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Doxycycline inhibition of interleukin-1 in the corneal epithelium.

PURPOSE: To evaluate the effect of doxycycline on the regulation of interleukin (IL)-1 expression and activity in human cultured corneal epithelium. METHODS: Human corneal limbal epithelium (HLE) was cultured from explants prepared from limbal rings of donor corneas. Primary cultured limbal epithelial cells were treated with either 10 microg/ml lipopolysaccharide (LPS), LPS with 10 microg/ml doxycycline, or LPS with 0.1 mg/ml methylprednisolone (MP) for 24 hours. The intracellular and supernatant protein amounts of IL-1alpha, the precursor and mature forms of IL-1beta, IL-1 receptor antagonis…

[Chemotherapeutic effectiveness of doxycycline in experimental Q fever].

Comparative chemotherapeutic efficacy of doxycycline administered orally or parenterally was studied on a model of experimental Q fever in guinea pigs and albino mice. The advantage of the parenteral use of the antibiotic was observed only in the treatment of the albino mice. Optimization of the doses and time of doxycycline use providing the maximum therapeutic effect and the required levels of the complement binding antibodies was achieved with employing the multifactorial analysis.

[Treatment of cutaneous leishmaniasis with methacycline and doxycycline (vibramycin)].

Sixty-nine patients suffering from acute necrotic cutaneous leishmaniasis have been effectively treated with methacycline, 60 ones with doxycycline. Many parameters of these drug's efficacies are similar to those of monomycin, the most active drug for cutaneous leishmaniasis. Therapy with the afore-said antibiotics, in combination with methyluracil, an immunocorrecting drug, is a simple and available effective method, that may be used for outpatient treatment of leishmaniasis patients.

Influence of milk on the bioavailability of doxycycline--new aspects.

This study was conducted to examine the pharmacokinetics of doxycycline in nine healthy volunteers who had fasted overnight. Single-dose cross-over design was used. Each subject received orally 0.2 g doxycycline. The subjects swallowed the antibiotic capsules with 300 ml of water or 300 ml of fresh milk. Simultaneous ingestion of milk diminished the peak plasma concentration by 24% and the absorption by 9-53% (mean 30%). It is concluded that, like the other tetracyclines, doxycycline should not be administered together with milk.

Randomized treatment of mucopurulent cervicitis with doxycycline or amoxicillin.

A randomized trial of doxycycline versus amoxicillin was performed to treat mucopurulent cervicitis. Chlamydia trachomatis, the most common single agent associated with mucopurulent cervicitis, was isolated from 30 (47%) and Neisseria gonorrhoeae from five (8%) of 64 patients. Patients were followed up for 3 months, and the effect of treatment was assessed by clinical (presence of endocervical mucopus, cervicitis severity score, and number of polymorphonuclear leukocytes on Gram-stained smears of endocervical secretions) and microbiologic criteria. Doxycycline and amoxicillin were equally effe…

A retrospective study of doxycycline in the treatment of genitourinary infections.

A retrospective study was conducted to assess the prevalence of Chlamydia trachomatis, Ureaplasma ureolyticum, and Mycoplasma sp in patients with suspected genital infection, and to assess the efficacy of doxycycline and other current antibiotic therapies. Over a three-year period, 1,048 records of patients (64% female; 36% male) were reviewed. C trachomatis, U ureolyticum, or Mycoplasma hominis was found in 39% of the men and 49% of the women. Other pathogens included Gardnerella vaginalis (in 21%), Candida albicans (in 12%), Neisseria gonorrhoeae (in 4%), and Trichomonas vaginalis (in 1%). D…

Doxycycline in the treatment of chlamydial urethritis: a therapeutic study.

The effect of doxycycline treatment was studied in 46 men with chlamydial non-gonococcal urethritis. Treatment with 200 mg doxycycline daily for 10 days rendered 22 of 22 patients free of urethritis. The treatment had no effect on the complications of urethritis like prostatitis and Reiter's syndrome. In the other group where 200 mg doxycycline was given on the first day and 100 mg on the subsequent days for 8 days, urethritis was resolved in 18 of 22 patients. C. trachomatis was not re-isolated from any of the patients after doxycycline treatment.

Treatment of chronic prostatitis. Comparison of Minocycline and Doxycycline.

The results of minocycline and doxycycline therapy in 41 patients with chronic prostatitis and minocycline therapy in 6 patients with acute prostatitis were evaluated. In the comparative study of chronic prostatitis, minocycline and doxycycline were given on the same dosage schedule, milligram for milligram: a loading dose of 200 mg. followed by 100 mg. twicd daily. Over-all clinical responses to therapy with either agent were generally satisfactory, and no statistically significant difference was demonstrable in this regard. In the group with chronic prostatitis treated wtih minocycline, howe…

Doxycycline as an antimalarial: Impact on travellers' diarrhoea and doxycycline resistance among various stool bacteria - Prospective study and literature review.

BACKGROUND: Antibiotics predispose travellers to acquire multidrug-resistant bacteria, such as extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE). Although widely used in antimalarial prophylaxis, doxycycline has scarcely been studied in this respect. METHODS: We explored the impact of doxycycline on rates of traveller's diarrhoea (TD), ESBL-PE acquisition and, particularly, doxycycline co-resistance among travel-acquired ESBL-PE in a sample of 412 visitors to low- and middle-income countries. We reviewed the literature on traveller studies of doxycycline/tetracycline resis…

Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention.

Consider prescribing doxycycline as prophylaxis for bacterial sexually transmitted infections (STIs) in certain clinical scenarios. New data suggests that a one-time dose of 200 mg doxycycline taken within 72 hours of an unprotected sexual encounter may reduce transmission of syphilis, gonorrhea and chlamydia by a combined two thirds in a high-risk population.

Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections.

BACKGROUND: Interventions to reduce sexually transmitted infections (STIs) among men who have sex with men (MSM) are needed. METHODS: We co … or syphilis in the past year. Participants were randomly assigned in a 2:1 ratio to take 200 mg of doxycycline within 72 hours after condomless sex (doxycycline postexposure prophylaxis) or receive standard care without doxycycline. STI testing was performed quarterly. The primary end point was the incidence of at least one STI per follow-up quarter. RESULT …

Doxycycline-Induced Acute Pancreatitis: A Rare Adverse Event.

Doxycycline is a broad-spectrum antibiotic belonging to the tetracycline group which acts by inhibiting bacterial protein synthesis. It is considered to be a relatively safe drug. We report a case of doxycycline-induced acute pancreatitis (DIAP) in an adult female patient who was started on the usual therapeutic dose 1 week before for acne vulgaris. The WHO causality assessment was possible, and the Naranjo scale confirmed it as "definite" adverse drug reaction. A brief literature review on case reports previously reporting DIAP has also been summarized.

Азитромицин против Доксициклина для врожденной хламидии трахоматиза.

Врожденная инфекция хламидии трахоматиса по-прежнему широко распространена и вызывает значительную репродуктивную заболеваемость. Недавние исследования вызвали обеспокоенность по поводу эффективности азитромицина для лечения хламидиозной инфекции. МЕТОДЫ: Мы провели случайное испытание с целью сопоставления перорального азитромицина с доксициклином для лечения люминесцентной хламидии среди подростков в исправительных учреждениях для оценки неинфекционности азитромицина (1 г в одной дозе) и доксициклина (100 мг дважды в день в течение 7 дней). Лечение было непосредственно замечено. Основными ко

Совпадение в аннотации оригинала
BACKGROUND: Urogenital Chlamydia trachomatis infection remains prevalent and causes substantial reproductive morbidity. Recent studies have raised concern about the efficacy of azithromycin for the treatment of chlamydia infection. METHODS: We conducted a randomized trial comparing oral azithromycin with doxycycline for the treatment of urogenital chlamydia…

Newly acquired Onchocerca volvulus filariae after doxycycline treatment.

Despite successful mass drug administration and vector control programs, the nematode Onchocerca volvulus is far from being eradicated. Therefore, new long-term sterilizing or macrofilaricidal drugs are needed. The depletion of Wolbachia endobacteria using doxycycline leads to long-term sterilizing effects and macrofilaricidal activity against female filariae of more than 60%. The worms die or degenerate 18-27 months after doxycycline. However, during this time patients may be exposed to new infections. We evaluated these newly acquired worms in onchocercomas of doxycycline-treated patients in…

Doxycycline versus doxycycline and rifampin in undifferentiated spondyloarthropathy, with special reference to chlamydia-induced arthritis. A prospective, randomized 9-month comparison.

OBJECTIVE: Chlamydia is a known trigger of reactive arthritis (ReA). It may also be common cause of undifferentiated spondyloarthropathy (uS … e is noted when rifampin is added to antimicrobials that are active against Chlamydia. Rifampin and doxycycline also show synergistic effect against Chlamydia. In addition, rifampin inhibits chlamydial production of heat shock proteins (HSP). HSP60 plays a key role in the chronic persistent state of Chlamydia. We conducted a prospective, randomized 9-month tr …