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Lycopene restores the effect of ischemic postconditioning on myocardial ischemia‑reperfusion injury in hypercholesterolemic rats.

Ischemic postconditioning (IPoC) has been demonstrated to prevent myocardial ischemia‑reperfusion injury (MIRI), but its cardioprotective effect is abrogated by hypercholesterolemia. The aim of the present study was to determine whether lycopene (LP), a type of carotenoid, can restore the cardioprotective effect of IPoC in hypercholesterolemic rats. Male Wistar rats were fed a cholesterol‑enriched diet for 12 weeks to establish a hypercholesterolemic model. The rat hearts were isolated and subjected to 30 min ischemia and 60 min reperfusion using a Langendorff apparatus. LP was administered to…

Comparison of therapeutic response of lycopene and curcumin in oral submucous fibrosis: A randomized controlled trial.

OBJECTIVES: To evaluate and compare the therapeutic response of lycopene and curcumin with placebo in patients suffering from oral submucous fibrosis (OSMF) and to correlate the habit variables of smoked and smokeless tobacco products in OSMF. METHODS: A randomized placebo-controlled parallel clinical study was conducted on ninety OSMF patients, who were divided into three treatment groups using computer-generated randomization. Group A patients (n = 30) were given curcumin tablet (300 mg) twice daily, Group B patients (n = 30) received lycopene capsules (8 mg) twice daily, and for Group C (n…

The effects of lycopene on DNA damage and oxidative stress on indomethacin-induced gastric ulcer in rats.

BACKGROUND AND AIMS: Lycopene, the main antioxidant compound present in tomatoes, has high singlet oxygen- and peroxyl radicals-quenching ability, resulting in protection against oxidative damage in aerobic cell. Indomethacin is a nonsteroidal anti-inflammatory drug, and can promote oxidative damage in gastric tissue. The aim of this study was to investigate the protective effects of lycopene on an indomethacin-induced gastric ulcer model. METHODS: A total of 42 adult male Wistar rats were divided into six groups of seven animals as follows: control, indomethacin, lansoprazole, lycopene 10 mg…

Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat.

The aim of the study was to evaluate the androgen (AR) and estrogen receptors' (ER) expression in epididymis of polychlorinated biphenyls (PCBs)-exposed rats. The rats were assigned to groups. Group I controls were treated with corn oil 80 µL/d intraperitoneally (ip), group II were treated with 2 mg/kg/d of A1254 ip; and group III were treated with 2 mg/kg/d of A1254 ip along with simultaneous oral supplementation of 4 mg/kg/d lycopene . The treatment was given daily for 30 days. After 24 hours of treatment, the rats were killed, and the epididymal regions (caput, corpus, and cauda) were disse…

[Effect of lycopene on oxidative stress and behavioral deficits in rotenone induced model of Parkinson's disease].

OBJECTIVE: To investigate the neuroprotective potential of lycopene on oxidative stress and neurobehavioral abnormalities in rotenone induced Parkinson' disease (PD). METHODS: Forty adult C57BL/6 mice were randomly divided into four groups (n = 10): control, lycopene (10 mg/kg body weight, orally), rotenone (3 mg/kg bw, intraperitoneally) and rotenone plus lycopene, which were sacrificed for 5 weeks. The spectrophotometry was used to determine the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) and the content of malondialdehyde (MDA) in substantia ni…

Radioprotective effect of lycopene on chromosomal aberrations (CAs) induced by gamma radiation in human lymphocytes.

The present study was carried out to evaluate the radioprotective role of lycopene on chromosomal aberrations (CAs) induced by gamma (gamma) radiation in human lymphocytes. For this purpose, we used in vitro dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, tricentric, acentric, fragment and ring. Mitotic index (MI) and aberrant metaphase number (AMN) were also calculated. Nine groups of lymphocyte culture were prepared: (I) Control group did not received radiation or lycopene, (II) positive control; lymp…

Lycopene improves cisplatin induced hepatointestinal injury in rats by modulating the microbe-gut-liver axis.

Cisplatin (CIS) is a commonly used antitumor drug in clinics, but its application is limited due to hepatotoxicity, nephrotoxicity and gastrointestinal toxicity. In recent years, a large number of studies have shown that the imbalance of intestinal flora is one of the important factors in the malignant development of diseases. Therefore, improving organ function by regulating intestinal flora may be an important strategy to prevent the side effects of chemotherapy drugs. Lycopene (LYC) is found in a wide range of red foods and has antioxidant, anti-inflammatory and immune-enhancing effects. So…

Ликопен дополнил средиземноморские диеты экспериментальными аутоиммунными энцефаломелитами (EAE) в мышах и изменениями кишечного микробиома.

Цель этого исследования заключалась в определении воздействия средиземноморского рациона питания (MD) и ликопена на развитие EAE и на подстрекательские маркеры. В 43-day :: исследование, 72 Женский C57BL/6 Мыши были случайно разделены на eight группы в зависимости от того, были ли они EAE или наивными (контрольными) мышами, питались западной диетой или MD, и получали ли они ликопен. Во время исследования мышей кормили ад-либитумом, а ликопиновые группы - ликопинами. 10 мг/кг/сут ликопен на мышь каждый день 28 днями в оральной желудке. Мыши были забраны за EAE, принесены в жертву, и их селезенк

Совпадение в аннотации оригинала
This study aimed to determine the effects of the Mediterranean diet (MD) and lycopene on the development of EAE and on inflammatory markers. In the 43-day study, 72 female C57BL/6 mice were randomly divided into eight groups according to whether they were EAE or naive (control) mice, fed a Western diet or a MD, and whether they received lycopene. During the …

Lycopene Alleviates Endoplasmic Reticulum Stress in Steatohepatitis through Inhibition of the ASK1-JNK Signaling Pathway.

Lycopene has been proven to alleviate nonalcoholic steatohepatitis (NASH), but the precise mechanisms are inadequately elucidated. In this study, we found a previously unknown regulatory effect of lycopene on the apoptosis signal-regulating kinase 1 (ASK1) signaling pathway in both in vivo and in vitro models. Lycopene supplementation (3 and 6 mg/kg/day) exhibited a significant reduction in lipid accumulation, inflammation, and fibrosis of the liver in mice fed with a high-fat/high-cholesterol diet or a methionine-choline-deficient diet. RNA sequencing uncovered that the mitogen-activated prot…

Protective effect of lycopene against celecoxib induced fat deposition and glycogen reduction in liver cells.

OBJECTIVE: Oxidative stress develops because of a shift in the prooxidant-antioxidant balance toward the former, because of disturbances in redox signaling and control. Celecoxib (Cb), a selective COX-2 inhibitor, is a drug that effectively decreases pain and inflammation. However, Cb causes oxidative injury to hepatic tissues via enhanced lipid peroxidation, thus resulting in excessive production of reactive oxygen species. Consequently, frequent or long-term Cb use may lead to hepatic, renal, and other noticeable adverse effects. Lycopene (lyco), a potent antioxidant naturally occurring in p…

Comprehensive toxicity screening of Pazarsuyu stream water containing heavy metals and protective role of lycopene.

In this study, heavy metal pollution in the Pazarsuyu stream of Giresun province and the protective role of lycopene against the toxicity caused by this pollution were investigated using the Allium test. Germination percentage, root length and weight gain as physiological markers of toxicity; mitotic index (MI), micronucleus (MN) and chromosomal aberrations (CAs) as genetic markers of toxicity; malondialdehyde (MDA) level, superoxide dismutase (SOD) and catalase (CAT) activities as biochemical markers of toxicity, and meristematic cell damages were used as anatomical markers. For this aim Alli…

Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice.

As a plasticizer, di(2-ethylhexyl) phthalate (DEHP) is the most usually used phthalate. Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and masculinization by the androgens of synthesis and secretion. Numerous researchers have indicated that DEHP can result in testicular toxicity by inducing oxidative stress. Lycopene (LYC) is a possible treatment option for male infertility due to its natural antioxidant properties. Our study was aimed to investigate whether LYC could rescue DEHP-induced Leydig cell damage. The mice were treated with DEHP (500 mg/kg BW/day…

trans-Lycopene from tomato juice attenuates inflammatory biomarkers in human plasma samples: An intervention trial.

SCOPE: The effect of carotenoids from tomato juice (TJ) on inflammatory biomarkers was evaluated by performing a 4-week dose-response nutrit … lower (p ˂ 0.001), after each TJ intervention. Decreases were correlated remarkably with the trans-lycopene, while the other carotenoids present in TJ have presented a minor association or no association with changes in these molecules. CONCLUSION: trans-Lycopene from TJ may attenuate the risk of cardiovascular disease by reducing the concentration of im …

Selenium and lycopene attenuate cisplatin-induced testicular toxicity associated with oxidative stress in Wistar rats.

OBJECTIVE: To investigate the potential protective effects of selenium and lycopene, either alone or in combination, for cisplatin-induced oxidative stress and testicular dysfunction in male rats. METHODS: A total of 50 adult male Wistar rats were divided into 5 groups of 10 animals each, as follows: control group (treated with placebo); cisplatin-alone group; cisplatin + lycopene group; cisplatin + selenium group; and cisplatin + selenium + lycopene group. The weights and dimensions of testes, epididymes, and accessory glands as well as sperm concentration, motility, and proportion of normal…

Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects.

AIM: To evaluate the efficacy of antioxidant lycopene in preventing pre-eclampsia in healthy primigravidas. METHODS: A prospective randomized double blind placebo-controlled study was undertaken with informed written consent. A total of 159 primigravidas at gestational ages between 12 and 20 weeks, with singleton pregnancy and without any medical disorders were enrolled. Seventy-seven (subjects) of these women received 2 mg oral lycopene daily and 82 (controls) received a placebo daily until delivery. The women were followed up until delivery for the development of pre-eclampsia and maternal,…

Lycopene: An antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes.

The present study aimed to evaluate the radioprotective effect of lycopene, a naturally occurring dietary carotenoid on gamma-radiation-induced toxicity. The cellular changes were estimated by using lipid peroxidative indices like thiobarbituric acid reactive substances (TBARS), hydroperoxides (HP), the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH). The DNA damage was analyzed by cytokinesis blocked micronucleus assay (CBMN), dicentric aberration (DC) and translocation frequency. The gamma-radiation at different doses (1, 2 …

Cubosomal nanoparticles of lycopene as a novel platform for enhancement in antioxidant and anticancer properties with a molecular docking study.

Lycopene is the highest concentration of red, hydrophobic carotenoids in various fruits and vegetables. Because of low solubility and poor bioavailability, a delivery system must be utilized to have a prolonged target therapeutic site. The current research is focused on assessing the potential antioxidant and anticancer activity of Lycopene Cubosomal Nanoparticles against the HT-29 colon cancer cell line. The nanoformulation was ensured by various characterization methods, including FTIR, TEM, SEM, particle size, and zeta potential. The structure of Lycopene was energy-minimized and was docked…

Microbial Electrosynthetic Biohybrid System to Synergistically Supply Electrons and CO2 to Rhodopseudomonas palustris for Lycopene Production.

Microbial electrosynthesis (MES) systems aim to use electroactive microorganisms (EAMs) to achieve electricity-driven CO2 fixation for biosynthesis of multicarbon chemicals. However, the low efficiencies of extracellular electron transfer (EET) and CO2 assimilation of EAMs remain the essential limiting factors that restrict performance of MES systems. Herein, we developed an electrosynthetic biohybrid system to synergistically supply electrons and CO2 to Rhodopseudomonas palustris (an EAM) for lycopene biosynthesis. Intracellular carbon and energy fluxes were redirected by strengthening the ly…

Triphenylphosphonium-functionalised cubosomes for mitochondrial-targeted delivery of 5-fluorouracil and lycopene in skin cancer therapy.

The importance of mitochondria in cancer is undeniable, as they serve as a vital centre for energy metabolism and regulating apoptosis. Herein, we engineered cubosomes as a nanocarrier with encapsulation of the chemotherapeutic agent 5-fluorouracil and an antioxidant with reported antitumor activity, lycopene. The formulation was fabricated by utilising glyceryl monooleate, oleic acid, and polaxamer-407, facilitating simultaneous encapsulation of hydrophobic lycopene and hydrophilic 5-fluorouracil. To target mitochondria, the nanoparticle surface was decorated with triphenylphosphine, a lipoph…

Negative impact of soluble, gel-forming dietary fibres on the bioaccessibility of β-carotene, lutein, and lycopene.

Carotenoids, including β-carotene, lutein and lycopene, the 3 main carotenoids present in our body, are lipophilic phytochemicals associated with several health benefits. Dietary fibre may influence the bioavailability of carotenoids by altering their release from the food matrix and their solubilisation into mixed micelles during digestion and thus their subsequent absorption by enterocytes. We examined the dose-dependent influence of major soluble (pectin, guar, alginate, fructooligosaccharides,) and insoluble dietary fibres (cellulose, type-2 resistant starch) at nutritional relevant doses …