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[Lumbar and lumbo-sacral fusion using Twinflex devices in 114 cases with minimal follow-up of 1 year].

UNLABELLED: The author presents a series of 114 cases of lumbo-sacral fusion with a minimum follow-up of 1 year and a mean of 21.7 months.Si … ses, L4-S1.35 cases, L5-S1 20 cases, others 12 cases).• COMPLICATIONS: No infections were seen. No phlebitis or pulmonary embolism.•Mechanical complications: They are analysed with an average follow up of 21.7 months and a minimum of 12 months. Screw fractures: Only one case occured at 4 months post op in a L4-5 isthmic spondylolisthesis. Fusion was still …

Effective treatment of advanced breast cancer with vinorelbine, mitomycin C plus human granulocyte colony-stimulating factor.

A phase II trial was performed to evaluate the efficacy and tolerance of vinorelbine (VNB), mitomycin C (MMC), and recombinant human granulo … nausea/vomiting in 7%, constipation in 9%, peripheral neuropathy in 5%, infectious episodes in 7%, phlebitis due to drug extravasation in 5%, alopecia in 9%, and acute reversible pulmonary toxicity in 11%. Our data suggest that vinorelbine, mitomycin C plus G-CSF has an excellent anti-tumour activity in advanced breast cancer, probably superior to most oth …

Anterior lumbar fusion with titanium threaded and mesh interbody cages.

The authors report their experience with 42 patients in whom anterior lumbar fusion was performed using titanium cages as a versatile adjunc … left common iliac vein lacerations); one injury to the sympathetic plexus; one case of superficial phlebitis; two cases of prolonged ileus (greater than 48 hours postoperatively); one anterior femoral cutaneous nerve palsy; and one superficial wound infection. No deaths were directly related to the surgical procedure. There were no cases of dural laceratio …

[The comparative costs of vancomycin treatment versus teicoplanin in osteoarticular infection caused by methicillin-resistant staphylococci].

This clinical and economical study compared two glycopeptides regimen i.e., vancomycin and teicoplanin in the treatment of osteoarticular infection involving methicillin-resistant staphylococcus. After randomization, 15 patients (group 1) received vancomycin (23 F per gram) in continuous infusion through a central venous catheter and 15 others (group 2) intramuscular teicoplanin (311-357 F a 400 mg vial). The clinical study focused on treatment tolerance in an in-patient setting as well as in a non in-patient one. The cost analysis focused on total expenses including those of antibiotics, thos

Experience with concomitant ultrasound-guided foam sclerotherapy and endovenous laser treatment in chronic venous disorder and its influence on Health Related Quality of Life: interim analysis of more than 1000 consecutive procedures.

AIM: The aim of this paper was to evaluate the efficacy of the concomitant use of endovenous laser treatment (ELT) and ultrasound-guided foa … , due to dressing tape. These required no additional treatment. There were two cases of superficial phlebitis that resolved with continued compression and NSAIDs. There was one asymptomatic popliteal DVT and one uncomplicated superficial skin burn that both resolved uneventfully with no treatment other than observation. No pulmonary embolism (PE), thromboph …

Menopause following cancer treatment-induced menopause: unique considerations and current recommendations.

UNLABELLED: This is a retrospective study of 173 chronic laxities of the knee operated on between May 1985 and December 1988 using the Mac I … ses (2.3 per cent) of joint stiffness, 2 cases of reflex sympathetic dystrophy and 5 cases of sural phlebitis (2.9 per cent). Moreover, the few minor complications that arose resolved with the appropriate treatment. Anatomical results, evaluated using. Lachmans test (maximum manual Lachman measured with the Bercovy Laximeter) showed 24 cases (22.4 per cent) …

Analysis of Peripherally Inserted Central Catheter Line in Cancer Patients: A Single-Center Experience.

Background Peripherally inserted central venous catheters are now widely used in cancer patients who require long-term treatment, for delivering multiple infusates. We aimed to evaluate the overall use of peripherally inserted central catheter (PICC) line in cancer patients, with the objective to study the demographic profile, complications, and safety related to PICC line in cancer patients. Methods All the patients undergoing treatment for hematological and solid malignancies with PICC line inserted at the Healthcare Global Hospital during the study were evaluated prospectively. The complica

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… We observed overall 10.2% complications in our patients, where mainly 3.4% was due to infective causes (CRBSI and phlebitis combined), while 3% was due to thrombosis. … The remaining 2.2% patients were salvaged with regular dressing and oral antibiotic, especially in cases of phlebitis. We did not observe any death due to PICC line complications, although 4% of the patients who died were because of the progression of the disease. …

MPO-ANCA-Associated Hypertrophic Pachymeningitis Mimicking IgG4-Related Disease: A Case Report and Literature Review.

Hypertrophic pachymeningitis (HP) is a rare and chronic clinical disease characterized by thickening of the dura mater, leading to persistent headache, cranial neuropathy, seizures, and other neurological symptoms. Immune-mediated causes, particularly antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and IgG4-related disease (IgG4-RD), are among the most common etiologies. We report a case of a 54-year-old female with recurrent headache, blepharoptosis, hearing loss, and markedly elevated inflammatory markers. Blood tests, and serum levels of IgG4 were within normal ranges. Cont

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… However, there was no evidence of storiform fibrosis, vascular occlusion, or obliterative phlebitis ( Figure 3 ). However, serum level of IgG4 and IgE were within normal ranges. … IgG4-RD is a chronic inflammatory fibrosing disease characterized by histopathological features, including storiform fibrosis, obliterative phlebitis, and dense infiltration of IgG4-positive plasma cells. …

[Clinical comprehensive evaluation of Ginkgolide Injection in treatment of cerebral infarction].

This clinical value-oriented comprehensive evaluation of drugs was carried out in accordance with Guidelines for Management of Comprehensive … ng platelet aggregation, the resulting adverse reactions such as flushing, dizziness, headache, and phlebitis were caused by vasodilation. Skin rash and gastrointestinal symptoms were mainly attributed to the patients' sensitivity to drugs and their own allergic constitution. According to the sufficiency of evidence and the incidence of adverse reactions in …

Interventions for men and women with their first episode of genital herpes.

BACKGROUND: Genital herpes is incurable, and is caused by the herpes simplex virus (HSV). First-episode genital herpes is the first clinical … were coryza, dizziness, tiredness, diarrhoea and renal colic. For intravenous acyclovir these were phlebitis, nausea and abnormal liver function tests and for topical acyclovir there was pain with the topical application.Those undergoing interferon treatment had significantly more adverse events compared to those taking placebo. AUTHORS' CONCLUSIONS: Ther …

Clinical pharmacology of DP-b99 in healthy volunteers: first administration to humans.

AIMS: To investigate the safety, tolerability and pharmacokinetics of DP-b99 in healthy volunteers. DP-b99 is a newly developed lipophilic, … six of the seven young subjects treated with four repeated doses of 1.0 mg kg(-1), with reversible phlebitis being the most frequently reported adverse event. The drug was tolerated better at the injection site by the elderly group compared with the younger subjects. No adverse effects were observed in cardiovascular parameters sensitive to trans-membranou …

[Uncemented knee prosthesis. Results apropos of 58 cases with a minimum of 5-year follow-up].

PURPOSE OF THE STUDY: The aim of this study was to evaluate, after at least 5 year's follow-up, the results of 64 PCA (TM) cementless total … ative outcome. RESULTS: There were no local postoperative complications or any early reoperations. PHlebitis occurred in 12 per cent of cases. With the exception of 8 patients who were reoperated due to mechanical complications, the Hungerford score raised from 37.5 preoperatively to 88.3 postoperatively. The results of 43 of the 48 patients were rated goo …

A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank.

BACKGROUND: Mendelian randomisation allows for the testing of causal effects in situations where clinical trials are challenging to do. In t … type 1 diabetes; and 1·46, 1·25-1·70 for hypothyroidism), circulatory diseases (1·96, 1·53-2·51 for phlebitis and thrombophlebitis; 1·89, 1·39-2·57 for cardiomegaly; 1·68, 1·35-2·09 for congestive heart failure; 1·55, 1·37-1·76 for hypertension; 1·31, 1·13-1·52 for ischaemic heart disease; and 1·25, 1·14-1·37 for cardiac dysrhythmias), and inflammatory or d …

Is Gonadal Therapy a Promoter of Breast Cancer? Incidence of Breast Cancer in a Cohort of Survivors of Oncological Diseases Treated with Gonadal Steroids.

There is a great controversy about hormonal replacement therapy in women among the members of the scientific community. Cancer survivors have sometimes had their ovary function totally or partially destroyed, thus affecting their development and quality of life. In this study, we were looking for adverse effects caused, eventually, by estroprogestative therapy in a cohort of supplemented survivors. The occurrence of breast cancer was our main concern. Ours is a retrospective study based on the clinical records of 174 survivors of several cancer diseases. Their median ages within each of the fo

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… Vascular Disease During the follow-up, 6 vascular complications were observed, 4 of which were thrombosis occurring in areas treated with radiotherapy, and the remaining 2 were leg phlebitis (Table 7 ). … Overall, 6 cardiovascular events were reported (4 thrombosis and 2 phlebitis). …

Central Venous Access Device Complications and Premature Removal in Patients With Haematological Malignancies: A Multi-Site Cohort Study.

BackgroundPatients with haematological malignancies require urgent and reliable venous access for the administration of systemic anticancer therapies (SACTs) commonly via central venous access devices (CVADs). Disease pathophysiology and side effects of SACTs increase the risk of complications during the dwell time and premature removal. CVAD complications are associated with treatment disruption, increased morbidity and mortality. This study aimed to comprehensively describe CVAD performance over a 12-month period in patients with haematological malignancies.MethodsA multi-site cohort study a

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… Premature removals were categorised into clinically meaningful groups: dressing and securement related, clinician related, occlusion related, thrombosis or phlebitis were included (Table 1 ). … CVAD ‘Routine’ 7‐day replacement in ICU Sufficient veins to complete treatment peripherally Patient request related to physical issue with device ‘Routine’ 7‐day replacement in ICU & local infection Clinician related other b Occlusion related Occlusion CVAD device rupture/damage c Thrombosis related Phlebitis …

IgG4-related kidney disease complicated with retroperitoneal fibrosis: A case report.

BACKGROUND: IgG4-related disease (IgG4-RD) is a chronic fibrotic disease mediated by immunity recognized by clinicians in recent years. When the kidney is involved, it is called IgG4-related kidney disease (IgG4-RKD). IgG4-related tubulointerstitial nephritis (IgG4-TIN) is a representative manifestation of IgG4-RKD. IgG4-TIN can cause obstructive nephropathy complicated by retroperitoneal fibrosis (RPF). Cases of IgG4-TIN complicated with RPF are rare. Glucocorticoids are the first-line therapeutic medication for IgG4-RD and can significantly improve renal function. CASE SUMMARY: Herein, we r

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… INTRODUCTION IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that can affect almost any organ, and it is characterized by dense lymphoplasmacytic infiltrates with a high percentage of IgG4-bearing plasma cells, abundant storiform fibrosis, obliterative phlebitis, and frequent tissue … The pathological characteristics of IgG4-RKD are as follows: Lymphoplasmacytic infiltrates with prominent IgG4+ plasma cells, storiform fibrosis, obliterative phlebitis, and an increased IgG4+/IgG+ plasma cell ratio[ 5 ]. Glucocorticoids are the first-line therapy for IgG4-RD[ 6 ]. …

Carfilzomib plus dexamethasone in patients with relapsed and refractory multiple myeloma: A retro-prospective observational study.

ObjectiveWe investigate safety and efficacy in common clinical practice of the combination of carfilzomib and dexamethasone (Kd56) approved for the ENDEAVOR trial for the treatment of relapsed or refractory multiple myeloma.MethodsWe retro-prospective analyzed 75 patients in three centers in Tuscany, 48 of whom had a clinically relevant comorbidity and 50 of whom were older than 65 years, treated with a median use in the fourth line of therapy. We assessed the efficacy based on the International Myeloma Working Group criteria.ResultsThe overall response rate was 60%. Median PFS was 10 months i

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… symptoms | 1 | Generalized edema | 4 | Headache | 1 | Heart failure | 5 | 2 Hyperglycemia | 1 | Hypertension | 2 | 8 Pneumonia (of which COVID19) | 2 (1) | 4 (1) Myalgia | 1 | Nausea | 2 | Otitis | 1 | Palpitations | 2 | Pericardial effusion | | 1 Periodontal disease | | 1 Pharyngitis | 1 | Phlebitis … | 1 | Phlebitis infective | 1 | Rash maculo‐papular | 2 | 1 Renal colic | 1 | Sepsis | | 2 Shingles | 1 | Skin infections | 1 | Skin ulceration | 1 | 3 Stroke | | 1 Supraventricular tachycardia | 1 | Syncope | | 1 Thromboembolic event | | 1 Urinary tract infections | 2 | 1 Urinary tract obstruction …

Коронарная артерия, пересадка пациентов с хроническими почечными заболеваниями: хроническая болезнь почек оказывает независимое отрицательное воздействие на долгосрочный результат пересадки коронарных артерий.

Мы изучили краткосрочные и долгосрочные результаты пересадки коронарной артерии (CABG) у пациентов с ишемической болезнью сердца и влияние почечной функции на эти результаты. Мы в том числе 2783 пациентов, прошедших первичную выборную КПЖ в одном учреждении 2002 и 2020 (возраст: 67.6 ± 10.2 годы; мужчина: 2281 мужского пола). Они были стратифицированы на основе их предварительной оценки скорости глумеркулярной фильтрации и прошли через насос CABG (коэффициент завершения, 98.1%); 57.6% в случаях использования двусторонних внутренних грудных артерий (БИТА). Коэффициент смертности в больницах 1.0

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… Additionally, the SVG of the lower extremity may not have been suitable for grafting, as patients may have developed stasis dermatitis and phlebitis due to fluid overload, and anemia and hypoproteinemia due to worsening renal function. … In contrast, worsening CKD tends to be associated with lower extremity swelling and congestive phlebitis, with the SVG often showing inflammation and intimal thickening. …

Cancer-associated thrombosis: clinical presentation and survival.

BackgroundThromboembolic events are important causes of morbidity and mortality in cancer patients. Clinical presentation in a community-based setting has not been fully clarified. The purpose of this study was to evaluate the incidence, risk factors, role of thrombophilia, and subsequent survival following thrombosis in cancer patients.MethodsA retrospective review was undertaken of clinical data for all consecutive patients with histologically confirmed cancer seen by the author at a regional cancer center, with emphasis on cancer-related thrombosis.ResultsBetween 2005 and 2012, of 1874 canc

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… 58.3) | 24 (60.0) | | 158 (58.5) Age at thrombosis ≤64 years | 105 (45.7) | 12 (30.0) | 0.06521 | 117 (43.3) ≥65 years | 125 (54.4) | 28 (70.0) | | 153 (56.6) Type of thrombosis DVT | 104 (45.2) | 0 | <0.0001 | 104 (38.5) PE | 27 (11.7) | 0 | | 27 (10.0) DVT and PE | 63 (27.4) | 0 | | 63 (23.3) Phlebitis … Thirty-six (1.9%) patients developed thrombosis at other venous sites, such as superficial phlebitis (23, 1.2%) or intra-abdominal venous occlusion (13, 0.7%). …