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[Successful treatment with clarithromycin for Mixed phenotype acute leukemia, T/myeloid, NOS].

A 79-year-old woman was admitted with submandibular lymphadenopathy and was diagnosed as having bacterial and fungal lymphadenitis by lymph nodal biopsy. Laboratory examination demonstrated leukopenia with 7% blasts. The bone marrow was infiltrated with about 90% blasts and surface antigen analysis of these blasts demonstrated expression of cyCD3, TdT and MPO. The diagnosis was Mixed phenotype acute leukemia, T/myeloid, NOS. The patient was treated with prednisone (10 mg/day) for fever and subsequently CAM (800 mg/day) for pneumonia. Three months later, leukemic cells had disappeared on both b…

Bacille Calmette-Guérin osteomyelitis of the proximal femur.

All newborns in Hong Kong are given bacille Calmette-Guérin vaccinations. Reported complications include formation of regional and extra-regional localised abscesses, osteomyelitis, and lymphadenitis. Several cases of bacille Calmette-Guérin osteomyelitis have been reported in Europe, but there are few reports of this in Asia. To the author's knowledge, this is the first case report of bacille Calmette-Guérin osteomyelitis in Hong Kong. Bacille Calmette-Guérin osteomyelitis, although rare, should be kept in mind as a potential complication of bacille Calmette-Guérin vaccination. Clinical suspi…

Acquired lymphangioma circumscriptum of the vulva.

Lymphangiomas are rare benign proliferations of the lymphatic system. Acquired lymphangioma circumscriptum of the vulva is induced by impair … ecomes the fifth reported case of acquired lymphangioma circumscriptum of the vulva with tubercular lymphadenitis. The single antituberculosis treatment is insufficient to control lymphangioma. Ablative methods seem encouraging.

Locoregional silicone spread after high cohesive gel silicone implant rupture.

A 45-year-old patient had routine cosmetic bilateral breast augmentation 6 years previously using cohesive gel implants. She presented 4 years later with a breast lump and multiple axillary lymph nodes. Exploration revealed that the breast implant had a large tear at the posterior wall of the shell with intra-capsular leakage of silicone. The axilla had eight enlarged lymph node--all were removed. Histology showed silicone granuloma in the capsule and silicone lymphadenitis. High cohesive gel implants may not be as safe as is commonly believed and all implant ruptures, irrespective of the cohe…

[Unusual manifestations of Bartonella infections].

The authors review the cases of two patients with an atypical form of cat scratch disease. The first case exhibited ileocoecal and hepatoportal lymphadenitis, and the second case the emerging symptoms of a non-specific granulomatous process in the middle third of the right forearm, which caused a differential-diagnostic problem. Establishment of a diagnosis was possible only on the basis of the disease process and the pathological, serological and histopathological pictures of the lymphatic glands after other causes of the lymphadenopathy had been excluded. Following two weeks of antibiotic tr…

Generalised demodicosis in a Friesian heifer from a zero-grazing unit.

A Friesian heifer with generalised skin lesions was slaughtered after unsuccessful treatment. It had thickened skin with lumps and nodules, … odectic mites were seen. Some mites had migrated to the peripheral lymph nodes causing eosinophilic lymphadenitis and panniculitis of the subcutis.

Cat-scratch disease: report of a case with liver lesions and no lymphadenopathy.

The usual presentation of cat-scratch disease (CSD) is a subacute regional lymphadenitis following cutaneous inoculation. We present the case of a 10-yr-old white female with a 4-wk history of abdominal pain and fever, without associated lymphadenopathy. A 67Ga scintigram showed inhomogenous uptake by the liver. An abdominal computed tomographic (CT) scan revealed multiple low density lesions in the liver and the spleen, that were confirmed at laparotomy. Stellate microabscesses were seen on a wedge biopsy of the liver and a CSD antigen skin test was positive. CSD should be considered in the d…

[Clinical experience with flomoxef in the pediatric field].

Flomoxef (FMOX, 6315-S) was given intravenously to 21 children with the following acute bacterial infections; 10 cases of bronchopneumonia, 3 cases each of purulent lymphadenitis and urinary tract infection, 2 cases of staphylococcal scalded skin syndrome and 1 case each of peritonsillar abscess, pyothorax and purulent meningitis. Good clinical responses were obtained in 18 out of 21 patients, and bacteriologically, all of the 17 isolated strains were eradicated. No side effect was observed except for 1 case with soft stool and 2 cases of eosinophilia. From the above clinical results, it is ap…

Быстрая лабораторная диагностика инфекционных заболеваний.

Проверки иммуноэлектрических и латексных твердых частиц проводятся быстро, не требуют дорогостоящего оборудования и при наличии конкретных антигенов и антисеры с легкостью. Оба теста оказались полезными для диагностики бактериальных инфекций (таких, как инфекция, вызванная H. гриппом, стрептококковой пневмонией, N. meningitidis, E. coli, Staphilococcus aureus и группой B streptococus) и вирусных инфекций (HRVLA и гепатит B); они также могут быть полезными для грибковых и паразитических инфекций. Этиологический диагноз часто наблюдаемых клинических заболеваний (таких, как пневмония, менингит, ц

Совпадение в аннотации оригинала
The countercurrent immunoelectrophoresis and latex particle agglutination tests are rapid, do not require expensive apparatus, and are easy … sis of commonly seen clinical conditions (such as pneumonia, meningitis, cellulitis, osteomyelitis, lymphadenitis, and arthritis) by practicing physicians can be made using these tests to detect antigens in various body fluids in a hospital laboratory.

Rifampicin induced purpura of left lower limb: Illustrative medical image.

Rifampicin-induced purpura is a rare hypersensitivity reaction encountered during anti tubercular therapy (ATT). We report a 43-year-old male with cervical tubercular lymphadenitis who developed purpuric lesions with distinctive orange-colored serous discharge over the left lower limb after initiation of ATT. Investigations excluded thrombocytopenia and systemic vasculitis. A temporal relationship between drug intake and symptom onset confirmed rifampicin as the causative agent. Prompt withdrawal of rifampicin and initiation of systemic corticosteroids led to complete resolution of the lesions…

Local and regional adverse reactions to BCG-SSI vaccination: a 12-month cohort follow-up study.

In a 12-month cohort follow-up study of 2435 children vaccinated in 2007 by Statens Serum Institute BCG strain (BCG SSI, 17.8% had an adverse event (AE): erythema 12.4%, induration 12.2%, abscesses 2.5%, ulceration 0.9%, lymphadenitis 0.1%. The factors associated with a lower risk of AE were: age at vaccination <1 year compared to age >1 year (OR=0.35 [0.2-0.6] for age <28 days, 0.29 [0.2-0.42] for age 29 days to 2 months, and 0.53 [0.37-0.74] for age 3-11 months), a visible papule (OR=0.48 [0.36-0.63]), and a low vaccine dose (OR=0.42 [0.31-0.58]). AE to BCG SSI vaccination were frequent but …

Successful surgical treatment of an infrarenal abdominal pseudoaneurysm caused by tuberculosis: report of a case.

A 76-year-old man was admitted to our hospital for investigation of an apparent abdominal aortic aneurysm detected during treatment for epid … by tuberculosis. The pseudoaneurysm appeared to have resulted from direct extension of tuberculous lymphadenitis to the aortic wall, which ruptured. We review 24 other cases of tuberculous aortic aneurysms surgically treated in Japan before 2004.

Color Doppler US of children with acute lower abdominal pain.

The authors review the color Doppler ultrasonographic (US) features of appendicitis and other diseases that can manifest with acute lower abdominal pain. Causes of acute abdominal pain, other than appendicitis, include gynecologic abnormalities (ovarian cyst, ovarian torsion, pelvic inflammatory disease), gastrointestinal abnormalities (infectious enteritis, Crohn disease, mesenteric lymphadenitis, intussusception), and urinary tract diseases. On color Doppler images, inflammatory and infectious processes usually show locally increased blood flow, whereas cysts and twisted masses have absent b…

Lesions caused by Parelaphostrongylus odocoilei (Nematoda: Metastronglyloidea) in two cervid hosts.

Pathologic effects and host response were evaluated in seven white-tailed deer (Odocoileus virginianus) and six mule deer (O. hemionus hemionus) each exposed per os to 300 or 1000 third-stage larvae of Parelaphostrongylus odocoilei. Pathologic effects in mule deer consisted of hemorrhagic myositis throughout skeletal muscles, severe verminous pneumonia, and moderate lymphadenitis. The major host response was a granulomatous inflammation associated with nematode eggs and larvae. Granulomas obliterated the normal architecture of affected tissues. Pathologic effects and host response were minimal…

X-linked hyper-IgM syndrome presenting as severe Pneumocystis pneumonia in a 6-month-old infant: a case report.

BACKGROUND: X-linked hyper-immunoglobulin M (XHIGM) syndrome is a rare primary immunodeficiency caused by mutations in the CD40 ligand gene (CD40LG), characterized by defective T-cell-dependent B-cell class-switch recombination. Patients typically present with recurrent infections in early childhood, but diagnosis is often delayed due to heterogeneous clinical manifestations and the fact that serum IgM levels may remain within the normal range in a significant proportion of patients. Here we report a case of XHIGM in an infant whose diagnostic journey began with recurrent lymphadenitis and cul…

Temporal trends, diagnostics, and outcomes of pediatric nontuberculous mycobacterial disease in Slovakia (2017-2024).

BACKGROUND: Nontuberculous mycobacteria (NTM) are rare but emerging pathogens in pediatric populations, particularly in countries where BCG … ed. RESULTS: In total, 30 patients were diagnosed. The majority of cases (27/30) involved cervical lymphadenitis (including two with concurrent pulmonary involvement), most commonly affecting children between 1 and 2 years. In addition, one patient was diagnosed with a pulmonary form of NTM disease, one with NTM-associated osteomyelitis, and one with a skin an …

Adverse reactions to Mycobacterium bovis bacille Calmette-Guérin vaccination against tuberculosis in Iranian children.

PURPOSE: There are considerable variations in the number of adverse reaction reports related to vaccine from different countries. The aim of … cation were less than 1 year old. Among hospitalized patients due to BCG complications, suppurative lymphadenitis was occurred in 28 children (61%) and lymphadenopathy was seen in 9 children (20%). Disseminated BCG was detected in 8 patients (17%) and only 1 child (2%) was presented with abscess. In 7% (n = 3) of children, the family history of BCG complication …

Extrapulmonary Nontuberculous Mycobacteria Infection: The New-Age Neglected Infectious Disease.

Nontuberculous mycobacteria (NTM), otherwise known as atypical mycobacteria, primarily cause pulmonary disease. However, with the increase in the immunocompromised population, infections caused by NTM at extrapulmonary (EP) sites have been on the rise in the past decade. Clinical presentations can commonly include lymphadenitis and skin and soft tissue infections. The diagnosis is challenging due to the invasive nature of the sample collection and the low degree of suspicion. Furthermore, detection up to the speciation level is important as management is species-specific. With limited data and…

Case Report: Multiple autoimmune syndrome (MAS)-An unusual combination.

This is a case report of a Chinese adolescent boy who had multiple autoimmune syndrome (MAS) of a rare combination comprising type 1 diabetes, Hashimoto thyroiditis and childhood-onset systemic lupus erythematosus (SLE). He developed SLE within one year of symptom onset, presenting with necrotising histiocytic lymphadenitis and hepatitis. We highlight the importance for physicians to be aware of the need for continued surveillance for developing new autoimmune diseases in patients with multiple autoimmune diseases. It is also essential to remain vigilant for overlap syndrome as autoimmune dise…

Mycobacterium intracellulare-Related Immune Reconstitution Syndrome in an HIV Patient: A Case Report.

Immune reconstitution syndrome (IRIS) is an uncommon complication seen in patients living with human immunodeficiency virus (HIV) characteri … yte counts of below 50 cells/µL. Here, we present the case of an HIV-positive patient who developed lymphadenitis caused by Mycobacterium intracellulare as an unmasked IRIS after initiating treatment for HIV.