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The Role of Vitamin D in the Management of Chronic Pain in Fibromyalgia: A Narrative Review.

INTRODUCTION: Fibromyalgia (FM) is a complex disorder characterized primarily by chronic, widespread musculoskeletal pain. Currently, the Food and Drug Administration (FDA) has approved the use of three medications to treat FM: pregabalin, duloxetine, and milnacipran. The pharmaceutical intervention has lacked consistent pain relief among all patients. Therefore, the investigation into alternative treatment options has grown in interest. This narrative review aims to evaluate the evidence regarding vitamin D for the treatment of FM. METHODS: Narrative review. RESULTS: Low serum vitamin D has…

Pain management in living related adult donor hepatectomy: feasibility of an evidence-based protocol in 100 consecutive donors.

OBJECTIVE: Living donor hepatectomy (LDH) has important consequences in terms of acute and chronic pain. We proposed an anesthetic protocol based on the best currently available evidence. We report the results of this protocol's application. RESULTS: We performed a retrospective descriptive study of 100 consecutive donors undergoing LDH. The protocol included standardized information provided by the anesthetist, pharmacological anxiolysis and preventive analgesia. Specifically, pregabalin premedication (opioid-free) intravenous anesthesia (with clonidine, ketamine, magnesium sulphate and keto…

[Surveillance system on drug abuse: Interest of the French national OPPIDUM program of French addictovigilance network].

It is important to assess drug abuse liability in 'real life' using different surveillance systems. OPPIDUM ('Observation of illegal drugs a … ted emergent behaviors of abuse with some analgesic opioids (like tramadol, oxycodone or fentanyl), pregabalin, or quetiapine. OPPIDUM highlighted variations of drugs use regarding geographic approaches or by drug dependence care centers (like in harm reduction centers). OPPIDUM clearly demonstrated that collection of valid and useful data on drug abuse is p …

Effect of curcumin in mice model of vincristine-induced neuropathy.

CONTEXT: Curcumin exhibits a wide spectrum of biological activities which include neuroprotective, antinociceptive, anti-inflammatory, and a … ), nitric oxide (NO), and lipid peroxidation (LPO) were also estimated after the 14th day of study. Pregabalin (10 mg/kg, p.o.) and curcumin (15, 30, and 60 mg/kg, p.o.) were administered for 14 consecutive days. RESULTS: Curcumin at 60 mg/kg significantly attenuated the vincristine-induced neuropathic pain manifestations in terms of thermal hyperalgesia (p …

Complications of varicella zoster virus reactivation.

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. Primary infection causes varicella (chickenpox), after wh … r. First-line treatments for post-herpetic neuralgia include tricyclic antidepressants, gabapentin, pregabalin, and topical lidocaine patches. VZV vasculopathy, meningoencephalitis, and myelitis are all treated with intravenous acyclovir.

Association of antiepileptic drugs with nontraumatic fractures: a population-based analysis.

OBJECTIVE: To explore the relationship between antiepileptic drug (AED) use and nontraumatic fractures in those aged 50 years and older. DE … ximide, felbamate, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, phenobarbital, phenytoin, pregabalin, primidone, topiramate, valproic acid, and vigabatrin) was determined from pharmacy data in the repository. Odds ratios (OR) for fracture from AED exposure were adjusted for sociodemographic and comorbidity factors known to affect fracture risk. RE …

Perioperative use of gabapentinoids for the management of postoperative acute pain: protocol of a systematic review and meta-analysis.

BACKGROUND: Opioids are commonly used for the management of postoperative pain, but their use is limited by important adverse events, such as respiratory depression and the potential for addiction. Multimodal opioid-sparing analgesia regimens can be effectively employed to manage postoperative pain and reduce exposure to opioids. Gabapentinoids (pregabalin and gabapentin) represent an attractive class of drugs for use in multimodal regimens. The American Pain Society recommends the use of gabapentinoids during the perioperative period; however, evidence to inform such a recommendation is uncle…

Cost-Utility of Group Acceptance and Commitment Therapy for Fibromyalgia Versus Recommended Drugs: An Economic Analysis Alongside a 6-Month Randomized Controlled Trial Conducted in Spain (EFFIGACT Study).

UNLABELLED: The aim of this study was to analyze the cost utility of a group-based form of acceptance and commitment therapy (GACT) in patients with fibromyalgia (FM) compared with patients receiving recommended pharmacological treatment (RPT) or on a waiting list (WL). The data were derived from a previously published study, a randomized controlled trial that focused on clinical outcomes. Health economic outcomes included health-related quality of life and health care use at baseline and at 6-month follow-up using the EuroQoL and the Client Service Receipt Inventory, respectively. Analyses in

Analgesic Medication in Fibromyalgia Patients: A Cross-Sectional Study.

There is no approved drug for fibromyalgia syndrome (FMS) in Europe. In the German S3 guideline, amitriptyline, duloxetine, and pregabalin are recommended for temporary use. The aim of this study was to cross-sectionally investigate the current practice of medication in FMS patients in Germany. We systematically interviewed 156 patients with FMS, while they were participating in a larger study. The patients had been stratified into subgroups with and without a decrease in intraepidermal nerve fiber density. The drugs most commonly used to treat FMS pain were nonsteroidal anti-inflammatory drug…

Neuropathic Pain Due to an Extremely Rare Anatomical Variation of the Canalis Sinuosus After Dental Implant Placement: A Case Report.

Accurate knowledge of anatomical structures is essential for safe and effective dental implant placement. Although conventional imaging moda … ent, pressure-like pain in the upper left first molar region. Despite treatment with analgesics and pregabalin, the symptoms continued, and CBCT revealed the implant compressing the anterior superior alveolar nerve due to CS invasion. Following implant removal, the patient's symptoms resolved completely within 1 week. At the 3-month follow-up, the site showe …

Possible Diclofenac-Related Fulminant Toxic Epidermal Necrolysis: A Case Report.

Toxic epidermal necrolysis (TEN) is a rare but life-threatening cutaneous adverse effect characterized by extensive epidermal detachment and … of 2, which points to a possible side effect, while the re-exposure to febuxostat, etoricoxib, and pregabalin was an alternate pharmacological variable during the course of the adverse event. This case highlights the potential for rapidly progressive and fatal TEN following recent NSAID exposure and underscores the importance of early recognition, prompt wi …

Он-таргет, офф-туморные оральные токсичности талкетамаба у тяжело предварительно обработанной множественной миеломы.

БАКGROUND: Талкетамаб (TAL), биспектический антитело первого поколения, мишени GPRC5D и CD3, демонстрирует высокую эффективность в тяжело предварительно обработанных рецидивирующих и рефрактерных множественных миелом (RRMM), достигая показателей ответа около 70%. Однако TAL часто связан с на-таргет, офф-тумор оральным токсичностью. ЦЕЛЬ: Настоящее исследование направлено на обзор особенностей оральной токсичности, связанной с TAL. МЕТОДЫ: Проведена всесторонняя оценка недавней литературы по оральной токсичности, связанной с T. Извлеченные данные включают время наступления, частоту, степень о

Совпадение в аннотации оригинала
BACKGROUND: Talquetamab (TAL), a first-in-class bispecific antibody targeting GPRC5D and CD3, has demonstrated high efficacy in heavily pret … ongoing TALISMAN trial is evaluating prophylactic interventions such as dexamethasone mouthwash and pregabalin. CONCLUSION: Oral toxicities often emerge early and may persist throughout the therapy. Consequently, early recognition, preventive care, and multidisciplinary management are essential to mitigate oral complications and preserve quality of life in …

Post-COVID-19 Small Fiber Neuropathy as a New Emerging Quality of Life-Threatening Disease: A Systematic Review.

Post-acute sequelae of COVID-19 (PASC) syndrome is considered an emergent and diffuse multidisciplinary problem. Compelling evidence suggest … ed for the treatment of this condition with the achievement of partial results, including steroids, pregabalin, gabapentin, duloxetine, vitamins, homotaurine and phosphatidylserine, alpha lipoic acid, immunosuppressants, and intravenous immunoglobulin therapy. PASC-SFN is a complex emerging disease and extremely challenging for physicians. At present, the on …

Pro-con debate on perioperative gabapentinoids: a nuanced approach is the best one.

In the age of the opioid epidemic and a widespread desire to reduce opioid prescriptions, both in outpatient practices and hospitals, we have welcomed non-opioid medications as one possible strategy to reduce the reliance on opioids for the treatment of pain. For anesthesiologists, surgeons, and other perioperative physicians, minimizing exposure to opioids in the perioperative period has been a focal point for several decades now and countless protocols have been described, adopted, and studied. Gabapentin and pregabalin, known collectively as gabapentinoids, have been included in many of the…

[Current opioid consumption among younger patients : A comparison between the years 2019 and 2023 in a large addiction clinic in Hamburg].

BACKGROUND: It remains unclear whether an opioid crisis similar to that in the United States can be expected in Germany. In September 2024, … aken nasally. The use of oxycodone increased significantly. Additionally, a significant increase in pregabalin consumption was noted. CONCLUSIONS: Although the collected data may not be representative of Germany as a whole, our study suggests a growing issue with opioid addiction. Possible causes may include psychological stress, potentially influenced by t …

Electroacupuncture for Refractory Chronic Pelvic Pain: A Case Report with 24-Month Follow-Up.

INTRODUCTION: Chronic pelvic pain (CPP) is a common condition involving multiple systems, characterized by complex manifestations and divers … f 6-7) after a medical abortion and intense exercise. Despite treatment with leuprolide acetate and pregabalin, her pain persisted (NRS score of 7-8). In January 2022, she was diagnosed with CPP and underwent superior hypogastric plexus neurolysis. Postoperatively, she experienced severe pain exacerbation (NRS score of 10). Traditional Chinese medicine and a …

ROCIP: robust continuous inertial position tracking for complex actions emerging from the interaction of human actors and environment.

OBJECTIVES: The superiority of true drug treatment over placebo in reducing symptoms of fibromyalgia syndrome (FMS) is small and bought by r … ndomized double-blind placebo controlled trials with a parallel design for duloxetine, milnacipran, pregabalin and sodium oxybate in FMS-patients. The magnitude of placebo response was assessed by the pooled estimate of a 50% placebo pain reduction. The magnitude of nocebo response was determined by the pooled estimate of drop-out rates due to adverse events …

Pharmacological interactions of sulforaphane and gabapentin in a murine fibromyalgia-like pain model.

Therapeutic management of a chronic painful syndrome such as fibromyalgia (FM) lacks effective and safe single or combined analgesics. Current medications such as gabapentin (GPB) or pregabalin are moderately effective but in the presence of several adverse effects. Natural products derived from cruciferous vegetables such as sulforaphane (SFN) produce neuroprotective effects due to their potent antioxidant and anti-inflammatory properties. However, it is unknown whether positive or negative pharmacological interactions may occur when GBP and SFN are combined. The aim of this study was to esti…