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Соответствующие патологии и их влияние на болезнь Паркинсона: описывающий обзор текущих доказательств.

Многие медицинские и патологические исследования указывают на наличие множества коморбидов/сопатологий в ходе болезни Паркинсона (PD). Патология тела леви, морфологическая характеристика PD, редко существует в изоляции, но обычно ассоциируется с другими сопутствующими патологиями, в частности с изменениями, связанными с болезнью Альцгеймера (ALDC), цереброваскулярными патологиями (макро- и микроинфаркты, болезнью церебральных малых судов, церебральной амилоидной ангиопатией), патологией TDP-43, а также множественными патологическими комбинациями. К ним относятся сердечно-сосудистые расстройств

Periodic limb movements and obstructive sleep apneas before and after continuous positive airway pressure treatment.

Periodic limb movements during sleep (PLMS) and obstructive sleep apnea syndrome (OSAS) are two common sleep disorders. The similarity in periodicity of periodic limb movements (PLMs) and obstructive sleep apneas (OSAs) led us to hypothesize the existence of a common central generator responsible for the periodicity of both OSAs and PLMs. In order to test this hypothesis, we compared apnea periodicity before continuous positive airway pressure (CPAP) treatment with PLMs periodicity during CPAP treatment in 26 OSA patients, consecutively recorded and treated in our sleep laboratory. The investi

[Sleep fragmentation as the cause of daytime sleepiness and reduced performance].

Studies in healthy young adults revealed that periodic arousals during the night result in increasing sleepiness as a function of the interval of time between arousals. When arousals are frequent, deficits similar to those seen after total sleep deprivation have been found. Observed decrements appear to be specifically related to EEG arousals and do not require complete awakening. In patients with fragmenting sleep disorders such as periodic leg movements and central sleep apnea, improved nocturnal sleep is related to increased alertness and daytime performance.

Periodic limb movements in sleep in community-dwelling elderly.

The prevalence of periodic limb movements in sleep (PLMS) in a randomly selected elderly sample is reported. In San Diego, 427 elderly volunteers aged 65 yr and over were recorded in their homes. Forty-five percent had a myoclonus index, MI greater than or equal to 5. Correlates of PLMS included dissatisfaction with sleep, sleeping alone and reported kicking at night. Although statistically significant, the strengths of the associations between interview variables and myoclonus indices were all small. No combination of demographic variables and symptoms allowed highly reliable prediction of PL

Analysis of potential categories of sleep problems in non-dialysis patients with chronic kidney disease.

INTRODUCTION: Sleep disturbances are highly prevalent among patients with non-dialysis chronic kidney disease (CKD) and are associated with … rgh Sleep Quality Index (PSQI), the Hospital Anxiety and Depression Scale (HADS), the International Restless Legs Syndrome Assessment Scale (IRLS), and a Visual Analog Scale (VAS). Mplus 8.0 was used for latent class analysis, and unordered multinomial logistic regression analysis was performed to evaluate factors associated with the different latent classes. RESULTS: …

An interpretable nomogram for predicting sleep disturbance risk in maintenance hemodialysis patients.

BACKGROUND: This study aimed to develop and validate an interpretable nomogram to predict the risk of sleep disturbance in maintenance hemod … RESULTS: Among 208 patients, 144 (69.2%) had sleep disturbance. Multivariable analysis identified restless legs syndrome (RLS) (OR = 4.52, 95% CI: 2.22-9.18), older age (OR = 1.04, 95% CI: 1.01-1.07), lower serum albumin (Alb) (OR = 0.86, 95% CI: 0.77-0.96), and lower parathyroid hormone (PTH) (OR = 0.99, 95% CI: 0.99-0.99) as independent predictors. Primary kidney di …

Addressing cognitive impairment in drivers on hemodialysis through reaction time.

UNLABELLED: End-stage kidney disease affects cognition and is associated with sleep disorders (SD), both increasing reaction time (RT) and i … thirds had been on HD for less than four years; 47.5% had 9.5 years or less of education; 14.3% had restless legs syndrome/Willis-Ekbom disease (RLS/WED); 68.6% showed a high likelihood of obstructive sleep apnea (OSA). HD patients showed higher RT than controls (p<0.001), and RT was positively associated with age (p<0.001). Less than 9.5 years of education and being on …

Sleep disturbance in CKD: patient‑prioritized outcomes, management, and perceptions - a multicenter mixed-methods study in Australia.

BACKGROUND: Sleep disturbances are common in chronic kidney disease (CKD), yet patient priorities, reporting behaviors, and experiences of s … s (62%). Overall, 73% were classified as poor sleepers. Fragmented sleep (56%), nocturia (44%), and restless legs syndrome (27%) were the most common contributors. Feeling refreshed on waking and satisfaction with sleep were the highest-priority outcomes, ranked above social participation, ability to work, and hospital admissions. Forty-one percent reported that their t …

Impaired glymphatic function assessed by DTI-ALPS in drug-naïve Parkinson's disease and its association with motor and non-motor symptoms.

BACKGROUND AND PURPOSE: Glymphatic dysfunction is implicated in Parkinson's disease (PD), contributing to α-synuclein accumulation. This stu … a, including Hoehn and Yahr (H&Y) stage, new Freezing of Gait Questionnaire (n-FOGQ), International Restless Legs Syndrome (IRLS) scores, and the Mini-Mental State Examination (MMSE) scores, were collected. Correlations between the DTI-ALPS index and clinical measures were analyzed. Receiver operating characteristic was performed to test the predictive value of DTI-ALPS …

Fatigue, Insomnia, and Disability as Independent Predictors of Depressive Symptoms in Multiple Sclerosis: A Prospective Observational Study.

OBJECTIVES: This study aimed to identify the clinical factors independently associated with depressive symptoms in patients with multiple sc … le, and the EuroQol 5-Dimension 3-Level (EQ-5D-3L) questionnaire were administered. The presence of restless legs syndrome (RLS) was also recorded. Depression severity was measured using the Patient Health Questionnaire-9 (PHQ-9). First, univariable associations were examined, and relevant variables were subsequently entered into a multivariable linear regression model …

Эффективность нефармакологического вмешательства в случае нарушений сна у людей с множественным склерозом: систематический обзор и мета-анализ.

Нарушения сна оказывают значительное воздействие на качество жизни людей с множественным склерозом (СМС), что затрагивает до 60% этой группы населения. Эти расстройства, включая бессонницу, апноэ сна, синдром беспокойных ног, нарколепсия и расстройства сна КГР, являются результатом как прямого неврологического воздействия MS, так и вторичных факторов, таких, как боль и побочные эффекты лекарств. Нефармакологические меры могут принести потенциальные выгоды без негативных последствий, связанных с лекарственными препаратами. Цель этого систематического обзора и метаанализа заключалась в оценке эф

Совпадение в аннотации оригинала
Sleep disorders significantly impact the quality of life in people with multiple sclerosis (pwMS), affecting up to 60% of this population. These disorders, including insomnia, sleep apnea, restless legs syndrome, narcolepsy, and REM sleep behaviour disorders, result from both the direct neurological impacts of MS and secondary factors, such as pain and medic…

Sleep disorders in Parkinson's disease, an early and multiple problem.

In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. We sought to determine the prevalence and combinations of the main sleep disorders, and their clinical and polysomnographic associations in early stage PD. Sleep disorders were systematically diagnosed after medical interview and video-polysomnography in 162 participants with …

Phenomenological patterns and aetiological spectrum in patients visiting a tertiary care Movement disorders service in India: An observational study.

OBJECTIVE: Although previous studies have described phenomenological diagnoses, they lacked description of aetiological spectrum in patients … logy [such as parkinsonism, dystonia, ataxia, tremor, chorea, ballism, myoclonus, tics, stereotypy, restless legs syndrome (RLS) and others], diagnostic evaluations and detected aetiology. RESULTS: This observational study included 1140 MD patients over a span of 5 years. The median (IQR) age of onset was 49 (35-60) years and age at presentation was 54 (40-65) years, w …

Motor and non-motor features in Parkinson's Disease patients carrying GBA gene mutations.

BACKGROUND: Mutations of the Glucocerebrosidase (GBA) gene are the most common genetic risk factor yet discovered for Parkinson's Disease (P … PA-AUT Questionnaire, Apathy Evaluation Scale, Beck Depression Inventory, Epworth Sleepiness Scale, Restless Legs Syndrome Rating Scale, REM Sleep Behavior Disorder Screening Questionnaire, and Questionnaire for Impulsive-Compulsive Disorders in Parkinson's disease. RESULTS: GBA-PD patients showed a more severe and rapidly progressive disease, and more frequent positiv …

Sleepiness and comorbid sleep disorders in functional motor disorders: a comparative study with central hypersomnia.

Sleep symptoms, including excessive sleepiness, are frequently reported by patients with functional motor disorders (FMD). We aimed to class … time sleepiness. Evidence of specific sleep disorders was identified in our cohort, with 35% having restless legs syndrome; 49% obstructive sleep apnea; and 8% periodic limb movements in sleep; however, the presence of these disorders was not correlated with subjective sleepiness. Patients with FMD with self-reported sleepiness reported higher fatigue (p = 0.002), depre …

Phenytoin-associated movement disorder: A literature review.

Phenytoin (PHT) was first synthesized as a barbiturate derivative and was approved in 1953 by the Food and Drug Administration. This work ai … MDs found: 126 dyskinesias, 49 myoclonus, 19 dystonia, 14 parkinsonism, 6 tics, 3 stuttering, and 2 restless legs syndrome. The mean age was 35 years (standard deviation [SD]: 23.5) and the predominant sex was male (53.4%). The mean PHT dose when the MD took place was 370.4 mg (SD: 117.5). A serum PHT concentration was reported in 103 cases, ranging from 4 to 110 μg/mL …

Sleep Disorders and Cognitive Dysfunctions in Parkinson's Disease: A Meta-Analytic Study.

A relationship between sleep disorders and cognitive dysfunctions was reported in Parkinson's Disease (PD), however, some studies did not co … order (RBD), 22 for Excessive Daytime Sleepiness (EDS), 7 for Obstructive Sleep Apnea (OSA), 13 for Restless Legs Syndrome (RLS), and 5 for insomnia, the meta-analysis on longitudinal data included 7 studies.RBD was related to deficits of global cognitive functioning, memory, executive functions, attention/working memory, language, and visuospatial abilities. EDS was as …

Relative frequency of drug-induced sleep disorders for 32 antidepressants in a large set of Internet user reviews.

STUDY OBJECTIVES: It is known that antidepressant drugs can induce sleep disorders in patients, but little data exist about high or low-risk molecules. The aim was to study the frequency of antidepressant drug-induced sleep disorders (DISD) by molecule. METHODS: 77,391 patient comments for 32 antidepressant drugs were collected from drug review websites and screened for DISD. Association between drugs and nightmare disorder, restless legs syndrome, sleep paralysis, sleep terrors, sleep-related hallucinations, or sleep walking was expressed as relative proportion [proportional reporting ratio …

Cannabis in Parkinson's Disease: The Patients' View.

BACKGROUND: Little is known about the patients' view on treatment with medical cannabis (MC) for Parkinson's disease (PD). OBJECTIVE: To as … d by more than 40% of cannabis users. Stiffness/akinesia, freezing, tremor, depression, anxiety and restless legs syndrome subjectively improved for more than 20% and overall tolerability was good. Improvement of symptoms was reported by 54% of users applying oral CBD and 68% inhaling THC-containing cannabis. Compared to CBD intake, inhalation of THC was more frequently …