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Predicting high-risk human papillomavirus infection, progression of cervical intraepithelial neoplasia, and prognosis of cervical cancer with a panel of 13 biomarkers tested in multivariate modeling.

Comprehensive multivariate models were used to disclose whether any of our previously analyzed 13 markers would be independent predictors of … ned by combining the 2 most powerful predictors in panel 1 (VEGF-C and LR67), giving the area under ROC curve, 0.897 (95% confidence interval [CI], 0.847-0.947); odds ratio, 86.27 (95% CI, 19.71-377.47); SE, 86.0%; SP, 93.3%; positive predictive value (PPV), 99.1%; and negative predictive value (NPV), 43.1%. In a hypothetical screening setting (10,000 women …

DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis.

BACKGROUND: Cervical carcinoma is a common malignancy among women worldwide, and its pathogenesis is related causally to human papillomaviru … nificantly higher in HSIL samples compared with LSIL and negative samples. Using the area under the ROC curve as a measure of test performance, the methylation of IGSF4 and DAPK1 had areas that were significantly greater than 0.5; thus, each had the ability to distinguish HSIL samples from combined LSIL/negative samples. The areas under the curve for the be …

Rethinking the threshold for an abnormal capillary blood lead screening test.

OBJECTIVES: To examine the test characteristics of the capillary blood lead screening test as a predictor of elevated venous blood lead leve … ure. Paired samples of venous blood were drawn from all children. For these children we examine the ROC curves for capillary blood lead levels as a predictor of elevated venous blood lead levels above 2 thresholds, 0.48 and 0.97 mumol/L (10 and 20 micrograms/dL). Contaminated capillary specimens were defined as those in which the capillary result exceeded t …

Association of serum HMGB1 and TLR4 levels with early-onset post-stroke depression in type 2 diabetes: a prospective cohort study.

BACKGROUND: To explore the relationship between HMGB1 and TLR4 in early-onset post-stroke depression (PSD) among patients with type 2 diabet … pendent and significant risk factors for early-onset PSD in individuals with T2DM. The results from ROC curve analysis demonstrated that the area under the curve (AUC) values for HMGB1, TLR4, and their combined predictive capacity regarding early-onset PSD were 0.786 (95% CI: 0.676-0.897), 0.893 (95% CI: 0.802-0.984), and 0.902 (95% CI: 0.816-0.989). CONCLU …

Optimal androgen concentration cut-off values for identifying abnormal insulin sensitivity in Korean women with polycystic ovary syndrome.

OBJECTIVE: This study evaluated the relationship between serum androgen concentrations and validated insulin sensitivity indices in Korean w … h most insulin resistance (IR) parameters, whereas 17-OHP showed no significant correlation. In the ROC curve analysis, only FT achieved moderately accurate predictive performance (area under the curve [AUC], 0.759), while TT, DHEA-S, and 17-OHP showed AUC values indicating less accurate predictions. The optimal FT cutoff to detect abnormal insulin sensitiv …

Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study.

BACKGROUND: This study aimed to identify independent factors and develop a nomogram for spontaneous preterm birth in twin pregnancies. METHODS: In this retrospective study, a total of 218 women with twin pregnancies from Jiaxing Women and Children's Hospital, Wenzhou Medical University between June 2021 and May 2024 were enrolled. Univariate analysis and subsequent multivariate logistic regression analysis were used to identify independent factors. A nomogram prediction model was constructed using R software and evaluated by the area under the ROC curve (AUC), concordance index (C-index), and…

Predicting intradialytic exercise intolerance in maintenance hemodialysis patients: an interpretable machine learning approach integrating functional assessments.

Exercise intolerance, primarily manifesting as intradialytic hypotension (IDH), is common in maintenance hemodialysis patients, interrupting interventions and contributing to adverse outcomes. This prospective observational study enrolled 128 adults on thrice-weekly hemodialysis for ≥3 months, generating 896 dialysis records. Four classifiers-logistic regression with elastic net penalty, Random Forest, histogram-based gradient boosting decision tree (HGBDT), and eXtreme Gradient Boosting (XGBoost)-were evaluated using a 10-fold GroupKFold cross-validation strategy on the entire dataset. Perfor

Triglyceride glucose-waist circumference as a useful predictor for diabetes mellitus: a secondary retrospective analysis utilizing a Japanese cohort study.

BACKGROUND AND OBJECTIVE: While the connection between the Triglyceride glucose-waist circumference (TyG-WC) index and the risk of diabetes … ed with incident Diabetes Mellitus (DM) (Hazard Ratio (HR): 1.004, 95%C: 1.001-1.006). Furthermore, ROC curve analysis demonstrated that TyG-WC outperformed both the triglycerides-glucose index and triglyceride glucose-body mass index in predicting the onset of diabetes. CONCLUSION: High levels of TyG-WC are autonomously linked to a heightened risk of diab …

Circular RNAs MTO1 and ZNF292 as potential diagnostic biomarkers in HIV patients treated with antiretroviral therapy.

INTRODUCTION: Circular RNAs (circRNAs) are unique, abundant, and stable non-coding RNAs having regulatory roles and potential clinical signi … ic FC: 3.0) may act as robust biomarkers for distinguishing HIV patients from healthy controls. The ROC curve analysis showed that for circMTO1 expression, the area under curve (AUC) value was 0.7492 (p = 0.0077), and for circZNF292 expression AUC value was 0.7231 (p = 0.0176). This study has also revealed the involvement of circMTO1 and circZNF292 in key r …

Diagnostic Value of CA-125 and Other Tumor Biomarkers in Children with Suspected Malignancy: A Retrospective Cohort Study.

Background/Objective: Tumor biomarkers are widely used in adult oncology, but their diagnostic value in pediatric patients remains unclear. … were more frequent in CA-125-positive cases (p < 0.001) and in patients with confirmed malignancy. ROC curve analysis demonstrated that CA-125 had an area under the curve (AUC) of 0.642, indicating modest discriminatory power. No significant associations were found for CA 19-9, CA 15-3, or CEA. Conclusions: CA-125 may serve as an adjunctive diagnostic biom …

Prediction of postoperative SIRS risk factors in MetS patients undergoing PCNL.

This study aimed to identify preoperative risk factors for systemic inflammatory response syndrome (SIRS) in patients with metabolic syndrom … n calculi (P < 0.05). The nomogram demonstrated good discriminative ability, with an area under the ROC curve (AUC) of 0.888 (95% CI: 0.834-0.942) in the training cohort and 0.882 (95% CI: 0.802-0.962) in the validation cohort. The calibration curve and the Hosmer-Lemeshow test (P = 0.1485) indicated good model calibration and fit. DCA further confirmed the …

Critical Reappraisal and Validation of the Bern Score System for Diagnosing Spontaneous Intracranial Hypotension.

BACKGROUND AND PURPOSE: Diagnosing spontaneous intracranial hypotension (SIH) remains a clinical challenge. The Bern score offered a structu … graph. RESULTS: A total of 45 patients with SIH and 45 age-sex-matched controls were included. The ROC curve showed moderate diagnostic accuracy (area under the curve 0.775, 95% confidence interval 0.675-0.874; sensitivity 42.2%, specificity 95.6%) using the original cutoff of 3. Using a revised cutoff was ≥2, the Youden index was highest (sensitivity 66.7 …

Analysis of risk factors and the predictive value of a nomogram model for coronary heart disease in patients with rheumatoid arthritis.

BACKGROUND: Rheumatoid arthritis (RA) is associated with an elevated risk of coronary heart disease (CHD) due to a complex interplay of trad … G abnormalities. The nomogram demonstrated excellent discriminative ability, with an area under the ROC curve (AUC) of 0.868 (95% CI: 0.819-0.916) and robust calibration (P = 0.908). Internal validation confirmed its reliability (AUC = 0.866). DCA indicated that the nomogram provided superior clinical utility by optimizing the net benefit across a range of …

Prevalence, associated factors, and bioelectrical impedance phase angle measurement for sarcopenia in patients undergoing cardiac rehabilitation.

This study aimed to determine the prevalence and associated risk factors of sarcopenia among patients with cardiovascular diseases (CVD) und … ficantly lower in patients with sarcopenia compared to those without (3.61 vs. 4.47 °, P  < 0.001). ROC curve analysis demonstrated good diagnostic accuracy of PhA for identifying sarcopenia, with an area under the curve of 0.83 (95% confidence intervals: 0.75-0.91). The optimal PhA cutoff value to distinguish sarcopenia was 4.01 °, yielding both sensitivit …

Validity and Diagnostic Accuracy of Using a Smartphone for the Measurement of the Angle of Trunk Rotation and the Stiffness Scoliosis Test in Adolescents With Scoliosis.

OBJECTIVES: The purpose of this study was to determine the validity and diagnostic accuracy of the angle of trunk rotation (ATR) and the sti … son's correlation test, the root mean square (RMS) error, the Bland-Altman graphic analysis and the ROC curve analysis were conducted (P < .05). RESULTS: The sample consisted of 50 gibbosities of 38 participants, where 74% (n = 28) were girls and 26% (n = 10) boys, with a mean age of 13.4 ± 2.5 years. The correlations were excellent, ranging from 0.77 to 0 …

Существует ли пороговая или зависимость &quot; доза-реакция &quot; между физической активностью и когнитивной функцией при множественном склерозе?

ЦЕЛЬ: Когнитивное расстройство широко распространено, недействителен и плохо регулируется при множественном склерозе (МС). Физическая активность, зачастую выраженная в виде шагов в день, связана с когнитивной функцией этой группы населения. В этом кратком докладе рассматривается возможность установления 1) порогового показателя в день, связанного с отсутствием когнитивного расстройства, или 2) соотношения &quot; доза-реакция &quot; между ступенями в день и когнитивной функцией в MS. МЕТОД: В выборке приняли участие 358 человек, имеющих MS, которые представили демографическую (возраст, пол, рас

Совпадение в аннотации оригинала
OBJECTIVE: Cognitive impairment is prevalent, disabling, and poorly managed in multiple sclerosis (MS). Physical activity, often expressed a … with cognitive impairment on SDMT (area under the curve [AUC] ranged between 0.606 and 0.691). The ROC curve analysis further did not identify a threshold of steps/day associated with cognitive impairment based on CVLT-II (AUC range 0.606 to 0.691). The regression analysis indicated significant linear relationships between steps/day and SDMT (R2 = .06; β=. …

Clinical value of γ-glutamyl transpeptidase to platelet ratio and triglyceride measurement in the diagnosis of nonalcoholic fatty liver disease: A cross-sectional study.

OBJECTIVE: In clinical practice, there are few effective biomarkers for identifying non-alcoholic fatty liver disease (NAFLD). The aim of th … rrelation between GPR and HDL-C (p < 0.01). TG was only positively correlated with GPR (p < 0.001). ROC curve analysis demonstrated that the area under the curve (AUC) of GPR combined with TG for diagnosis of NAFLD was 0.855 (95 % CI: 0.819-0.891), sensitivity was 83.45 % and specificity was 73.56 %. CONCLUSION: This study indicated that high levels of GPR …

The Use of Pre-Chemoradiotherapy Total Masseter Muscle Volume as a Novel Predictor of Radiation-Induced Trismus in Locally Advanced Nasopharyngeal Carcinoma Patients.

BACKGROUND: We sought to determine whether pretreatment total masseter muscle volume (TMMV) measures can predict radiation-induced trismus ( … rea under the curve: 79.5%; sensitivity: 75.0%; and specificity: 78.6%; Youden index: 0.536] in the ROC curve analysis. The incidence of RIT was significantly higher in patients with TMMV ≤ 5.0 cc than in those with TMMV > 35.0 cc [51.2% vs. 8.7%; Odds ratio: 6.79; p < 0.001]. A multivariate logistic regression analysis revealed that pre-C-CRT MMO ≤ 41.6 mm …

Differential miR-195-5p and its potential role during the development of carotid artery stenosis.

ObjectivesCarotid artery stenosis (CAS) is a leading cause of cerebral ischemic events (CIE). Timely detection and risk assessment can aid in managing CAS patients and improving their prognosis. The aim of the current study is to identify a new biomarker for CAS and to further investigate the impact of miR-195-5p on cellular processes in vascular smooth muscle cells (VSMCs).MethodsThis study involved 112 CAS patients and 65 healthy individuals. Serum miR-195-5p levels were measured using RT-qPCR. The ROC curve was then plotted to evaluate the diagnostic potential of miR-195-5p for CAS. The Kap…

Analysis of risk factor for peritonitis in peritoneal dialysis patients.

OBJECTIVE: To investigate the risk factors for peritonitis in peritoneal dialysis patients and to develop and validate a predictive model. … in, diabetes mellitus, and dialysis duration as independent risk factors for PDAP (all P<0.05). The ROC curve analysis of the predictive model yielded an area under the curve (AUC) of 0.914. A validation cohort consisting of 75 patients who underwent peritoneal dialysis between September 2023 and May 2024 included 22 PDAP. In this validation set, the predic …