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A Review of the Efficacy of Nanodrug Delivery Systems: Is It Worth the Hype?

Nanodrug delivery systems are gradually becoming the current "talk of the town" due to their efficiency in treating different diseases in a more advanced manner when compared to conventional drug-delivery systems. It is well known that drugs can be given through various routes of administration, such as the popular oral, subcutaneous, and intravenous routes. It is quite surprising that formulating these same drugs as nanoparticles (NPs) and administering them to the patient could produce better results. Different studies have shown the effects of nanodrug delivery systems in targeting cancer c…

From implantable to wearable: recent advances in microfluidic platforms for precision drug delivery.

Wearable and implantable microfluidic drug delivery systems have emerged as promising platforms that address key limitations of conventional systems, including poor dosing control, variable bioavailability, and systemic toxicities. By enabling precise manipulation of fluids at the microscale, microfluidic systems could provide precise control over drug dosing rate, timing, and localization, supporting continuous or controlled patient-centered therapy. Recent advances in materials science, microfabrication, and soft bioelectronics have further enabled devices that conform to body tissues, opera…

A review of matrix metalloproteinase-2-sensitive nanoparticles as a novel drug delivery for tumor therapy.

Matrix metalloproteinase-2 (MMP-2)-responsive nanodrug vehicles have garnered significant attention as antitumor drug delivery systems due to the extensive research on matrix metalloproteinases (MMPs) within the tumor extracellular matrix (ECM). These nanodrug vehicles exhibit stable circulation in the bloodstream and accumulate specifically in tumors through various mechanisms. Upon reaching tumor tissues, their structures are degraded in response to MMP-2 within the ECM, resulting in drug release. This controlled drug release significantly increases drug concentration within tumors, thereby …

Nanobiotechnology-based drug delivery in brain targeting.

Blood brain barrier (BBB) found to act as rate limiting factor in drug delivery to brain in combating the central nervous system (CNS) disor … ivery. At present NPs are found to play a significant advantage over the other methods of available drug delivery systems to deliver the drug across the BBB. Nanoparticles may be because of its size and functionalization characteristics able to penetrate and facilitate the drug delivery through the barrier. There are number of mechanisms and strategies found to be invo …

Sustained-release delivery of antimicrobial drugs for the treatment of periodontal diseases: Fantasy or already reality?

Periodontal diseases are prevalent in humans. Conventional means of combating these diseases involve basic oral hygiene, mostly toothbrushing, use of mouthwashes, and flossing. Supplementary means of treatment, either clinical or pharmaceutical, are often necessary. The use of sustained-release delivery systems, applied locally to the periodontal pocket, seems to be one feasible approach: local sustained-release delivery of antibacterial agents to treat periodontal diseases is conceivable. The use of local (intrapocket) sustained-release delivery systems has numerous clinical, pharmacologic, a

Theoretical model for the diclofenac release from PEGylated chitosan hydrogels.

Controlled drug delivery systems are of utmost importance for the improvement of drug bioavailability while limiting the side effects. For the improvement of their performances, drug release modeling is a significant tool for the further optimization of the drug delivery systems to cross the barrier to practical application. We report here on the modeling of the diclofenac sodium salt (DCF) release from a hydrogel matrix based on PEGylated chitosan in the context of Multifractal Theory of Motion, by means of a fundamental spinor set given by 2 × 2 matrices with real elements, which can describ…

Evaluation of Encapsulation Potential of Selected Star-Hyperbranched Polyglycidol Architectures: Predictive Molecular Dynamics Simulations and Experimental Validation.

Polymers, including non-linear copolymers, have great potential in the development of drug delivery systems with many advantages, but the design requires optimizing polymer-drug interactions. Molecular dynamics (MD) simulations can provide insights into polymer-drug interactions for designing delivery systems, but mimicking formulation processes such as drying is often not included in in silico studies. This study demonstrates an MD approach to model drying of systems comprising either hydrophilic tinidazole or hydrophobic clotrimazole drugs with amphiphilic hyperbranched copolyethers. The sim…

Nanoparticulate Drug Delivery to the Retina.

Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are the leading causes of blindness worldwide. The main … r each administration route are provided, followed by critical appraisal of various nanoparticulate drug delivery systems for the retinal diseases, including their formulation designs, therapeutic merits, limitations, and future direction. It is believed that a greater understanding of the nano-biointeraction in eyes will lead to the development of more sophisticated d …

Innovative Drug Delivery Strategies for Enhanced Treatment of Antimicrobial Resistance.

INTRODUCTION: Antimicrobial resistance (AMR) presents a major global health threat, driven by the overuse and misuse of antibiotics. Traditional drug delivery systems face significant limitations in effectively addressing this issue, including poor targeting, low bioavailability, and the development of resistance. Nanoparticle-based drug delivery systems (NDDS) have emerged as a novel approach to overcome these limitations and combat resistant bacteria by improving drug delivery and targeting. This review aims to evaluate the mechanisms of AMR and the effectiveness of nanoparticle- based drug …

Advancing Arthritis Therapy: The Frontier of Targeted and Responsive Nanomedicine.

Arthritis, a prevalent joint disorder with significant socioeconomic burden, poses considerable therapeutic challenges due to its complex pathophysiology and the limitations of conventional treatments, including systemic toxicity and poor intraarticular retention. Nanomedicine has emerged as a transformative platform to overcome these hurdles, offering precise drug delivery, prolonged retention, and multifunctional therapeutic capabilities. This review systematically summarizes the current landscape and future directions of nanomedicine for arthritis therapy. We first classify and analyze the

Transporting carriers for intracellular targeting delivery via non-endocytic uptake pathways.

To develop novel therapies for clinical treatments, it increasingly depends on sophisticated delivery systems that facilitate the drugs entry into targeting cells. Profound understanding of cellular uptake routes for transporting carriers promotes the optimization of performance in drug delivery systems. Although endocytic pathway is the most important part of cellular uptake routes for many delivery systems, it suffers the trouble of enzymatic degradation of transporting carriers trapped in endosomes/lysosomes. Therefore, it is desirable to develop alternative transporting methods for deliver…

Advances in Microemulsion Drug Delivery: From Fundamentals to Therapeutic Applications.

Microemulsion-based drug delivery systems are increasingly attracting attention in the pharmaceutical field owing to their remarkable capacity to enhance solubility, stability, and bioavailability, as well as enable targeted drug delivery. These systems comprise clear, stable, isotropic blends of oil, water, and surfactant, often accompanied by a co-surfactant. Their appeal to pharmaceutical scientists lies in their versatility as effective drug-delivery vehicles, accommodating a diverse array of drug molecules. Microemulsions have demonstrated effectiveness in protecting fragile drugs, contro…

[Advances in inhalable nano-formulations].

Nano-drug delivery systems offer significant benefits, including high specific surface area, structural and functional diversity, and surface modifiability. When formulated as inhalable nano-formulation, these can not only enable precise pulmonary drug delivery but also improve pulmonary bioavailability and enhance thera-peutic efficacy. Currently, there are four types of inhalable nano-formulations for the treatment of respiratory diseases. Inhalable liquid preparations exhibit facile manufactur-ability and broad applicability yet demonstrate compromised stability during aerosolization. Throu…

The Role and Advancement of Liposomes for Oral Diseases Therapy.

As many as 48.0% of the global population suffers from disabilities caused by oral conditions. These conditions encompass dental caries, per … ed drug delivery and achieving desired therapeutic outcomes. To overcome these challenges, advanced drug delivery systems have been developed. Among these systems, liposomes have been extensively explored as nanocarriers in targeted drug delivery systems, particularly in mucosal drug delivery, due to their biocompatibility and degradability, making them promising agent …

Advances in Acne Vulgaris: From Pathogenesis to Innovative Drug Delivery.

INTRODUCTION: Acne vulgaris (AV) is a common chronic inflammatory disorder of the pilosebaceous unit that affects adolescents and adults globally. Despite the availability of multiple therapeutic approaches, limitations such as poor patient adherence, adverse effects, and antibiotic resistance necessitate improved treatment strategies. This review explores recent advances in acne pathogenesis and innovative drug delivery systems to improve therapeutic outcomes. METHODS: This narrative review is based on a comprehensive analysis of published literature. Relevant data were collected from peer-r…

Основанные на экспозиции платформы для лечения множественных склерозов.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, характеризующееся воспалением и обезвоживанием центральной нервной системы (КНС). Эффективная доставка терапевтических агентов в ЦНС по-прежнему является важным препятствием в лечении MS из-за кровеносного барьера и ограниченного доступа в пострадавшие районы. Системы доставки экзотических наркотиков стали привлекательным вариантом для целевой терапии в НР. Экзосомы, небольшие внеклеточные везы, получаемые из различных типов клеток, обладают уникальными биологическими свойствами, которые делают их идеальными нанокарьерами для д

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune illness characterized by inflammation and demyelination of the central nervous system (CNS). The effective delivery of therapeutic agents to the CNS continues to be an important barrier in MS treatment due to the blood-brain barrier and limited access to the affected areas. Exosome-based drug delivery systems h…

Targeted Delivery Strategies for Multiple Myeloma and Their Adverse Drug Reactions.

Currently, multiple myeloma (MM) is a prevalent hematopoietic system malignancy, known for its insidious onset and unfavorable prognosis. Recently developed chemotherapy drugs for MM have exhibited promising therapeutic outcomes. Nevertheless, to overcome the shortcomings of traditional clinical drug treatment, such as off-target effects, multiple drug resistance, and systemic toxicity, targeted drug delivery systems are optimizing the conventional pharmaceuticals for precise delivery to designated sites at controlled rates, striving for maximal efficacy and safety, presenting a promising appr…

The current applications of nano and biomaterials in drug delivery of dental implant.

BACKGROUND AND AIM: Dental implantology has revolutionized oral rehabilitation, offering a sophisticated solution for restoring missing teeth. Despite advancements, issues like infection, inflammation, and osseointegration persist. Nano and biomaterials, with their unique properties, present promising opportunities for enhancing dental implant therapies by improving drug delivery systems. This review discussed the current applications of nano and biomaterials in drug delivery for dental implants. METHOD: A literature review examined recent studies and advancements in nano and biomaterials for…

"Smart" drug delivery: A window to future of translational medicine.

Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both cancer and healthy cells, causing a variety of adverse effects such as lack of specificity, cytotoxicity, short half-life, poor solubility, multidrug resistance, and acquiring cancer stem-like characteristics. There is a paradigm shift in drug delivery systems (DDS) with the advent of smarter ways of targeted cancer treatment. Smart Drug Delivery Systems (SDDSs) are stimuli responsive and can be modified in chemical structure in response to light, pH, redox, magnetic fields, and e…

Advances in carrier-free nanodrug delivery systems.

Nanotechnology has propelled the development of nanodrug delivery systems (NDDS) with remarkable potential in disease diagnosis and therapy. Nevertheless, conventional NDDS relying on exogenous nano-carriers suffer from intrinsic limitations, including suboptimal drug-loading capacity and biocompatibility issues. In this context, carrier-free nanodrug delivery systems (CFNDDS), constructed through the intrinsic self-assembly of therapeutic molecules, have emerged as a paradigm-shifting alternative. CFNDDS enables drug loading efficiency close to the theoretical maximum, while effectively avoid…