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Feature fusion Siamese network for breast cancer detection comparing current and prior mammograms.

PURPOSE: Automatic detection of very small and nonmass abnormalities from mammogram images has remained challenging. In clinical practice fo … ages only (ResNet and VGG) and also use current and prior images (long short-term memory [LSTM] and vanilla Siamese) in terms of accuracy, sensitivity, precision, F1 score, and area under the curve (AUC). Results show that the proposed models outperform the baseline models and the proposed model with the distance learning network performs the best (accura …

SimBinder-IF: Structure-Aware Antibody Affinity Optimization via Efficient Preference Learning.

MOTIVATION: Antibody therapeutic efficacy depends on high-affinity target engagement, yet laboratory affinity maturation is slow and costly. … nder-IF shows a 22% numerical increase in average Spearman correlation (0.26 to 0.32) compared with vanilla ESM-IF and outperforms ESM-IF on five of seven assays; however, the assay-level paired Wilcoxon test does not reach statistical significance (p = 0.188). For seed-averaged top-ranking enrichment, SimBinder-IF has the highest 20-fold improvement@20 m …

FSCL-BC: Federated supervised contrastive learning for breast cancer diagnosis with high sensitivity.

BACKGROUND AND OBJECTIVE: Accurate diagnosis of breast cancer in dense breasts requires expert radiologists to examine multiple ultrasound i … antially higher diagnostic performance - especially sensitivity - than standardized centralized and vanilla federated training, while providing intrinsic privacy protection. On average, compared to the best baseline, FSCL-BC improved sensitivity by 11.5%, Youden's J index by 7.2%, and F1 score by 3.7%. The improvements in MCC and balanced accuracy were mo …

Feasibility and Tolerability of Ketogenic Interventions in Amyotrophic Lateral Sclerosis-A Dose-Finding Case Series.

Background/Objectives: Weight loss and hypermetabolism are negative prognostic factors in amyotrophic lateral sclerosis (ALS). Ketone bodies … healthy subjects (once) and in patients (3×/day over 2 days). For the KD, KetoCal® 2.5:1 LQ MCT MF Vanilla (Nutricia, Frankfurt, Germany) was applied via percutaneous endoscopic gastrostomy over four weeks. Regular capillary βHB measurements were conducted, and adverse events were recorded. Results: Between January 2021 and March 2025, we treated nine pa …

Nonunitary Variational Quantum Eigensolver with the Localized Active Space Method and Cost Mitigation.

Accurately describing strongly correlated systems with affordable quantum resources remains a central challenge for quantum chemistry applic … th our measurement mitigation protocols, nuVQE becomes a cheaper and more accurate alternative than vanilla VQE with HEA. Taken together, these developments illustrate a practical pathway toward performing multireference chemical simulations with accuracy and affordable resources on today's quantum hardware, achieving both accuracy and affordability in ch …

Automated classification of nasal polyps in endoscopy video-frames using handcrafted and CNN features.

Nasal polyps are edematous polypoid masses covered by smooth, gray, shiny, soft and gelatinous mucosa. They often pose a threat for the patients to result in allergic rhinitis, sinus infections and asthma. The aim of this paper is to design a reliable rhinology assistance system for recognizing the nasal polyps in endoscopic videos. We introduce NP-80, a novel dataset that contains high-quality endoscopy video-frames of 80 participants with and without nasal polyps (NP). We benchmark vanilla machine learning and deep learning-based classifiers on the proposed dataset with respect to robustness…

Electronic Cigarette Liquid Constituents Induce Nasal and Tracheal Sensory Irritation in Mice in Regionally Dependent Fashion.

INTRODUCTION: Electronic cigarettes (e-cigs) are currently used by millions of adults and adolescents worldwide. Major respiratory symptoms, … mixtures, and tussigenic stimuli. Also, mice were subjected to inhalation exposure to aerosol of a vanilla-flavored e-liquid or air (control), and the activated-trigeminal nociceptive neurons and brainstem neurons were examined using immunohistochemistry. RESULTS: Individual constituents and mixtures of e-liquids, capsaicin, and citric and acetic acids …

Vanillin and vanillin analogs relax porcine coronary and basilar arteries by inhibiting L-type Ca2+ channels.

Vanillin (VA) and vanillyl alcohol (VAA), components of natural vanilla, and ethyl vanillin (EtVA; synthetic analog) are used as flavoring agents and/or as additives by the food, cosmetic, or pharmaceutic industries. VA, VAA, and EtVA possess antioxidant and anti-inflammatory properties, but their vascular effects have not been determined. Therefore, we compared in isolated porcine coronary and basilar arteries the changes in isometric tension caused by VA, VAA, and EtVA. VA and its analogs caused concentration-dependent relaxations of both preparations during contractions from U46619 (9,11-di…

Outbreak of staphylococcal food intoxication after consumption of pasteurized milk products, June 2007, Austria.

On June 13, 2007, the public health authority informed the Austrian Agency for Health and Food Safety about 40 children from two neighboring … en (16.2%) at the 10 institutions fulfilled the case definition. Consumption of milk, cacao milk or vanilla milk originating from dairy X was associated with a 37.8 times higher risk of becoming a case (95% CI: 2.3-116.5). Unopened milk products left over at the affected institutions yielded staphylococcal enterotoxins A and D. Six out of 64 quarter milk …

Improving the Analysis of E-Cigarette Emissions: Detecting Human "Dry Puff" Conditions in a Laboratory as Validated by a Panel of Experienced Vapers.

INTRODUCTION: E-cigarette product regulation requires accurate analyses of emissions. User behavior, including device power setting selectio … alog scale (VAS). They assessed e-cigarettes equipped with 1.2 Ω or 1.6 Ω coils containing menthol, vanilla or fruit-flavored e-liquids. In a machine-vaping experiment, emissions from the same liquid/coil/power setting combinations were subjected to HPLC-DAD analysis of dinitrophenol hydrazine (DNPH)-derivatized carbonyls, such as lactaldehyde and formald …

Self-paced DenseNet with boundary constraint for automated multi-organ segmentation on abdominal CT images.

Automated multi-organ segmentation on abdominal CT images may replace or complement manual segmentation for clinical applications including … y superior to the average DSC of 63.12% and 76.35% and average ASD of 3.87 mm and 4.33 mm using the vanilla DenseNet, respectively, for the two organs. We demonstrated the effectiveness of the proposed self-paced DenseNet to automatically segment abdominal organs with low boundary conspicuity. The self-paced DenseNet achieved consistently superior segment …

Perceived Sensory Characteristics of Blended and Ambiguous "Concept" Flavors Among Adolescent and Young Adult E-cigarette Users.

INTRODUCTION: Flavors with names describing blended tastes/sensations or with ambiguous terminology ("concept flavors") are available on the … Ice, Iced Mango, Melon Ice, Blue B Ice, Cool Cucumber, Lush Ice, and Menthol Purple); sweet (Vivid Vanilla) and mint (Mint-sation). RESULTS: Most respondents had used at least one product with blended descriptors (74.8%) or concept flavor (57.9%) in the past 30 days. All flavors had high perceived strength for at least two sensory attributes. Mint taste …

Weakly supervised video-based cardiac detection for hypertensive cardiomyopathy.

INTRODUCTION: Parameters, such as left ventricular ejection fraction, peak strain dispersion, global longitudinal strain, etc. are influenti … ertensive cardiomyopathy detection in the test data set, and outperformed the corresponding 3D CNN (vanilla I3D: ACC (0.90), AUC (0.89), SEN (0.94), and SPE (0.84)). On the whole, the video-based methods remarkably appeared superior to the image-based methods, while few evaluation metrics of image-based methods exhibited to be more compelling (sensitivity …

Safety of lotilaner flavoured chewable tablets (CredelioTM) after oral administration in cats.

BACKGROUND: Lotilaner is a new member of the isoxazoline class for treatment of flea and tick infestations in cats. This laboratory study with lotilaner vanilla-yeast flavoured chewable tablets (CredelioTM, Elanco) investigated the safety in healthy kittens starting at 8 weeks of age in a randomized, blinded, parallel-group design. Lotilaner tablets were given orally once a month over eight months at one, three and five times the upper level of the maximum recommended dose range (26 mg/kg). METHODS: The safety of lotilaner flavoured chewable tablets was assessed in healthy kittens when admini…

Genotype X Environment Interaction and Stability of Quinoa (Chenopodium quinoa, Willd.) Genotypes for Yield and Yield-Related Traits in Ethiopia.

Agriculture is the pillar of Ethiopia's economy, employing over 80% of the population. However, it remains highly vulnerable to the impacts … the ASV, the most stable genotypes were 'Amarilla Sacaca', 'Amarilla Maranganí', 'Bio-bio', 'Cherry Vanilla', 'Multi-Hued', and 'Brightest Brilliant Rainbow'. The GGE biplot identified 'Brightest Brilliant Rainbow' and the Holeta location as the most ideal genotype and testing environment, respectively. 'Multi-Hued' and 'Brightest Brilliant Rainbow' emerg …

RC-Mamba: regime-conditioned selective state-space models for probabilistic time-series forecasting.

Selective state-space models (SSMs) such as Mamba achieve linear-time sequence modeling through input-dependent recurrence, yet they apply t … ), RC-Mamba achieves a mean Continuous Ranked Probability Score (CRPS) of 0.00532, improving on the Vanilla Temporal Fusion Transformer by 4.7 %, DeepAR by 8.9 %, S-Mamba by 15.2 %, and an HMM-conditioned DeepAR by 18.5 %. All models share robust-MAD preprocessing, a common ceiling of 11,450 optimizer updates with validation-based early stopping, and a 30 …

Нейроинфламмация вызывает митральную дисфункцию клеток и обонятельное расстройство в множественной склерозовой модели.

Олокационная дисфункция является недооцененным симптомом множественного склероза (МС). Здесь мы изучили патогенные механизмы, лежащие в основе вызванной воспалением дисфункции обонятельной луковицы, используя животную модель MS, экспериментальный аутоиммунный энцефаломиелит (EAE). Результаты: Сокращенная обонятельная функция в EAE была связана с дегенерацией короткоаксоновых нейронов, незрелых нейронов, а также как митральных, так и тушёных клеток наряду с их синаптическим взаимодействием и аксонным репертуаром. Чтобы расчленить механизмы, лежащие в основе восприимчивости митральных клеток, гл

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… In trial 2, we applied vanilla to hole 1 and no odor (control condition) to hole 2. In trial 3, almond was applied to hole 2, with vanilla reapplied to hole 1. … EAE mice revealed a significantly reduced preference for the unfamiliar odor vanilla (Fig.  1 B) and almond (Fig.  1 C) compared to healthy mice. …

Semi-supervised learning framework with shape encoding for neonatal ventricular segmentation from 3D ultrasound.

BACKGROUND: Three-dimensional (3D) ultrasound (US) imaging has shown promise in non-invasive monitoring of changes in the lateral brain vent … used as metrics for comparing to other benchmarks. The baseline benchmark was the fully supervised vanilla 3D U-Net while dual task consistency, shape-aware semi-supervised network, correlation-aware mutual learning, and 3D U-Net Ensemble models were used as state-of-the-art benchmarks with DSC, MAD, and VD as comparison metrics. The Wilcoxon signed-rank …

FastSurfer-LIT: Инфракрасный инструмент для разделения всего мозга на МРТ с опухолями, пятнами и аномалиями.

Кривые резекции, опухоли и другие повреждения могут коренным образом изменить структуру мозга и вызвать аномалии в МРТ мозга. Если говорить конкретно, то для оценки воздействия опухолей, хирургических операций, химиотерапии/радиотерапии или лекарственных препаратов необходимо количественно оценить тонкие нейроатомные изменения в других, непосредственно не затронутых районах мозга. Однако эта важная задача решается лишь в ограниченном числе решений, в то время как многие стандартные газопроводы просто не поддерживают ненормальные образы мозга вообще. В этом документе мы представляем метод для п

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… For the second scenario (using FreeSurfer), failures occur when using vanilla FreeSurfer (no inpainting) (4/15) and SynthSR for inpainting (1/15). … For the FastSurfer combinations, LIT is fastest, followed by vanilla FastSurfer (no inpainting), VBG, and SynthSR. …

Синергическое регенеративное, иммунодуляционное и антивоспалительное воздействие ваниллина и адипозы производных стволовых клеток в животной модели купризонного склероза.

ЦЕЛИ: Ваниллин как потенциальный терапевтический агент наряду с трансплантацией нейротрофических факторов, отделяющих клетки, считается перспективным средством лечения неврологических расстройств. В этом исследовании последствия ваниллина в сочетании с трансплантацией стволовых клеток, полученных человеком, были оценены с точки зрения дифференциации олигодендроцитов, повторного сглаживания и улучшения моторных функций. МАТЕРИАЛЫ И МЕТОДЫ: Женский C57BL/6 Мышей кормили кухонной зоной.400 мг/кг/сут.) 5 неделями, чтобы вызвать MS. Демилинированные мыши были разделены на группы MS, MS/vanillin, MS

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… Vanillin (4-hydroxy-3-methoxybenzaldehyde), a phenolic compound and the most popular food flavoring, is extracted from the pods of the orchid Vanilla planifolia ( 19 - 21 ). … (Vanilla planifolia Andrews) lowers total blood glucose in alloxan-induced hyperglycemic mice Eur J Pharm Med Res 2019 6 314 316 26 Kumar R Sharma P Mishra PS Vanillin derivatives showing various biological activities Int J Pharmtech Res 2012 43 27 Praet J Guglielmetti C Berneman Z Van der Linden …