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Пример MobileNetV2-Based Искусственный интеллект для быстрого и точного диагностирования множественных склерозов

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое сильно влияет на молодых людей из-за его изнурительной природы. Патогенез болезни сосредоточен на воспалении и процессах нейродегенерации. Воспаление ассоциируется с рецидивами, в то время как нейродегенерация возникает на прогрессивных стадиях болезни. Для диагностики MS обычно используется магнитно-резонансная съемка (MRI), и имеются такие руководящие принципы, как критерии McDonald. МРТ является важным инструментом для демонстрации пространственного распределения и изменений во времени в э

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that prominently affects young adults due to its debilitating nature. The pathogenesis of the disease is focused on the inflammation and neurodegeneration processes. Inflammation is associated with relapses, while neurodegeneration emerges in the progressive stages of the d…

Methyl-CpG-Binding Protein 2 Emerges as a Central Player in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders.

MECP2 and its product methyl-CpG binding protein 2 (MeCP2) are associated with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), which are inflammatory, autoimmune, and demyelinating disorders of the central nervous system (CNS). However, the mechanisms and pathways regulated by MeCP2 in immune activation in favor of MS and NMOSD are not fully understood. We summarize findings that use the binding properties of MeCP2 to identify its targets, particularly the genes recognized by MeCP2 and associated with several neurological disorders. MeCP2 regulates gene expression …

Long-term safety of rituximab induced peripheral B-cell depletion in autoimmune neurological diseases.

BACKGROUND: B-cells play a pivotal role in several autoimmune diseases, including patients with immune-mediated neurological disorders (PIMND), such as neuromyelitis optica (NMO), multiple sclerosis (MS), and myasthenia gravis (MG). Targeting B-cells has been an effective approach in ameliorating both central and peripheral autoimmune diseases. However, there is a paucity of literature on the safety of continuous B-cell depletion over a long period of time. OBJECTIVE: The aim of this study was to examine the long-term safety, incidence of infections, and malignancies in subjects receiving con…

[Stem cell transplantation for multiple sclerosis. Hamburg experiences and state of international research].

BACKGROUND: Autologous hematopoietic stem cell transplantation (aHSCT) is still not the standard treatment for highly inflammatory multiple sclerosis (MS). Even though randomized controlled trials are lacking, predictors for treatment response have been established. Since 2007, ten patients have received aHSCT in Hamburg. OBJECTIVE: To present observational data from patients treated in Hamburg and a review of the literature. METHODS: Descriptive statistics were used for evaluating the course of the expanded disability status scale (EDSS) as a measure for clinical outcome, magnetic resonance…

Role of MRI in multiple sclerosis II: brain and spinal cord atrophy.

A growing body of evidence indicates that irreversible tissue destruction including axonal and neuronal degeneration is a key component of the multiple sclerosis (MS) disease process. Magnetic resonance imaging (MRI) is a powerful technique that can be combined with semiautomated or automated computer assisted analysis approaches to detect progressive atrophy of the brain and spinal cord with high sensitivity and reproducibility. The pathophysiology of central nervous system (CNS) atrophy in MS is unknown but likely represents an epiphenomenon related to the effects of inflammation including c…

Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients.

Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Recently, a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds FasL and inhibits FasL-induced apoptosis, has been identified. Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities. We have found that serum soluble Fas (sFas) levels are elevated in silicosis patients and that sFas message is dominantly expressed in PBMC derived from th

Targeting neuroinflammation in neurodegenerative disorders: the emerging potential of semaglutide.

BACKGROUND: Chronic neuroinflammation is increasingly recognized not as a secondary effect but as a primary driver of neurodegenerative disease progression. In conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Huntington's disease (HD), and Lewy body dementia (LBD), dysregulated glial activity, marked by sustained microglial and astrocytic activation, initiates a cascade of cytokine release, oxidative stress, and impaired neuronal support. This review synthesizes recent advances in…

Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.

BACKGROUND: Rheumatic diseases are chronic immune-mediated disorders affecting multiple organ systems and significantly impairing patients' quality of life. Current treatments primarily provide symptomatic relief without offering a cure. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option due to their ability to differentiate into various cell types and their immunomodulatory, anti-inflammatory, and regenerative properties. This review aims to summarize the clinical progress of MSC therapy in rheumatic diseases, highlight key findings from preclinical and clinical stud

The Cambridge Centre for Myelin Repair trial Two (CCMR Two): a trial protocol for a phase 2a, randomised, double-blind, placebo-controlled clinical trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease-modifying therapy.

BACKGROUND: In multiple sclerosis (MS), progressive disability occurs following degeneration of demyelinated axons. A tractable approach to delay, prevent or reverse disability progression is through enhancement of endogenous remyelination. Clinical trials have deployed drugs, such as clemastine, to target the rate-limiting step in this process: differentiation of oligodendrocyte progenitor cells (OPCs). Preclinical research has shown that metformin can reverse an age-associated deficit in the responsiveness of OPCs to pro-differentiation factors. The purpose of the Cambridge Centre for Myelin…

Эффективность с точки зрения затрат приложения " Flowlight " в Австрии Разблокировать загадку затрат и результатов цифрового медицинского приложения для пациентов с множественным склерозом.

ЦЕЛЬ: Множественный склероз (MS) представляет собой хроническое воспламенительное демиелинирующее заболевание, затрагивающее 2.9 million люди во всем мире, часто приводящие к постоянной инвалидности. Пациенты, страдающие синдромом MS, часто пользуются средствами электронного здравоохранения в силу своего относительно молодого возраста. Приложение Flowlight_MS — научно разработанное приложение для смартфонов, которое помогает пациентам следить за навыками ручной моторной работы, ходьбой и когнитивностью между врачами. В этом исследовании оценивается рентабельность использования приложения &quot

Совпадение в аннотации оригинала
OBJECTIVE: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting 2.9 million people worldwide, often leading to permanent disability. MS patients frequently use eHealth tools due to their relatively young age. The Floodlight® MS app is a scientifically designed smartphone application that helps patients monitor hand motor skills, …

The Prevalence of Comorbidities Associated with Multiple Sclerosis in Saudi Arabia.

BACKGROUND: Multiple sclerosis (MS) is a chronic, immune mediated demyelinating illness of the central nervous system. This study looks at various comorbidities associated with MS, focusing on their impact on disease progression. Understanding comorbidities in MS is important as it can impact treatment selection and overall disease management and prognosis. AIMS AND OBJECTIVES: Our aim is to show the prevalence of comorbidities along with MS. This research focuses on the comorbidities associated with MS and their impact on disease progression in the Arab Gulf region, with a special emphasis o…

Бензойлацетонитрил как новый антивоспалительный соединение для смягчения микроглии и энцефалитогенной Т активации экспериментального аутоиммунного энцефаломиелита.

Множественный склероз (MS) — аутоиммунное расстройство, характеризующееся иммунной нейроинфламмацией и демиелинацией, вызванной иммунными клетками CNS, микроглией (MG) и патогенными клетками CNS. Экспериментальный аутоиммунный энцефаломиелит (EAE) — это животная модель MS, а активация MG и патогенная инфильтрация клеток Th1/TH17 отвечает за развитие и развитие EAE. Ранее мы продемонстрировали, что бензолацетонитрилы проявляли нейроиммуномодулическую активность, и определили соединение 7а (далее именуемое BTA) как многообещающий аналог. Здесь мы изучили вопрос о том, имеет ли БТА влияние на мод

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an autoimmune disorder and characterized by immune-mediated neuroinflammation and demyelination triggered by the CNS resident immune cells, microglia (MG), and CNS infiltrating pathogenic T cells. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS, and MG activation and pathogenic Th1/Th17 cell infiltration is…

Apolipoprotein E4 and its later-life health effects on the multiple sclerosis population.

BACKGROUND AND OBJECTIVES: Multiple sclerosis (MS) is a chronic autoimmune disease causing neuroinflammation and neurodegeneration. The apolipoprotein E4 (APOE4) allele, a major genetic risk factor for late-onset Alzheimer's Disease, accelerates cognitive decline and neuroinflammatory processes, including blood-brain-barrier disruption. This study explores the impact of APOE4 on later-life health in MS patients using biomarkers from the UK Biobank. METHODS: MS patients were grouped by APOE4 carrier status: MS-E4 and MS-nonE4. Age- and sex-matched non-MS controls (control-E4, control-nonE4) we…

LncRNA AFAP1-AS1 mediates therapy-dependent expression of CCL5, CXCL10 and MMP9 in multiple sclerosis.

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. It is characterized by inflammation, areas of demyelination and axonal loss called plaques, recruitment of lymphocytes and monocytes, and bursts of focal blood-brain barrier leakage. Treatment strategies for MS focus on delaying disease progression and increasing patients' quality of life. However, most therapies have inconsistent efficacies and are associated with various side effects. Recently, long non-coding RNAs have been found to play a major role in the pathogenesis and development of sev…

Декодирование молекулярных и клеточных аспектов множественного склероза: от диагностики до терапевтических стратегий.

Множественный склероз (MS) представляет собой многогранное хроническое нейро-воспалительное состояние центральной нервной системы (CNS), характеризующееся обезвоживанием, глиозом и аксонной деградацией. Несмотря на всеобъемлющее исследование, точная этиология остается неясной и требует сложного взаимодействия между генетическими, эпигенетическими и экологическими переменными. Этот обзор свидетельствует о настоятельной необходимости интеграции новых данных, связывающих генетическую предрасположенность, в частности вариантов HLA-DRB1*15:01 и более 200 не связанных с HLA, с изменяющимися экологич

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a multifaceted, chronic neuroinflammatory condition of the central nervous system (CNS) marked by demyelination, gliosis, and axonal degradation. Despite the comprehensive investigation, the exact etiology remains unclear, requiring complex interactions among genetic, epigenetic, and environmental variables. This review highlights …

Exploring cortical activation patterns during linear vs. curvilinear walking in people with multiple sclerosis using a walking aid.

Multiple Sclerosis (MS) is a chronic disease of the central nervous system characterized by inflammation, demyelination, axon loss and gliosis. Mobility impairment is one of the key clinical symptoms of MS, and a decline in walking abilities can significantly affect quality of life in people with MS (PwMS). As the disease progresses, these symptoms typically worsen, requiring the support of walking aid during gait. Here, we aimed to identify the cortical activation patterns associated with walking in PwMS using walking aids, by means of functional Near-Infrared Spectroscopy (fNIRS). Also, sinc…

The impact of autoimmune comorbidities on multiple sclerosis progression: insights from a longitudinal single-center study.

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The presence of other conditions alongside MS imposes a substantial personal and socioeconomic burden. In particular, the impact of comorbid autoimmune diseases (AID) on MS outcomes remains uncertain. In this retrospective longitudinal study, we examined the prevalence of AID in a cohort of patients with different types of MS. For patients with relapsing-remitting MS (RRMS), negative binomial and linear regression models were used to assess adjusted associations between the presence of AID and vari…

От воспаления к вмешательству: изучение общих механизмов и стратегий образа жизни в условиях сахарного диабета и множественного склероза.

Диабет mellitus (DM) и множественный склероз (MS), хотя и влияет соответственно на метаболические и неврологические системы, имеют общие иммунометаболические пути. В этом обзоре обобщаются последние данные, свидетельствующие о наличии дублирующих механизмов, связывающих DM и MS, с упором на метаболическую дисфункцию и системное воспаление, с терапевтическим потенциалом вмешательства в образ жизни наряду с фармакотерапией. В ходе всеобъемлющего анализа литературы были изучены общие патогенезы в ходе недавних исследований. Мы предлагаем новую концептуальную основу, объединяющую поведенческие дви

Совпадение в аннотации оригинала
Diabetes mellitus (DM) and multiple sclerosis (MS), while affecting metabolic and neurological systems respectively, share convergent immunometabolic pathways. This review synthesizes recent evidence elucidating overlapping mechanisms linking DM and MS, emphasizing metabolic dysfunction and systemic inflammation, with therapeutic potential of lifestyle inter…

Интерлейкин 15 и аутоиммунные расстройства: патофизиология, терапевтический потенциал и клинические последствия.

Interleukin-15 (IL-15) — плейотропный цитокин из семейства, играющий центральную роль в развитии, выживании и активации клеток естественного убийцы (NK) и памяти CD8+T. Его строго регулируемое выражение имеет важное значение для сохранения иммунного гомеостаза, в то время как дисрегулирование сигнала IL-15 было связано с патогенезом различных аутоиммунных и хронических подстрекательских заболеваний. В настоящем обзоре рассматриваются структурные особенности, рецепторный комплекс и сигнальные механизмы IL-15, с уделением особого внимания его иммунодуляторным функциям как врожденного, так и адап

Совпадение в аннотации оригинала
Interleukin-15 (IL-15) is a pleiotropic cytokine of the common γ-chain (γc) family, playing a central role in the development, survival, and … nd progression of autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis (MS), type 1 diabetes, celiac disease, inflammatory bowel disease, psoriasis, and ankylosing spondylitis. Special focus is given to IL-15-mediated activation of tissue-resident memory T cells (TRM), cytotoxic CD8+ T cells, and NK cells, which contri …

Microbiota-Driven Mechanism in Multical Sclerosis: патогенез, терапевтические стратегии и биомаркерский потенциал.

Множественный склероз (MS) — известное хроническое аутоиммунное расстройство центральной нервной системы (КНС), связанное с демиэлированием и нейродегенерацией. Исследования, ранее проведенные в области кишечного микробиома, показали, что он является важнейшим источником патогенеза MS. Изменения в комменсовом микробиоте, или дисбиозе, оказывают воздействие на иммунный гомеостаз, что приводит к повышению уровней провоспалительных цитокинов и нарушению оси кишечника. В этом обзоре мы представляем всеобъемлющий обзор взаимодействия между кишечной микробиотой и MS с уделением особого внимания имму

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a well-known, chronic autoimmune disorder of the central nervous system (CNS) involving demyelination and neurodegeneration. Research previously conducted in the area of the gut microbiome has highlighted it as a critical contributor to MS pathogenesis. Changes in the commensal microbiota, or dysbiosis, have been shown to affect im…