/calmodulin-dependent protein kinase kinase 2; CBD: cannabidiol; CF: cystic fibrosis; CGA: chlorogenic acid; CGAS: cyclic GMP-AMP synthase; CHUK/IKKα: component of inhibitor of nuclear factor kappa B kinase complex; CLP: cecal ligation and puncture; CLR: clarithromycin; CMA: chaperone-mediated autophagy; CoV: coronavirus; DHT: dihydrotanshinone I; EGCG: e …

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota

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… acid C 16 H 18 O 9 PS , PV ( Han et al., 2020 ; Liu et al., 2013a ) 111 Caffeic acid C 9 H 8 O 4 PS , PV ( Han et al., 2020 ; Xia et al., 2010 ) 112 Iso-chlorogenic acid A C 25 H 24 O 12 PS , PV Liu and Lei (2019) 113 Iso-chlorogenic acid C C 25 H 24 O 12 PS , PV Liu and Lei (2019) 114 Ferulic acid … The contents of chlorogenic acid (110), caffeic acid (111) and protocatechuic acid (115) are higer. …

Yerba Mate (Ilex paraguariensis) Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Regulatory T Cell Function.

Background/Objectives: In Latin America, yerba mate (YM) is a popular infusion processed from the leaves and stems of Ilex paraguariensis. YM has been shown to have anti-inflammatory properties in several studies, although the effect of YM on multiple sclerosis (MS) remains elusive. The purpose of this study was to examine the effect of YM on the development of MS, by using the experimental autoimmune encephalomyelitis (EAE) mouse model while also evaluating its effect over infiltration of immune cells into the central nervous system (CNS) and regulatory T cell (Treg) function. Methods: YM or

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… Additionally, it has been recently described that chlorogenic acid increases the Treg population in racehorses, suggesting that chlorogenic acid could be responsible for the increase in the Treg population and the suppressive activity in our study [ 41 ]. … Considering the high levels of chlorogenic acid in our YM infusion, we can speculate that the reduced peripheral immune cell infiltration into the brain parenchyma observed in the animals treated with YM could be explained in part by the improved BBB integrity induced by chlorogenic acid that decrease …