Результаты поиска

Ангина из-за обструкционистской болезни коронарной артерии в сочетании с периферической болезнью артерии.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The patient has treated with ramipril 5 mg, which was switched to the ramipril/hydrochlorothiazide 10/12.5 mg combination and metoprolol succinate 50 mg once daily was added to the regimen. …

NITROSOGENESIS, ANTIDEPRESSANTS AND THE SERTRALIN INDUCED NEVUS ASSOCIATED CUTANEOUS MELANOMA: THE NDMA/ NNK (NDSRIS) CONTAMINATION AS MOST POTENT MELANOMA INDUCTORS: ALEA IACTA EST.

The purposeful oblivion of the objective truth, the disregard of scientific reality, the denial of the contributions and successes of surrou … ines. Whether the drugs affected by the contamination are from the group of sartans, beta blockers, hydrochlorothiazide, calcium antagonists, ACE inhibitors or antidepressants- the ultimate side effect remains the same and is known to the scientific community as or by the frightening and loud name : melanoma. We report the occurrence of another case of nevus associat …

Arrhythmias, conduction disorders and sudden cardiac death in cancer patients and survivors: expert opinion of the working groups on cardio-oncology and on electrophysiology of the hellenic cardiac society.

Advances in cancer therapeutics have significantly improved patient survival; however, cardiotoxic effects-including arrhythmias-have emerged as a growing clinical concern. This expert opinion, developed by the Working Groups on Cardio-Oncology and Electrophysiology of the Hellenic Cardiological Society, aims to raise awareness of the increasing burden of arrhythmias in cancer patients and survivors. This document explores the multifactorial etiology of arrhythmias in this population, including patient-related factors, the direct effects of malignancy, and the arrhythmogenic potential of thera

Совпадение в полном тексте источника
… and indapamide) Calcium channel blockers (e.g. isradipine, nicardipine) | Enhanced QT prolongation | ↑ TdP risk Platinum-Based Chemotherapy (e.g., cisplatin, carboplatin) | Diuretics (e.g., furosemide, hydrochlorothiazide) | Electrolyte Imbalance | ↑ risk of hypokalemia and hypomagnesemia, leading to … arrhythmias Fluoropyrimidines (e.g., 5-FU, capecitabine) | Digoxin | Increased Digoxin Toxicity | ↑ risk of digoxin toxicity due to electrolyte disturbances Other antineoplastic agents: Arsenic trioxide Cyclophospahamide Eribulin Tamoxifen Taxanes Thalidomide | Diuretics (e.g. furosemide, hydrochlorothiazide …

Access to and use of high blood pressure medications in Brazil.

OBJECTIVE: To analyze the access to and use of medicines for high blood pressure among the Brazilian population according to social and demo … 9) were obtained from other locations. The five most commonly used drugs were, in descending order, hydrochlorothiazide, losartan, captopril, enalapril and atenolol. Of the total number of patients on treatment, 36.1% (95%CI 34.1-37.1) were using two medicines and 13.5% (95%CI 12.3-14.9) used three or more. CONCLUSIONS: Access to medicines for the treatment of high …

Lenalidomide and Dexamethasone in Scleromyxedema: A Case Report of Long-Term Efficacy and Challenges in a 54-Year-Old Patient.

Lichen myxedematosus (LM) is characterized by dermal mucin buildup, fibroblast proliferation, and variable presentation. The diffuse variant, known as scleromyxedema, is identified by monoclonal paraprotein presence and lack of thyroid issues, with considerations for infections and underlying conditions. Despite lacking FDA-approved treatment, intravenous immunoglobulin stands as effective, although resource-intensive, while targeting the clonal source of pathogenic immunoglobulin offers an alternate therapeutic route. Our case explores the efficacy of an oral plasma cell-focused lenalidomide

Совпадение в полном тексте источника
… The medications he was taking at the time of presentation included atenolol, levothyroxine, hydrochlorothiazide, simvastatin, and losartan. Physical examination revealed exaggerated wrinkling of the glabella and firm skin on the sides of the nose, upper back, and shoulders. …

Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway.

The objectives of this study were to evaluate the relative contribution of the direct pathway in overall brain transport for 17 model drugs with different physicochemical properties after nasal administrations and to identify factors that govern the fraction of the dose transported to the brain via the direct pathway (F(a, direct)). When the model drugs were nasally administered to rats, 5 of the 17 model drugs were delivered to a significant extent to the brain via the direct pathway. Multiple linear regression analyses showed that the correlation between various physicochemical properties an

Systemic pharmacological interventions for Ménière's disease.

BACKGROUND: Ménière's disease is a condition that causes recurrent episodes of vertigo, associated with hearing loss and tinnitus. A number … e of isosorbide (220 participants), and the other used a combination of amiloride hydrochloride and hydrochlorothiazide (80 participants). Again, we were unable to conduct any meta-analyses for our primary outcomes, as only one study reported on the outcome 'improvement in vertigo' (at 6 to ≤ 12 months), one study reported on change in vertigo (at 3 to < 6 months) an …

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

Despite the various initiatives carried out in Brazil and in the world, the challenge of offering essential medicines in adequate presentations remains, especially to the public affected by diseases considered neglected and the pediatric population, for whom the therapeutic options remain limited. The main objective of this study was to evaluate the production of manipulated medicines as a strategy to mitigate therapeutic and access gaps to essential medicines within the Brazilian public health system, called the Unified Health System (SUS). The evaluation, carried out between 2020 and 2021, i

Совпадение в полном тексте источника
… These are drugs such as Artesunate oral solution, used to treat malaria or Hydrochlorothiazide 12.5 mg tablet, which despite being in the list of Rename, do not present valid health registration in the country. … causes. | Infantile Griseofulvin | 125 mg/5 mL Oral solution | Fungal infections of the skin, scalp or hair where topical treatment has failed or is inappropriate. | Infantile Hydralazine | 5 mg/mL Oral solution | Severe and refractory systemic arterial hypertension; Hypertensive emergency. | Infantile Hydrochlorothiazide …

Left Ventricular Hypertrophy: Etiology-Based Therapeutic Options.

Determining the etiologies of left ventricular hypertrophy (LVH) can be challenging due to the similarities of the different manifestations in clinical presentation and morphological features. Depending on the underlying cause, not only left ventricular mass but also left ventricular cavity size, or both, may increase. Patients with LVH remain asymptomatic for a few years, but disease progression will lead to the development of systolic or diastolic dysfunction and end-stage heart failure. As hypertrophied cardiac muscle disrupts normal conduction, LVH predisposes to arrhythmias. Distinguishin

Совпадение в полном тексте источника
… “CHIP” diuretics (CHlorthalidone, Indapamide, and Potassium-sparing diuretic/hydrochlorothiazide) were compared with hydrochlorothiazide and found to be more effective in reducing LVM. … Hydrochlorothiazide and alternative diuretics versus renin-angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis. J Hypertens. 2018;36(6):1247–1255. doi: 10.1097/HJH.0000000000001691. 30. Gu J, Fan YQ, Han ZH, et al. …

Sternal Tumor Resection and Complex Chest Wall Reconstruction of a Solitary Plasmacytoma: A Report of a Rare Case.

Localized sternal plasmacytoma is a rare and aggressive oncologic condition. Surgical resection followed by radiotherapy offers the highest chance of cure. Radical resection of the chest wall is technically feasible and is associated with improved outcomes. Subsequent reconstruction using meshes, plates, and both autologous and allogenic tissues allows for the restoration of chest wall function and may prolong survival. Patients with solitary plasmacytoma require close follow-up to monitor for local recurrence or distant disease progression. We present a case of a 63-year-old man diagnosed wit

Совпадение в полном тексте источника
… His past medical history included chronic obstructive pulmonary disease (COPD) and chronic ischemic heart disease, for which he was receiving maintenance therapy with tiotropium two inhalations daily, bisoprolol 5 mg once daily, and amlodipine/valsartan/hydrochlorothiazide 160/10/12.5 mg once daily. …

Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.

Rhabdomyolysis (RML), characterized by the breakdown of skeletal muscle fibers and the release of muscle contents into the bloodstream, has emerged as a notable complication associated with Coronavirus disease 2019 (COVID-19) infection and vaccination. Studies have reported an increased incidence of RML in individuals with severe COVID-19 infection. However, the exact mechanisms remain unclear and are believed to involve the host's immune response to the virus. Furthermore, RML has been documented as a rare adverse event following COVID-19 vaccination, particularly with mRNA vaccines. Proposed

Совпадение в полном тексте источника
… The patient was on Lisinopril, Hydrochlorothiazide, Metformin with positive past myotoxic DH. The patient had a CK level of 426,700 and creatinine of 12.03. … He expired. | ( 100 ) Singh et al. (2020) | A 37-year-old male with hypertension, on Amlodipine, Clonidine, Hydrochlorothiazide, and Furosemide, presented with fever, myalgia, dyspnea, and altered mental status. …

Renal failure due to primary amyloidosis: a case report and literature review.

ContextPrimary amyloidosis, also known as AL amyloidosis, is commonly caused by clonal expansion of plasma cells in the bone marrow, thereby segregating light chains of clonal immunoglobulin that settle in tissues in the form of insoluble amyloid fibrils. The aim of this study was to report a case of primary amyloidosis with renal failure, diagnosed in Hospital São João, Porto, Portugal, focusing on the diagnostic difficulties and presenting a literature review.Case reportA 68-year-old Caucasian man was admitted to the Internal Medicine Department of the hospital with a condition of anasarca a

Совпадение в полном тексте источника
… He was medicated with lisinopril in association with hydrochlorothiazide, lorazepam, finasteride, lansoprazole and furosemide. While under observation, he seemed to be aware, well-oriented and cooperative in time and space, and was hemodynamically stable. …

Колониальная ишемия без мезентерического оккулирования: случай, имплицитирующий интерферон-β.

Интерфероны типа I являются широко используемыми иммунодуляторными агентами. Интерферон-α (интерферон-α) связан с ишемическим колитом, но случаи, связывающие интерферон-β (IFN-β) с ишемическим колитом, редки. Мы представляем 66-year-old Женщина с множественным склерозом лечила IFN-β, у которой возникли острая боль в животе и диарея. Воображение продемонстрировало правую колонную воспаление пневматозом. Колоноскопия с биопсией тканей подтвердила ишемический колит, несмотря на патентную мезентерическую васкулатуру на ангиографической съемке. Ее симптомы устранены после прекращения действия IFN-β

Совпадение в полном тексте источника
… Home medications included aspirin 81 mg daily, bisoprolol-hydrochlorothiazide, metformin, tirzepatide, pravastatin, verapamil, and pantoprazole. The patient was not receiving anticoagulation at presentation. She denied tobacco use or other identifiable precipitating factors. …

Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure.

Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations

Совпадение в полном тексте источника
… Her current medications included clonazepam, amlodipine, L-thyroxin, metformin, repaglinide, spironolactone, furosemide, minoxidil, irbesartan, hydrochlorothiazide, acyclovir, pantoprazole, and fenofibrate. …

Severe Hypocalcemia due to Denosumab in Metastatic Prostate Cancer.

Denosumab is a monoclonal antibody used for prevention of skeletal-related events (SREs) in patients with bone metastases from solid tumors. Hypocalcemia is a rare and dangerous side effect of the drug Denosumab. We present a case of a patient with metastatic prostate cancer who developed severe hypocalcemia after the administration of the drug. The patient's vitamin D levels were low when checked after administration of the drug, which likely predisposed him to the development of hypocalcemia. He was placed on high doses of oral and intravenous (IV) calcium and vitamin D without any appreciab

Совпадение в полном тексте источника
… He continued to have worsening lower-extremity edema, for which he was started on treatment with hydrochlorothiazide (HCTZ) to help with diuresis as well as with the hypocalcemia. His renal function kept worsening during his hospital stay and his creatinine reached 4.12 mg/dL. …

Gestational Pityriasis Rosea: Suggestions for Approaching Affected Pregnant Women.

Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivatio … : a. Exposure to drugs prior to the development of the rash (biologic agents, captopril, clonidine, hydrochlorothiazide, atenolol, lamotrigine, nortriptyline, barbiturates, metronidazole, terbinafine, omeprazole, non-steroidal anti-inflammatory drugs, and isotretinoin), which are capable of inducing a pityriasis rosea-like eruption (6) and b. Disorders included in th …

Pharmacological interventions for hypertension in children.

BACKGROUND: Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data … 20 mmHg 95% CI -7.12 to 0.72) (low-quality evidence). Beta blocker/diuretic combination (Bisoprolol/hydrochlorothiazide, one trial, n = 94)when compared with placebo , did not result in a significant reduction in systolic blood pressure (-4.0 mmHg, 95% CI -8.99 to -0.19) but did have an effect on diastolic blood pressure (-4.50 mmHg, 95% CI -8.26 to -0.74) (low-quali …

Cochrane in context: pharmacological interventions for hypertension in children.

BACKGROUND: Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data … fidence interval .7.12 to 0.72) (low-quality evidence). ..-Blocker-diuretic combination (bisoprolol/hydrochlorothiazide, one trial, n=94) when compared with placebo did not result in a significant reduction in systolic blood pressure (.4.0 mmHg, 95% confidence interval .8.99 to .0.19), but did have an effect on diastolic blood pressure (.4.50 mmHg, 95% confidence int …

Pharmacological interventions for hypertension in children.

BACKGROUND: Hypertension is a major risk factor for stroke, coronary artery disease and kidney damage in adults. There is a paucity of data … 20 mmHg 95% CI -7.12 to 0.72) (low-quality evidence). Beta blocker/diuretic combination (Bisoprolol/hydrochlorothiazide, one trial, n = 94)when compared with placebo , did not result in a significant reduction in systolic blood pressure (-4.0 mmHg, 95% CI -8.99 to -0.19) but did have an effect on diastolic blood pressure (-4.50 mmHg, 95% CI -8.26 to -0.74) (low-quali …

NITROSOGENESIS OF SKIN (HUMAN) CANCER- THE HIDDEN TRUTH OF A NEVERENDING STORY: NITROSAMINE CONTAMINATION IN OLMESARTAN, VALSARTAN AND HCT AS MAIN RISK FACTOR FOR THE DEVELOPMENT OF KERATINOCYTE CANCER.

The pathogenesis of skin cancer remains shrouded in mystery. Nevertheless, a substantial amount of new data is now available to provide a lo … been taking 2 sartans (valsartan/ olmesartan) over the years as monotherapy and in combination with hydrochlorothiazide, who developed over time and within this intake two forms of keratinocytic cancer: verrucous carcinoma and basal cell carcinoma. The focus of discussion concerns a newly introduced medical concept: nitrosogenesis of skin cancer. The detailed study o …