Результаты поиска

[Low molecular weight heparin combined with aspirin to prevent perioperative venous thromboembolism in patients with splenic rupture and lower extremity fracture].

OBJECTIVE: To investigate the effectiveness and safety of low molecular weight heparin combined with aspirin for perioperative prophylactic … 0.302, P=0.860). There were 4 cases of bleeding related complications, including 1 case of incision ecchymosis in groups A and B respectively, with the incidence of 6.66% and 6.25%, respectively; there was 1 case of incision hematoma and 1 case of bleeding in group C, with the incidence of 11.76%; showing no significant difference in the incidence of bleedin …

Heparin for assisted reproduction.

BACKGROUND: Heparin as an adjunct in assisted reproduction (peri-implantation heparin) is given at or after egg collection or at embryo tran … es, with no comparative data available. However, LMWH did cause adverse effects including bruising, ecchymosis, bleeding, thrombocytopenia and allergic reactions. It appeared that these adverse effects were increased if heparin therapy was used over a longer duration. AUTHORS' CONCLUSIONS: The results of this Cochrane review of three randomised controlled t …

Radiofrequency Thermoablation of the Gasserian Ganglion Versus the Peripheral Branches of the Trigeminal Nerve for Treatment of Trigeminal Neuralgia: A Randomized, Control Trial.

BACKGROUND: Trigeminal neuralgia is the most painful condition of facial pain leading to impairment of routine activities. Although radiofre … ater. No major complication was reported in the study group except for 1 patient who reported local ecchymosis. LIMITATIONS: The main limitation of the study is that the patients and the investigator performing the procedure were not blinded, though the person who assessed the patient during follow-up was blinded to the group assignment. Another limitation …

Laser cryo-sclerotherapy versus conventional sclerotherapy for reticular veins and telangiectasias: A randomized controlled trial.

OBJECTIVE: To evaluate whether the hybrid laser cryo-sclerotherapy (LCS; Nd:Y-AG 1064 nm + 75% hypertonic glucose [HG]) protocol produces su … continued improving between Day 30 and Day 90 vs 29.1% in the CS group (70.8% with No Change). The ecchymosis duration was significantly shorter in the LCS group (median, 5.0 vs 10.0 days; P = .012). Severe pigmentation on Day 90 was observed exclusively in the CS group (8.3% vs 0%; P = .019; r = 0.22; small effect; power = 36.4%; this finding is explorator …

Comparison of the effects of greater occipital nerve blockage versus combined greater occipital nerve and supraorbital nerve blockage therapy on sleep, pain, anxiety, depression, and quality of life in chronic migraine.

OBJECTIVE: This study aimed to evaluate and compare the effects of isolated greater occipital nerve (GON) blockage, combined GON with suprao … tenderness in the forehead region during the procedure or more frequent development of redness and ecchymosis afterward, isolated bilateral GON blockage was performed in patients who did not consent to the SON blockage. Following ethical approval, 80 patients with CM were prospectively assigned to either the GON blockage group (n = 40) or the combined GON a …

[Therapeutic effect of Huoxue prescription combined with extracorporeal shock wave on rotator cuff injury].

OBJECTIVE: To explore early clinical efficacy and advantages of Huoxue Fang's directional dialysis combined with extracorporeal shock wave i … een two groups (P>0.05). There were no complications such as skin allergy, subcutaneous hemorrhage, ecchymosis, vascular and nerve injury occurred in both groups. CONCLUSION: For the treatment of rotator cuff injury, Huoxue prescription combined with extracorporeal shock wave is effective, which could not only release the local adhesion tissue, improve loca …

Review of Potential Barriers to Effective Hemostatic Management of Acquired Hemophilia A by Non-Hemophilia Experts in the United States.

Acquired hemophilia A (AHA) is an ultra-rare autoimmune disorder caused by autoantibodies against factor VIII. It often presents with life-threatening bleeding to non-hemophilia experts, who have limited awareness of this condition. This review evaluated hemostatic management and identified barriers to optimal management of AHA by non-hemophilia experts in the United States through a literature review. AHA case reports published by non-hemophilia experts from January 2016 through November 2021 in non-hematology journals were critically reviewed for a chronology of clinical course and managemen

Совпадение в полном тексте источника
… at first presentation, then large IM hematoma in posterior right thigh | Single unit of PRBCs used on first admission then aPCC 100 mg/kg twice daily for 2 days | Admitted first time five months post-op (transurethral resection of bladder tumor) for non-traumatic ecchymosis; AHA diagnosis was made Treated … four weeks) | Patient had underlying diagnosis of papillary urothelial carcinoma Was readmitted four days post discharge for severe IM hematoma FVIII levels took more than four weeks to rise Singh et al., 2021 [ 18 ] | 59/M | COPD, tobacco use | Skin tear evaluated in ED prior to admission; diffuse ecchymosis …

Successful treatment of an adult with Kasabach-Merritt syndrome using thalidomide, vincristine, and prednisone.

ObjectiveKasabach-Merritt syndrome is a rare disease that mainly occurs in infants and adolescents. It usually manifests as disseminated intravascular coagulation and severe bleeding, and is associated with high mortality. However, its low incidence and clinical rarity in adults mean that there is currently no well-verified treatment regimen for this disease. We report on an effective novel therapeutic regimen in a patient with Kasabach-Merritt syndrome.MethodsA woman with Kasabach-Merritt syndrome presented with a recurrent subcutaneous mass and disseminated intravascular coagulation, and was

Совпадение в полном тексте источника
… She subsequently developed ecchymosis on her left calf and suffered from swelling pain, which restricted her daily activities. She initially attended her local hospital, where her full blood count, liver and renal function tests, and coagulation profile were normal. … Her postoperative recovery appeared uneventful, but extensive ecchymosis appeared successively on her right thigh, left thigh, and right elbow joint after the operation, accompanied by muscle pain and limited joint flexion. …

[Five-year results of cyanoacrylate adhesive сlosure in the treatment of patients with varicose veins of the lower extremities].

BACKGROUND: Cyanoacrylate adhesive сlosure (САС) of subcutaneous veins is a modern method of treating varicose veins of the lower extremitie … scessed soft tissue granuloma was diagnosed at the vein puncture site 5.5 months after the CT scan. Ecchymosis was observed in 4 (10.2%) patients. There were no postoperative neurological complications, pulmonary embolism, or deep vein thrombosis in this group of patients. The incidence of target vein occlusion at 3 months, 6 months, and 3 years after the in …

Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study.

BACKGROUND: The anticoagulant warfarin, which is administered as a racemic mixture of R- and S-enantiomers, has been reported to interact wi … ring the course of the study, 9 subjects (60%) reported a total of 32 adverse events. Catheter-site ecchymosis, venipuncturesite hematoma, dizziness, vasovagal reaction, and adhesive-tape allergy were the most common adverse events reported. During coadministration of ESL and warfarin, 7 subjects reported a total of 17 adverse events, of which 6 (epigastric …

Dermatological Manifestations of Amyloid Light-Chain (AL) Amyloidosis: A Case Report Highlighting Early Diagnosis and Treatment.

This case report describes a 52-year-old man who presented with gradually progressive dark cutaneous discoloration over the upper trunk and periorbital region, accompanied by painless enlargement of the tongue, which initially interfered with speech and eating. Over the subsequent months, he experienced marked unintentional weight loss, persistent fatigue, and symptoms consistent with autonomic involvement, including postural dizziness and altered bowel habits. Clinical examination revealed waxy skin changes and macroglossia. Laboratory evaluation demonstrated a monoclonal light-chain abnormal

Совпадение в полном тексте источника
… Figure 1 Patient before treatment showing periorbital lesions (as indicated by the arrows) Prominent bilateral periorbital purpura, ecchymosis patches, and periorbital edema are visible. … Ecchymosis patches improved, bilateral periorbital purpura and edema showed significant improvement. …

Oral health status of patients with multiple myeloma.

ObjectiveTo describe the oral health status of patients with multiple myeloma and compare to a control group.Materials and methodsThe medical history of the studied subjects was obtained from the medical records and through interviews. Trained examiners evaluated the oral mucosa, teeth, periodontium and imaging aspects. The dental status was evaluated by the decayed, missing and filled teeth index. The presence of bone lesions was investigated with cone beam computer tomography images of the jaws.ResultsThe most common oral mucosa features were paleness (31%) and coated tongue (14.3%) in the m

Совпадение в полном тексте источника
… Table 2 Oral features Multiple myeloma N = 42 (%) Control N = 28 (%) Oral mucosa features associated with MM or its treatment Pale mucosa 13 (31) – Swelling 4 (9.5) – Facial palsy 2 (4.7) – Osteonecrosis of the jaws 2 (4.7) – Depapillation of the tongue 1 (2.4) – Petechiae/ecchymosis 1 (2.4) – Other … Oral features | Multiple myeloma N = 42 (%) | Control N = 28 (%) Oral mucosa features associated with MM or its treatment Pale mucosa | 13 (31) | – Swelling | 4 (9.5) | – Facial palsy | 2 (4.7) | – Osteonecrosis of the jaws | 2 (4.7) | – Depapillation of the tongue | 1 (2.4) | – Petechiae/ecchymosis …

Serpiginous mycosis fungoides in a 21-year-old man.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Ecchymosis-like hyperpigmented mycosis fungoides. Ann Saudi Med. 2008;28(3):228–229. doi: 10.5144/0256-4947.2008.228. 9. Hanna S., Walsh N., D'Intino Y., Langley R.G. Mycosis fungoides presenting as pigmented purpuric dermatitis. …

Hematology

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Thus, von Willebrand disease (vWD) leads to ↓ factor VIII Clinical Features Bleeding Syndromes platelet dysfunction —skin/mucous membrane (petechiae, purpura, small/superficial ecchymosis, epistaxis, gingival bleed, menorrhagia), immediate bleed coagulation factors —joints/muscles (hemarthroses, muscle … hematomas, large/palpable ecchymosis), delayed bleed Investigations Basic labs —CBCD, peripheral smear, AST, ALT, ALP, bilirubin, albumin, INR, PTT, D-dimer, fibrinogen Special hepzyme study —to remove heparin from blood samples to distinguish if isolated elevation of PTT is spurious 50:50 mixing …

Diagnosis and referral of patients with AL amyloidosis in Portugal: results from a Delphi panel.

Light chain amyloidosis (AL) is a complex disorder defined by the extracellular deposition of insoluble amyloid fibrils formed by intact or fragmented immunoglobulin light chains, leading to cell dysfunction, rapid organ deterioration, and, ultimately, death. Although the clinical presentation of AL is directly connected to organ involvement, signs and symptoms of AL are frequently nonspecific, misinterpreted, and late recognized. Thus, an early diagnosis combined with effective therapies to cease disease progression and rescue organ function is essential. The aim of this study was to assess t

Совпадение в полном тексте источника
… electrocardiogram with low-voltage complexes, I always suspect AL amyloidosis. (9) | AL amyloidosis should be considered in patients with monoclonal gammopathy who present changes in cardiac (NT-proBNP/TNT) or urinary (albuminuria) markers during their follow-up. (10) | Macroglossia and periorbital ecchymosis … relating to (8) In patients with albuminuria and cardiac dysfunction (left ventricular hypertrophy with “infiltrative” shiny appearance and interatrial septal thickening) associated with electrocardiogram with low-voltage complexes, I always suspect of AL amyloidosis ; (10) Macroglossia and periorbital ecchymosis …

Localized nasopharyngeal amyloidosis: A case report.

Amyloidosis is a rare condition on its own but finding localized amyloidosis of a site such as the nasopharynx is an extremely rare condition with very few cases described in the literature. The condition occurs due to the accumulation of misfolded proteins in the extracellular space disrupting the cell architecture and causing eventual dysfunction. In this case report we discuss the pathophysiology, symptoms, and imaging findings of a patient initially thought to have giant cell arteritis, but who was found on CT to have a mass later determined to be localized nasopharyngeal amyloidosis. Eval

Совпадение в полном тексте источника
… Amyloidosis after sufficient amyloid deposition has occurred may manifest as cardiac, renal, and liver damage/ failure as well as macroglossia, easy bruising, periorbital ecchymosis, or even carpal tunnel [1] . …

Bilateral Proptosis in a Case of Recurring Multiple Myeloma: Uncommon Orbital Presentation of Plasmacytoma.

Multiple myeloma is a malignant plasma cell dyscrasia that may invade the orbits in extramedullary presentations. Common manifestations of orbital involvement include unilateral proptosis, injection, chemosis, diplopia, and occasionally pain. Additionally, the soft-tissue tumors associated with multiple myeloma typically cause bony destruction of adjacent structures. However, in certain patients, bilateral proptosis and a lack of bony destruction may occur. In these instances, it is important for physicians to consider patient history, presentation, and progression in order to ensure that a po

Совпадение в полном тексте источника
… After one week, the ophthalmology service was consulted due to worsening proptosis, lid ecchymosis, and conjunctival hyperemia. …

From Clinical Clues to Final Diagnosis: The Return of Detective Work to Clinical Medicine in Cardiac Amyloidosis.

Cardiac amyloidosis is frequently misdiagnosed, denying patients the opportunity for timely and appropriate management of the disease. The purpose of this review and case studies is to raise awareness of the diagnostic "red flags" associated with cardiac amyloidosis and the currently available non-invasive strategies for diagnosis. The review focuses on the identification of one of the two main types of cardiac amyloidosis, transthyretin amyloid cardiomyopathy, and non-invasive tools to distinguish this from light-chain amyloidosis. A diagnostic algorithm centered around the use of non-invasiv

Совпадение в полном тексте источника
… Her dizziness subsequently worsened, and she experienced abdominal pain, syncope , hypotension with worsening anemia and more frequent periorbital ecchymosis and bilateral subconjunctival hemorrhage . … Figure 5 Bilateral heliotrope rash (A) Spontaneous subconjunctival ecchymosis (B) . Investigations Laboratory work-up revealed markedly elevated troponin (0.074 μg/L) and NT proBNP levels (1,556 ng/L) ; however, the patient did not exhibit signs of heart failure. …

Uncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.

Amyloidosis is a localized or systemic disease caused by deposition of proteins in the extracellular space of various organs and tissues. As part of the disease, proteins that were originally soluble misfold and acquire a fibrillar conformation that renders them insoluble and resistant to proteolysis. Systemic amyloidosis is a rare, often underdiagnosed condition. In recent years, the incidence of newly diagnosed cases of amyloidosis has been increasing in association with the aging of the population and greater access to diagnostic tests. From a clinical perspective, systemic amyloidosis is f

Совпадение в полном тексте источника
… causes amyloid deposits | serum amyloid A (SAA) protein | kappa or lambda light chains | mutated transthyretin misfolding | age-related transthyretin misfolding | beta2-microglobulin Clinical features | renal involvement with edema, isolated proteinuria, and/or renal failure | heart failure, spontaneous ecchymosis … amyloidosis have the classic characteristics of renal involvement with nephrotic syndrome. [ 33 ] The heart is the second most affected organ, with severe heart failure (HF) being the main determinant of survival. [ 6 , 7 ] Classic findings specific to AL amyloidosis include the presence of spontaneous ecchymosis …

Neisseria meningitidis Induced Fatal Waterhouse-Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure.

Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic lesion are worrisome signs reflecting disseminated intravascular coagulation (DIC) and hint at Waterhouse-Friderichsen syndrome (WFS). Here, we describe a rare case of a patient with a fulminant Neisseria meningitidis-induced acute systemic meningococcal disease presenting with high-grade fever without meningitis symptoms. Fatal septicemia with DIC

Совпадение в полном тексте источника
… The typical symptoms of WFS include fever, maculopapular skin rash, petechiae, ecchymosis, cyanosis of the extremities, and shock resulting from severe sepsis via coagulopathy [ 9 ]. …