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Gut microbiome in adult Asians with obesity, type 2 diabetes mellitus, and a combination of obesity and type 2 diabetes mellitus.

Obesity and type 2 diabetes (T2D) are two of the most common health problems in the world, particularly in adult Asians, with a significant … the gut microbiome with health status, thereby serving as a foundation for developing probiotics or prebiotics to modulate the gut microbiome and improve metabolic health.

The gut-heart axis: a review of gut microbiota, dysbiosis, and cardiovascular disease development.

BACKGROUND: Cardiovascular diseases (CVDs) are a major cause of morbidity and mortality worldwide and there are strong links existing betwee … utput, and polypharmacy are all associated with worse cardiovascular outcomes. Supplementation with prebiotics and probiotics potentially alleviates some CVD risk. Blood and stool samples may be used in clinical practice to quantify and qualify gut bacterial ratios and byproducts, assess patients' risk for adverse cardiovascular outcomes, and track their gut …

[Lactose Malabsorption and Intolerance].

Lactose malabsorption and lactose intolerance are common yet clinically distinct conditions. Lactose malabsorption refers to the passage of … nd may include low-lactose diets, oral lactase enzyme supplementation, and the use of probiotics or prebiotics. Avoiding unnecessary dietary restrictions is essential to prevent nutritional deficiencies or the development of avoidant/restrictive food intake disorder. An individualized diagnostic and therapeutic approach improves both clinical outcomes and qu …

Оценка связи кишечного микробиота с неврологическими, психиатрическими и нейродегенеративными расстройствами: обзор повествования.

Ось кишечника - это двунаправленная коммуникационная сеть, регулируемая иммунной, нервной и эндокринной системами, микробиологическими метаболитами и такими экологическими факторами, как диета, стресс, циркадийский ритм и лекарства/химикаты. Цель этого обзора заключается в изучении текущей литературы о связи между дисбиозом кишечной микробиоты и серьезными заболеваниями мозга, а также в изучении стратегий улучшения результатов лечения пациентов.МЕТОДЫ: Этот обзор (несистематический) был посвящен изучению связи между кишечным микробиотическим дисбиозом и психическим расстройством (шизофрения, с

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OBJECTIVES: The gut-brain axis is a bidirectional communication network regulated by the immune, nervous, and endocrine systems, microbial m … myloid affecting neurogenesis and myelination. Balanced dietary patterns and the use of probiotics, prebiotics, or fermented foods are associated with healthier gut microbiota and improved neurological function. CONCLUSIONS: Further research is needed to clarify whether gut dysbiosis causes or contributes to these disorders, and to develop evidence-based, g …

Интерплей между гуттом и кетогенными диетами в области здравоохранения и болезней.

Интуиция играет центральную роль в преобразовании сигналов питания в системные последствия для здоровья, что делает ее ключевым посредником кетогенного режима питания (КД) с высоким содержанием жира, низким содержанием углеводов. В настоящем обзоре обобщаются текущие знания о взаимодействии между KD и кишечником, при этом особое внимание уделяется кишечным механизмам в качестве связующего звена между пищевым вмешательством и системными результатами в области здравоохранения, охватывающими желудочно-кишечник и неврологическое здоровье. Темы охватывают кишечную физиологию (гутное пищеварение и п

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The gut plays a central role in translating dietary signals into systemic health effects, making it a key mediator of the ketogenic diet (KD … ng the use of alternative formulations, ketone esters, and microbiome-focused interventions such as prebiotics and probiotics are examined. Strategies to maximize the diet's benefits while reducing potential side effects are considered. Together, these insights herein offer a comprehensive framework for understanding the interactions between the KD and the g …

Освещение перспектив пробиотической акермансии слизистой кишечной воспаления и канцерогенного заболевания.

A. muciniphila (A. muciniphila) изображается как выгодный интестинальный бактерий с конкретным свойством использования слизи. Появляющиеся данные свидетельствуют о том, что A. muciniphila может видоизменить хроническое воспаление кишечника, улучшить кишечные эпителиальные узкие перекрестки и привлечь внимание таких рецепторов, как платные 2 (TLR2), и TLR4, с тем чтобы удержать инфильтрирующие цитотоксичные Т лимфоциты и макрофаги. Кроме того, аналогичная роль обнаружена на поверхности А. слизистой пили, внешней мембранной протеины Amuc_1100, β-galatosidase ферментом Amuc_2172 и внеклеточных ве

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Akkermansia muciniphila (A. muciniphila) is portrayed as an advantageous enteric bacterium with a particular property of mucin utilization. … ts on immune checkpoint inhibitors therapy. A. muciniphila supplementation through diet, probiotics-prebiotics, fecal microbiota transplantation, and certain drugs, would be a promising therapeutic strategy. Nevertheless, data profiles decipher A. muciniphila is linked to multiple sclerosis and Parkinson's disease occurrence and evolvement. Thus, how to avoi …

Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.

Microbial dysbiosis may manifest as inflammation both orally and in the gastrointestinal tract. Altered oral and gut microbiota composition and decreased diversity have been shown in inflammatory bowel disease (IBD) and periodontal disease (PD). Recent studies have verified transmission of oral opportunistic microbes to the gut. Prebiotics, probiotics, or dietary interventions are suggested to alleviate IBD symptoms in addition to medicinal treatment. Lingonberries contain multiple bioactive molecules, phenolics, which have a broad spectrum of effects, including antimicrobial, anti-inflammator…

Гут Микробиота Нарушение гематологовой терапии рака: Молекулярное понимание и последствия для эффективности лечения.

Гематологическая магнелезность (ГМ), включая лейкемию, лимфому и множественные миеломы, связана с бесконтрольным распространением аномальных кровеносных клеток, что создает серьезные клинические проблемы из-за их неоднородности и различных методов лечения. Несмотря на недавние достижения в области лечения, благодаря которым повысились показатели выживаемости, особенно в случае хронической лимфоцитической лейкемии и острой лимфоболической лейкемии, такие методы лечения, как химиотерапия и трансплантация стволовых клеток, часто нарушают микробиоту, что может негативно сказаться на результатах ле

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Hematologic malignancies (HMs), including leukemia, lymphoma, and multiple myeloma, involve the uncontrolled proliferation of abnormal blood … ent. Future research should focus on personalized microbiome-based therapies, including probiotics, prebiotics, and fecal microbiota transplantation, to improve outcomes and quality of life for patients with hematologic malignancies.

Inulin Supplementation Alleviates Ochratoxin A-Induced Kidney Injury through Modulating Intestinal Microbiota.

Ochratoxin A (OTA) is a prevalent mycotoxin found in feed that causes significant kidney injury in animals. Further investigation was needed … age, which might provide a potential strategy to mitigate the harmful effects of mycotoxins through prebiotics and safeguard renal health.

Effect of organic acids and probiotics on intestinal health of Apis mellifera.

Apis mellifera is an important pollinator that has a prominent impact on crops' ecological balance. Beekeeping provides us with more valuable products like honey, pollen, propolis, beeswax, and royal jelly. The ongoing era demands more scientific and environment-friendly strategies to improve the beekeeping sector internationally. Nowadays, the use of synbiotics (a combination of probiotics and prebiotics) has been declared as the need of the hour. However, little bit studies have been carried out in this regard. To improve the beekeeping sector in Pakistan, a study was designed to exploration…

Hepatic Mitochondria-Gut Microbiota Interactions in Metabolism-Associated Fatty Liver Disease.

The prevalence of metabolism-associated fatty liver disease (MAFLD) represents an urgent pandemic, complicated by a higher risk of morbidity … homeostasis. Recent investigations have explored the potential of new treatment strategies, such as prebiotics, probiotics, and metabolites, to change the composition of gut microbiota and simultaneously exert a positive impact on mitochondrial function to improve MAFLD. This review summarizes the significance of mitochondria and reports modifications in the …

Human microbiomes in cancer development and therapy.

Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex huma … ctional interactions between microbiotas and endocrine systems need to be clarified. Probiotics and prebiotics are believed to benefit human health via a variety of mechanisms, in particular, in tumor inhibition. It is largely unknown how microbial agents cause cancer or how cancer progresses. We expect this review may open new perspectives on possible thera …

The polysaccharides from Auricularia auricula alleviate non-alcoholic fatty liver disease via modulating gut microbiota and bile acids metabolism.

The polysaccharides from Auricularia auricula (AAPs), containing a large number of O-acetyl groups that are related to the physiological and biological properties, seem to be potential prebiotics like other edible fungus polysaccharides. In the present study, therefore, the alleviating effects of AAPs and deacetylated AAPs (DAAPs, prepared from AAPs by alkaline treatment) on nonalcoholic fatty liver disease (NAFLD) induced by high-fat and high-cholesterol diet combined with carbon tetrachloride were investigated. The results revealed that both AAPs and DAAPs could effectively relieve liver inj…

Gut Dysbiosis in Pancreatic Diseases: A Causative Factor and a Novel Therapeutic Target.

Pancreatic-related disorders such as pancreatitis, pancreatic cancer, and type 1 diabetes mellitus (T1DM) impose a substantial challenge to … lop novel preventive and/or therapeutic strategies of targeted microbiome modulation by probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota transplantation (FMT) for these multifactorial disorders. Attempts to dissect the intestinal microbial landscape and its metabolic profile might enable deep insight into a holistic picture of these comp …

The gut microbiota and celiac disease: Pathophysiology, current perspective and new therapeutic approaches.

Celiac disease (CD) as a chronic gluten-sensitive intestinal condition, mainly affects genetically susceptible hosts. The primary determinants of CD have been identified as environmental and genetic variables. The development of CD is significantly influenced by environmental factors, including the gut microbiome. Therefore, gut microbiome re-programming-based therapies using probiotics, prebiotics, postbiotics, gluten-free diet, and fecal microbiota transplantation have shown promising results in the modification of the gut microbiome. Due to the importance and paucity of information regardin…

Targeting Gut Microbiota as a Novel Strategy for Prevention and Treatment of Hypertension, Atrial Fibrillation and Heart Failure: Current Knowledge and Future Perspectives.

Cardiovascular diseases (CVDs) remain the major public health concern worldwide. Over the last two decades, a considerable amount of literat … trategies designed to manipulate GMB composition and/or its metabolites include dietary approaches, prebiotics/probiotics supplementation, and fecal microbiota transplantation (FMT). In this review, we have focused on three main cardiovascular pathologies (arterial hypertension, atrial fibrillation and heart failure) due to their shared common pathophysiolog …

Microbiota and the Response to Vaccines Against Respiratory Virus.

This mini review describes the role of gut and lung microbiota during respiratory viral infection and discusses the implication of the micro … ciations vary among different vaccine strategies and are likely to be context-dependent. The use of prebiotics and probiotics in conjunction with vaccination demonstrated that bacterial components could act as adjuvants. Future microbiota-based interventions may potentially improve and optimize the responses of respiratory virus vaccines.

Polyphenol-Rich Ginger (Zingiber officinale) for Iron Deficiency Anaemia and Other Clinical Entities Associated with Altered Iron Metabolism.

Ginger (Zingiber officinale) is rich in natural polyphenols and may potentially complement oral iron therapy in treating and preventing iron deficiency anaemia (IDA). This narrative review explores the benefits of ginger for IDA and other clinical entities associated with altered iron metabolism. Through in vivo, in vitro, and limited human studies, ginger supplementation was shown to enhance iron absorption and thus increase oral iron therapy's efficacy. It also reduces oxidative stress and inflammation and thus protects against excess free iron. Ginger's bioactive polyphenols are prebiotics …

Dietary supplementation for female infertility: Recent advances in the nutritional therapy for premature ovarian insufficiency.

Premature ovarian insufficiency (POI) ranks top in the reproductive disorders that may impair multiple functioning systems, reduce the quali … opause. Apart from dietary nutrients, microbe-related nutritional substances, including probiotics, prebiotics and the combination-synbiotics, display high potential as well in supporting estrous cycle, ovarian viability and modulating other vital reproductive functions. The present review will discuss dietary and microbial nutrients and their roles and appl …

Microbiome Modulation as a Therapeutic Approach in Chronic Skin Diseases.

There is a growing quantity of evidence on how skin and gut microbiome composition impacts the course of various dermatological diseases. The strategies involving the modulation of bacterial composition are increasingly in the focus of research attention. The aim of the present review was to analyze the literature available in PubMed (MEDLINE) and EMBASE databases on the topic of microbiome modulation in skin diseases. The effects and possible mechanisms of action of probiotics, prebiotics and synbiotics in dermatological conditions including atopic dermatitis (AD), psoriasis, chronic ulcers, …