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Diagnostic accuracy of deep learning vs. human raters for detecting osteoporotic vertebral compression fractures in routine CT scans.

OBJECTIVES: Vertebral fractures are severe complications of osteoporosis but are frequently missed on computed tomography (CT). Differentiating true fractures from non-osteoporotic vertebral height loss remains challenging; deep learning (DL) models may improve detection and grading. MATERIALS AND METHODS: In this retrospective study, we evaluated eight human raters with different expertise (three students, three residents, and two attendings), four DL models, and one DL-based commercial software using the public Vertebral Segmentation (VerSe) 19 & 20 datasets. Vertebral fractures were graded

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… Osseous alterations, including Schmorl nodes, hemangiomas, degenerative changes, and foreign materials from kyphoplasty or spondylodesis, were deliberately retained in the dataset to capture the broadest possible spectrum of spinal morphology [ 19 – 21 ]. …

Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.

ObjectiveThis review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.MethodsA systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed. Using the Delphi method and two rounds of vot

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… Promising strategies which have emerged as less invasive alternatives in treatment of spinal metastases are a combination of radiofrequency ablation (RFA) and vertebral augmentation, such as balloon kyphoplasty and other techniques [ 30 ]. …

Quality of Life in Palliative Care: A Systematic Meta-Review of Reviews and Meta-Analyses.

BackgroundThe area of palliative care is a setting in which the evaluation of the quality of life (QoL) is fundamental. However, the topic has been covered from many different points of view, and there is a lack of comprehensive synthesis of the evidence drawn from the available literature.ObjectiveWe carried out a meta-review of all available systematic reviews and meta-analyses that have dedicated part or most of the investigation to the assessment of QoL in palliative care to provide the most updated and comprehensive depiction of all available information about measurement and intervention

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… Health Quality Ontario Vertebral augmentation involving vertebroplasty or kyphoplasty for cancer-related vertebral compression fractures: A systematic review. Ont. Health Technol. Assess. Ser. 2016;16(11):1–202. 9. Barnes H, McDonald J, Smallwood N, Manser R. …

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.

During the last few years, several new drugs have been introduced for treatment of patients with multiple myeloma, which have significantly improved the treatment outcome. All of these novel substances differ at least in part in their mode of action from similar drugs of the same drug class, or are representatives of new drug classes, and as such present with very specific side effect profiles. In this review, we summarize these adverse events, provide information on their prevention, and give practical guidance for monitoring of patients and for management of adverse events.

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… INR international normalized ratio, VTE venous thromboembolism a Defined as a body mass index ≥30 kg/m 2 b Comorbidities include diabetes, infections, cardiac diseases, chronic renal disease, and immobilization c Surgical procedures include general surgery, any anesthesia, trauma, vertebroplasty, and kyphoplasty …

Risk and response adapted therapy following autologous stem cell transplant in patients with newly diagnosed multiple myeloma (RADAR (UK-MRA Myeloma XV Trial): study protocol for a phase II/III randomised controlled trial.

IntroductionMultiple myeloma is a plasma cell malignancy that accounts for 1%-2% of newly diagnosed cancers.At diagnosis, approximately 20% of patients can be identified, using cytogenetics, to have inferior survival (high-risk). Additionally, standard-risk patients, with detectable disease (minimal residual disease (MRD)-positive) postautologus stem cell transplant (ASCT), fare worse compared with those who do not (MRD-negative). Research is required to determine whether a risk-adapted approach post-ASCT could further improve patient outcomes.MethodsRADAR is a UK, multicentre, risk-adapted, r

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… This would include surgical intervention for relief of cord compression but does not include vertebroplasty or kyphoplasty. Known gastrointestinal (GI) disease or GI procedure that could interfere with the oral absorption or tolerance of trial treatment, including difficulty swallowing. …

Е-постеры.

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… Kyphoplasty can more effectively restore vertebral height, correct kyphosis. The most common complication of the kyphoplasty is cement leakage (8.0% in our institute). The study aim was to investigate the morphological features of the posterior vertebral wall in Osteoporotic fracture patients. … Methods: Total of 196 patients with a thoracolumbar osteoporotic vertebral fracture who were managed with kyphoplasty from 2015 to 2018 retrospectively included in this study. …

Modern Treatment of Skeletal Metastases: Multidisciplinarity and the Concept of Oligometastasis in the Recent Literature.

Bone metastases are a major concern in cancer management since they significantly contribute to morbidity and mortality. Metastatic lesions, commonly arising from breast, prostate, lung, and kidney cancers, affect approximately 25% of cancer patients, leading to severe complications such as pain, fractures, and neurological deficits. This narrative review explores contemporary approaches to bone metastases, emphasizing a multidisciplinary strategy and the evolving concept of oligometastatic disease. Oligometastases, defined by limited metastatic spread (1-5 lesions), offer a potential window f

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… Minimally invasive strategies such as percutaneous vertebroplasty, kyphoplasty, and radiofrequency ablation (RFA) are increasingly used to manage spinal and pelvic metastases. …

Multidisciplinary Approach to Spinal Metastases and Metastatic Spinal Cord Compression-A New Integrative Flowchart for Patient Management.

Metastatic spine disease (MSD) and metastatic spinal cord compression (MSCC) are major causes of permanent neurological damage and long-term disability for cancer patients. The development of MSD is pathophysiologically framed by a cooperative interaction between general mechanisms of bone growth and specific mechanisms of spinal metastases (SM) expansion. SM most commonly affects the thoracic spine, even though multiple segments may be affected concomitantly. The great majority of SM are extradural, while intradural-extramedullary and intramedullary metastases are less frequently seen. The ma

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… radiotherapy and stereotactic body radiation therapy (regarding this matter, the radiosensitivity of the tumor should be considered); open surgery (decompressive laminectomy, pedicle screw fixation, intersomatic device implantation, separation surgery); and minimally invasive approaches (vertebroplasty, kyphoplasty …

Management of Adverse Events and Supportive Therapy in Relapsed/Refractory Multiple Myeloma.

Relapsed/refractory (RR) multiple myeloma (MM) patients are a fragile population because of prolonged drug exposure and advanced age. Preserving a good quality of life is of high priority for these patients and the treatment of disease- and treatment-related complications plays a key role in their management. By preventing and limiting MM-induced complications, supportive care improves patients' outcome. Erythropoietin-stimulating agents and bisphosphonates are well-established supportive strategies, yet novel agents are under investigation, such as anabolic bone agents and activin receptor-li

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… In particular, kyphoplasty is recommended for symptomatic vertebral compression fracture, surgery for long-bone pathological fractures or vertebral column instability, and radiotherapy should be considered for uncontrolled pain or spinal cord compression [ 39 ]. …

Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management.

Bone metastases (BM) are a common complication of cancer, whose management often requires a multidisciplinary approach. Despite the recent therapeutic advances, patients with BM may still experience skeletal-related events and symptomatic skeletal events, with detrimental impact on quality of life and survival. A deeper knowledge of the mechanisms underlying the onset of lytic and sclerotic BM has been acquired in the last decades, leading to the development of bone-targeting agents (BTA), mainly represented by anti-resorptive drugs and bone-seeking radiopharmaceuticals. Recent pre-clinical an

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… Besides traditional surgery, less invasive procedures such as percutaneous vertebroplasty and kyphoplasty can be considered for selected patients [37] . …

Myeloma bone disease: Pathophysiology and management.

Multiple myeloma bone disease is marked by severe dysfunction of both bone formation and resorption and serves as a model for understanding the regulation of osteoblasts (OBL) and osteoclasts (OCL) in cancer. Myeloma bone lesions are purely osteolytic and are associated with severe and debilitating bone pain, pathologic fractures, hypercalcemia, and spinal cord compression, as well as increased mortality. Interactions within the bone marrow microenvironment in myeloma are responsible for the abnormal bone remodeling in myeloma bone disease. Myeloma cells drive bone destruction that increases t

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… Bone disease is managed with a combination of bisphosphonate therapy, localized radiation, (for control of bone pain, treatment of impending fractures or solitary plasmacytomas) and kyphoplasty, vertebroplasty, or surgery. …

Текущая роль физиотерапии в системном свето-хайне (AL) амилоидозе и множественной миеломе.

Физиотерапия представляет собой научно обоснованную медицинскую работу, направленную на сотрудничество в диагностике, профилактике и лечении множества болезней и клинических сценариев на всех этапах жизни человека. Его развитие ускорилось за последние годы. two десятилетиями. Сфера физиотерапии постоянно эволютивна. Однако накопленных данных о редких заболеваниях мало. Следует отметить, что возможности для улучшения ситуации и получения потенциальных выгод от сложных заболеваний с низким уровнем заболеваемости также весьма высоки как в виде изолированного подхода, так и в рамках многодисциплин

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… The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: A consensus statement from the International Myeloma Working Group (IMWG) Blood Cancer J. 2019 9 27 10.1038/s41408-019-0187-7 30808868 PMC6391474 …

Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015-2024).

BackgroundCancer-induced bone pain (CIBP) represents a formidable clinical challenge with complex mechanisms, and existing treatments remain unable to effectively control pain in many patients. This study combined bibliometric and bioinformatic approaches to delineate key research trends, principal themes and future directions in the field of bone metastasis and pain research over the past decade (2015-2024).MethodsWe selected 1,822 relevant documents from the Web of Science Core Collection for bibliometric analysis to identify major research characteristics, collaboration networks and emergin

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… #9 percutaneous osteoplasty: Concerned the application of percutaneous osteoplasty (vertebroplasty/kyphoplasty) in treating spinal metastases and relieving pain. …

Symptomatic spinal metastasis: A systematic literature review of the preoperative prognostic factors for survival, neurological, functional and quality of life in surgically treated patients and methodological recommendations for prognostic studies.

PurposeWhile several clinical prediction rules (CPRs) of survival exist for patients with symptomatic spinal metastasis (SSM), these have variable prognostic ability and there is no recognized CPR for health related quality of life (HRQoL). We undertook a critical appraisal of the literature to identify key preoperative prognostic factors of clinical outcomes in patients with SSM who were treated surgically. The results of this study could be used to modify existing or develop new CPRs.MethodsSeven electronic databases were searched (1990-2015), without language restriction, to identify studie

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… Table 1 Inclusion and exclusion criteria. 1 Spinal surgery refers to a de novo surgical treatment involving any open or minimally invasive spinal interventions, including vertebroplasty and kyphoplasty, to achieve partial or complete spinal decompression and/or mechanical stabilization, with or without …

Oral Presentations

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… Surgical approach: Fixation with percutaneous screws in 72 patients, epidural decompression (tumor separation surgery) in 35 patients (48.6%) (using tubular or “mini-open” midline surgery), and associated kyphoplasty to fixation in 21 patients (29.1%). …

A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population.

Study designSystematic review and clinimetric analysis.ObjectivesFrailty and sarcopenia predict worse surgical outcomes among spinal degenerative and deformity-related populations; this association is less clear in the context of spinal oncology. Here, we sought to identify frailty and sarcopenia tools applied in spinal oncology and appraise their clinimetric properties.MethodsA systematic review was conducted from January 1st, 2000, until June 2022. Study characteristics, frailty tools, and measures of sarcopenia were recorded. Component domains, individual items, cut-off values, and measurem

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… not undergo spinal surgery for a spinal column or spinal cord tumor Intervention • Index (initial) surgery (minimally invasive or open) • Non-operative management, including patients treated solely with radiotherapy or stereotactic radiosurgery, chemotherapy, or immunotherapy • Patients treated with kyphoplasty … undergo spinal surgery for a spinal column or spinal cord tumor Intervention | • Index (initial) surgery (minimally invasive or open) | • Non-operative management, including patients treated solely with radiotherapy or stereotactic radiosurgery, chemotherapy, or immunotherapy • Patients treated with kyphoplasty …

Review of imaging techniques for evaluating morphological and functional responses to the treatment of bone metastases in prostate and breast cancer.

Bone metastases are very common complications associated with certain types of cancers that frequently negatively impact the quality of life and functional status of patients; thus, early detection is necessary for the implementation of immediate therapeutic measures to reduce the risk of skeletal complications and improve survival and quality of life. There is no consensus or universal standard approach for the detection of bone metastases in cancer patients based on imaging. Endorsed by the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Medical Radiology (SERAM), and the

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… (EBRT), stereotactic body radiation therapy (SBRT)); (4) bone-targeting radiopharmaceuticals (e.g., samarium-153, strontium-89, and radium-223); (5) surgery, which is typically reserved for patients with a complete or imminent pathological fracture; and (6) local treatments, such as vertebroplasty, kyphoplasty …

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus.

BackgroundThe COVID-19 pandemic has created enormous challenges for the clinical management of patients with hematological malignancies (HMs), raising questions about the optimal care of this patient group.MethodsThis consensus manuscript aims at discussing clinical evidence and providing expert advice on statements related to the management of HMs in the COVID-19 pandemic. For this purpose, an international consortium was established including a steering committee, which prepared six working packages addressing significant clinical questions from the COVID-19 diagnosis, treatment, and mitigat

Expert consensus on resection of chest wall tumors and chest wall reconstruction.

Chest wall tumors are a relatively uncommon disease in clinical practice. Most of the published studies about chest wall tumors are usually single-center retrospective studies, involving few patients. Therefore, evidences regarding clinical conclusions about chest wall tumors are lacking, and some controversial issues have still to be agreed upon. In January 2019, 73 experts in thoracic surgery, plastic surgery, science, and engineering jointly released the Chinese Expert Consensus on Chest Wall Tumor Resection and Chest Wall Reconstruction (2018 edition). After that, numerous experts put forw

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… The introduction of modern spinal fixation and stabilization methods, such as vertebroplasty and kyphoplasty, allows for a surgical solution for patients who develop vertebral fractures, vertebral instability, neurological complications, or a combination of these. …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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