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Artificial Intelligence-Enhanced Cardiac Point-of-Care Ultrasound: A Prospective Single-Arm Study.

OBJECTIVE: To evaluate the clinical utility of combining artificial intelligence (AI) with handheld focused cardiac ultrasound (FoCUS) performed by noncardiologist physicians in clinical care settings. PATIENTS AND METHODS: In this prospective, single-arm study conducted from July 1, 2022, through December 31, 2023 (ClinicalTrials.gov NCT05455541), 660 adult patients presenting to the emergency department or internal medicine wards were assessed with handheld ultrasound devices enhanced by AI algorithms. These algorithms provided automated analysis of ventricular function, valvular disease, p…

Beyond surgical risk: Multidimensional predictors of postoperative arm morbidity after breast cancer treatment.

BACKGROUND: Postoperative upper-limb morbidity following breast cancer treatment is common and clinically significant, encompassing pain, functional impairment, range-of-motion limitation, and lymphedema. While traditional risk models have focused primarily on surgical and treatment-related factors, less is known about the relative contribution of psychosocial and behavioral determinants. The Arm Morbidity following Breast Cancer Treatment (ARM-BCT) tool was developed as a clinically practical risk stratification instrument; however, its performance and underlying predictors require further ev…

Posterior Arm Artery Perforator Flap: An Ultrafast and Reproducible Perforator Flap Dissection Technique.

Axillary reconstruction after wide excision for hidradenitis suppurativa (HS) remains challenging, with no consensus regarding the optimal technique. Although multiple reconstructive options exist, many are limited by prolonged operative time, imperfect tissue match, functional restriction, or significant donor-site morbidity. The posterior arm artery perforator (PAAP) flap offers a reliable and efficient alternative due to its constant anatomy, thin and pliable tissue, and low donor-site morbidity. We present a standardized, landmark-based, Doppler-free, ultrafast harvesting technique, design…

Omadacycline for community-acquired infections: A systematic review and single-arm meta-analysis.

Introduction. Community-acquired infections have a significant burden on healthcare systems and are caused by a variety of pathogens with different severities. Increasing microbial resistance complicates treatment, highlighting the need for new therapies. Omadacycline, a novel antibiotic, has broad-spectrum activity against both Gram-positive and Gram-negative pathogens, particularly those involved in community-acquired infections.Objective. To evaluate omadacycline’s efficacy and safety for treating community-acquired infections.Materials and methods. We searched PubMed, Embase, and Cochrane

Tele-robot-assisted prostatectomy: the first systematic review and single-arm meta-analysis.

Telesurgery has emerged as an important frontier technology for overcoming geographical barriers and enabling the decentralization of high-q … ies, animal experiments, and studies from which data could not be extracted were excluded. A single-arm meta-analysis was performed using a random-effects model. Primary outcomes included technical success rate, complications, operative time, estimated blood loss, and postoperative hospital stay. Subgroup analyses were stratified by robotic system typ …

Разработка временных итоговых мер для многоступенчатых клинических испытаний при многоразовом склерозе.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: В ходе многоэтапных клинических испытаний с применением различных видов оружия (MAMS) используются промежуточные итоговые анализы для проверки нескольких методов лечения кандидатов, которые должны перейти к следующему этапу испытаний. Сокращение времени, расходов и числа участников по сравнению с нынешними отдельными этапами 2 и 3 Клинические испытания могли бы ускорить разработку методов лечения нейродегенеративных заболеваний, таких, как прогрессивный множественный склероз (ПМС). Промежуточные результаты испытаний МУПМ должны отражать конечный результат этапа и

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Multi-arm multistage (MAMS) clinical trials use interim outcome stage analyses to test multiple candidate treatments, determining which should proceed to the next trial stage. The reduced time, cost, and participant numbers, compared with current separated phases 2 and 3 clinical trials, could expedite the development of treatments…

Modulating arm swing via haptic cueing alters interlimb neural coupling in older adults.

PURPOSE: Age-related gait impairments are strongly associated with increased fall risk, disability, and mortality. While traditional rehabilitation focuses on the lower limbs, arm movements play a key role in stabilizing gait through interlimb neural coupling. This study investigates whether rhythmic haptic cueing of arm swing, which enhances gait, affects interlimb neuromuscular coordination in older adults. METHODS: Seventeen older adults (mean age = 73.2 ± 6.0 years) completed three walking conditions: Baseline walking, self-selected Fast walking, and walking while rhythmically receiving …

Task failure reveals range-dependent neuromuscular fatigue in shoulder muscles during arm elevation.

Repeated upper limb performance fatigues periscapular and/or rotator cuff muscles, which may alter humeral and scapular kinematics leading to increased subacromial impingement syndrome risk. However, the specific changes in neuromuscular patterns across different phases of a functional movement performed to failure remain unclear. This study investigated neuromuscular fatigue during a repeated arm elevation task to failure in asymptomatic individuals. Participants elevated their dominant arm while holding ∼ 30 % of their maximal isometric shoulder flexion load until task failure. High-density …

Beyond the numbers: rethinking evidence in pooled analyses of hand-arm vibration syndrome.

Hand-arm vibration syndrome (HAVS) continues to weigh heavily on workers’ health, yet how we study it often limits what we learn. Bovenzi et al. make an important contribution by pooling Italian datasets, but the heavy reliance on cross-sectional designs restricts causal insight. Inconsistent exposure metrics, varied outcome definitions, and limited adjustment for confounders risk blurring the true picture of vibration-related harm. The continued use of the ISO 5349-1 standard, despite questions about its accuracy, further complicates interpretation. Perhaps most concerning is the underreprese…

Single anastomosis sleeve ileal (SASI) bypass outcomes and complications: single-arm meta-analysis.

BACKGROUND: Single Anastomosis Sleeve Ileal (SASI) bypass combines sleeve gastrectomy with a single anastomosis to the ileum, preserving digestive continuity to reduce deficiencies while treating obesity-related conditions. METHODS: This study systematically reviewed SASI bypass outcomes and conducted a single-arm meta-analysis to assess its efficacy and safety. A comprehensive literature search across PubMed, Scopus, Embase, and Cochrane databases initially identified 387 articles, with 38 studies meeting inclusion criteria, contributing data on a maximum of 2,555 patients. Follow-up ranged …

Muscle Volume Gain Following 20 Training Sessions on an Eccentric Arm-Crank Ergometer.

Eccentric resistance training is a promising strategy for achieving physiological benefits at lower cardiovascular and metabolic costs compared to traditional concentric training. Whereas lower-body eccentric training has been studied extensively, only little is known regarding upper-body eccentric strength training. This study assessed the impact of an eccentric arm-crank training on arm muscle volume. A total of 20 eccentric arm-crank training sessions were completed over a maximum of 12 weeks (2-3 trainings/wk). A training progression from 20 to 50% of the individual peak power and a durati…

Evaluation of Diagnostic Recommendations Embedded in Medication Alerts: Prospective Single-Arm Interventional Study.

BACKGROUND: Potentially inappropriate prescribing in outpatient care contributes to adverse outcomes and health care inefficiencies. Clinica … onding diagnosis documented and meets medication appropriateness. METHODS: This prospective single-arm interventional study was conducted over 1 year in the outpatient departments of a hospital. The system provided diagnostic recommendations based on machine learning algorithms trained on data from the National Health Insurance Research Database. Out …

Comparison between arm port and chest port: A systematic review and meta-analysis.

OBJECTIVE: This meta-analysis aimed to compare the efficacy and safety of arm ports (APs) and chest ports (CPs) in clinical practice. METHODS: Randomized controlled trials (RCTs), controlled clinical trials, and retrospective studies were searched in both English and Chinese databases, encompassing PubMed, Embase, Cochrane Library, Web of Science, CNKI, WanFang Database, and SinoMed up to November 27, 2023. Data analysis was performed using Stata 15.0. RESULTS: Seventeen studies, including two RCTs, three cohort studies, and twelve case-control studies, were finally included, involving a tot…

Low-Level Laser Therapy in Maxillofacial Trauma: A Prospective Single-Arm Observational Study.

Background: Surgical management of trauma in the maxillofacial complex can result in iatrogenic nerve injuries, particularly involving the infraorbital, inferior alveolar, and mental nerves. Paresthesia is a common postoperative complication, often attributed to the anatomical positioning of these nerve structures, making them vulnerable to injury. Among current therapeutic options for nerve injuries, low-level laser therapy (LLLT) has shown promising results in published studies. Objectives: This prospective observational study evaluated the effects of LLLT on nerve recovery following maxillo

Management of dropped head syndrome: a systematic review and single-arm meta-analysis.

Dropped Head Syndrome (DHS) is a rare condition marked by severe neck extensor muscle weakness, leading to a chin-on-chest deformity caused by pathological kyphosis. This study aims to evaluate the efficacy of conservative versus surgical treatments for DHS. A systematic search of PubMed, Embase, and ScienceDirect was conducted for studies on DHS treatments. Outcomes included total/partial improvement, success, and failure rates. Statistical analyses were performed using R software and the "meta" package. We identified 1,252 articles, with 19 studies and 472 patients included. Of these, 134 (2

Long-Term Efficacy of a Mobile Mental Wellness Program: Prospective Single-Arm Study.

BACKGROUND: Rising rates of psychological distress (symptoms of depression, anxiety, and stress) among adults in the United States necessita … e aim to address the rising psychological distress among adults in the United States. METHODS: A 1-arm study design was used, with participants having access to the Noom Mood program for 16 weeks (N=273). Surveys were conducted at baseline, week 4, week 8, week 12, week 16, and week 32 (16 weeks' postprogram follow-up). This study assessed a range of …

AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial.

BACKGROUND: Autosomal recessive deafness 9, caused by mutations of the OTOF gene, is characterised by congenital or prelingual, severe-to-complete, bilateral hearing loss. However, no pharmacological treatment is currently available for congenital deafness. In this Article, we report the safety and efficacy of gene therapy with an adeno-associated virus (AAV) serotype 1 carrying a human OTOF transgene (AAV1-hOTOF) as a treatment for children with autosomal recessive deafness 9. METHODS: This single-arm, single-centre trial enrolled children (aged 1-18 years) with severe-to-complete hearing lo…

mHealth Intervention for Elevated Blood Pressure Among College Students: Single-Arm Intervention Study.

BACKGROUND: Current evidence reveals a growing pattern of hypertension among young adults, significantly increasing their risk for cardiovas … ticipant self-measured blood pressure (BP) with college-aged young adults. METHODS: Using a single-arm intervention, pilot study design, the mHealth to Optimize BP Improvement (MOBILE) intervention was implemented with college students aged 18 years to 39 years who had systolic BP >120 mm Hg and diastolic BP ≥80 mm Hg. Participants were required to m …