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Intravenous immunoglobulin for postpolio syndrome: a systematic review and meta-analysis.

BACKGROUND: Postpolio syndrome (PPS) is characterized by progressive disabilities that develop decades after prior paralytic poliomyelitis. Because chronic inflammation may be the process underlying the development of PPS, immunomodulatory management, such as intravenous immunoglobulin (IVIg) administration, may be beneficial. METHODS: We performed a systematic review and meta-analysis of published randomized controlled trials (RCTs) and prospective studies that evaluated the efficacy of IVIg in managing PPS. Electronic databases, including PubMed, EMBASE, CINAHL, and the Cochrane Central Reg

Индексы центральной и периферической усталости после упражнений на сопротивление с ограничением кровотока у людей с множественным склерозом и без него.

Утомление мышц является распространенным и сложным симптомом у людей с множественным склерозом (PwMS), который, как правило, связан с выраженным центральным (например, снижением кортикоспинной ритмичности) и относительно меньшим периферийным воздействием (например, метаболическим стрессом) по сравнению со здоровым контролем. Ограничение кровопотока (БКО), применяемое в ходе учений по повышению сопротивляемости, является новаторским подходом, облегчающим упражнение в системе PwMS. Поэтому цель этого исследования заключалась в изучении вопроса о том, каким образом различные подходы к обеспечению

Совпадение в аннотации оригинала
Muscle fatigue is a prevalent and challenging symptom in people with multiple sclerosis (PwMS), typically involving pronounced central (e.g., reduced corticospinal excitability) and relatively lower peripheral contributions (e.g., metabolic stress) compared with healthy controls. Blood flow restriction (BFR) applied during resistance exercise is an innovativ…

Effect of lower extremity muscular fatigue on motor control performance.

PURPOSE: The purpose of this study was to determine whether lower extremity fatigue affects the ability of an individual to balance on an unstable platform. METHODS: Twenty healthy subjects (average age, 29 yr, range, 20 to 39 yr) were tested on an instrumented balance assessment system. Static tests were done on the limbs unilaterally and then bilaterally, and finally a dynamic test was performed in which the subject moved the platform in a circular manner to chase a moving object on a computer screen. After testing, subjects were fatigued using an isokinetic dynamometer, which imposes close

A 62-year-old man with skin rash and an abnormal chest radiograph.

A 62-year-old man developed a scalp rash 2 months ago, followed by bilateral eyelid swelling. The nonpruritic rash then spread to involve most of his skin. He also had fatigue, muscle weakness, mild muscle soreness with activity, and dysphagia for solid foods for the last 3 weeks. He had no other symptoms. He had a 50 pack-year history of smoking and drank two to three shots of alcohol daily.

Effects of vibration-induced fatigue on the H-reflex.

Vibration exercise (VE) has been suggested as an effective training for improving muscle strength and coordination. However, the underlying physiological adaptation processes are not yet fully understood, limiting the development of safe and effective exercise protocols. To better understand the neuromuscular responses elicited by VE, we aimed at investigating the acute effects of superimposed vibration on the Hoffmann reflex (H-reflex), measured after fatiguing exercise. Twenty-five volunteers performed four isometric contractions of the right Flexor Carpi Radialis (FCR) with baseline load at

Neuromuscular Fatigue after Submaximal Intermittent Contractions in Motorcycle Riders.

Highly repetitive submaximal intermittent contractions of the forearm muscles during periods of 30-50 min partially explain why motorcycle races are so demanding for the neuromuscular system. This study investigated the contribution of central and peripheral mechanisms of fatigue on the exerted and contralateral extensor digitorum communis following an intermittent fatigue protocol (IFP) designed for motorcycle riders. 12 riders performed an IFP, which simulates the braking and throttle handle gesture. We examined the time course of recovery of maximal voluntary contraction (MVC), M-wave, moto

Identification of swallowing disorders: the perception of patients with neurodegenerative diseases.

PURPOSE: To verify the perception of patients with neurodegenerative diseases regarding swallowing changes and to know the perceptions of swallowing sensations that can promote the early identification of dysphagia. METHODS: It is a cross-sectional study with 44 patients with neurodegenerative diseases. All of them answered a questionnaire to know the sensation perceived during swallowing and its intensity. The Fatigue Severity Scale was applied to measure fatigue and the Swallowing Disturbance Questionnaire was applied to detect swallowing complaints. The Functional Oral Intake Scale was use

A semi-active hybrid neuroprosthesis for restoring lower limb function in paraplegics.

Through the application of functional electrical stimulation (FES) individuals with paraplegia can regain lost walking function. However, due to the rapid onset of muscle fatigue, the walking duration obtained with an FES-based neuroprosthesis is often relatively short. The rapid muscle fatigue can be compensated for by using a hybrid system that uses both FES and an active orthosis. In this paper, we demonstrate the initial testing of a semi-active hybrid walking neuroprosthesis. The semi-active hybrid orthosis (SEAHO) supports a user during the stance phase and standing while the electric mo…

Resistance training improves functional capacities in women with multiple sclerosis: a randomized control trial.

PURPOSE: This study aimed to investigate the effects of 12 weeks of resistance exercise training (RT) on oxidative status, muscle strength, functional capacity, quality of life (QoL), and fatigue in women with Multiple Sclerosis (MS). METHODS: In this randomized control trial (ethical code: SSRI.REC-1402-101; IRCT registration code: IRCT20120912010824N3, 07.09.2023), Iran) twenty-five women with relapsing- remitting MS (aged 18-45 years and expanded disability status scale (EDSS) ≤ 4) were randomly divided in two groups MS without resistance exercise (MS + non-RT; n = 13) and with RT (12 week

A randomized controlled trial of manual therapy and pneumatic compression for recovery from prolonged running - an extended study.

Manual therapy (MT) and intermittent pneumatic compression (IPC) are recovery methods used by endurance athletes with little evidence supporting effectiveness. This randomized controlled trial evaluated effectiveness of four daily post-race treatments of a specific MT protocol and IPC compared with supine rest on recovery following an ultramarathon among 56 ultramarathoners. Groups were comparable across all characteristics examined, including post-race plasma creatine kinase concentration. Subject completed timed 400 m runs before the race and on days three, five, seven and 14 post- race, and

Use of a footrest to reduce low back discomfort development due to prolonged standing.

Prolonged standing is common in many occupations and has been associated with low back discomfort (LBD). No recent studies have investigated a footrest as an intervention to reduce LBD associated with prolonged standing. This study investigated the effect of a footrest on LBD and sought to determine if LBD changes were accompanied by changes in muscle fatigue and low back end-range posture and movement. Twenty participants stood for two 2-h trials, one with and one without a footrest. LBD, lumbar erector spinae electromyography, upper lumbar (UL) and lower lumbar (LL) angles were measured. A s…

Changes of the psychophysical state and feeling of wellness of professional soccer players during pre-season and in-season periods.

Perceived changes due to training monotony, strain, sleep, stress, fatigue, muscle soreness and the influence of specific training sessions on the affective valence were explored in professional soccer players. Seventeen players completed the Hooper questionnaire, the ratings of perceived exertion and feeling scale (FS) every training/match day before and during the soccer season. Higher players' training loads were recorded during pre-season when compared with in-season period (2558.1 ± 262.4 vs. 1642.8 ± 169.3 a.u., p < 0.01; respectively). The ratings of sleep, stress, fatigue and muscle so

Ergonomic assessment of a multi-joint actuated lower extremity exoskeleton to assist dynamic lifting and carrying tasks.

The proof-of-concept study for a hip and knee joint actuated exoskeleton developed for repetitive manual lifting and carrying tasks is investigated. Fifteen participants completed the study which involved two laboratory manual handling tasks of (1) lifting a box weighing 9.5 kg (repeated in three trials as a standalone task) and (2) lifting and carrying same box over a distance (repeated in three trials as a single combined task), with and without the use of the exoskeleton suit. Monopolar surface EMG sensors are utilized to capture participants muscular activity from two quadricep femoris mus

Medial Gastrocnemius Muscle Architecture Is Altered After Exhaustive Stretch-Shortening Cycle Exercise.

Muscle architecture is an important component of muscle function, and recent studies have shown changes in muscle architecture with fatigue. The stretch-shortening cycle is a natural way to study human locomotion, but little is known about how muscle architecture is affected by this type of exercise. This study investigated potential changes in medial gastrocnemius (MG) muscle architecture after exhaustive stretch-shortening cycle exercise. Male athletes (n = 10) performed maximal voluntary contractions (MVC) and maximal drop jump (DJ) tests before and after an exercise task consisting of 100

Changes in nutritional status and associations with physical and clinical outcomes in acute myeloid leukemia patients during intensive chemotherapy.

BACKGROUND/OBJECTIVES: Patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) often receive medical nutrition therapy (MNT) during intensive remission-induction treatment. Since little is known about changes in nutritional status, specifically body composition, in this patient population, these changes and their associations with physical and clinical outcomes were assessed. SUBJECTS/METHODS: In this multicenter prospective observational study, newly diagnosed AML/MDS patients who received intensive remission-induction chemotherapy, routine dietary counseling by a dietic

Determinants of physical activity level in children and adolescents with juvenile idiopathic arthritis.

OBJECTIVE: One of the most frequently discussed physical parameters in juvenile idiopathic arthritis (JIA) is physical activity level. There is limited evidence about determinants of physical activity level in JIA. In this study, we aimed to investigate the determinants of physical activity level in children and adolescents with JIA. MATERIALS AND METHODS: Thirty-two JIA patients and 18 age- and sex-matched healthy individuals were included in the study. The age range was 8-18 years. Sociodemographic and clinical data of the participants were recorded. In both groups, anthropometry, fatigue,

Clinical Determinants of Incremental Shuttle Walk Test in Adults with Bronchiectasis.

INTRODUCTION: Exercise capacity is impaired in patients with bronchiectasis. Incremental shuttle walk test (ISWT) stresses cardiorespiratory system physiologically to symptom-limited maximal exercise capacity. The purpose of this study was to investigate the clinical determinants of ISWT in adults with non-cystic fibrosis (CF) bronchiectasis. METHODS: Forty-one clinically stable bronchiectasis patients aged 18-72 years (27 females, 14 males) participated in the study. Subjects' demographics and physical characteristics were recorded. Bronchiectasis Severity Index was used to identify disease

Effect of hydroalcoholic extract of Aegle marmelos fruit on radical scavenging activity and exercise-endurance capacity in mice.

CONTEXT: Aegle marmelos L. Corr (Rutaceae) is an important Indian Ayurvedic medicinal plant used for the treatment of various ailments. However, little information is available on the anti-fatigue properties of its fruit. OBJECTIVE: Evaluation of the physical endurance and exercise-induced oxidative stress modulating properties of A. marmelos fruit in mice. MATERIAL AND METHODS: Radical scavenging activity of the fruit hydroalcoholic extract was evaluated using in vitro systems. The extract was further evaluated for its endurance-enhancing properties at three oral doses (100, 200 and 400 mg/

Joint hypermobility syndrome subclassification in paediatrics: a factor analytic approach.

OBJECTIVE: To determine if exploratory factor analysis can identify subtypes comprising recognisable clinical patterns of the presenting signs and symptoms of children with joint hypermobility syndrome (JHS). PATIENTS: Eighty-nine children with JHS aged 6-16 years. METHODS: Twelve tests comprising anthropometric, musculoskeletal and functional assessments were conducted. Signs, symptoms and family history were recorded. Exploratory factor analysis was performed, factor scores generated, and correlations calculated to identify associations. RESULTS: Sixty-six percent of the variance in the s

Mitochondrial cardiomyopathy with skeletal muscle myopathy caused by m.3260A > G mutation in MT-TL1 gene: a case report.

BACKGROUND: Mitochondrial myopathies are a group of rare hereditary disorders that primarily affect muscle tissue, and present with muscle weakness, fatigue, exercise intolerance, and muscle pain. A key aspect of mitochondrial myopathies is the involvement of different organ systems, such as the cardiovascular system. Various disease features, including clinical and genetic heterogeneity, pose serious difficulties in the diagnostic process. We report a case of a young adult male, who presented with findings that suggested myositis, and was diagnosed with skeletal muscle myopathy and mitochondr