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Flavonoid-rich fraction of Cyclocarya paliurus enhances osteogenic differentiation through the PI3K-AKT signaling pathway in MC3T3-E1 cells.

Four types of macroporous resins (HPD-600, AB-8, D-101, and DM130) and a polyamide resin were compared for efficiency to extract total flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (CPF). Among them, HPD-600 was identified as the most effective. The ideal adsorption conditions were determined to be as follows: 70% ethanol was used as the eluent, with a flow rate of 2 BV/h and a CPF concentration of 1.0 mg/mL. Purification using HPD-600 resin resulted in a CPF yield of 69.76% ± 2.3%. Furthermore, in CPF-treated MC3T3-E1 cells, the osteogenic proliferation and differentiation activity …

Association between dietary flavonoid intake and stroke in Adults: The National Health and Nutrition Examination Survey 2007-2010 and 2017-2018.

Stroke remains a leading cause of global morbidity and mortality. While dietary flavonoids are recognized for their antioxidant and anti-inflammatory properties, their specific association with stroke prevalence in the U.S. population is not well-established. This study aimed to investigate the association between the intake of dietary flavonoid subclasses and stroke prevalence using a nationally representative U.S. adult cohort, and to elucidate potential mechanisms through network pharmacology. We analyzed data from 12,424 participants from the National Health and Nutrition Examination Surve…

Phytochemical investigation of Camellia flava leaves guided by response surface method-optimized extraction: New triterpenoid saponins and flavonoid glycosides.

Camellia flava has recently gained attention for its reported biological activities, but its phytochemical composition remains largely unexp … edge of C. flava leaves and highlight its potential as a promising source of bioactive saponins and flavonoids.

Protective effects of a commercial total flavonoid preparation from Puerariae Lobatae Radix on exhaustive exercise-induced liver injury in mice.

OBJECTIVE: This study investigated the protective effects of a commercial total flavonoid preparation derived from Puerariae Lobatae Radix on exhaustive exercise-induced liver injury in mice, with a focus on oxidative stress, inflammatory responses, and NF-κB-related signaling. METHODS: A mouse model of exhaustive exercise-induced liver injury was established by exhaustive swimming. Mice were assigned to a normal control group, an exercise model group, a silymarin-treated group, and low-, medium-, and high-dose total flavonoid preparation groups. Liver function, histopathological alterations,

Noncatechin flavonoid-rich extract from Camellia sinensis (L.) Kuntze seed residues ameliorates diabetes and vascular complications in SHRs.

OBJECTIVES: This study examined the effects of the noncatechin flavonoids (NCFs), a mixture of a range of flavonoids obtained from Camellia sinensis (L.) Kuntze seeds on Type 2 diabetes mellitus (T2DM). METHODS: Thirty-two 10-week-old SHR rats were randomly assigned to four groups. The RD group was fed a regular diet. The DM group was injected with 'streptozotocin (STZ, 50 mg/kg)' and nicotinamide '(NA, 100 mg/kg)' and fed a high-fat diet (HFD). The NCF0.5 group or NCF5 group was injected with 'STZ/NA' and fed HFD plus oral gavage NCF 0.5 or 5 mg/kg/day for four weeks, respectively. KEY FIND…

Antimalarial Activity of Methoxylated Flavonoid Fraction (Cirsimaritin-Dominated) from Artemisia kopetdaghensis in Plasmodium berghei-Infected Mice with in silico Analysis.

BACKGROUND: Building on our previous investigation of the total semipolar extract (SPE) of Artemisia kopetdaghensis in Plasmodium berghei-infected mice, the present study focuses specifically on the methoxylated flavonoid fraction (MFF). Flavonoids are increasingly recognized for their ability to suppress parasite growth and modulate host immunity. To clarify their role, we isolated and characterized the major flavonoid constituents of this plant and evaluated their antimalarial potential, both alone and in combination with chloroquine, in a mouse model. METHODS: Aerial parts of A. kopetdaghe…

Dietary Citrus Flavonoid Hesperetin Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease via Modulation of MAPK-RARα Axis.

Metabolic dysfunction-associated steatotic liver disease (MASLD) lacks effective nutrition-based interventions. Hesperetin, a dietary citrus flavonoid, was evaluated for its hepatoprotective mechanism using high-fat diet-induced MASLD mice and free fatty acid-challenged hepatocytes. Hesperetin improved glucose and lipid metabolism, alleviated steatosis and inflammation, and restored hepatic function. Integrated transcriptomics and network analysis indicated activation of retinol metabolism and inhibition of MAPK signaling. Mechanistic studies showed that hesperetin suppressed aberrant MAPK act

U-shaped association between dietary flavonoid and gallstone prevalence with sex-specific effects: Insights from a cross-sectional study.

ObjectiveTo examine the association between dietary flavonoid intake and gallstone prevalence in a representative United States sample using National Health and Nutrition Examination Survey 2017-2018 data.MethodsThis cross-sectional study included 4087 adults aged ≥20 years. Flavonoid intake was assessed using the United States Department of Agriculture Food and Nutrient Database for Dietary Studies and covered 29 flavonoids across six subclasses. Gallstones were defined by self-reported physician diagnosis. Covariates included demographics, lifestyle, and health status. Multivariate logistic …

The Natural Flavonoid Pectolinarigenin Targets On-Canonical NF-κB Pathway to Inhibit Esophageal Squamous Cell Carcinoma and Enhances Paclitaxel Efficacy.

Pectolinarigenin (PEC) is a natural flavonoid compound derived from Chinese herbal medicines. Previous studies have demonstrated its signifi … or combination therapy with PTX and points out a new strategy for the clinical treatment of natural flavonoids to ESCC.

Инсило-исследования для понимания взаимодействий флавонового ингибитора с nsp12-РНК-зависимой РНК-полимеразой SARS-CoV-2 и его гомологами.

Цель. ВИРУС COVID-19 продолжает быть важной проблемой здравоохранения. РНК-зависимый РНК-полимераза (RdRp) SARS-CoV-2, которая критична для репликации, поэтому является потенциальным объектом для лекарственной терапии. Методология. На основе экспериментальных структур RdRp от SARS-CoV-2 были сгенерированы вычислительные модели его гомологов от SARS-CoV-1, MERS и летучих мышей. SARS-CoV-2 RdRp был использован для виртуального скрининга в нуклеотидном связывающем сайте с молекулами из базы данных COCONUT Natural Products с помощью Glide. Комплексы с верхней ингибиторной молекулой были смоделиров

Совпадение в полном тексте источника
… Flavonoids: an overview. J. Nutr. Sci. 2016;5:e47. doi: 10.1017/jns.2016.41. 29. Kumar S., Pandey A.K. Chemistry and biological activities of flavonoids: an overview. Sci. World J. 2013;2013 doi: 10.1155/2013/162750. 30. Hariprasad G., Kumar M., Kaur P., Singh T.P., Kumar R.P. … Overview of dietary flavonoids: nomenclature, occurrence and intake. J. Nutr. 2003;133:3248S–3254S. doi: 10.1093/jn/133.10.3248S. …

Dietary effect of Galega orientalis Lam. flavonoid extract on broilers' growth performance, antioxidant capacity, immune function, and bone metabolism.

This study aimed to evaluate the impact of dietary Galega orientalis Lam. flavonoid extract (GOLFE) on production performance, biological markers, and bone health of white-feather broilers. A total of 540 one-day-old Cobb broilers were randomly assigned to six dietary groups: a negative control group (without additives; G0), four nutritional additive groups supplemented with GOLFE (G1:200 mg, G2: 400 mg, G3:800 mg, and G4:1600 mg), and a positive control group (supplemented with chlortetracycline; G5:100 mg). Each group consisted of 90 birds (6 replicates with 15 birds each) and the feeding tr

High flavonoid-producing tomato reduces whitefly phloem-feeding efficiency by inducing reactive oxygen species accumulation and callose deposition.

The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is economically one of the most threatening pests in tomato cultivation, which not only causes direct damage but also transmits many viruses. Breeding whitefly-resistant tomato varieties is a promising and environmentally friendly method to control whitefly populations in the field. Accumulating evidence from tomato and other model systems demonstrates that flavonoids contribute to plant resistance to herbivorous insects. Previously, we found that high flavonoid-producing tomato line deterred whitefly oviposition and settling behaviours, and…

A flavonoid-rich diet is associated with lower risk and improved imaging biomarkers of nonalcoholic fatty liver disease: a prospective cohort study.

BACKGROUND: Mechanistic studies and short-term randomized trials suggest higher intakes of dietary flavonoids may protect against nonalcoholic fatty liver disease (NAFLD). OBJECTIVES: We aimed to perform the first population-based study with long-term follow-up on flavonoid consumption, incident NAFLD, and validated NAFLD biomarkers. METHODS: In a prospective study, we assessed the associations between flavonoid intake based on ≥2 24-h dietary assessments and NAFLD risk among 121,064 adults aged 40-69 y by multivariable Cox regression analyses. We further assessed the associations between fl…

A flavonoid-rich extract of bergamot juice improves high-fat diet-induced intestinal permeability and associated hepatic damage in mice.

Consumption of high-fat diets (HFDs) is a contributing factor to obesity, insulin resistance and non-alcoholic fatty liver disease (NAFLD). Several studies suggested the protective role of bioactives present in Citrus fruits against the above mentioned chronic metabolic conditions. In this study, we evaluated if a flavonoid-rich extract of Citrus bergamia (bergamot) juice (BJe) could inhibit HFD-induced intestinal permeability and endotoxemia and, through this mechanism, mitigate the associated hepatic damage in C57BL/6J mice. After 12 weeks of the treatment, HFD consumption caused high body w

Studies on in vivo antithrombotic activity of quercetin, a natural flavonoid isolated from a traditional medicinal plant, African eggplant (Solanum indicum).

ETHNOPHARMACOLOGICAL RELEVANCE: Every year, cardiovascular diseases (CVDs) account for about 17.9 million deaths, making them the primary cause of both morbidity and mortality. Conventional drugs, which are often prescribed to treat cardiovascular diseases, are costly and have adverse effects. Consequently, dietary modifications and other medications are needed. Traditional use of Solanum indicum as cardiotonic to treat hypertension and anticoagulant potency has been reported but poorly evaluated scientifically. AIM OF THE STUDY: This study investigated the in vivo anticoagulant activity and

Effect of Micronized Purified Flavonoid Fraction Containing Hesperidin and Diosmin on Vincristine-Induced Neuropathy in Rats; the Role of Nitric Oxide Pathway.

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a potential complication that can develop following cancer chemotherapy. OBJECTIVES: Due to limited medical interventions for the prevention and management of CIPN caused by vincristine, a painful and common complication, further research to find the mechanisms of CIPN and the development of effective preventive and therapeutic strategies is needed. METHODS: We induced CIPN in male Wistar rats by administering intraperitoneal vincristine (VCR) at a dose of 0.1 mg/kg for 10 days. Treatment involved micronized purified flavonoid

Comparative analysis of microbiota in the ceca of broiler chickens with necrotic enteritis fed a commercial corn diet or with corn high in flavonoids (PennHFD1).

Necrotic enteritis (NE) is a disease of the gastrointestinal tract that is common in broiler chickens and causes substantial economic losses … 1) or control diet using commercial corns. It was previously shown that chickens fed a diet high in flavonoids had improved performance parameters, lower mortality rate, and lower incidence of intestinal lesions. Flavonoids have been shown to have anti-bacterial, immuno-modulatory, and anti-inflammatory activity. The current study included four experimental …

Improving Chronic Venous Disease Management with Micronised Purified Flavonoid Fraction: New Evidence from Clinical Trials to Real Life.

Chronic venous disease (CVD) develops in the microvessels, and is perpetuated by a vicious cycle of inflammation and endothelial activation, structural and functional changes to vessels and valves, and progressive venous hypertension. Data from animal models indicate that micronised purified flavonoid fraction (MPFF) has beneficial effects on a range of pathophysiological processes that contribute to CVD, including inflammation, micro-vessel permeability, valve and vessel wall remodelling, and reflux in microvalves. These effects explain its beneficial effects on the signs and symptoms of CVD,

Analysis of the Antibacterial Activity and the Total Phenolic and Flavonoid Contents of the Moringa oleifera Leaf Extract as an Antimicrobial Agent against Pseudomonas aeruginosa.

Pseudomonas aeruginosa is a bacterium that causes metal deterioration by forming biofilms on metal surfaces. This work was carried out to an … , and 12.33% for the 100%, 75%, and 50% methanol solvent ratios, respectively. The total amounts of flavonoids were 23.32%, 3.40%, and 0.64% for the 100%, 75%, and 50% methanol solvents, respectively. The chemical structure of M. oleifera consists of kaemferol-3-O-rutinoside, quercimeritrin, kaempferol-3-O-β-D-glucopyranoside, stearidonic acid, trichosanic a …

Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007-2010 to 2017-2018).

BACKGROUND: The association between exposure to environmental metals and chronic obstructive pulmonary disease (COPD) is preventing chronic lung diseases. However, little is currently known about the interaction between heavy metals and flavonoids in relation to the risk of COPD. This study aims to bridge this knowledge gap by leveraging The National Health and Nutrition Examination Survey (NHANES) database to evaluate thecorrelation between blood levels of heavy metals (cadmium, lead, mercury) and the intake of various flavonoid compounds (isoflavones, anthocyanidins, flavan-3-ols, flavanones…