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Нейропозащитные эффекты экстракта печени Курбиты в модели животных с множественным склерозом Cuprizon.

Cuprizone — нейротоксин с способностью цеплять медь, и он вызывает симптомы, похожие на симптомы, вызванные множественными склерозными повреждениями. Множественный склероз, вызванный капризоной в моделях животных, изображает окислительный стресс как один из основных факторов патогенеза. Нейродегенерация стала чрезвычайно серьезной проблемой в глобальном масштабе. Предпочтительно использовать естественную терапию, чтобы остановить прогресс и будущее развитие болезни. Curbita pepo — это растение с нейрозащитными свойствами и антиоксидантами. Цель этого исследования состояла в том, чтобы определи

Совпадение в аннотации оригинала
Cuprizone is a neurotoxin with copper-chelating ability, and it produces symptoms that are similar to those caused by multiple sclerosis les … mine and compare the oxidative stress between the inducer and treated group and also to analyze the remyelination ability of C. pepo in the disease-induced rat. Results revealed that the rats treated with C. pepo demonstrated significant improvements in motor coordination (P < 0.001) and reduced anxiety-like behavior (P < 0.01) and oxidative stress markers, suc …

Evaluation of the Regeneration Effects of Systemically Applied Methylprednisolone and Vitamin B12 on Mental Nerve Crush Injury.

AIM: To evaluate the effects of methylprednisolone and vitamin B12 injection on the regeneration of the nerves after a mental nerve crush in … .05). CONCLUSION: Systemic vitamin B12 and methylprednisolone administration effectively supported remyelination in the crushed mental nerve by increasing Schwann cell proliferation and differentiation.

The Evolving Use of Gold Nanoparticles as a Possible Reversal Agent for the Symptoms of Neurodegenerative Diseases: A Narrative Review.

Neurodegenerative diseases are broadly hallmarked by impaired energy metabolism and toxic intracellular accumulations such as damaged organe … In animal models of MS, oral delivery of CNM-Au8 was demonstrated to produce robust and significant remyelination activity, oligodendrocyte maturation, and expression of myelin markers. In these same MS animal models, CNM-Au8 improved the motor function of cuprizone-treated mice in both open-field and kinematic gait studies. Recent phase II trials of CNM-Au8 in …

Targeted DeSUMOylation as a therapeutic strategy for multiple sclerosis.

SUMO (small ubiquitin like modifier) conjugated proteins have emerged as an important post translational modifier of cellular function. SUMO … addition, the increase in the transcription of myelin genes with TAK981 and anacardic acid improved remyelination in experimental models of demyelination. In the present review paper, we examine the mechanism of action of inhibitors of the SUMO pathway on regulating the immune response and the possibility of the use of these agents as therapeutics for MS.

Coexistence of Charcot-Marie-Tooth 1A and nondystrophic myotonia due to PMP22 duplication and SCN4A pathogenic variants: a case report.

BACKGROUND: Charcot-Marie-Tooth disease (CMT) is a genetically heterogeneous hereditary neuropathy, and CMT1A is the most common form; it is caused by a duplication of the peripheral myelin protein 22 (PMP22) gene. Mutations in the transient sodium channel Nav1.4 alpha subunit (SCN4A) gene underlie a diverse group of dominantly inherited nondystrophic myotonias that run the spectrum from subclinical myopathy to severe muscle stiffness, disabling weakness, or frank episodes of paralysis. CASE PRESENTATION: We describe a Chinese family affected by both CMT1A and myotonia with concomitant altera

Analgesic Activity of Synaptamide in a Rat Sciatic Nerve Chronic Constriction Injury Model.

At present, there is a growing interest in the study of the neurotropic activity of polyunsaturated fatty acid ethanolamides (N-acylethanola … ciatic nerve chronic constriction injury (CCI) model. After CCI, synaptamide treatment enhanced the remyelination process in the site of sciatic nerve injury (33.4 ± 1.1% in the CCI+Syn group, compared to 28.4 ± 0.9% in the CCI group). Further, synaptamide suppressed the CCI-induced increase in the activity of microglia (13.1 ± 0.5% in CCI+Syn, compared to 15.3 …

Pathological changes in mice with long term cuprizone administration.

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). In MS, a long disease duration is know … n dysfunction in the balance beam test. However, 12-week withdrawal from the cuprizone diet induced remyelination in the regions and motor coordination dysfunction recovered. These results indicate that 34-week cuprizone administration induces and sustains demyelination and results in reversible motor coordination dysfunction. The change of intracellular PV dis …

Meningeal inflammation and cortical demyelination in acute multiple sclerosis.

OBJECTIVE: Cortical gray matter (GM) pathology, involving demyelination and neurodegeneration, associated with meningeal inflammation, could be important in determining disability progression in multiple sclerosis (MS). However, we need to know more about how cortical demyelination, neurodegeneration, and meningeal inflammation contribute to pathology at early stages of MS to better predict long-term outcome. METHODS: Tissue blocks from short disease duration MS (n = 12, median disease duration = 2 years), progressive MS (n = 21, disease duration = 25 years), non-diseased controls (n = 11), a

A novel approach to 32-channel peripheral nervous system myelin imaging in vivo, with single axon resolution.

OBJECTIVE Intravital spectral imaging of the large, deeply situated nerves in the rat peripheral nervous system (PNS) has not been well desc … resolution and magnification, and minimal movement artifact. The detailed microenvironment of nerve remyelination can be vividly observed, while exogenously applied Schwann cells and skin-derived precursor Schwann cells can be seen myelinating axons. CONCLUSIONS Topically applied Nile red enables intravital study of myelin in the living rat PNS. Furthermore, th …

[Case of pure motor Guillain-Barré syndrome with motor conduction block and anti-GM1/GalNAc-GD1a antibody].

A 38-year-old man presented with distal-dominant limb weakness two weeks after an upper respiratory infection. He had no sensory and autonom … n the median and ulnar nerve trunks and temporal dispersion in the tibial nerve, without an evident remyelination pattern during the course of the disease. A sensory nerve conduction study was normal. According to Hadden's criteria, the electrodiagnostic findings were judged as a primary demyelinating pattern. Weakness and abnormal motor nerve conduction recove …

Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment.

Multiple hippocampal processes and cognitive functions change with aging or Alzheimer's disease, but the potential triggers of these aging cascades are not well understood. Here, we quantified hippocampal expression profiles and behavior across the adult lifespan to identify early aging changes and changes that coincide with subsequent onset of cognitive impairment. Well powered microarray analyses (N = 49 arrays), immunohistochemistry, and Morris spatial maze learning were used to study male F344 rats at five age points. Genes that changed with aging (by ANOVA) were assigned to one of four on

Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice.

alpha2,8 Polysialic acid (PSA) is a carbohydrate attached to the glycoprotein backbone of the neural cell adhesion molecule (NCAM) and impli … neuron soma size and axonal diameters were not affected by treatment with the PSA mimetic. However, remyelination of regenerated axons distal to the injury site was considerably improved by the PSA mimetic indicating that effects on Schwann cells in the denervated nerve may underlie the functional effects seen in motor recovery. In line with this notion was the …

Light and ultrastructural study of sciatic nerve lesions induced using intraneural injection of viable Mycobacterium leprae in normal and immunosuppressed Swiss white mice.

Freshly harvested M. leprae were microinjected into the sciatic nerves of nonimmunosuppressed (non-TR) and immunosuppressed (TR) mice using … 6th and the 12th month intervals. b) The characteristic segmental demyelination and some attempt at remyelination were seen at the site. c) The influx of lymphocytes concorded well with demyelination. d) Bacteria were only seen in the macrophages and never in the Schwann cells or endothelial cells. e) Bacteria persisted in the macrophages, but appeared progress …

Neuropathology of Rett syndrome.

Autopsy studies in 8 girls with the Rett syndrome dying between 4 and 15 years showed: Diffuse cerebral atrophy/micrencephaly, with a decrease in brain weight by 13.8 to 33.8% of age-matched controls, apparently related to the duration of the disorder; Mild, but inconsistent diffuse cortical atrophy without developmental disorders apart from occasional microdysgenesis (three cases), but increased amounts of neuronal lipofuscin, and occasional mild astrocytic gliosis; Mild, but inconsistent spongy changes in cerebral and cerebellar white matter, optic nerve (two cases), and myelinated fascicles

Congenital hypomyelination polyneuropathy. Pathological findings compared with polyneuropathies starting later in life.

Biopsies from patients with congenital hypomyelination polyneuropathy (Group I) and with late infantile (Group II) and juvenile (Group III) … ore benign late infantile and juvenile forms of the disease in which a process of demyelination and remyelination takes place. The literature on the congenital neuropathies, a heterogeneous assembly of diseases, is reviewed.

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis.

BACKGROUND: Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. METHODS: The study sample comprised 53 Severe PMS patients (Expanded Disability Status Scale, EDSS score: 7.0-9.5) requiring skilled nursing and 53 age, sex- and disease duration-matched community-dwelling Control PMS patients (EDSS score: 3.0-6.5). Patients underwent neurological examinations and provided blood sample…

Longitudinal NODDI-DTI assessment of brain recovery following CPAP in obstructive sleep apnea: Tissue-compartment changes in white and gray matter.

OBJECTIVES: Continuous positive airway pressure (CPAP) can partially reverse brain abnormalities associated with obstructive sleep apnea (OS … al DTI, while the absence of RD and NDI changes suggests that early recovery may precede detectable remyelination or neurite-density changes. These findings support NODDI-based tissue-compartment imaging as a promising approach for investigating the biological basis of brain recovery following CPAP in OSA.

Development of Acellular Matrix-Based Bioprinted Scaffold for Inferior Alveolar Nerve Regeneration.

The inferior alveolar nerve (IAN) is a sensory branch of the mandibular nerve that supplies sensation to teeth, the chin, and the lower lip. … injury control. Alg/MC/ACM2 scaffolds also promoted cellular infiltration, axonal organization, and remyelination, as observed in hematoxylin and eosin and Luxol fast blue staining. Overall, the incorporation of Schwann-cell-derived ACM within Alg/MC scaffolds provided a bioactive microenvironment that supported neural regeneration. This study presents the firs …

Context-dependent roles of osteopontin in aging-related neurological disorders.

Osteopontin (encoded by secreted phosphoprotein 1) is a multifunctional matricellular phosphoglycoprotein that has emerged as an important m … ate chronic neuroinflammation and tissue injury or promote phagocytic clearance, neuronal survival, remyelination, neuroplasticity, and tissue repair. This review critically synthesizes studies indexed in PubMed and Google Scholar through 3 April 2026 on the role of osteopontin in brain aging, Alzheimer's disease and related dementias, Parkinson's disease and L …

Transferrin Promotes Oligodendroglial Differentiation Independently of Iron Binding and Release.

Transferrin (Tf), classically known as the major iron-transport protein in mammals, also engages in potent promyelinating activity within th … s insight opens new avenues for developing Tf-based or Tf-mimetic therapeutic strategies to enhance remyelination in demyelinating disorders such as multiple sclerosis.