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Relation of Aerobic Activity to Cognition and Well-being in Chronic Mild Traumatic Brain Injury: A LIMBIC-CENC Study.

INTRODUCTION: Because chronic difficulties with cognition and well-being are common after mild traumatic brain injury (mTBI) and aerobic phy … l-validated cognitive performance tests of executive function, learning, and memory: The California Verbal Learning Test-Second Edition Long-Delay Free Recall and Total Recall, Brief Visuospatial Memory Test-Revised Total Recall, Trail-Making Test-Part B, and NIH Toolbox for the Assessment of Neurological Behavior and Function Cognition Battery Picture Sequence M …

Do neurosteroids have impact on depression and cognitive functions in cases with acromegaly?

OBJECTIVE: Neurosteroids (NSs) are a distinct hormone group and, they are known for their contribution into the status of mood and cognitive functions. Whether they are also involved in the mood disturbances and cognition in acromegaly is not known. Herein we aimed to evaluate the relation of mood status and cognitive functions with the NS levels in cases with acromegaly. DESIGN: A total of 33 cases with acromegaly composed the acromegaly group (AG) and, 30 age and gender-matched cases without acromegaly composed the control group (CG). The levels of Allopregnanolone (AP), pregnenolone (PRG),

Longitudinal neuropsychological safety assessment of biperiden treatment following traumatic brain injury.

Traumatic brain injury (TBI) is associated with cognitive impairment and neurobiological alterations potentially influenced by cholinergic s … were assessed using tests from the Wechsler Adult Intelligence Scale, Five Digit Test, Rey Auditory Verbal Learning Test and Rey-Osterrieth Complex Figure Test. Fifty-four participants (placebo n = 30; biperiden n = 24) were included, with follow-up at 3-9, 10-16, and 20-36 months. Linear mixed-effects models showed no differences in cognitive outcomes between tr …

Differences in Physical and Cognitive Function among Caucasian and African American Adults with Multiple Sclerosis.

UNLABELLED: Multiple sclerosis (MS) affects both Caucasian and African Americans in the U.S., with evidence of faster disability progression among African Americans. OBJECTIVE: We compared physical and cognitive performance between groups and examined within-group associations between cognitive and motor outcomes (i.e., cognitive-motor coupling). DESIGN: Participants completed remote Zoom-based assessments, including the 30-Second Sit-to-Stand (30STS), Symbol Digit Modalities Test (SDMT), and the California Verbal Learning Test, Second Edition (CVLT-II). Data were analyzed using independent …

Hearing loss and cognitive function among older adults in 18 high-income countries: Moderating and Mediating factors.

BACKGROUND: Hearing loss is a major, potentially modifiable risk factor for cognitive impairment, but its moderating and mediating factors remain underexplored in cross-national settings. METHODS: We used the data from a cross-national survey, the Survey of Health, Ageing and Retirement in Europe (SHARE). 38,506 participants aged 65 and above across 17 European countries and Israel from SHARE wave 6 were included. The study applied the Double Machine Learning (DML) approach to evaluate the association of hearing aid use with cognitive function in older adults, and to test demographic moderato

Perceptions and Adaptation Strategies in Fundamental Movement Skills Among Children With Physical Disabilities.

Fundamental movement skills (FMS) are foundational to children's motor development and long-term participation in physical activity. However, standardized assessments often fail to capture the diverse abilities and lived experiences of children with physical disabilities. This qualitative study explored how these children perceive and perform FMS. Seventeen participants ages 3 to 10 took part in two sessions: one to assess their FMS using the Test of Gross Motor Development, the 3rd edition, and another to discuss their understanding of specific skills through an unstructured interview. Themat

Depressive symptoms and cognitive decline in older adults.

OBJECTIVES: Few studies have examined the impact of late-life depression trajectories on specific domains of cognitive function. This study … ion Test [COWAT]), processing speed (Symbol Digit Modalities Test [SDMT]), episodic memory (Hopkins Verbal Learning Test - Revised [HVLT-R]), and a composite z-score were assessed over a subsequent median 2 years. RESULTS: Subthreshold depression predicted impaired performance on the SDMT (Cohen's d -0.04) and composite score (-0.03); emerging depression predict …

Картирование когнитивной дисфункции при повторном склерозе с легкой инвалидностью: перекрестное исследование из Южной Индии.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Когнитивная дисфункция при множественном склерозе (МС) происходит рано. В Индии мало адаптированных к местным условиям нейропсихологических данных. ЦЕЛИ: Мы стремились определить структуру когнитивного расстройства при повторном замыкании MS (RMS) с легкой инвалидностью с использованием рентгеновской когнитивной батареи MS. МЕТОДОЛОГИЯ: В исследовании приняли участие 59 человек, имеющих MS (PwMS) с расширенной шкалой учета инвалидности (EDSS) ≤ 4 и 62 контроля. В аккумуляторе было проведено 8 нейропсихологических тестов (Paced Audity Serial Inflictive Test [PASAT], SDMT

Совпадение в аннотации оригинала
BACKGROUND: Cognitive dysfunction in multiple sclerosis (MS) occurs early. Locally adapted neuropsychological data from India in MS is scarc … sts (Paced Auditory Serial Addition Test [PASAT], Symbol Digit Modalities Test [SDMT], Rey Auditory Verbal Learning Test [RAVLT], Brief Visuospatial Memory Test-Revised [BVMT-R], verbal fluency [VF], Judgement of Line Orientation Test [JOLOT], Wisconsin Card Sorting Test [WCST] and Trail Making Test-B [TMT-B]) with 11 measures. The scores were compared between th …

Reduced overnight memory consolidation and associated alterations in sleep spindles and slow oscillations in early Alzheimer's disease.

Spatial navigation critically underlies hippocampal-entorhinal circuit function that is early affected in Alzheimer's disease (AD). There is growing evidence that AD pathophysiology dynamically interacts with the sleep/wake cycle impairing hippocampal memory. To elucidate sleep-dependent consolidation in a cohort of symptomatic AD patients (n = 12, 71.25 ± 2.16 years), we tested hippocampal place learning by means of a virtual reality task and verbal memory by a word-pair association task before and after a night of sleep. Our results show an impaired overnight memory retention in AD compared

Young adult Swedish patients with autoimmune Addison's disease report difficulties with executive functions in daily life despite overall good cognitive performance.

OBJECTIVES: Sub-optimal replacement of glucocorticoids (GC) in autoimmune Addison's disease (AAD) may affect cognitive functioning. The present study therefore sought to investigate cognitive performance and self-reported problems with executive functions in a cohort of young adult patients with AAD. DESIGN AND METHODS: 67 patients with AAD (39 females), mean age 32 yrs. (range 19-41), and 80 control participants (43 females), mean age 29 yrs. (range 19-43), completed neuropsychological tests estimating verbal and non-verbal intellectual ability, learning, memory and executive functioning, in

Effect of computerized cognitive rehabilitation in comparison between young and old age after traumatic brain injury.

INTRODUCTION: Cognitive dysfunction reduces patients' quality of life and social participation with traumatic brain injury (TBI). Computerized cognitive rehabilitation is increasingly being used for cognitive therapy in TBI patients. The purpose of this study was to investigate the influence of age on the effect of computerized cognitive rehabilitation in cognitive dysfunction after TBI. MATERIAL AND METHODS: A total of 34 patients with cognitive dysfunction after TBI were enrolled. Participants performed 30 sessions of computerized cognitive rehabilitation (Comcog) for 6 weeks. A cognitive e

Neurocognitive Outcomes from Memantine: A Pilot, Double-Blind, Placebo-Controlled Trial in Children with Autism Spectrum Disorder.

Objective: Studies interrogating therapeutics which alter the excitation-inhibition balance in the treatment of autism spectrum disorder (ASD) have reported mixed results on social and behavioral outcomes. Methods: The aim of this randomized, double-blind placebo-controlled pilot trial was to evaluate neurocognitive effects of memantine over a 24-week trial. Twenty-three children ages 6-12 years old with ASD were randomized to memantine or placebo. Primary outcomes included measures of apraxia and expressive language with evaluations at midpoint (week 12) and endpoint (week 24). Secondary outc

Association of blood pressure with cognitive function at midlife: a Mendelian randomization study.

BACKGROUND: Whether high blood pressure has a causal effect on cognitive function as early as middle age is unclear. We investigated whether high blood pressure (BP) causally impairs cognitive function at midlife using Mendelian Randomization (MR). METHODS: We applied a two-sample MR approach to investigate the causal relationship between BP and midlife cognitive performance measured by the Digit Symbol Substitution Test (DSST), Rey Auditory Verbal Learning Test (RAVLT), and Stroop Interference test. We used a total of 109 genetic polymorphisms with established associations with BP as instrum…

REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia.

OBJECTIVES: REM sleep behavior disorder (RBD) is associated with cognitive dysfunctions and is a risk factor for development of mild cogniti … domains were assessed by Mini Mental State Examination, total score and figure copying, California Verbal Learning Test-II, Visual Object and Space Perception Cube and Silhouettes, Boston Naming Test, Stroop test, Verbal Category Fluency, Trail Making Test A and B. RESULTS: Among the 246 subjects, 47 (19.1%) had pRBD at the baseline, and pRBD group was younger …

Clinical and Neuropsychological Outcome After Microsurgical and Endovascular Treatment of Ruptured and Unruptured Anterior Communicating Artery Aneurysms: A Single-Enter Experience.

BACKGROUND: Anterior communicating artery (ACoA) aneurysms have a high risk of rupture. Morbidity and mortality following rupture are higher … core digit span forward and backward test, phonemic and semantic verbal fluency tests, Rey auditory verbal learning test, comprehensive trail making test, and the Beck Depression Inventory. FINDINGS: 28 patients (56 %) underwent surgical treatment and 22 (44 %) endovascular coiling; there were 31 (63 %) ruptured and 19 (37 %) unruptured aneurysms. At 1 year foll …

Differences in praxis performance and receptive language during fingerspelling between deaf children with and without autism spectrum disorder.

Children with autism spectrum disorder present with a variety of social communication deficits such as atypicalities in social gaze and verbal and non-verbal communication delays as well as perceptuo-motor deficits like motor incoordination and dyspraxia. In this study, we had the unique opportunity to study praxis performance in deaf children with and without autism spectrum disorder in a fingerspelling context using American Sign Language. A total of 11 deaf children with autism spectrum disorder and 11 typically developing deaf children aged between 5 and 14 years completed a fingerspelling

Prenatal anti-Ro antibody exposure, congenital complete atrioventricular heart block, and high-dose steroid therapy: impact on neurocognitive outcome in school-age children.

OBJECTIVE: To determine the impact of prenatal exposure to maternal anti-Ro antibodies, slow fetal heart rate, and/or prolonged dexamethason … ed included intelligence, visual perceptual and visual motor skills, auditory and visual attention, verbal learning and memory, visual memory, executive function, and behavior. RESULTS: All cohorts scored within the normal range and were not significantly different in terms of intelligence scores, verbal comprehension, perceptional reasoning, working memory, and …

Possible dose-side effect relationship of antipsychotic drugs: relevance to cognitive function in schizophrenia.

Management of adverse events is a major concern of clinicians who use antipsychotic drugs. The incidence of motor side effects is dose dependent. Atypical antipsychotic drugs are less likely to induce neurologic side effects compared with typical (conventional) antipsychotics, such as haloperidol. Some recent, large-scale studies have shown that the incidence of metabolic side effects often associated with atypical agents does not differ among typical and atypical antipsychotics. Cognitive function, such as verbal learning memory, working memory, executive function, verbal fluency and attentio…

Memory and executive functions in adults with Gilles de la Tourette syndrome and chronic tic disorder.

INTRODUCTION: The main aim of the current study was to assess whether adults with either Tourette syndrome (TS) or chronic tic disorder (CTD … lligence. All participants completed two tests of memory (Rey-Osterreich Complex Figure, California Verbal Learning Test), one test of motor dexterity (Purdue pegboard), and four tasks of executive function (Stroop, Color Trail Test, Tower of London, Wisconsin Card Sorting Test). RESULTS: TS and CTD patients showed nonverbal memory impairments while verbal memor …

Auditory perception in auditory neuropathy: clinical similarity with auditory verbal agnosia.

The precise features of auditory perception in patients with auditory neuropathy have not been well described. In the present study, we examined auditory perception in a patient with auditory neuropathy. The patient was a right-handed 7-year-old boy. His chief complaint was delayed speech and suspected of verbal learning disability. He could talk, read and repeat rather fluently but could not understand fully what was asked. V-IQ, P-IQ and F-IQ of Wechsler Scale for Children III-R were 53, 118 and 81, respectively. Pure tone audiogram was completely normal. His speech discrimination ability wa…