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Antitumoral Agent-Induced Constipation: A Systematic Review.

BackgroundConstipation is a common symptom in patients receiving antitumoral treatment. The mechanisms underlying antitumoral agent-induced constipation (ATAIC) are poorly defined. This systematic review aimed to analyze and synthesize the available information related to the prevalence, etiology, and treatment of ATAIC.MethodsA systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines was conducted. The review included human studies written in English, French, or Spanish involving patients with cancer and containing information abou

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… The retrospective studies reported the use of prophylactic laxatives and lubiprostone [ 27 , 60 ]. The case report explained the benefits of metoclopramide in a patient with ileus secondary to vincristine [ 6 ]. The main contents are explained in Table 4 . 4. … Effect of lubiprostone on vinca alkaloid–induced constipation in patients with hematological malignancies: A propensity score–Matched analysis. Ann. Hematol. 2020;99:2429–2436. doi: 10.1007/s00277-020-04222-z. 28. Gay F., Palumbo A. Multiple myeloma: Management of adverse events. Med. …

Issues Related to the Frequency of Exploratory Analyses by Evidence Review Groups in the NICE Single Technology Appraisal Process.

BackgroundEvidence Review Groups (ERGs) critically appraise company submissions as part of the National Institute for Health and Care Excellence (NICE) Single Technology Appraisal (STA) process. As part of their critique of the evidence submitted by companies, the ERGs undertake exploratory analyses to explore uncertainties in the company's model. The aim of this study was to explore pre-defined factors that might influence or predict the extent of ERG exploratory analyses.ObjectiveThe aim of this study was to explore predefined factors that might influence or predict the extent of ERG explora

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… treating relapsing-remitting multiple sclerosis TA313 Ustekinumab for treating active psoriatic arthritis TA315 Canagliflozin in combination therapy for treating type 2 diabetes TA316 Enzalutamide for metastatic hormone-relapsed prostate cancer previously treated with a docetaxel-containing regimen TA318 Lubiprostone … relapsing-remitting multiple sclerosis TA313 | Ustekinumab for treating active psoriatic arthritis TA315 | Canagliflozin in combination therapy for treating type 2 diabetes TA316 | Enzalutamide for metastatic hormone-relapsed prostate cancer previously treated with a docetaxel-containing regimen TA318 | Lubiprostone …

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations.

BackgroundAmyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under-recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis. This comprehensive systematic review aimed to summarize current literature on GI and hepatic manifestations of amyloidosis, highlighting diagnostic and management strategies across the major subtypes of amyloidosis, in particular AL (immunoglobulin light chain), ATTR (transthyretin), and AA (serum amylo

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… used in outpatient setting in severe diarrhea or consideration of long acting alternative such as lanreotide Constipation | Osmotic laxatives, in particular polyethylene glycol (macrogel, up to 13–80 mg daily) Alternatives: Lactulose 15–60 mL daily Picosulfate 10–20 drops daily In refractory cases: lubiprostone … In ATTRv amyloidosis, dietary modifications and increased fiber intake are often insufficient [ 25 ] Lubiprostone, prucalopride, and linaclotide, though not specifically studied in AL or AA amyloidosis, are reasonable options in refractory cases [ 25 ]. …

Correlation between Constipation Symptoms and Abdominal CT Imaging: A Cross-Sectional Pilot Study.

Evaluation of chronic constipation is important, although it is often difficult to satisfactorily treat due to the complex interplay of factors. This study aimed to determine whether the volume of intraluminal contents and lateral diameter of the colon measured from computed tomography (CT) images were correlated with the symptoms of chronic constipation and stool consistency. Consecutive patients who underwent the Constipation Scoring System (CSS), Bristol Stool Form Scale (BSFS) questionnaires and simple abdominal CT were selected retrospectively. The intestinal tract diameter at each site w

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… Laxative users were those who had taken any laxatives (bulk-forming laxatives, osmotic laxatives, carbohydrate laxatives, irritant cathartic, lubiprostones, linaclotides, elobixibat hydrate, herbal medicine) daily for more than 8 weeks. 2.5. …

Diffuse large B cell lymphoma originating from the maxillary sinus with skin metastases: A case report and review of literature.

BackgroundDiffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma (ML), accounting for 30%-40% of cases of non-Hodgkin's lymphoma (NHL) in adults. Primary paranasal sinus lymphoma is a rare presentation of extranodal NHL that accounts for only 0.17% of all lymphomas. ML from the maxillary sinus (MS) is a particularly rare presentation, and is thus often difficult to diagnose. We have reported the first known case of DLBCL originating from the MS with rapidly occurrent multiple skin metastasis.Case summaryAn 81-year-old Japanese man visited our hospital due to contin

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… He was given 15 mg of mosapride, 75 mg of clopidogrel, 20 mg of esomeprazole magnesium, 4 mg of benidipine, 5 mg of linagliptin, 1500 mg of metformin, and 24 µg of lubiprostone on a regular basis. Personal and family history The patient had no history of smoking or drinking alcohol. …

An approach to treating older adults with chronic kidney disease.

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… judiciously in such patients, and can help excrete potassium with or without added potassium binders. 29 Sorbitol and phosphate-based enemas should be avoided, and magnesium-based laxatives should be used with caution, given the risk of hypermagnesemia. 27 Newer agents such as secretagogues (linaclotide and lubiprostone …

Opioid-Induced Constipation among a Convenience Sample of Patients with Cancer Pain.

BACKGROUND: Little is known regarding the burden of opioid-induced constipation (OIC) among patients who suffer from cancer-related pain. METHODS: A prospective longitudinal study was conducted among cancer patients in the United Kingdom (UK), Canada, and Germany, which included medical record data abstraction, Internet-based patient surveys, and physician surveys. Patients on daily opioid therapy (≥30 mg for ≥4 weeks) for treatment of cancer pain with self-reported OIC were recruited. Response to laxatives was defined by classifying participants into categories of laxative use and evaluating

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… (MiraLAX ® , Dulcolax ® balance)], stimulants [bisacodyl (Ducolax ® laxative), senna (Senokot ® , Exlax ® )], salines [magnesium hydrochloride (Milk of Magnesia ® , Citroma ® )], rectal options (suppositories, enemas), and prescription therapies [polyethylene glycol 3350, lactulose (Constulose ® ), Lubiprostone …

Нейрогенная желудочно-кишечная, мочевая и сексуальная дисфункция при множественном склерозе: многодисциплинарная основа для клинической практики.

Нейрогенные желудочно-кишечные, мочевые и сексуальные симптомы широко распространены у людей с множественным склерозом и существенно ухудшают качество жизни, повседневное функционирование и психосоциальное благополучие. Несмотря на их частотность и клиническую актуальность, управление по-прежнему носит разрозненный характер по различным специальностям, тесная взаимосвязь между этими симптомами зачастую игнорируется, а у клинических работников отсутствует прагматическая основа, адаптированная к различным условиям здравоохранения. Этот обзор преобразует нынешние данные в прагматичную модель уход

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… Data on intestinal secretagogues for constipation secondary to neurological disorders are limited (options include linaclotide, lubiprostone and plecanatide). …

Неделя ГЭЭ 2018 Презентации на плакате

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