Результаты поиска

Vitamin D and Kawasaki disease.

BACKGROUND: Vitamin D deficiency has been widely reported worldwide. Vitamin D is essential for mineral homeostasis and skeletal health, and is also associated with numerous extra-skeletal diseases, including cancer, autoimmune diseases, psychosis, allergies and cardiovascular disease. Recent evidence suggests that vitamin D deficiency might be a risk factor for immunoglobulin resistance in Kawasaki disease (KD), and that levels of 25-hydroxyvitamin D3 (25(OH)D3) could predict the risk of coronary artery disease in KD patients. These findings have sparked growing interest in exploring the mech

Витамин D и здоровье мозга.

Витамин D широко известен своим влиянием на гомеостаз кальция и фосфата в организме и его участием в поддержании мускулоскелета. В своей активной форме, 1,25-дигидрокси холекалциферол, этот витамин оказывает иммуномодулятивное воздействие как на врожденную, так и на адаптивную иммунную систему. Активная форма витамина D играет нейрозащитную роль в центральной нервной системе, подчеркивая ее важность для поддержания здоровья мозга. В исследованиях отмечается роль витамина D в формировании антиоксидантов, снижении цитокина, способствующего воспалению, снижении окислительного стресса, улучшении м

Совпадение в аннотации оригинала
Vitamin D is widely known for its influence on the homeostasis of calcium and phosphate levels in the body and its involvement in maintainin … is essential to conduct further studies in the future to better understand the mechanisms by which vitamins affect brain health. It is also necessary to determine the potential benefits of vitamin D supplementation in patients with neurological diseases.

Vitamin D and Cognitive Impairment.

BACKGROUND: Vitamin D deficiency is recognized as a significant public health concern, and it has been identified as one of the potentially modifiable risk factors for mild cognitive impairment (MCI). However, evidence regarding the relationship between vitamin D status and cognitive function remains conflicting. OBJECTIVE: Therefore, this study aimed to examine the prevalence of vitamin D deficiency in the Thai elderly population and an association between vitamin D status and cognitive function, adiposity, and insulin sensitivity. METHODS: This study enrolled participants aged 55-80 years

Inherited disorders of vitamin metabolism.

Vitamins are essential cofactors of various enzyme reactions in amino acid, neurotransmitter, nucleotide and energy metabolism. Over the past decade a number of inborn errors of metabolism have been identified, that affect different steps in vitamin absorption, transport, activation or recycling and repair of active vitamin cofactors. According to the respective cofactor function this may result in acute or chronic multisystem disease or in disorders that selectively affect the nervous system. Most of these disorders are amenable to specific treatment with excellent results, but diagnostic del…

Нейропозащитный потенциал витамина D3.

Витамин D3 играет ключевую роль не только в здоровье костей, но и в функционировании нервной системы, особенно в контексте связанных с возрастом нейродегенеративных заболеваний, таких, как болезнь Альцгеймера, множественный склероз и болезнь Паркинсона. Недостаток витамина D3 связан с когнитивным упадком, повышенным воспалением и сокращением длины теломера лейкоцита, что может способствовать ускоренному старению клеток. В ходе отдельных клинических исследований и метаанализов сообщалось о терапевтических вмешательствах с использованием витамина D3 в целях возможного повышения когнитивной функц

Vitamin D and immune system.

The active metabolite of vitamin D 1,25(OH)2D is well known for its role in regulating calcium-phosphate homeostasis of the human body. However, the immunomodulating activity of 1,25(OH)2D has been known for many years. There are numerous reports correlating low vitamin D levels in blood serum with the onset of autoimmune diseases and with the severe course of acute infections. In this chapter, we address the role of 1,25(OH)2D in these diseases, and we discuss the possible mechanisms of action of 1,25(OH)2D in immune cells.

Vitamin D and celiac disease.

Celiac disease (CD) is an immune-mediated condition affecting the small intestine. Its reported global prevalence falls within the range of 0.7% to 1.4%. Notably, historically, higher rates, reaching 1% in Western Ireland, have been documented. Recent research has even revealed prevalence rates as elevated as 2% in northern Europe. These findings underscore the urgency for swift and cost-effective diagnosis, especially in individuals identified through screening efforts. At present, the diagnosis of CD relies on a multifaceted approach involving positive serological markers such as IgA anti-ti

Vitamin D and allergic diseases.

In recent years, the relationship between vitamin D and allergic diseases has received widespread attention. As a fat-soluble vitamin, vitamin D plays a crucial role in regulating the immune system and may influence the onset and progression of diseases such as atopic dermatitis, allergic rhinitis, and asthma. To understand the underlying mechanisms, we have summarized the current research on the association between vitamin D and allergic diseases. We also discuss the impact of vitamin D on the immune system and its role in the course of allergic diseases, particularly focusing on how vitamin

Vitamin B12-Related Biomarkers.

BACKGROUND: Adult vitamin B12 (B12) deficiency may present itself with nonspecific mainly neurological symptoms, and thus plasma biomarkers are often judged to be of major importance in the further diagnostic process. Four biomarkers are of special relevance: total B12, holotranscobalamin (the part of B12 bound to the active transport protein, transcobalamin, also named holoTC or active B12) and the 2 so-called metabolic markers that accumulate if B12 is lacking, methylmalonic acid (MMA) and homocysteine. OBJECTIVE: This article briefly reviews the inherent limitation of biomarkers, discusses

Vitamin D and myopia: a review.

Myopia is a worldwide public health problem of vision disorder caused by multiple factors, which has posed a huge socioeconomic burden, raising concerns about sight-threatening ocular complications. Vitamin D, as a kind of fat-soluble vitamin, related to time-spent-outdoors, has been considered by extensive studies to have potential relationship with myopia. We reviewed studies published in a decade which estimated the association of blood vitamin D status with myopia and summarized the universality and individuality of all research articles. Several research articles suggested the known envir

Anti-vitamin D antibodies.

BACKGROUND: Low vitamin D levels are commonly observed in autoimmune diseases, suggesting a potential role in disease pathogenesis. The presence of anti-vitamin D antibodies may contribute to these deficiencies and influence autoimmune processes. OBJECTIVE: To review and analyze studies investigating the occurrence of anti-vitamin D antibodies in autoimmune diseases. RESULTS: Three studies, comprising a total of 345 patients, were reviewed. The autoimmune conditions included systemic lupus erythematosus (SLE), scleroderma (SSc), primary antiphospholipid antibody syndrome (pAPS), and pemphigu

Autoimmune Thyroiditis and Vitamin D.

Hashimoto's thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance. The aim of this study is to elaborate a narrative review of the relationship between vitamin D status and HT and the role of vitamin D supplementation in reducing HT risk by modulating the immune system. There is extensive literature confirming that vitamin D levels are significantly lower in HT patients compared to healthy people

Neonatologists and vitamin K hesitancy.

Hemorrhagic disease of the newborn, more aptly termed "Vitamin K Deficiency Bleeding (VKDB)," has long been recognized as a cause of significant morbidity and mortality in early infancy. A single intramuscular dose of vitamin K administered at birth has virtually eliminated VKDB, and this prophylactic regimen has been recommended by the American Academy of Pediatrics since 1961. Although most newborns in the United States receive vitamin K at birth, a growing number of parents are hesitant about this intervention, citing concerns about harm from the injection, preservatives contained in the me

Vitamin B12 reference intervals.

INTRODUCTION: P-Vitamin B12 is a commonly used biochemical test. Evaluation of test results and diagnosis of vitamin B12 deficiency are challenging, and the role of different biochemical methods remains unclear. METHODS: The aim of this study was to establish reference intervals for plasma vitamin B12 concentration using different immunoassays (method 1: Alinity, Abbott Laboratories; method 2: Cobas 6000, Roche Diagnostics; method 3: Atellica IM, Siemens Healthineers). Direct reference intervals were established among blood donors (n = 129) and indirect reference intervals among adult patient

Pregnancy, Breastfeeding, and Vitamin D.

Exclusive breastfeeding is considered the ideal food in the first six months of life; however, paradoxically, vitamin D content in human breast milk is clearly low and insufficient to obtain the recommended intake of 400 IU daily. This article summarizes the extraordinary metabolism of vitamin D during pregnancy and its content in human breast milk. The prevalence of hypovitaminosis D in pregnant women and/or nursing mothers and its potential maternal-fetal consequences are analyzed. The current guidelines for vitamin D supplementation in pregnant women, nursing mothers, and infants to prevent

Vitamin D for the management of asthma.

BACKGROUND: Since the previous Cochrane Review on this topic in 2016, debate has continued surrounding a potential role for vitamin D in reducing risk of asthma exacerbation and improving asthma control. We therefore conducted an updated meta-analysis to include data from new trials completed since this date. OBJECTIVES: To evaluate the effectiveness and safety of administration of vitamin D or its hydroxylated metabolites in reducing the risk of severe asthma exacerbations (defined as those requiring treatment with systemic corticosteroids) and improving asthma symptom control. SEARCH METHO

Vitamin D and Pigmented Skin.

The default supply of vitamin D3 to humans is its endogenous production in UV-B-exposed skin [...].

Vitamin D in Neurological Diseases.

Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course of progressive neurological diseases. In this narrative review, we summarise vitamin D chemistry, metabolism, mechanisms of action, and the recommended daily intake. The role of vitamin D on gene transcription and the immune response is also reviewed. Finally, we discuss the scientific evidence that links low 25-hydroxyvitam