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Prospective Development of a Whole-Brain Connectivity and Electric Field-Guided Transcranial Magnetic Stimulation Atlas for Posttraumatic Stress Disorder Symptoms.

BACKGROUND: Although trauma-focused psychotherapy remains the first-line treatment for posttraumatic stress disorder (PTSD), 14% to 35% of individuals with PTSD fail to achieve symptom remission. Transcranial magnetic stimulation (TMS) has shown promise as an adjunctive intervention, but its efficacy for PTSD remains inconsistent and may be better informed by the incorporation of brain-based signals to guide stimulation. To address this, we developed a connectivity-based modeling framework to identify functional networks that predict symptom severity and to estimate where stimulation would mos…

Электроконвульсивная терапия (ЭКТ) и репетитивная транскраниальная магнитная стимуляция (rTMS), пособия и вредные последствия для пациентов с депрессией: обзор.

Справочная информация: Серьезное депрессивное расстройство, особенно в его стойкой к лечению форме, остается одной из основных причин инвалидности во всем мире. В тех случаях, когда фармакотерапия и психотерапия не дают результатов, все шире используются такие методы нейромодуляции, как электроконвульсивная терапия (ЭКТ) и повторяющаяся транскраниальная магнитная стимуляция (rTMS). Однако изменчивость протоколов и отчетности о результатах по-прежнему вызывает неопределенность в отношении их сравнительных преимуществ и характеристик безопасности. Цель: Всеобъемлющий анализ и обобщение имеющихся

Совпадение в аннотации оригинала
Background: Major depressive disorder, particularly in its treatment-resistant form, remains a leading cause of global disability. When pharmacotherapy and psychotherapy fail, neuromodulation techniques such as electroconvulsive therapy (ECT) and repetitive transcranial magnetic stimulation (rTMS) are increasingly utilized. However, variability in protocols …

Repetitive transcranial magnetic stimulation for autism spectrum disorder: A systematic review and meta-analysis of treatment regimens, efficacy, and safety.

OBJECTIVE: To evaluated the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) treatment for autism spectrum disorder (ASD). METHODS: We included RCTs comparing rTMS to sham or non-rTMS controls in individuals with ASD (any age/sex). PubMed, CNKI, and other databases were searched from inception to May 2026 (PROSPERO/CRD420251244998). Random-effects meta-analyses were performed, and certainty of evidence was assessed using GRADE. RESULTS: A total of 53 RCTs (52 references) were included. rTMS significantly improved core ASD symptoms (ABC: SMD=-1.48; CARS: SMD=-0.95; A…

Cortical excitability and brain function in patients with insomnia: a pilot transcranial magnetic stimulation and functional near-infrared spectroscopy study.

BACKGROUND: Insomnia significantly impairs well-being, cognitive function, and social functioning, yet subjective psychological assessments often yield equivocal results regarding the extent of this impairment. Neural function may underlie this discrepancy and offer a more precise foundation for guiding treatment. This study therefore employed non-invasive transcranial magnetic stimulation (TMS) and functional near-infrared spectroscopy (fNIRS) to investigate cortical excitability and brain activity patterns in patients with short-term insomnia disorder (SID) and chronic insomnia disorder (CID…

Global white matter microstructure changes induced by repetitive transcranial magnetic stimulation in cocaine use disorder: a longitudinal correlational tractography study.

Cocaine use disorder (CUD) is a significant public health problem with few treatment options. Repetitive Transcranial Magnetic Stimulation (rTMS) targeting the left dorsolateral prefrontal cortex has shown promise as a therapeutic tool for neural alterations in CUD. However, its effects on white matter (WM) microstructure and their role in treatment efficacy remain uncertain. This study aimed to assess the global impact of rTMS on WM microstructure in CUD patients. In this study, we made a longitudinal correlational tractography analysis that was conducted using Quantitative Anisotropy (QA) on…

Efficacy of combined repetitive transcranial magnetic stimulation and occupational therapy in spinal cord injury patients: a randomized controlled clinical study.

STUDY DESIGN: Randomized controlled trial, clinical trial. OBJECTIVE: Impact evaluation of combined occupational therapy (OT) and transcranial magnetic stimulation (rTMS) on upper limb function in patients with spinal cord injury (SCI). SETTING: National Rehabilitation Center, Seoul, Korea. METHODS: This randomized controlled trial included patients with cervical SCI. One treatment group received OT and rTMS, while the other received OT and sham-rTMS, three times per week for 5 weeks. The primary study outcome (change in upper limb function) was assessed using the graded and redefined asses…

Ventrolateral prefrontal-amygdala repetitive transcranial magnetic stimulation (rTMS) modulation of impulsivity in borderline personality disorder: a proof-of-concept study.

Impulsivity and emotional dysregulation are core symptoms of Borderline Personality Disorder (BPD) for which therapeutic options are very limited. Prior neuroimaging studies suggest that BPD symptoms may be related to fronto-amygdala circuit dysfunction. This proof-of-concept study examined whether individualized ventrolateral prefrontal cortex (VLPFC)-amygdala circuit modulation with Repetitive Transcranial Magnetic Stimulation (rTMS) could alter impulsivity and emotional dysregulation in BPD. Eleven participants with BPD underwent resting-state functional Magnetic Resonance Imaging (rsfMRI) …

Efficacy of repetitive transcranial magnetic stimulation in Parkinson's disease: an updated systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a potential noninvasive treatment option for managing motor and non-motor symptoms in Parkinson's disease (PD). While numerous randomized controlled trials have evaluated its efficacy, the evidence remains inconsistent. This updated systematic review and meta-analysis aims to consolidate the available data to assess the effectiveness of rTMS in improving motor symptoms, cognitive function, and quality of life in patients with PD. METHOD: A comprehensive search was conducted across multiple databases, including PubM…

Effects of Repetitive Transcranial Magnetic Stimulation on Upper and Lower Limb Motor Function and Spasticity After Stroke: A Meta-Analysis.

Repetitive transcranial magnetic stimulation (rTMS), a non-invasive neuromodulation technique, has emerged as a potential adjunct to conventional rehabilitation though findings remain inconsistent. This study investigated the efficacy of rTMS combined with conventional rehabilitation in improving motor function and spasticity after stroke through a systematic review and meta-analysis. MEDLINE, Embase, and the Cochrane Library were comprehensively searched through February 2022. Sixty-eight randomized controlled trials were included based on Preferred Reporting Items for Systematic Reviews and …

Repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex in binge eating disorder: a double-blind randomized controlled trial.

BACKGROUND: Binge-eating disorder (BED) is characterized by highly distressing episodes of loss-of-control over-eating. We have examined the use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of people with BED and associated obesity. Such non-invasive brain stimulation (NIBS) techniques are used therapeutically in several psychiatric conditions and there is an associated scientific rationale. METHODS: Sixty participants were randomly allocated to receive 20 sessions of neuronavigated 10 Hz rTMS administered to the left dorsolateral prefrontal cortex (dlPFC) or sham …

Navigate Transcranial Magnetic Stimulation Is More Reliable Than Tractography for Placing Subdural Electrodes Used for Cortico-Cortical-Evoked-Potentials Recording.

OBJECTIVE: The aim of the study is to verify whether preoperative navigated transcranial magnetic stimulation (nTMS) is a reliable tool for the positioning of subdural electrodes for cortico-cortical evoked potentials (CCEPs) recording in the presence of minicraniotomy. METHODS: This is a monocentric, prospective, observational cohort study in which we included adults with lesions that were compressing or infiltrating the perisylvian area. In the preoperative phase, we performed nTMS to identify language areas. During the intervention, we performed CCEP recordings using subdural strip electro…

Effectiveness of high-frequency repetitive transcranial magnetic stimulation coupled with rehabilitation in patients with spinal cord injury: a systematic review.

BACKGROUND: Spinal Cord Injury (SCI) leads to partial or complete sensorimotor loss because of the spinal lesions caused either by trauma or any pathological conditions. Rehabilitation, one of the therapeutic methods, is considered to be a significant part of therapy supporting patients with spinal cord injury. Newer methods are being incorporated, such as repetitive Transcranial Magnetic Stimulation (rTMS), a Non-Invasive Brain Stimulation (NIBS) technique to induce changes in the residual neuronal pathways, facilitating cortical excitability and neuroplasticity. STUDY DESIGN: PRISMA-guided …

Long-term electroacupuncture and repetitive transcranial magnetic stimulation differentially slow the progression of Alzheimer's disease in AppNL-G-F mice.

Both electroacupuncture (EA) and repetitive transcranial magnetic stimulation (rTMS) possess the potential in combating the progression of Alzheimer's disease (AD). In this study, we compared the effects of the two regimens as early long-term intervention in AppNL-G-F mice, a new amyloid precursor protein (APP) knock-in model that recapitulates multiple AD-associated pathologies, including amyloid-β (Aβ) plaques, microgliosis, astrocytosis, dendritic and synaptic degeneration. The 2-month-old freely moving model mice randomly received EA or rTMS for 2~3 sessions a week for 6 months. Cognitive …

Repetitive transcranial magnetic stimulation for cognitive and emotional symptoms in neurodegenerative diseases: a systematic review and dose-response meta-analysis.

OBJECTIVE: We summarized the existing clinical evidence of repetitive transcranial magnetic stimulation (rTMS) for cognitive and emotional symptoms in Parkinson's disease (PD) and alzheimer's disease (AD), and conducted a series of dose-response meta-analyses to determine the magnitude and curve relationship between pulse quantity changes and treatment effect sizes. METHODS: We retrieved existing evidence from 5 databases and collected relevant results data on rTMS treatment for cognitive and emotional symptoms in PD and AD. We analyzed the data using R software to evaluate the effect size us…

Beyond the Surface: Deep Transcranial Magnetic Stimulation Efficacy in Reducing Craving in Addictive Disorders: A Systematic Review and Meta-Analysis.

BACKGROUND: Substance use disorders (SUDs) and gambling disorder (GD) are addictive diseases with a chronic course. Due to the limited efficacy of conventional treatments, there is growing interest in alternative approaches that target the altered neural circuits underlying these disorders. Deep transcranial magnetic stimulation (dTMS) has emerged as a promising neuromodulation technique capable of reaching deep and bilateral brain regions. However, no definite recommendation for its use in addiction treatment exists. In this study, we systematically reviewed and quantitatively analyzed dTMS e…

Clinical Study on the Combined Therapy of Sinew Acupuncture and Low-Frequency Repetitive Transcranial Magnetic Stimulation for Hemiplegic Shoulder Pain.

OBJECTIVE: To observe the clinical efficacy of combining sinew acupuncture with low-frequency repetitive transcranial magnetic stimulation (rTMS) for treating hemiplegic shoulder pain. METHODS: A total of 90 patients with hemiplegic shoulder pain were randomly divided into three groups: the sinew acupuncture group, the rTMS group, and the combined group (30 patients each). All received conventional symptomatic medication and routine interventions. The sinew acupuncture group received subcutaneous shallow needling on the affected side; the rTMS group received 1 Hz rTMS stimulation on the contr…

Exploring Perceptions and Experiences of Patients Undergoing Transcranial Magnetic Stimulation (TMS) for Depression and Adjustment Disorder in Romanian Private Practices.

Background and Objectives: Mental health disorders, including major depressive disorder and adjustment disorder with mixed anxiety and depressed mood, present a significant global burden, with early onset and progression leading to substantial individual and social impacts. While pharmacotherapy remains the standard treatment, many patients experience inadequate symptom relief or intolerable side effects. In this context, transcranial magnetic stimulation (TMS) has emerged as a non-invasive, well-tolerated neuromodulation technique offering an alternative treatment option. Although its clinica…

Repetitive transcranial magnetic stimulation focusing on patients with neuropathic pain in the upper limb: a randomized sham-controlled parallel trial.

This study aimed to evaluate the efficacy and safety of navigation-guided repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex in patients with neuropathic pain in the upper limb. This randomized, blinded, sham-controlled, parallel trial included a rTMS protocol (10-Hz, 2000 pulses/session) consisting of five daily sessions, followed by one session per week for the next seven weeks. Pain intensity, as well as pain-related disability, quality of life, and psychological status, were assessed. For the primary outcome, pain intensity was measured daily using a numerica…

Deep transcranial magnetic stimulation for adolescents with treatment-resistant depression: A preliminary dose-finding study exploring safety and clinical effectiveness.

BACKGROUND: Transcranial magnetic stimulation (TMS) is an intervention for treatment-resistant depression (TRD) that modulates neural activity. Deep TMS (dTMS) can target not only cortical but also deeper limbic structures implicated in depression. Although TMS has demonstrated safety in adolescents, dTMS has yet to be applied to adolescent TRD. OBJECTIVE/HYPOTHESIS: This pilot study evaluated the safety, tolerability, and clinical effects of dTMS in adolescents with TRD. We hypothesized dTMS would be safe, tolerable, and efficacious for adolescent TRD. METHODS: 15 adolescents with TRD (Age,…

Role of Electroconvulsive Therapy, Ketamine Infusion, and Deep Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Bipolar Depression: A Case Report.

Background and Objectives: Options for treatment-resistant bipolar depression (TRBPD) are limited. Electroconvulsive therapy (ECT) has shown … , 22 sessions of ketamine infusion at 0.5-0.75 mg/kg for 40 min, and 39 sessions of deep repetitive transcranial magnetic stimulation (dTMS). Results: The patient had some benefit from ECT, but declined continuation of ECT due to memory concerns. The patient tolerated ketamine infusion well but had limited benefit. However, the patient responded well to acute treatment with dTMS a …