Результаты поиска

Hyaluronic acid-based selegiline nanostructured lipid carriers incorporated dissolving microneedles: A localised transdermal delivery strategy for obesity management.

Obesity is a multifactorial disorder correlated with metabolic complications. Conventional oral therapy for obesity has limitations due to i … of 82.95 ± 3.76 over 8 h. Optimised selegiline-loaded NLCs were combined with hyaluronic acid (HA), polyvinyl alcohol (PVA), and polyvinylpyrrolidone (PVP) based dissolving microneedles (DMNs). The tip of the microneedle, which is made up of HA, a biodegradable polymer that can efficiently release the activity of SEL-NLCs into the bloodstream. In addition, the comb …

A light-controlled hydrogel for regulating oxidative stress in the treatment of psoriasis.

Psoriasis is a common chronic autoinflammatory skin disease characterized by excessive proliferation of keratinocytes and marked thickening … ng a composite system denoted as Chl-Ag@ZnO/C-P (Chlorella and Ag@ZnO‑loaded carboxymethyl chitosan/polyvinyl alcohol hydrogel). In the initial dark phase, Chlorella scavenges pathological ROS to alleviate inflammation. Upon light irradiation, Ag@ZnO generates therapeutic ROS to induce keratinocyte apoptosis, while Chlorella simultaneously produces oxygen to enhanc …

Eco-Friendly Carbon Dots from Pistia stratiotes L.: Development of a Biodegradable Sensor for Selective Detection of Levofloxacin in Water.

Carbon dots (CDs), recognised for their stable and tunable emission properties, have gained momentum as eco-friendly fluorescent probes. Thi … ion (LOD) of 0.799 μM. A biodegradable polymer composite film (PVA-CA-CDs) incorporating the CDs in polyvinyl alcohol (PVA) matrix was also developed, maintaining strong fluorescence and stability, detecting LFN in micro volumes (20 μL) with an LOD of 7.16 μM. TEM, FE-SEM, and atomic force microscopy (AFM) confirmed uniform dispersion of CDs within the polymer matr …

Evaluation of Carboxymethyl Chitosan Hydrogel Containing Caviar Extract Effect on Skin Regeneration.

Skin aging involves changes in extracellular matrix components, such as wrinkles and pigmentation. Caviar extract (CE) is a promising compound for skin rejuvenation, but effective topical delivery requires optimized carriers. This study evaluated polyvinyl alcohol/carboxymethyl chitosan (PVA/CMC) hydrogels loaded with CE at concentrations of 2%, 3.5%, and 5% as scaffolds to influence the epithelial differentiation of adipose-derived mesenchymal stem cells (ADMSCs). Hydrogels were synthesized using a freeze-thaw method and characterized by Fourier-transform infrared spectroscopy (FTIR), scannin…

Polyurethane-based bilayer wound dressing with snail mucin, Calendula extract, and zinc-doped carbon dots for enhanced therapeutic and antibacterial performance.

This study develops a bilayer wound dressing with enhanced antibacterial, mechanical, and biological properties, incorporating polyurethane, snail mucin, Calendula officinalis extract, and Zn-doped carbon dots. The bilayer system is designed as a multifunctional platform, achieved through electrospinning of core-shell nanofibers (core: polyurethane and Calendula extract; shell: polyvinyl alcohol and snail mucin) for the contact layer and a polyurethane foam for the top layer. Zn-doped carbon dots are incorporated into a porous polyurethane foam to improve antibacterial activity and mechanical …

Synergistic action of chaotropic agents on the partial casein unfolding and solution stabilization for improved electrospinnability and herb extract loading.

This study presents a synergistic strategy to enhance caseinate electrospinning and incorporation of plant-derived antioxidants, employing chaotropic agents to modulate protein conformation. Sodium dodecyl sulfate (SDS) and ethanol were used to disrupt the protein hydrophobic interactions and to promote unfolding of caseinate in highly concentrated (20 wt%) solutions. A minimal amount of polyvinyl alcohol (24 wt% relative to caseinate) was included to improve electrospinning while preserving the protein-dominant character of the matrix. Methanol and water extracts from rosemary and oregano wer…

Development of a dissolving microneedle patch for transdermal delivery of SARS-CoV-2 mRNA vaccine with enhanced stability and immunogenicity.

Microneedles (MNs)-based transdermal delivery systems present a promising alternative to intramuscular injection (IM) for mRNA vaccines, offering improved patient compliance, enhanced skin-targeted delivery, and increased vaccine stability while reducing hepatic accumulation of lipid nanoparticles (LNPs). Here, we developed a dissolving microneedle patch (DMP) for SARS-CoV-2 mRNA vaccine RQ3013 delivery, employing a matrix composed of 15 % polyvinyl alcohol (PVA) and 10 % polyvinylpyrrolidone (PVP) for its optimal mechanical properties and mRNA-LNPs compatibility. We utilized the one-step vacu…

A buoyant plasmonic microbubble-based SERS sensing platform for amyloid-beta protein detection in Alzheimer's disease.

Amyloid-β (Aβ) plaques are a key pathological hallmark of Alzheimer's disease (AD), highlighting the need for highly sensitive bioassays for Aβ detection to enable AD diagnosis. Here, we synthesized a buoyant plasmonic substrate composed of polyvinyl alcohol microbubbles (MBs) decorated with in situ-reduced gold nanoparticles (Au NPs). Benefiting from its inherent buoyancy and near-infrared plasmonic properties, the Au/MB substrate serves as an ideal platform for biomolecular sensing via the surface-enhanced Raman spectroscopy (SERS) technique. Compared to conventional flat SERS substrates, th…

A visual mining analysis of middle meningeal embolization and other factors associated with recurrence requiring re-operation in subdural hematomas: a single-center series.

PURPOSE: to comprehensively and hierarchically assess risk factors for recurrence requiring reoperation (RrR) in chronic subdural hematoma (cSDH) in the era of middle meningeal artery embolization (MMAE). METHODS: Patients treated for a cSDH from January 2019 to October 2024 at Fondazione Gemelli research hospital were considered for inclusion. Clinical, coagulation, radiological, and treatment factors were recorded. MMAE was performed systematically from October 2022, using polyvinyl alcohol (PVA) particles injected directly from the main trunk of MMA. The dataset comprised 45 quantitative a…

Functional hollow porous microfiber scaffold with BMP-2 for macrophages polarization and bone regeneration.

Artificial bone substitutes have garnered significant attention within the field of biomaterials, and the use of tissue engineering technolo … tyrate-co-4-hydroxybutyrate) (P34HB) and polyethylene glycol (PEG) were used as shell solutions and polyvinyl alcohol (PVA) and bone morphogenetic protein-2 (BMP-2) peptides as core solutions. Compared to PVA/P34HB-PEG (P/P-P) scaffolds, PVA-BMP-2/P34HB-PEG (P-B/P-P) scaffolds polarized more human monocytic leukemia cell line (THP-1 cells) toward alternatively acti …

High Anti-Swelling Zwitterion-Based Hydrogel with Merit Stretchability and Conductivity for Motion Detection and Information Transmission.

Hydrogel sensors show unique advantages in underwater detection, ocean monitoring, and human-computer interaction because of their excellent flexibility, biocompatibility, high sensitivity, and environmental adaptability. However, due to the water environment, hydrogels will dissolve to a certain extent, resulting in insufficient mechanical strength, poor long-term stability, and signal interference. In this paper, a double-network structure was constructed by polyvinyl alcohol (PVA) and poly([2-(methacryloyloxy) ethyl]7 dimethyl-(3-sulfopropyl) ammonium hydroxide) (PSBMA). The resultant PVA/P…

A Self-Adhesive Ginsenoside Rk3/Metformin-Loaded Hydrogel Microneedle for Management of Systemic Sclerosis.

Microcirculation damage, dermal thickening, and difficulty in the spatiotemporal coordination of key platelet factor 4 (CXCL4) and transform … edle system (Rk3/Met URS MN). The rapidly dissolving tips of this hydrogel microneedle consisted of polyvinyl alcohol and polyvinylpyrrolidone, and were loaded with polydopamine-coated, coordination-induced self-assembled Rk3/Met nanomedicines. These micro-tips could spatiotemporally synchronize transdermal delivery of the hydrophobic Rk3 and hydrophilic Met, provi …

Phytochemical-Loaded Thermo-responsive Liposome for Synergistic Treatment of Methicillin-Resistant Staphylococcus aureus Infection.

Objective: This study engineers leaflet- and 3-dimensional (3D) printing-based implant prototypes for infant mitral valve repair via in vitr … l and 3D printing biofabrication. Methods: Four materials are evaluated: UHMWPE, UHMWPE coated with polyvinyl alcohol (PVA), UHMWPE coated with PVA and collagen, and 3D-printed GelMA hydrogels. The prototypes are characterized for micro/nanostructural, physicochemical (degradation, contact angle, Fourier transform infrared spectroscopy), and mechanical properties ( …

Подготовка и характеристика повода для высвобождения PVA: Na-Alg Микросфера, содержащая фамфридин.

ЦЕЛИ: В настоящем исследовании основное внимание уделяется как формулированию микросфер на основе биоизоляции, содержащих фэмфридин, для лечения множественного склероза, так и альтернативе коммерчески доступному продукту (Fampyra 10 мг, Biogen). МАТЕРИАЛЫ И МЕТОДЫ: Инкапсулирование фамфридина было достигнуто с использованием поливинил-алкоголиков (PVA) и алгинатов натрия (Na-Alg). Глутаральдегид (ГА) и соляная кислота (ГКИ) использовались в качестве связующих веществ. Проведена оценка полимерного соотношения (PVA: Na-Alg), лекарственного средства: полимерного соотношения (d:p), перекрестного с

Совпадение в аннотации оригинала
OBJECTIVES: This study focuses on both the formulation of bio-based microspheres containing fampridine for the treatment of multiple sclerosis and provides an alternative to the commercially available product (Fampyra 10 mg, Biogen). MATERIALS AND METHODS: The encapsulation of fampridine was achieved using polyvinyl alcohol (PVA) and sodium alginate (Na-Alg…

Sustained dual delivery of metronidazole and viable Lactobacillus crispatus from 3D-printed silicone shells.

Bacterial vaginosis (BV) is an imbalance of the vaginal microbiome in which there are limited lactobacilli and an overgrowth of anaerobic an … with multiple formulations including biomaterials sodium alginate (SA), polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyethylene oxide (PEO), and kappa-carrageenan (KC). The vehicles were loaded with 50 μg of metronidazole/mg polymer and 5 × 107 CFU of L. crispatus/mg scaffold. Metronidazole-containing shells exhibited cumulative drug release of 324.2 ± 31 …

Hydrate-Based Methane Storage in Biodegradable Hydrogels Absorbing Dilute Sodium P-Styrenesulfonate Solution.

Developing an exceptional reaction medium with high promotion efficiency, desirable biodegradability and good recyclability is necessary for hydrate-based methane storage. In this work, a kind of eco-friendly hydrogel, polyvinyl alcohol-co-acrylic acid (PVA-co-PAA), was utilized to absorb dilute sodium p-styrenesulfonate (SS) solution, for constructing a hybrid reaction medium for methane hydrate formation. Hydrogels or dilute SS solutions (1-4 mmol L-1) had weak or even no promoting effects on hydrate formation kinetics, while the combination of them could synergistically promote methane hydr…

Application of Box-Behnken design in the optimization and development of albendazole-loaded zein nanoparticles as a drug repurposing approach for colorectal cancer management.

Colorectal cancer (CRC) is the second cancer worldwide representing a major global health challenge. Numerous effective anticancer drugs hav … loaded with ALB. Box-Behnken design was selected to optimize the loaded NPs, the concentrations of polyvinyl alcohol, acetic acid, and the weight of zein were the independent variables. The dependent variables were the particle size, polydispersity index, and zeta potential. The optimized formula displayed a size of 84.3 ± 0.41 nm, PDI 0.13 ± 0.012, and a zeta pot …

Antimicrobial Properties of Newly Developed Silver-Enriched Red Onion-Polymer Composites.

Simple low-cost, nontoxic, environmentally friendly plant-extract-based polymer films play an important role in their application in medicine, the food industry, and agriculture. The addition of silver nanoparticles to the composition of these films enhances their antimicrobial capabilities and makes them suitable for the treatment and prevention of infections. In this study, polymer-based gels and films (AgRonPVA) containing silver nanoparticles (AgNPs) were produced at room temperature from fresh red onion peel extract ("Ron"), silver nitrate, and polyvinyl alcohol (PVA). Silver nanoparticle…

Extraction of cellulose from halophytic plants for the synthesis of a novel biocomposite.

Cellulose nanofibers, a sustainable and promising material with widespread applications, exhibit appreciable strength and excellent mechanic … methylated (with a degree of substitution of 2.4) and subsequently converted into a composite using polyvinyl alcohol. Scanning electron microscopy and Fourier-transform infrared spectroscopy confirmed the successful synthesis of the composites. The composites made up of cellulose from C. cretica and S. fruticosa had a high tensile strength (21.5 and 15.2 MPa) and …

Prevention of anastomotic stenosis for decellularized vascular grafts using rapamycin-loaded boronic acid-based hydrogels mimicking the perivascular tissue function.

Abnormal proliferation of vascular smooth muscle cells (VSMCs) induces graft anastomotic stenosis, resulting in graft failure. Herein, we developed a drug-loaded tissue-adhesive hydrogel as artificial perivascular tissue to suppress VSMCs proliferation. Rapamycin (RPM), an anti-stenosis drug, is selected as the drug model. The hydrogel was composed of poly (3-acrylamidophenylboronic acid-co-acrylamide) (BAAm) and polyvinyl alcohol. Since phenylboronic acid reportedly binds to sialic acid of glycoproteins which is distributed on the tissues, the hydrogel is expected to be adherent to the vascul…