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An immunoinformatics-derived DNA vaccine encoding human class II T cell epitopes of Ebola virus, Sudan virus, and Venezuelan equine encephalitis virus is immunogenic in HLA transgenic mice.

Immunoinformatics tools were used to predict human leukocyte antigen (HLA) class II-restricted T cell epitopes within the envelope glycoproteins and nucleocapsid proteins of Ebola virus (EBOV) and Sudan virus (SUDV) and the structural proteins of Venezuelan equine encephalitis virus (VEEV). Selected epitopes were tested for binding to soluble HLA molecules representing 5 class II alleles (DRB1*0101, DRB1*0301, DRB1*0401, DRB1*0701, and DRB1*1501). All but one of the 25 tested peptides bound to at least one of the DRB1 alleles, and 4 of the peptides bound at least moderately or weakly to all 5 …

Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity.

BACKGROUND: Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioner … events, breastfeeding, nutrition and environmental exposure in early life was collected through an informatics platform shared by the whole network of clinical centers (AllergyCARD™). RESULTS: Among the 1360 recruited patients (68% males, age 10.5 ± 3.4 yr), 695 (51%) had moderate-to-severe AR, 533 (39%) asthma, and 325 (23.9%) oral allergy syndrome (OAS). …

Hypertension management using mobile technology and home blood pressure monitoring: results of a randomized trial in two low/middle-income countries.

OBJECTIVE: Hypertension and other noncommunicable diseases represent a growing threat to low/middle-income countries (LMICs). Mobile health … enters could make these services available in areas with limited infrastructure for patient-focused informatics support.

Establishment and operation of a biorepository for molecular epidemiologic studies in Costa Rica.

BACKGROUND: The Proyecto Epidemiológico Guanacaste (PEG) has conducted several large studies related to human papillomavirus (HPV) and cervi … cesses of the PEG molecular epidemiology laboratories and biorepository prove that the physical and informatics infrastructures of a modern biorepository can be transferred to a resource-limited and weather-challenged region. Technology transfer is an important and feasible goal of international collaborations.

Impacts of epic MyChart and healthy planet on clinical care measures: a scoping review protocol.

INTRODUCTION: Epic MyChart, used as a patient portal or within Epic Healthy Planet programmes, is integrated with the Epic electronic health … s guidance; qualitative data will undergo thematic synthesis. Stakeholder consultations with health informatics experts, clinicians, data scientists and health system managers, alongside a patient and public involvement workshop, will support interpretation of findings. A logic model will illustrate relationships between portal features, implementation factor …

Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma.

Feline oral squamous cell carcinoma (FOSCC) and human head and neck squamous cell carcinoma (HNSCC) are the 4th most common malignant neopla … q6000 as 2 × 150 bp reads. The data was analysed with the McDonnell Genome Institute's (MGI) cancer informatics pipelines, namely the Genome Modelling System (GMS), which was adapted to the feline genome. TP53 harboured consequential variants in 71% of the FOSCC tumours and was the most commonly mutated gene. Consequential variants in TTN were seen in 18% tum …

Content quality and source credibility of fall prevention videos for older adults on Chinese short-video platforms: A cross-sectional content analysis.

BACKGROUND: Falls constitute a leading cause of injury-related mortality among older adults globally. Chinese short-video platforms collecti … ndependent medical-school graduates with formal medical education and research expertise in medical informatics assessed video quality using the modified DISCERN instrument (mDISCERN; range 5-25) and Global Quality Scale (GQS; range 1-5). Interrater agreement was quantified using both intraclass correlation coefficients (ICC) and Cohen's weighted κ. User enga …

Serial Plasma Comprehensive Genomic Profiling Captures Therapy Resistance and Guides Management of Non-Small Cell Lung Cancer.

UNLABELLED: Plasma comprehensive genomic profiling (pCGP) is implemented in the clinical care of non-small cell lung cancer (NSCLC). Althoug … implementation of serial pCGP within a thoracic oncology program, supported by a precision oncology informatics framework, in a tertiary healthcare institution. We show that pCGP enables genotyping when tissue testing is not feasible and identifies actionable mutations at resistance. The clinical implementation of pCGP can drive improved clinical outcomes by …

Comprehensive geriatric assessment in Chinese oncology practice: Adoption, training, and barriers. A mixed-methods study.

INTRODUCTION: Comprehensive geriatric assessment (CGA) is recommended to support individualized care for older adults with cancer, yet its u … ning streamlined oncology-relevant assessments, explicit trigger points, task-sharing, and embedded informatics may provide a feasible direction for future implementation, pending validation in prospective, co-designed studies.

Evaluating the Cyclical Hybrid Imputation Technique (CHIT) under MCAR, MAR, and MNAR missing data mechanisms: Evidence from health datasets.

Choosing an appropriate imputation strategy for clinical datasets requires understanding which missing data mechanism is operative, yet most … aken together, these results provide mechanism-specific guidance for imputation selection in health informatics pipelines. Statistical significance of classifier accuracy differences between CHIT and MICE was assessed using McNemar's test (two-tailed, continuity-corrected chi-square) applied to the exact binary prediction vectors from each experiment [n_test …

Reliability-aware transfer learning with BEATs for variable-length respiratory sound classification: a patient-disjoint evaluation in two public databases.

Random or central placement of respiratory sounds within padded windows can cause length-based masks to exclude recorded audio. We developed … verage. The study included 15 987 events from the International Conference on Biomedical and Health Informatics (ICBHI) 2017 and SPRSound databases, using patient-disjoint training, model-selection, calibration and primary test partitions at a fixed decision threshold of 0.5. The three-seed full-fine-tuning ensemble achieved average scores (AS; mean sensitivi …

Fatal neuroleptic malignant syndrome: a forensic case series on postmortem diagnostic challenges.

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse reaction to antipsychotic and other dopamine-modulating medicat … edicine Board (FFMB) reports between 2013 and 2024 (n = 53,677) obtained via the National Judiciary Informatics System (UYAP) were screened. Cases in which NMS or malignant hyperthermia was considered underwent detailed manual review, and only those in which the FFMB established NMS or malignant hyperthermia as the final cause of death were included. Demograp …

Osteoporosis treatment gap and prescribing patterns in Ireland: a cross-sectional analysis of the DXA HIP project.

OBJECTIVES: Previous studies suggest Ireland has the smallest osteoporosis treatment in Europe and very little inappropriate prescribing, in contrast to our experience. In this study, we examine the osteoporosis treatment gap in Ireland by assessing the prevalence of appropriate and inappropriate prescribing in 2 subgroups of the Irish dual-energy X-ray absorptiometry (DXA) Health Informatics Prediction (HIP) Project. Treatment eligibility was defined using established intervention thresholds, including prior fracture, femoral-neck T-score ≤-2.5, glucocorticoid use, or Fracture Risk Assessment…

Enterocutaneous Fistula-Associated Sepsis and Mortality: Development and Validation of a Multimodal Artificial Intelligence Prediction Model.

BACKGROUND: Predicting enterocutaneous fistula (ECF)-associated sepsis and mortality poses significant challenges in digital health care due … +) T cells. CONCLUSIONS: This multimodal AI model offers an innovative digital solution in medical informatics, enabling precise early risk stratification for ECF-associated sepsis. By integrating multisource data and providing interpretable insights into immune-inflammatory pathways, the model enhances health care quality for patients with ECF and paves the …

Stakeholder Perspectives on Health System Readiness for Integrating Artificial Intelligence into Public Health in Saudi Arabia.

Background/Objectives: Although artificial intelligence (AI) has the potential to strengthen disease surveillance, predictive analytics, pre … d using semi-structured interviews with 32 participants, including healthcare professionals, health informatics experts, and policymakers or healthcare planning stakeholders in Saudi Arabia. Participants were purposively selected based on their relevant professional experience. Data were analyzed using Braun and Clarke's six-phase reflexive thematic analysis. …

Current Utilization and Research Status of the Herbal Medicine Guibi-Tang and Its Variants for Cognitive Impairment: A Scoping Review.

Background/Objectives: Guibi-tang (GBT) and its variant Kami-guibi-tang (KGBT) are traditional East Asian multi-herb formulas prescribed for … onal Knowledge Infrastructure, ScienceON, Scopus, Citation Information by the National Institute of Informatics) from inception to 31 January 2025, for human studies evaluating GBT or KGBT in subjective cognitive decline, mild cognitive impairment (MCI), dementia, or post-stroke cognitive impairment (PSCI). Two reviewers independently screened, extracted, and …

Elevated Interleukin-6 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans.

BACKGROUND: Although accumulating data indicate that IL-6 (interleukin-6) can promote heart rate-corrected QT interval (QTc) prolongation vi … ion of unselected subjects. METHODS AND RESULTS: An observational study using the Veterans Affairs Informatics and Computing Infrastructure was performed. Participants were US veterans who had an ECG and were tested for IL-6. Descriptive statistics and univariate and multivariate regression analyses were performed to study the relationship between IL-6 and Q …

The relationship between the structural changes in the cervical spinal cord and sensorimotor function of children with thoracolumbar spinal cord injury (TLSCI).

STUDY DESIGN: Cross-sectional study. OBJECTIVES: To study the relationship between the structural changes in the cervical spinal cord (C2/3 level) and the sensorimotor function of children with traumatic thoracolumbar spinal cord injury (TLSCI) and to discover objective imaging biomarkers to evaluate its functional status. SETTING: Xuanwu Hospital, Capital Medical University, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, China. METHODS: 30 children (age range 5-13 years) with TLSCI and 11 typically developing (TD) children (age range 6-12 years) were rec…

Alignment of contraception use with the ACR reproductive health guidelines in women with systemic lupus erythematosus within the RISE registry.

OBJECTIVES: Contraception is crucial for safely timing pregnancies in patients with SLE. This study investigated predictors of contraception documentation in patients with SLE, and the alignment of contraception practices with the 2020 American College of Rheumatology (ACR) guidelines, within the Rheumatology Informatics System for Effectiveness (RISE) registry. MATERIALS AND METHODS: Female patients (aged 18-44 years) with SLE were identified via International Classification of Diseases (ICD)-9/ICD-10 coding within the RISE registry, which includes data from rheumatology clinics across the U…

Усовершенствованная последовательность транскриптомов и искусственный интеллект/машинное обучение (AI/ML) в имитируемом псориазом воспалении кератиноцитов человека.

ВВЕДЕНИЕ: Несмотря на то, что модель Keratinocyte HaCAT использовалась в предыдущих исследованиях для изучения воздействия антипсориатических агентов, по-прежнему отсутствует полное понимание механизма имитируемого имимодом распространения и трансдукции сигналов в псориазных кератиноцитах. ЦЕЛИ: Данное исследование было направлено на изучение молекулярных механизмов и путей, связанных с воспалением, подобным псориазу, в результате IMQ в кератиноцитах человека. МАТЕРИАЛЫ И МЕТОДЫ: Клетки HACAT подвергались воздействию различных концентраций IMQ, чтобы вызвать воспаление, аналогичное тому, котор

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INTRODUCTION: Although the HaCaT keratinocyte model has been used in previous research to study the effects of antipsoriatic agents, there i … opy. Gene expression profiles were analyzed through whole transcriptome sequencing, followed by bio-informatics network analysis using IPA software. The GSEA was conducted with the aim of identifying enriched pathways. The expression of key cytokines IL-6 and TNF-α was confirmed by QPCR. Artificial intelligence/machine learning (AI/ML) algorithms were used to …