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A multifunctional contrast dye for morphological Исследование.

OBJECTIVES: We sought to devise and test a multifunctional contrast dye agent for X-ray based digital radiography (DR) or computer tomography (CT), magnetic resonance imaging (MRI), and colored staining in ex vivo validation part of animal experiments. MATERIALS AND METHODS: The custom-formulated contrast dye namely red iodized oil (RIO) was prepared by solubilizing a lipophilic dye Oil Red O in iodized poppy seed oil (Lipiodol or LPD) followed by physicochemical characterizations. To explore and test the utility of RIO, normal rats (n = 10) and rabbits (n = 10) with myocardial infarction (MI

[Progress in Исследование of tick-borne encephalitis].

Tick-borne encephalitis, also called forest encephalitis, is caused by tick-borne encephalitis virus. Central nervous system lesion is the major clinical symptom of tick-borne encephalitis, as an acute infectious disease, the case fatality rate is as high as 10%-20%. Virology experts consider it as a key and difficult point in recent years. This paper summarizes the progress in Исследование of epidemiological characteristics, pathogenesis, clinical manifestations, outcome, diagnosis and treatment of tick-borne encephalitis to provide evidence for the prevention and treatment of tick-borne encephal…

Informed Consent in the Changing Landscape of Research.

The history of informed consent dates back as early as the 16th century (Selek, 2010). The current tenets of informed consent pertaining to the ethical conduct of Исследование on human participants predominately stems from the 1947 Nuremberg Code (National Institutes of Health, 2016), which was created following the Nuremberg trials at the end of World War II. The unethical conduct of Исследование on human participants during the Holocaust, coupled with experiments (e.g., the Tuskegee syphilis study), prompted a more formalized structure for ensuring the well-being and autonomy of human participants i…

Research Progress of Moyamoya Disease in Children.

During the onset of Moyamoya disease (MMD), progressive occlusion occurs at the end of the intracranial internal carotid artery, and compensatory net-like abnormal vessels develop in the skull base, generating the corresponding clinical symptoms. MMD can affect both children and adults, but MMD in pediatric patients exhibits distinct clinical features, and the treatment prognoses are different from adult patients. Children are the group at highest risk for MMD. In children, the disease mainly manifests as ischemia, while bleeding is the primary symptom in adults. The pathogenesis of MMD in chi

Scandinavian epidemiological Исследование in gastroenterology and hepatology.

In the last decades, a large number of epidemiological studies in gastroenterology and hepatology have originated from the Scandinavian countries. With the help of large health databases, with good validity and other registries related to patient outcomes, Исследованиеers from the Scandinavian countries have been able to make some very important contributions to the field. These countries, Sweden, Norway, Finland, Denmark and Iceland, have all universal access to health care and have shown to be ideal for epidemiological Исследование. Population-based studies have been frequent and follow-up studies h…

[Research Achievements and Challenges for Echinococcosis Control].

Echinococcosis is an important communicable disease that has remarkable impacts on the global health. The disease is highly endemic in western China. In the last decades, achievements were obtained for the surgery and drug therapies for echinococcosis, as well as for studies on genomics, signaling pathways, and liver proliferation and injury of the intermediate hosts. Although steps have entered vaccine development, challenges remainin immunodiagnosis and drug treatment for intermediate hosts, and in vaccine development for definitive hosts. This paper gives an overview on the current achievem

Tribes in Karnataka: Status of health Исследование.

The south Indian State of Karnataka, once part of several kingdoms and princely states of repute in the Deccan peninsula, is rich in its historic, cultural and anthropological heritage. The State is the home to 42,48,987 tribal people, of whom 50,870 belong to the primitive group. Although these people represent only 6.95 per cent of the population of the State, there are as many as 50 different tribes notified by the Government of India, living in Karnataka, of which 14 tribes including two primitive ones, are primarily natives of this State. Extreme poverty and neglect over generations have

A framework for prescription in exercise-oncology Исследование.

The field of exercise-oncology has increased dramatically over the past two decades, with close to 100 published studies investigating the e … c application of these principles in the design and conduct of clinical trials in exercise-oncology Исследование. We contend that the application of these guidelines will ensure continued progress in the field while optimizing the safety and efficacy of exercise treatment following a cancer diagnosis.

Nephrology Исследование--the past, present and future.

Important advances have been made in basic and clinical nephrology Исследование over the past decade, with improved pathological insights into various disease processes and the introduction of new treatments for diseases such as atypical haemolytic uraemic syndrome. However, many challenges remain. In this Viewpoint, we asked five Nature Reviews Nephrology Advisory Board members, who have been associated with the journal since its launch in November 2005, to reflect on the progress and roadblocks of the past 10 years. They also comment on areas where effort and money should be invested and how the…

Протеин кристаллография в области исследований и разработок вакцин.

Использование кристаллографии белковых рентгеновских лучей для структурно-конструкционной разработки малых молекулярных препаратов хорошо задокументировано и включает в себя несколько примечательных примеров успеха. Однако менее хорошо известно, что структурная биология стала одним из основных инструментов разработки новых антигенов вакцин. Здесь мы рассматриваем важный вклад кристаллографии белков в исследования и разработки вакцин. Мы обсуждаем несколько примеров кристаллографической характеристики антигенных структур вакцин в отдельности или в комплексах с лигандами или рецепторами. Мы покр

Совпадение в аннотации оригинала
The use of protein X-ray crystallography for structure-based design of small-molecule drugs is well-documented and includes several notable … Here, we review the important contributions that protein crystallography has made so far to vaccine Исследование and development. We discuss several examples of the crystallographic characterization of vaccine antigen structures, alone or in complexes with ligands or receptors. We cover the critical role of high-resolution epitope mapping by reviewing structur …

[Advance in Исследование on spinocerebellar ataxia 17].

Hereditary spinocerebellar ataxia type 17 (SCA17) is an autosomal dominantly inherited progressive degenerative disease of the nervous system. Also known as Huntington's disease-like 4(HDL4), SCA17 mainly features ataxia, muscle dystonia and psychiatric symptoms. The gene predisposing to SCA17 has been mapped and cloned, which encodes a TATA-binding protein (TBP). A CAG repeat expansion in the coding region of TBP gene can cause polyglutamine chain extension in the protein. This paper reviews recent progress in the Исследование on SCA17 in regard to its clinical, etiology, pathology and pathogenes…

A reflection on plasticity Исследование in writing dystonia.

Much attention has focused on the hypothesis that there is enhanced plasticity of sensorimotor circuits in patients with dystonia. A common experimental method to assess plasticity in dystonia Исследование is paired associative stimulation (PAS). Excessive, nonfocal effects of PAS were observed in early studies of dystonia; however, these large effects have not been uniformly replicated. In this viewpoint, data from 15 patients with writing dystonia are presented. We suggest that, as in healthy individuals, the effects of PAS are highly variable. A review of previous studies examining PAS in writi…

[Ballistocardiography as a part of cardiac function Исследование].

Provided an overview of materials on the history of the formation method ballistocardiography for diagnosis of cardiovascular disease, an assessment of its current status and prospects for further development. Investigation of the physiological changes in the myocardium by recording ballistocardiogram acquires greater relevance since the existing knowledge in the field of cardiac diagnosis were obtained using instruments that do not meet modern requirements. Although the results of previous studies and define the basic characteristics ballistocardiography nonetheless update and clarification o

A review of substance abuse Исследование in malaysia.

This is a review of Исследование done in the area of substance abuse in Malaysia. There were 109 articles related to substance abuse found in a search through a database dedicated to indexing all original data relevant to medicine published in Malaysia between the years 2000-2013. Only 39 articles were reviewed, and case series, case report, reviews and reports were excluded. Research reviewed include the epidemiology of substance abuse, genetics, treatment and its relation to health behaviour, and health management. Studies have shown that more males than females use drugs. There was also a high …