Результаты поиска

Standardized aqueous extract of Abutilon theophrasti Medic. ameliorates oxidative stress and inflammatory responses against hydrochloric acid/ethanol-induced gastric ulcer in rats.

BACKGROUND: The herb Abutilon theophrasti Medic. (AT, Qingma in Chinese), a widely distributed medicinal plant in various regions worldwide, … in ATAE, comprising 10 flavonoids, 7 organic acids, 5 amines, and 4 other compounds. The content of rutin in ATAE was 0.38%. In vivo, ATAE markedly attenuated the HCl-/EtOH-induced GU and mucosal injuries; decreased the levels of pro-inflammatory/oxidant mediators, including TNF-α, IL-1β, IL-6, and malondialdehyde (MDA); increased the anti-oxidant activ …

Conservation of Verbascum sinaiticum Benth using innovative tissue culture technique and DNA barcoding.

Egypt has diverse medicinal plants, many of which are endangered because of environmental and human pressures. Verbascum sinaiticum Benth (V … creased germination.HPLC analysis revealed that the ethanolic extract had the highest quantities of rutin (19.07 µg/mL) and vanillin (6.29 µg/mL), while the aqueous extract had the highest levels of gallic acid (7.02 µg/mL) and chlorogenic acid (6.02 µg/mL). SDS-PAGE examination revealed five protein bands ranging in molecular weight from 240 kDa to 28 …

Cochlospermum regium (Mart. ex Schrank) Pilg.: Evaluation of chemical profile, gastroprotective activity and mechanism of action of hydroethanolic extract of its xylopodium in acute and chronic experimental models.

ETHNOPHARMACOLOGICAL RELEVANCE: Cochlospermum regium (Bixaceae) is a native shrub of Brazil and its xylopodium (infusion/decoction) is being … broth microdilution method. RESULTS: The HPLC analysis data revealed the presence of gallic acid, rutin, myricetin, morin and kaempferol. HECr promoted protective effect against acute ulcers induced by HCl/EtOH with inhibitions of 47.52% (p < 0.01) and 62.69% (p < 0.001) at 100 and 400 mg/kg, and in piroxicam by 34.11% (p < 0.05), 49.14% (p < 0.01) an …

Chemical composition and cardiotropic activity of Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f.

ETHNOPHARMACOLOGICAL RELEVANCE: Ziziphora clinopodioides subsp. bungeana (Juz.) Rech.f. is a subshrub that is widely distributed in China, K … 7a-hydroxymintlactone (6), 7-hydroxypiperitone (7) together with six polyphenols - pinocembrine-7-O-rutinoside (8), chrysine-7-O-rutinoside (9), acacetin-7-O-rutinoside (10), luteolin-7-O-rutinoside (11), rutin (12) and rosmarinic acid (13) were isolated from Z. clinopodioides subsp. bungeana extracts. CONCLUSION: Our results support the traditional us …

[A novel intraoperative imaging tool to follow the cochlear implant electrode array insertion dynamics].

UNLABELLED: Összefoglaló. Bevezetés: A cochlearis implantátum egy műtétileg behelyezett elektromos eszköz, amely az akusztikus hanghullámoka … atása a scala tympaniba, miközben a cochlea belső struktúrája a lehető legkisebb mértékben sérül. A rutin intraoperatív elektrofiziológiai tesztek fontos információt adnak a készülék működőképességéről és a hallóideg stimulációjáról, azonban nem hagyatkozhatunk rájuk az elektródasor cochleán belüli helyzetének igazolásában. Mivel előfordulhat, hogy a re …

[Detection of “tip fold-over” of the cochlear implant electrode array with transimpedance matrix (TIM) measurement].

UNLABELLED: Összefoglaló. Bevezetés: Az elmúlt években a cochlearis implantátum a súlyos halláskárosodás vagy a teljes siketség rutinszerű és hatékony kezelési eszközévé vált. Korunk egyik leggyakrabban használt és leghatékonyabb újítása a cochlearis implantációban a perimodiolaris vékony elektródasorok alkalmazása. A cochlea középtengelyét, a modiolust szorosan ölelő atraumatikus elektródasor igen meggyőző eredménnyel bizonyítja népszerűségét, mind az elektrofiziológiai mérések során, mind az akusztikus hallás megőrzése terén nyújtott teljesítményével. Ugyanakkor igen kevés publikáció írja le…

Flavonoids Derived from Abelmoschus esculentus Attenuates UV-B Induced Cell Damage in Human Dermal Fibroblasts Through Nrf2-ARE Pathway.

BACKGROUND: Ultraviolet-B (UV-B) radiation is a smaller fraction of the total radiation reaching the Earth but leads to extensive damage to … S: Flavonoid-rich EA fraction depicted a significant antioxidant potential also showing presence of rutin. Pretreatment of cells with EA fraction (10-30 μg/ml) prevented UV-B-induced cytotoxicity, depletion of endogenous enzymatic antioxidants, oxidative DNA damage, intracellular ROS production, apoptotic changes, and overexpression of Nrf2 and HO-1. C …

[A 50-year history of new drugs in Japan-the development and trends of hemostatics and antithrombotic drugs].

The developments and trends of hemostatic and antithrombotic drugs in Japan were investigated chronologically for the last 50 years after the 2nd World War. 1. Hemostatic drugs are classified into three groups ; capillary stabilizers, blood coagulants and antifibrinolytics. l) As to capillary stabilizers, flavonoid (rutin, 1949), adrenochrome derivative (carbazochrome, 1954) and conjugated estrogen (Premarin, 1964) were introduced therapeutically. Especially, the soluble types of adrenochrome compounds (Adona 1956, S-Adchnon, 1962) were devised and used widely in Japan. 2) Drugs concerning blo…

Evaluation of anti-inflammatory and mechanism of action of extract of Macrosiphonia longiflora (Desf.) Müll. Arg.

ETHNOPHARMACOLOGICAL RELEVANCE: Macrosiphonia longiflora (Desf.) Müll. Arg (Apocynaceae), popularly known as 'velame' and 'velame branco', i … 7 modulation. Phytochemical analysis revealed the predominant presence of the flavonoids (naringin, rutin, myricetin, morin, quercetin, (±)-naringenin, and luteolin) and phenols (ellagic acid), which are possibly involved in the anti-inflammatory effect of HEMl. The current study provided supportive evidence for the popular use of HEMl in the treatment …

Модуляторные эффекты традиционной китайской медицины и производные активных метаболитов на аутоиммунально-воспалительных путях сигнала при множестве склерозов: обзор повествования.

Множественный склероз (MS) — нервно-воспалительное заболевание с иммунной помощью, характеризующееся обезвоживанием, аксоновой травмой и обширным разрушением целостности центральной нервной системы. Экспериментальный аутоиммунный энцефаломиэлит (EAE) — наиболее часто применяемая модель для имитации патологических особенностей человека. В настоящее время еще многое предстоит сделать для совершенствования стратегии лечения MS. Все больше исследований показывают, что традиционная китайская медицина (TCM) и связанные с ней активные метаболиты полезны для лечения MS и умело регулируют уровни подстр

Совпадение в полном тексте источника
… The available data are primarily limited to baicalin and rutin, and since the mechanism of action of rutin has not been studied in the EAE model, the evidence is insufficient. … In addition, these substances are commonly found in a variety of sources, such as rutin. …

A case of recto-sigmoid endometriosis mimicking carcinoma.

OBJECTIVE: To evaluate the technical success, safety and outcome of endovascular coiling procedure in intracranial aneurysms. METHODS: From April 2003 to April 2009, 43 patients (23 males and 20 females), age range 11 to 70 years, mean age 46.67 +/- 11.57 years were treated for intracranial aneurysms by detachable coil deployment at Radiology Department of Aga Khan University Hospital. Aneurysm rupture with subarachnoid haemorrhage was the cause of presentation in 39 patients while 4 patients were diagnosed with un-ruptured aneurysms. At time of presentation, grading of subarachnoid haemorrha

Совпадение в полном тексте источника
… Rutin, acetic acid, and glucuronic acid were analyzed using a Mightysil RP-18 column under the chromatographic conditions summarized in Table S2. … DPPH radical-scavenging activity also increased over time, but the magnitude of change was smaller than that observed for TFC, TPC, and rutin (Table  2 ). …

Нацеливание на природные полифенолы антиоксидантов в целях защиты от нейроинфламмации и нейродегенеративных заболеваний: всеобъемлющий обзор.

Полифенолы, природные фитонутриенты, встречающиеся в растительных продуктах питания, привлекли значительное внимание к их потенциальному терапевтическому воздействию в неврологических заболеваниях и нейроинфламмации. Эти соединения обладают различными возможностями нейрозащиты, включая антиоксидантные, антивоспалительные и антиамильоидные свойства, которые способствуют смягчению развития таких нейродегенеративных заболеваний, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), деменция, множественный склероз (MS), Строк и болезнь Хантингтона (HD). Полифенолы были тщательно изучены на предме

Совпадение в полном тексте источника
… In AD, it has been noted that the quercetin and rutin decreased the Aβ formation and also inhibited the aggregation of Aβ fibrils ( Monteiro et al., 2024 ). The animal model studies revealed that both compounds also inhibited scopolamine-mediated amnesia. … Research with flavonoid rutin has been shown in neuroblastoma cells SH-SY5Y, which can regulate oxidative stress, malondialdehyde and glutathione disulfide ( Amiri et al., 2024 ). It also reduced the activation of inflammatory cascade by reducing cytokines such as TNF-α and IL-1β. …

The Protective Effects of Sesamin against Cyclophosphamide-Induced Nephrotoxicity through Modulation of Oxidative Stress, Inflammatory-Cytokines and Apoptosis in Rats.

Cyclophosphamide is an anticancer drug with a wide spectrum of clinical uses, but its typical side effects are multiple complications, including nephron toxicity. The possible molecular mechanism of the nephroprotective action of sesamin (SM) against cyclophosphamide (CP) induced renal toxicity was investigated in rats by understanding oxidative stress and inflammatory cytokines. In this study, rats were arbitrarily grouped into the following four groups: a normal control group (CNT); a CP-induced toxicity group; a treatment group with two doses of sesamin SM10 and SM20; a group with sesamin (

Совпадение в полном тексте источника
… Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats BMC Nephrol. 2017 18 194 10.1186/s12882-017-0601-y 28619064 PMC5472980 43. Galluzzi L. Vitale I. Abrams J.M. Alnemri E.S. Baehrecke E.H. Blagosklonny M.V. Dawson T.M. Dawson V.L. El-Deiry W.S. Fulda S. … Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats, role of NFκB/MAPK pathway Chem. Biol. Interact. 2015 231 98 107 10.1016/j.cbi.2015.02.021 25753322 46. Liu Q. Lin X. Li H. Yuan J. Peng Y. Dong L. Dai S. …

Olive Leaf Extract (OLE) Anti-Tumor Activities Against Hematologic Tumors: Potential Therapeutic Implications for Pediatric Patients with B-Acute Lymphoblastic Leukemia.

Background/Objectives: Several studies reported that olive leaf extract (OLE) may exert potent anti-cancer activities against human solid and hematological tumors. Such effects are mostly related to the polyphenol oleuropein and its derivatives, which are highly concentrated in OLE. Here, we investigated the anti-tumor effects of OLE in vitro against human acute leukemia and lymphoma cells. Methods: Cell proliferation and apoptosis have been evaluated by flow cytometry (using CFSE and Annexin-V/7AAD, respectively) in the presence or absence of OLE at different concentrations and in combination

Совпадение в полном тексте источника
… The mean phytochemical compounds and their concentrations contained in OLE were the following: Oleuropein 2656 mg/L, Hydrohytyrosol 213 mg/L, Tyrosol 174 mg/L, Elenolic Acid 1393 mg/L, and Rutin 237 mg/L. … Rutin Promotes Pancreatic Cancer Cell Apoptosis by Upregulating miRNA-877-3p Expression Molecules 2022 27 2293 10.3390/molecules27072293 35408691 PMC9000526 47. Zhou M. Zhang G. Hu J. Zhu Y. Lan H. Shen X. Lv Y. Huang L. …

Yerba Mate (Ilex paraguariensis) Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Regulatory T Cell Function.

Background/Objectives: In Latin America, yerba mate (YM) is a popular infusion processed from the leaves and stems of Ilex paraguariensis. YM has been shown to have anti-inflammatory properties in several studies, although the effect of YM on multiple sclerosis (MS) remains elusive. The purpose of this study was to examine the effect of YM on the development of MS, by using the experimental autoimmune encephalomyelitis (EAE) mouse model while also evaluating its effect over infiltration of immune cells into the central nervous system (CNS) and regulatory T cell (Treg) function. Methods: YM or

Совпадение в полном тексте источника
… These potential therapeutic effects of YM have been attributed to saponins and polyphenols (chlorogenic acid and tannins) found in its leaves [ 18 ], flavonoids (quercetin, kaempferol, and rutin), xanthines (caffeine and theobromine), purine alkaloids (caffeic acid, 3,4-dicaffeoylquinic acid, and 3,5 … The YM extract contained theobromine (892 ± 55 mg/Kg), rutin (486 ± 16 mg/Kg), chlorogenic acid (2461 ± 122 mg/Kg), quinic acid (18 ± 4 mg/Kg), quercetin (39 ± 7 mg/Kg), and caffeine (2388 ± 189 mg/Kg). …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

Совпадение в полном тексте источника
… Flavonoids, such as quercetin, kaempferol, and rutin, are known for their ability to induce apoptosis, inhibit cancer cell proliferation, and suppress metastasis. 61–63 See Figure 5 at the end of the manuscript for a detailed visualization of the structures of secondary metabolites identified, including … Cynaroside, Astragalin, Isorhamnetin 3-O-glukosida, Quercetin, Rutin, Flavonol, Phellopterin, Bergapten, and Isoquinoline. …

Hesperidin Mitigates Cyclophosphamide-Induced Testicular Dysfunction via Altering the Hypothalamic Pituitary Gonadal Axis and Testicular Steroidogenesis, Inflammation, and Apoptosis in Male Rats.

Cyclophosphamide (CP) is a cytotoxic, cell cycle, non-specific, and antiproliferative drug. This study aimed to address the toxic effects of CP on male fertility and the possible ameliorative role of hesperidin (HSP). Thirty-two adult albino rats were randomly divided into four groups, namely, the negative control, HSP, CP-treated, and CP+HSP-treated groups. The CP-treated rats showed a significant reduction in the levels of serum LH, FSH, testosterone, prolactin, testicular glutathione peroxidase (GPx), and total antioxidant capacity (TAC) with an elevation in levels of malondialdehyde (MDA),

Совпадение в полном тексте источника
… Amelioration of titanium dioxide nanoparticle reprotoxicity by the antioxidants morin and rutin Environ. Sci. Pollut. Res. 2019 26 29074 29084 10.1007/s11356-019-06091-0 31392614 39. Salimnejad R. Soleimani Rad J. Nejad D. … Quercetin and rutin ameliorates sulphasalazine-induced spermiotoxicity, alterations in reproductive hormones and steroidogenic enzyme imbalance in rats Andrologia 2018 50 e12981 10.1111/and.12981 29512831 82. Sharma P. Aslam Khan I. Singh R. …

Computational study of SENP1 in cancer by novel natural compounds and ZINC database screening.

Introduction: Sentrin-specific protease 1 (SENP1) is a protein whose main function is deSUMOylation. SENP1 inhibits apoptosis, and increases angiogenesis, estrogen and androgen receptor transcription and c-Jun transcription factor, proliferation, growth, cell migration, and invasion of cancer. The in vivo and in vitro studies also demonstrated which natural compounds, especially phytochemicals, minerals, and vitamins, prevent cancer. More than 3,000 plant species have been reported in modern medicine. Natural compounds have many anti-cancerous andanti-turmeric properties such as antioxidative,

Совпадение в полном тексте источника
… Molecular docking of SENP1 was performed with natural compounds including apigenin, aspirin, berberine, catechin, curcumin, cinnamic acid, ethyl gallate, ferulic acid, kaempferol, naringin, naringenin, quercetin, resveratrol, rutin, rusmarinic acid, silybin, silymarin, senegenin, sulforaphane, tangeretin … | 13 −5.38 | Kaempferol | 14 −5.33 | Rusmarinate | 15 −5.23 | Silibinin | 16 −5.07 | Silymarin | 17 −4.89 | Cinnamic acid | 18 −4.86 | Urolithin A | 19 −4.85 | Catechin | 20 −4.77 | Ugonin | 21 −4.7 | Quercetin | 22 −4.49 | Urolithin M5 | 23 −3.87 | Naringin | 24 −3.68 | Ethyl gallate | 25 −3.68 | Rutin …

New Avenues and Major Achievements in Phytocompounds Research for Glioblastoma Therapy.

Phytocompounds have been evaluated for their anti-glioblastoma actions for decades, with promising results from preclinical studies but only limited translation into clinics. Indeed, by targeting multiple signaling pathways deregulated in cancer, they often show high efficacy in the in vitro studies, but their poor bioavailability, low tumor accumulation, and rapid clearance compromise their efficacy in vivo. Here, we present the new avenues in phytocompound research for the improvement of glioblastoma therapy, including the ways to enhance the response to temozolomide using phytochemicals, th

Совпадение в полном тексте источника
… In a different investigation, the capacity to decrease MGMT expression in glioma cells was assessed in regards to rutin, catechin, dehydrozingerone, naringenin, and quercetin treatment, both individually and in combination with TMZ [ 24 ]. … For the first time, they described the anti-GBM activity of a 70% methanol extract from the aerial part (leaves and stems) of Smilax aspera , which is rich in flavonoids, especially in rutin and luteolin. …

Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs.

The cardiovascular toxicity of anticancer drugs promotes the development of cardiovascular diseases. Therefore, cardiovascular toxicity is an important safety issue that must be considered when developing medications and therapeutic applications to treat cancer. Among anticancer drugs, members of the anthracycline family, such as doxorubicin, daunorubicin and mitoxantrone, are known to cause cardiotoxicity and even heart failure. Using human-induced pluripotent stem cell-derived cardiomyocytes in combination with "Omic" technologies, we identified several cardiotoxicity mechanisms and signal t

Совпадение в полном тексте источника
… Rutin (a poly phenolic flavonoid) may be a protective agent against cardio toxicity of anticancer drugs via antioxidant and anti-inflammatory mechanisms. … Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis . Biochim Biophys Acta Mol Basis Dis. ( 2017 ) 1863 : 1904 – 11 . 10.1016/j.bbadis.2016.12.021 28069395 56. Almeida AS Figueiredo-Pereira C Vieira HLA . …