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Bilateral optic neuritis in a patient with idiopathic intracranial hypertension: a case report.

BACKGROUND: The differential diagnosis of bilateral optic disc edema with painless vision loss poses significant challenges between idiopathic intracranial hypertension (IIH) and optic neuritis (ON). While IIH classically presents with elevated intracranial pressure (ICP), headaches, and papilledema, ON typically manifests as inflammatory optic nerve demyelination with characteristic pain on eye movement. This case illustrates the diagnostic complexity arising from overlapping features of both conditions in a patient with concurrent venous sinus stenosis, underscoring the critical role of mult…

The clinical profile and therapeutic outcome of patients diagnosed with "atypical" optic neuritis.

PURPOSE: Our aim was to evaluate the clinical characteristics and prognosis of patients diagnosed with atypical optic neuritis (AON). METHODS: We performed a retrospective study in patients with AON collected between 1991 and 2024. Clinical features, laboratory findings, and treatment modalities of patients with AON were investigated and the relationship between therapeutic approaches and the visual prognosis of these patients were evaluated. RESULTS: Eighty-eight patients with AON were evaluated and 51 patients were included in the study. Patients were divided in two groups (Group 1: full r…

Structural network disruption after optic neuritis in Myelin oligodendrocyte glycoprotein antibody associated disease.

BACKGROUND: Optic neuritis is a common manifestation of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), which displays distinctive features that differ from other demyelinating diseases. OBJECTIVES: In this study, we investigated the alterations in white matter (WM) connectivity post-optic neuritis in patients with MOGAD. METHODS: We enrolled patients with MOGAD presenting with optic neuritis (MOGAD-ON) (N = 18) and healthy controls (HC) (N = 35). Structural connections between any pair of 90 cortical and subcortical regions were established using diffusion tensor im…

Функциональный МРТ в оптическом неврите: изучение кортикальной модуляции и возможных механизмов восстановления.

Оптический неурит (ON) — воспалительный, демиелинизирующий оптический нейропат, который обычно ассоциируется с множественным склерозом. Обычно она представляет собой монокулярную зрительную потерю, при этом большинство визуальных функций восстанавливаются в течение нескольких недель. Помимо спонтанного воспоминания, считается, что адаптация мозга способствует процессу восстановления. В ходе этого обзора мы обсуждаем роль функциональных МРТ (МВМР) в качестве мощного инструмента для изучения корковых изменений, связанных с НО. Мы изучаем исследования, в которых используется целый ряд методологий

Совпадение в аннотации оригинала
Optic neuritis (ON) is an inflammatory, demyelinating optic neuropathy commonly associated with multiple sclerosis. It typically presents as monocular visual loss, with most visual functions recovering within several weeks. In addition to spontaneous remyelination, brain adaptation is thought to contribute to the recovery process. In this review, we discuss …

An atypical case of bilateral optic neuritis after strabismus surgery under general anesthesia.

INTRODUCTION: Strabismus surgery under general anesthesia is a common procedure with rare complications in the form of hemorrhage, infection, slipped muscle, lost muscle, scleral perforation, and anterior segment ischemia. We report a unique case of bilateral optic neuritis following squint surgery under general anesthesia in a 15-year-old girl. METHODS: A 15-year-old girl presented with accommodative esotropia with V pattern. She underwent uneventful bilateral inferior oblique recession surgery under general anesthesia with Propofol 60 mg, Atracurium 30 mg, and Fentanyl 70 mcg. On the first …

Structural changes in spinal cord following optic neuritis: Insights from quantitative spinal MRI.

OBJECTIVES: Previous studies have demonstrated that optic neuritis (ON) affects brain plasticity. However, whether ON affects the spinal cord remains unclear. We aimed to investigate the spinal cord changes in ON and their associations with disability. METHODS: A total of 101 ON patients, and 41 healthy controls (HC) were retrospectively recruited. High-resolution imaging was conducted using a Magnetization Prepared Rapid Acquisition Gradient-Echo (MP-RAGE) sequence for T1-weighted images and an echo planar imaging (EPI) sequence for Diffusion Tensor Imaging (DTI) data collection. Additionall…

Clinical Relevance of Plasma Prolylcarboxypeptidase Level in Patients with Idiopathic Acute Optic Neuritis.

Objectives: This study evaluated the plasma concentration of prolylcarboxypeptidase (PRCP) and its clinical relevance in patients with idiopathic acute optic neuritis (ON). Methods: We investigated the expression of PRCP in the optic nerves of experimental autoimmune optic neuritis (EAON)-induced mice. Peripheral blood samples were collected from ON patients (n = 20) and healthy controls (n = 20). ELISA was used to measure the plasma PRCP levels. We performed measurements of visual acuity and the mean thicknesses of the macular ganglion cell layer plus inner plexiform layer (GCL+IPL) at diagno…

A rare case of bilateral optic neuritis post-Covishield (ChAdOx1-S [recombinant]) vaccination.

Multiple adverse effects have been reported in people receiving the COVID-19 vaccinations including few reports of optic neuritis. However, there is no report till date, of bilateral optic neuritis post-ChAdOx1-S (recombinant) vaccination. We report here, for the first time, such a case in a previously healthy woman. Although a direct causal relationship cannot be proven, there was a temporal association between the vaccination and the onset of optic neuritis. Some vaccine adjuvants inciting disproportionate systemic inflammation, molecular mimicry, and the hypercoagulable state seen after COV…

Risk of optic neuritis in type 2 diabetes mellitus: A nationwide cohort study.

BACKGROUND/PURPOSE: This study aimed to investigate the association between the time course of type 2 diabetes mellitus (DM) and the development of optic neuritis (ON) in the Korean population aged 20 years and older. METHODS: A total of 10,069,044 subjects were included in this study, which utilized stratified random sampling from the national cohort. The hazard ratios (HRs) for incident ON were compared between subjects with normal fasting glucose (NFG) levels, impaired fasting glucose (IFG) levels, patients with new-onset DM, diabetes duration of fewer than 5 years (early DM), and diabetes…

Choroid plexus volume is enlarged in clinically isolated syndrome patients with optic neuritis.

OBJECTIVES: We investigated choroid plexus (CP) volume in patients presenting with optic neuritis (ON) as a clinically isolated syndrome (CIS), compared to a cohort with established relapsing-remitting multiple sclerosis (RRMS) and healthy controls (HCs). METHODS: Three-dimensional (3D) T1, T2-FLAIR and diffusion-weighted sequences were acquired from 44 ON CIS patients at baseline, 1, 3, 6 and 12 months after the onset of ON. Fifty RRMS patients and 50 HCs were also included for comparison. RESULTS: CP volumes was larger in both ON CIS and RRMS groups compared to HCs, but not significantly d…

Gut microbiota dysbiosis associated with different types of demyelinating optic neuritis in patients.

BACKGROUND: Demyelinating optic neuritis (DON) causes rapid vision loss in young and middle-aged people. The limited efficacy of treatment and the toxic side effects of drugs significantly affect the quality of life of patients with DON. Therefore, DON pathogenesis has always been a research hotspot in terms of prevention and treatment. Studies have suggested that gut microbiota imbalances may be involved in autoimmune disease development via the modulation of multiple inflammatory cytokines and anti-inflammatory metabolites. Therefore, this study aims to explore gut microbiota differences bet…

Colombian Ocular Inflammatory Diseases Epidemiology Study (COIDES): Optic Neuritis Incidence Between 2015-2020.

PURPOSE: To estimate the incidence of Optic Neuritis (ON) in Colombia using data from the national health registry between January 1, 2015, and December 31, 2020. METHODS: A population-based study was conducted using the Integrated Social Protection Information System from the Colombian Ministry of Health and the International Classification of Diseases-10 code for ON to estimate the incidence of ON from 2015 to 2020. We also evaluated the impact of the COVID-19 lockdown on the epidemiology of the disease in 2020. Finally, a standardized morbidity rate map was created to assess a country's ON…

Optic neuritis following COVID-19 vaccination: Coincidence or side-effect? - A case series.

The whole world waiting for the elimination of COVID-19. This is a short series of three cases that presented with optic neuritis. On further inquiry, all had received the Covishield vaccine within 5-12 days just before the presentation, with no history of COVID-19 positive RT-PCR. The range of age was 27-48 years. All patients improved after pulse steroid therapy and are still under follow-up. After being plagued by COVID-19 for nearly 2 years, the whole world wishes for little more than complete eradication of the disease. Our country commenced the much-awaited vaccination drive from Jan 202…

Myelin oligodendrocyte glycoprotein antibody-associated bilateral optic neuritis with unilateral prepapillary vitreous hemorrhage.

We present a case of bilateral myelin oligodendrocyte glycoprotein antibody optic neuritis (MOG-ON) with unilateral vitreous hemorrhage in a 6-year-old boy. Multidisciplinary team care, including extensive investigations and prolonged follow-up, excluded alternative causes of vitreous hemorrhage. Early suspicion and diagnosis of MOG-ON led to timely intravenous methylprednisolone treatment, with protracted oral steroid taper, resulting in complete resolution of optic nerve swelling, vitreous hemorrhage, and visual function.

Analysis of choroidal vascularity index in multiple sclerosis patients without optic neuritis attack.

BACKGROUND: To evaluate the choroidal structural changes in multiple sclerosis (MS) patients without previous optic neuritis (ON) attacks. METHODS: Forty eyes of 20 MS patients without a history of ON and 40 eyes of 20 age-matched healthy volunteers were included in this study. The choroidal thickness (CT) was measured at three points; subfoveal, 1500 µm nasal to the fovea, and 1500 µm temporal to the fovea. Choroidal area (CA), luminal area (LA), and choroidal vascularity index (CVI) were calculated using ImageJ. RESULTS: The mean subfoveal, nasal and temporal CT were decreased in MS patien…