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Microplastics and the Endocrine-Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid-Adipose Axis.

Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of parti … nd understanding of MP-induced endocrine and metabolic issues. Quantum-dot nanosensors, single-cell multiomics, machine learning-assisted endocrine profiling, and microfluidic organ-on-chip systems offer high-resolution insights into how MPs interact with thyroid follicular cells and adipose tissues. These platforms, which combine environmental analysis and …

Subacute Exposure to Macrocyclic Lactone Insecticides Induces Parkinson's Disease-like Motor Deficits and Neuropathology in Mice.

Evidence links multiple environmental contaminants to an increased risk of Parkinson's disease (PD), yet the identification of PD-relevant p … Rv2) analysis identified mitochondrial dysfunction as a key event underlying combined cytotoxicity. Multiomics analyses of differentially abundant metabolites and proteins suggested that the combined cytotoxicity is associated with mitochondrial Ca2+ overload, extracellular matrix-receptor interactions, ferroptosis, reactive oxygen species accumulation, and …

Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.

Oncolytic viruses (OVs) represent a versatile platform for cancer immunotherapy, capable of selectively infecting and lysing tumor cells whi … ely amplifying OV replication and oncolytic potency. The integration of artificial intelligence and multiomics profiling further enables precise patient stratification and optimization of combination regimens. In parallel, advanced engineering strategies, such as arming OVs with immunomodulatory transgenes and mitigating host antiviral responses, further rei …

Updates on Kidney Transplantation From the World Transplant Congress 2025.

The World Transplant Congress 2025 showcased pivotal advances shaping the future of transplantation. Global efforts to expand access to tran … biomarkers reflects a shift toward precision medicine. Artificial intelligence tools that integrate multiomics data are emerging as powerful predictors of graft outcomes. Collectively, these innovations address critical challenges of organ shortage, rejection, and individualized care, charting the next era in transplantation.

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions.

Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality worldwide, and the burden is particularly severe in low-i … f CVDs throughout the disease development process. Special emphasis is placed on the integration of multiomics methods, artificial intelligence (AI), and digital health technologies (including wearable devices and AI-enhanced electrocardiograms), which are transforming risk prediction and personalized prevention approaches. We also summarize current preclini …

Developmental contexts of gene-regulatory evolution following whole genome duplication in salmonids.

Whole genome duplication (WGD) events during early vertebrate evolution may have promoted phenotypic innovation by expanding the genetic material for functional diversification. However, their ancient origins obscure how gene regulation evolved during rediploidization, the process that generates duplicate genes and regulatory elements following WGD. Salmonids provide a unique window to these mechanisms, because they experienced a more recent autotetraploid WGD and remain at an earlier stage of rediploidization. Here we generated 771 multiomics datasets spanning embryonic and adult tissues in A…

Следующие биомаркеры в нескольких миеломах: расширение диагностики, стратификация рисков и достоверная терапия за пределами нынешних руководящих принципов.

Множественная миелома (ММ) — онкогематологическая неоплазма, характеризующаяся аномальным распространением неопластических плазменных клеток в костном мозге и чрезмерным сечением моноклонных антител в кровоток. Примерно 3 в адрес 5% :: пациенты, имеющие разновидность болезни, в которой нет секреции моноклонных белков, характеризующие несекретарскую картину MM. Она имеет весьма сложную и разнородную генетическую сигнатуру, позволяющую классифицировать болезнь в предмалярные организмы и симптомные формы. В этом контексте был проведен комплексный обзор описательной части, охватывающий геномные, э

Совпадение в аннотации оригинала
Multiple myeloma (MM) is an oncohematological neoplasm characterized by the abnormal proliferation of neoplastic plasma cells in the bone ma … recent recommendations. Several categories of biomarkers, particularly ctDNA methylome, single-cell multiomics, proteomics of surface antigens, functional ex vivo assays, and PET/CT radiomics, demonstrate strong potential for enhancing risk stratification, detecting early progression, guiding therapy selection, and identifying novel therapeutic targets. Thes …

Targeting the Vim-PGI2 Pathway Enhances CD8+ T Cell-Mediated Antitumor Immunity in Breast Cancer.

Breast cancer is the most prevalent malignancy in women, and the limited effectiveness of current treatments highlights the need for novel immune regulatory mechanisms to improve long-term survival. This study investigated the role of Vim in PGI2 synthesis and its impact on tumor immune regulation. Multiomics profiling revealed molecular alterations following Vim deletion, which were validated in murine breast cancer models using RT-qPCR, Western blot, ELISA, and flow cytometry, with rescue experiments involving exogenous PGI2. The findings showed that Vim deletion downregulated arachidonic ac…

Predictive biomarkers for immunotherapy response in renal cell carcinoma: why have they failed?

PURPOSE OF REVIEW: The heterogeneity of response to immunotherapies in renal cell carcinoma has created a strong need for predictive biomark … plexity and dynamic nature of renal cell carcinoma, biomarker development is increasingly exploring multiomics approaches, longitudinal assessments, and artificial intelligence-driven composite models. SUMMARY: Establishing predictive biomarkers in clinical practice has not yet succeeded due to biological complexity, methodological and trial design limitati …

Bisphenol F Exposure Induces Ovarian Ferroptosis via the ERβ-ATM-Ferritinophagy Axis.

Bisphenol F (BPF) has rapidly emerged as a primary substitute for bisphenol A (BPA) and a ubiquitous environmental contaminant, yet its reproductive toxicity remains poorly understood, particularly at low doses. Here, we demonstrate that oral exposure to BPF (as low as 250 μg/kg) induces ovarian hypertrophy, disrupted follicular architecture and cumulus-oocyte communication, and reduced serum estradiol and progesterone in mice by triggering ferroptosis. Integrating multiomics approaches, we identified NCOA4-mediated ferritinophagy as the central cellular driver of this process. In granulosa ce…

Retinoblastoma: unveiling molecular pathogenesis and pioneering organoid-driven therapeutic innovations.

Retinoblastoma (RB), which is the most common pediatric intraocular malignancy driven by RB1 inactivation, presents with clinical challenges … ms partially address vascularization but lack functional perfusion. Future efforts should integrate multiomics, refine vascularization via 3D bioprinting, and develop immunocompetent models to address the disparity between preclinical research and clinical application. Organoid technology has the potential to advance personalized therapies and ultimately enh …

Acellular nerve perineurium repairs peripheral nerve injuries in a rat model via ECM-mediated barrier and optimization of the regenerative microenvironment.

Building upon the clinically established platform of acellular nerve allografts (ANAs), we developed an advanced derivative: acellular nerve … recovery in ANP-treated animals approached the functional levels observed in crush-injury controls. Multiomics analyses provided mechanistic insight, revealing that ANP-mediated repair activates multiple pro-regenerative signaling pathways. These collective findings position ANP grafts as a highly promising and clinically translatable biomaterial strategy fo …

Gene regulatory innovations from transposable elements in primate cerebellum development.

Transposable elements are hypothesized to have driven gene regulatory innovation, yet their contributions to primate brain development at the cell type level remain underexplored. Here, we use single-cell multiomics data from human, macaque, marmoset, and mouse cerebella to show that transposable element contributions to different cell types are shaped by varying degrees of constraints across cell types, as well as the preferential co-option of certain transposable elements in specific cell states. Using a sequence-based deep-learning model that predicts cell-type-specific chromatin accessibil…

MAPK-driven glioma progression and reprogramming of the tumor-associated immune response.

BACKGROUND: In brain tumors, the immunosuppressive microenvironment leads to tumor aggressiveness and immunotherapy resistance. To identify factors that regulate the glioma immune landscape, we took advantage of the disease trajectory of the MAPK-driven glioma, pleomorphic xanthoastrocytoma (PXA), which evolves from an immune-rich low-grade tumor to an aggressive glioma. METHODS: Using a multiomics approach that included single-nucleus RNA sequencing (snRNA-seq), spatial transcriptomics, and spatial proteomics, a cohort of 38 tumors, including 10 longitudinal pairs, was profiled. RESULTS: Tu…

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions.

Type 2 diabetes mellitus (T2D) is a pervasive metabolic disorder driven by insulin resistance and progressive pancreatic β-cell failure, wit … ors and GLP-1 receptor agonists that confer proven cardio-renal protection. Personalized treatment, multiomics integration, next-generation precision therapies, and holistic art-based interventions that promote sustainable lifestyle changes are further discussed. By connecting molecular insights to clinical application, this review provides a comprehensive r …

Neuro-Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets.

The advent of neuroimmunology has dismantled the traditional doctrine of the brain's immune privilege, uncovering a sophisticated and dynami … al potential and challenges of innovative strategies such as vagus nerve stimulation, optogenetics, multiomics sequencing, and cytokine-targeted therapies. By integrating multidisciplinary perspectives, this review consolidates a theoretical framework for neuro-immune research and provides insights into precision medicine for related diseases. On the basis o …

Advances in laboratory diagnostic studies of pheochromocytoma and paraganglioma.

Pheochromocytoma (PCC) and paraganglioma (PGL), collectively referred to as pheochromocytomas and paragangliomas (PPGLs), are rare neuroendo … veness and treatment-oriented decision making. In the future, laboratory-test driven integration of multiomics data and artificial intelligence assisted models may facilitate precise diagnosis, dynamic monitoring, and personalized management of PPGLs.

Pathogenesis of Neovascular Glaucoma in Diabetic Retinopathy: A Review.

Neovascular glaucoma (NVG) secondary to diabetic retinopathy (DR) is a severe complication driven by ischemia-induced angiogenesis. Current … rognosis of this devastating disease, shifting toward systemic metabolic management and prospective multiomics-based risk stratification may represent future directions.

New genomic understanding and challenges in clinical care of Turner syndrome.

Turner syndrome is a sex chromosome abnormality in female individuals characterised by the complete or partial loss of one X chromosome in a … y of life among women with Turner syndrome. We review advances in the clinical characterisation and multiomics of Turner syndrome, which should lead to new insights and inform new treatment strategies for individuals with Turner syndrome.

Itaconate and its derivatives in human health and diseases.

Metabolic reprogramming forms the foundation of immune effector functions and the regulation of inflammation. As a pivotal node connecting t … isms, and optimize the pharmacokinetic properties of itaconate derivatives. With the advancement of multiomics integration, systems immunology, rational drug design, and engineered itaconate delivery technologies, the IRG1/ACOD1-itaconate axis and derivative-based therapeutic strategies are poised to emerge as key metabolic checkpoints and therapeutic target …