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FIBRINOGEN OF THE BLOOD AS INFLUENCED BY THE LIVER NECROSIS OF CHLOROFORM POISONING.

1. Chloroform anesthesia for two hours or more will cause more or less central liver necrosis in dogs, depending on the length of the anesthesia and the susceptibility of the animal. 2. If the fibrinogen of the blood of such an animal be estimated at intervals, it is found that this proteid shows a drop corresponding to the amount of liver necrosis. 3. By administering chloroform, the fibrinogen may be almost eliminated from the circulating blood, and the poisoned animal may bleed for hours from small skin pricks or cuts. 4. The liver can recover from a grave injury due to chloroform and retur…

Development of a recombinant adenovirus-vectored vaccine against both infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus in rainbow trout (Oncorhynchus mykiss).

Infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV) are typical pathogens of rainbow trout Oncorhynchus mykiss, and the concurrent infection of the two viruses is very common among modern trout hatcheries, which has caused huge economic losses to the rainbow trout farming industry. To prevent and control the spread of IHNV and IPNV in juvenile trout simultaneously, in this study a bivalent recombinant adenovirus vaccine with IHNV Glycoprotein (G) and IPNV VP2 genes was developed. After immunizing juvenile trout with this bivalent vaccine via the immer…

Contribution of the TNF-α (Tumor Necrosis Factor-α)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus.

Objective- Deep vein thrombosis results from a combination of risk factors including genetic conditions, obesity, drugs, pregnancy, aging, and malignancy. We examined pathophysiological roles of the TNF-α (tumor necrosis factor-α)-TNF-Rp55 (tumor necrosis factor receptor p55) axis in thrombus resolution using Tnfrp55-/- (TNF-Rp55-deficient) mice. Approach and Results- On ligating the inferior vena cava of wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days but shrunk to <50% of the thrombus weight at day 14. Concomitantly, inferior vena cava ligation enhanced intrath…

Tumour necrosis factor induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells--analysis of tumour necrosis factor-receptor interactions.

Induction of the adhesion molecules ELAM-1 and ICAM-1 on endothelial cells is a key pro-inflammatory effect of tumour necrosis factor (TNF). Earlier work in non-human systems has suggested that unlike other cell types, endothelial cells interact with the N-terminus of the TNF molecule, thereby implying novel TNF receptors on endothelial cells. This is also supported by 125I-TNF cross-linking studies on bovine endothelial cells. The present study aimed to see whether TNF induction of ELAM-1 and ICAM-1 on human umbilical vein endothelial cells (HUVECs) involved novel TNF-receptor interactions. T…

Necrotic pancreatitis: modern approaches to the prevention of infected necrosis.

The investigation of etiological factors in acute pancreatitis is a critical task, as their elucidation contributes to advancing both the diagnosis and prevention of the disease. Necrotizing pancreatitis (NP) is a severe complication of acute pancreatitis associated with high morbidity and mortality due to enzymatic tissue destruction, systemic inflammation, and the risk of infected necrosis. This review synthesizes current knowledge on the pathogenesis, classification, and epidemiology of NP, with emphasis on strategies aimed at preventing infectious complications. Evidence consistently suppo…

Epilepsy in Patients with Cerebral Radiation Necrosis: A Scoping Review.

Background and Objectives: Cerebral radiation necrosis (CRN) is a delayed complication of radiation therapy (RT), that can appear either as radiological findings without clinical symptoms (i.e., asymptomatic CRN) or symptomatic CRN (sCRN). There is currently a knowledge gap regarding CRN-induced epilepsy, a potentially severe manifestation of sCRN. We aim to give a comprehensive overview of the existing literature on CRN-induced epilepsy, including its prevalence, potential risk factors, and treatment options. Materials and Methods: A scoping analysis was performed according to the PRISMA scop…

Remodeling of ferroptotic necroinflammation by dexamethasone in acute tubular necrosis.

Ferroptosis, a modality of regulated necrosis caused by iron-dependent lipid peroxidation, has emerged as a key contributor to the pathogenesis of acute tubular necrosis (ATN) - especially in the context of solid organ transplantation. While recent studies have identified hormones as extracellular signals that modulate cellular susceptibility to ferroptosis, their pathophysiological relevance in vivo remains incompletely defined. Here, we investigated the role of dexamethasone, a potent synthetic glucocorticoid previously reported to sensitize cells to ferroptosis, in the context of renal tubu…

Hypoparathyroidism and Avascular Necrosis of the Hip Joint: A Case Report.

A 30-year-old man presented with left hip pain and was diagnosed with femoral head avascular necrosis associated with idiopathic hypoparathyroidism, hypocalcemia, and vitamin D deficiency. Treatment with calcium, calcitriol, analgesia, and physiotherapy improved symptoms. This case suggests hypoparathyroidism may play a role in the development of avascular necrosis.

Острый ретинальный некроз в младенце с корной и макулярной скаррингом.

Цель: Сообщить о редком случае неонатального острого некроза сетчатки (ARN), вызванного герпесом сывороточного вируса типа 2 (HSV-2), с указанием его клинических особенностей, диагностических проблем и результатов управления. Методы: Был рассмотрен один случай. Результаты: АРН является редким и быстро прогрессирующим окулярным заболеванием, вызванным внутриокульными герпесвирусными инфекциями, включая вирус HSV и вирус варицелла-зостер (VZV). АРН редко встречается у новорожденных, и лишь немногие из них зарегистрированы в литературе. Его неконкретные признаки и симптомы, такие, как красность,

Совпадение в аннотации оригинала
Purpose: To report a rare case of neonatal acute retinal necrosis (ARN) caused by herpes simplex virus type 2 (HSV-2), highlighting its clinical features, diagnostic challenges, and management outcomes. Methods: A single case was reviewed. Results: ARN is a rare and rapidly progressive ocular condition caused by intraocular herpesvirus infections, including …

Behçet's disease and avascular necrosis of the knees: a case report.

INTRODUCTION AND IMPORTANCE: Behçet's disease (BD) is a rare, autoimmune vasculitis usually characterized by oral and genital ulcers with systemic involvement of multiple organ systems. Its diagnosis is usually clinical as it lacks the disease-specific markers seen in other autoimmune pathologies. Avascular necrosis (AVN) is extremely rare in BD and if it were to occur, it would usually be unifocal. CASE PRESENTATION: This case report presents an odd case of BD that was complicated by bilateral AVN of the knees in a 36-year-old man. His diagnosis was confirmed by MRI of both knees after he st…

It is not always what it seems: allantochorion cervical pole necrosis.

A 286-day pregnant mare was referred for signs of impending abortion. The ultrasonographic evaluation revealed a high normal combined thickn … s isolated from all the fetal membranes, fetal fluids and tissues. Histologically, degeneration and necrosis with dystrophic calcification of the chorial villi at the cervical pole was found. The final diagnosis was abortion due to placental infarction with secondary placentitis. Cervical pole necrosis is a poorly understood condition of the allantochorion …

Bowel Necrosis in Leptospirosis: A Case Series of a Rare Complication.

BACKGROUND AND OBJECTIVES: Leptospirosis, a globally prevalent zoonotic disease, exhibits diverse clinical manifestations, often with severe multiorgan involvement. Gastrointestinal complications are uncommon, but their potential severity and impact on patient outcomes warrant attention. We present two cases of severe leptospirosis complicated by terminal ileal and colonic necrosis. PATIENTS AND METHODS: Two patients presented with acute febrile illness, severe myalgia, oliguria, and hypotension. Both had occupational exposure to paddy fields, a known risk factor for leptospirosis. Based on c…

Meropenem versus piperacillin-tazobactam for the treatment of pancreatic necrosis.

PURPOSE: To date, there are three published guidelines discussing management of infected pancreatic necrosis (IPN) with conflicting recommendations. Specifically, The World Society of Emergency Surgery lists piperacillin-tazobactam as a treatment option in addition to meropenem and ciprofloxacin plus metronidazole. Piperacillin-tazobactam may serve as an effective carbapenem-sparing alternative. Although previous studies shed light on antimicrobial penetration data, there is a lack of clinical data comparing piperacillin-tazobactam to meropenem. The purpose of this study is to compare the effi…

Endothelial Cell Apoptosis but Not Necrosis Is Inhibited by Ischemic Preconditioning.

This study aimed to assess the influence of ischemic preconditioning (IP) on hypoxia/reoxygenation (HR)-induced endothelial cell (EC) death. Human umbilical vein endothelial cells (HUVECs) were subjected to 2 or 6 h hypoxia with subsequent reoxygenation. IP was induced by 20 min of hypoxia followed by 20 min of reoxygenation. Necrosis was assessed by the release of lactate dehydrogenase (LDH) and apoptosis by double staining with propidium iodide/annexin V (PI/AV), using TUNEL test, and Bcl-2 and Bax gene expression measured using RT-PCR. In PI/AV staining, after 24 h of reoxygenation, 30-33% …

A case of delayed necrosis of reconstructed colon after esophagectomy.

We report a very rare case of delayed necrosis of the reconstructed colon 6 months after esophagectomy.A 67-year-old male patient had undergone esophagectomy with gastric tube reconstruction for esophageal cancer in 2014. Subsequently, total gastrectomy and ileo-colon reconstruction via a retrosternal route was performed for gastric tube cancer in 2022. Six months later, he suffered acute chest pain and came to our hospital. Contrast-enhanced CT showed severe dilation of the reconstructed colon with poor enhancement of the wall opposite mesentery, without arterial obstruction. Endoscopy showed…

A rare cause of acute esophageal necrosis: A case report.

Acute esophageal necrosis (AEN) or black esophagus is a rare entity characterized by diffuse circumferential black pigmentation of the esophageal mucosa due to ischemic necrosis. It may be lethal, especially among elderly patients with multiple comorbidities and hemodynamic instability. Diagnosis is based on gastroscopy. Treatment consists of intravenous fluids, proton pump inhibitors, and additional therapies to treat the underlying illness. We report a rare case of a woman in her 50s with cervical cancer who presented with hematemesis and sepsis. Upper gastrointestinal endoscopy showed a bla…

Operative Management and Outcome of Idiopathic Rectal Necrosis in an Octogenarian.

Idiopathic acute rectal necrosis (IARN) is a rare condition due to a robust rectal blood supply. This report describes an 83-year-old man presenting with septic shock due to distal sigmoid and complete rectal necrosis with perforation. He underwent emergent exploratory laparotomy, sigmoid and proximal rectum resection, and end sigmoid colostomy creation with delayed distal rectal evaluation. Bedside proctoscopy revealed pale, viable-appearing distal rectal mucosa on postoperative day 3. The patient had a protracted, complicated hospital stay but required no further operative intervention. Subs…

[Tumor necrosis factor in the ejaculate as an indicator of reduced fertility].

INTRODUCTION: Pro-inflammatory cytokine - tumor necrosis factor-alpha (TNF) is one of the components of the seminal plasma proteome; its meaning has not been definitively revealed. A comparative analysis of the concentration of this protein in the blood serum and in the ejaculate and changes in its level in the semen of men with infertility is f scientific interest. THE PURPOSE OF THE STUDY: determination of TNF- level in the blood serum and seminal plasma of healthy men and patients with reduced fertility. MATERIALS AND METHODS: 70 men of reproductive age with azoospermia (main group, n=18)…

Immature Granulocyte Percentage as an Early Predictor of Necrosis in Volvulus.

AIM: Volvulus is a disease characterized by the abnormal twisting of a gaseous distension of the loop of the intestine around itself. Colonic volvulus is the third common cause of colonic obstruction. The study aimed to determine whether the percentage of immature granulocytes is a marker of early necrosis in the volvulus. METHODS: Demographic characteristics of the cases were collected in the study. In addition, age, gender, white blood cell count, immature granulocyte count, immature granulocyte percentage, platelet lymphocyte ratio, and neutrophil-lymphocyte ratio were compared between gro…