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Spatial lipidomics identifies α-synuclein-induced lipid changes in an AAV-induced Parkinsonian mouse model.

Parkinson's disease (PD) is characterized by Lewy body pathology, mainly consisting of accumulation of aggregated α-synuclein and lipid cont … ltered certain monosialotetrahexosylgangliosides (GM1s), sphingomyelins (SMs), and sulfated hexosyl ceramides (SHexCers; a.k.a. sulfatides). Glycerophospholipid changes followed a desaturation pattern: polyunsaturated fatty acid (PUFA)-containing species were decreased, while saturated and mono-unsaturated species were increased. Additionally, oxidized phos …

Decoding the diabetic transition: a lipidomic approach for biomarker discovery in an Indian cohort.

Type 2 diabetes mellitus (T2DM) is a significant public health burden in India, where the disease presents with unique clinical characterist … diabetic states, with the advanced diabetic group exhibiting the highest number of unique species. Ceramides (Cer) were detected across the glycemic spectrum and exhibited a distinct remodeling pattern. Partial least squares discriminant analysis identified 20 candidate lipid species with variable importance in projection scores > 1.0, prominently includin …

Heat therapy attenuates hepatic lipid accumulation via CSAD-driven metabolic reprogramming of fatty acid oxidation.

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) represents a significant global health challenge, predominantly managed through non-pha … that HT reduced diacylglycerol (DAG), triacylglycerol (TAG), free fatty acids (FFA), and saturated ceramides (CER); it also increased taurine levels, enhanced the utilization of vitamins B2, B5, and B6, and corrected amino acid imbalances. Furthermore, HT upregulated the expression of CSAD, ACADL, and ATP5A. In vitro studies demonstrated that heat treatmen …

Sphingolipids in Emotional Well-Being.

Emotional well-being is a multifactorial concept, which comprises not only life quality of human individuals, but also their mental and phys … ses that SLs mediate multiple components of emotional well-being. The most abundant brain SL types, ceramides and gangliosides, dynamically shape the composition of protein carrying cellular membranes and overall neuronal plasticity. Multiple studies show the contribution of SLs to normal brain functioning and corresponding beneficial behavioral phenotypes, …

Differential analysis of lipid profiles in natural Calculus Bovis and Bovis Calculus Sativus by UHPLC-MS/MS.

Natural Calculus Bovis (NCB) and Bovis Calculus Sativus (BCS) are both used clinically but exhibit different therapeutic effects, the materi … greater molecular diversity of intact GP (phosphatidylcholines and phosphatidylethanolamines), SP (ceramides), fatty acid-derived lipids (polyunsaturated N-acylethanolamines, PU-NAE), and sterol esters. In comparison, BCS exhibited a simplified profile dominated by GL, with reduced GP, SP and ST species, enrichment of lysophospholipids and bile acid-relate …

Intermittent fasting ameliorates diabetes-induced meibomian gland dysfunction in mice.

AIM: To investigate the effect of intermittent fasting (IF) on diabetes-induced meibomian gland dysfunction (MGD) in a mice model. METHODS: … of lipidomics indicated that IF can effectively modify the types and content of lipids, especially ceramides and cholesterol esters. Transcriptomic results suggested that IF effectively ameliorated cell death and modulated ion channels signaling. IF could ameliorate cell death which might be mediated by the calcium ion signaling pathway to mitigate diabete …

Средиземноморская модель диета при множестве склерозов: обзор с акцентом на иммуномтаболитах.

Множественный склероз (MS), наиболее часто встречающееся демиелинизирующее заболевание центральной нервной системы (CNS), характеризуется в его патогенезе взаимодействием механизмов, связанных с аберрантной иммунной реакцией, острым и хроническим воспалением, глиноводством и выживанием нейронов, что в конечном счете приводит к обезвоживанию, синаптической дисфункции и нейроаксональной потере. Экспериментальные модели, а также эпидемиологические наблюдения подтверждают гипотезу о роли питания в наступлении, активности и развитии болезни. Высказывалось мнение, что диеты западного типа могут быть

Совпадение в аннотации оригинала
Multiple Sclerosis (MS), the most common demyelinating disease of the Central Nervous System (CNS), is characterized in its pathogenesis by … itrate, itaconate, lactate, glutamate, glutamine, alfa-ketoglutarate, 2-hydroxyglutarate, fumarate, ceramides, whose turn-over reflects metabolic reprogramming of immune cells, might be viewed as significant regulators of cellular responses against either local or systemic noxious stimuli, both in the periphery and in the CNS. The present narrative review a …

ART26.12, an FABP5 Inhibitor, Shows Efficacy in Preclinical Psoriasis Models.

FABP5 is upregulated in psoriasis. This study assessed the efficacy of the potent, selective, and orally active FABP5 inhibitor ART26.12 in … s likely downstream of lipid modulation. Lipidomic analysis showed widespread modulation, including ceramides and linoleic acid derivatives. These data suggest that ART26.12 may be a potential psoriasis treatment.

Distinguishing the Metabolic Effect of Fetal and Adult Fibrinogen on Human Fibroblast Cell Culture by IR-MALDESI Mass Spectrometry Imaging.

Mass spectrometry imaging (MSI) of cells can elucidate metabolic changes with cellular and molecular specificity. Fibroblasts are mesenchyma … m and fibrinogen type were elucidated, with changes in many membrane lipids such as cholesterol and ceramides potentially contributing to the observed morphological effects of fibrinogen types on fibroblasts.

Obesity and Depression: A Pathophysiotoxic Relationship.

Obesity and depression are two of the most prevalent diseases with increasing trends worldwide; it has been some time since the first epidem … aptic plasticity); (4) lipid-derived neurotoxicity and mitochondrial stress (saturated fatty acids, ceramides, oxidative stress); and (5) gut-brain axis perturbations (microbiota dysbiosis, increased intestinal permeability, LPS-driven endotoxemia, altered short-chain fatty acids and tryptophan-kynurenine metabolism). We highlight how these convergent pathw …

Therapeutic implications for sphingolipid metabolism in metabolic dysfunction-associated steatohepatitis.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), a leading cause of chronic liver disease, has increased … dence suggests that the accumulation of lipid species derived from sphingolipid metabolism, such as ceramides, contributes significantly to the structural and functional tissue damage observed in more severe grades of MASLD by triggering inflammatory and fibrogenic mechanisms. In this context, MASLD can further progress to metabolic dysfunction-associated s …

Repetitive transcranial magnetic stimulation elicits weight loss and improved insulin sensitivity in type 2 diabetic rats.

BACKGROUND: Type 2 diabetes (T2D) accounts for the majority of diabetes incidences and remains a widespread global chronic disorder. Apart f … weight loss. Circulating serum lipid levels, including those of cholesteryl ester, tryglyceride and ceramides, were also reduced following rTMS application. RNA-seq analyses further revealed a changed expression profile of hepatic genes that are related to sterol production and fatty acid metabolism. Altered expression of hypothalamic genes that are related …

Glycolipidomics of Liver Flukes and Host Tissues during Fascioliasis: Insights from Mass Spectrometry Imaging.

Fascioliasis, a zoonotic disease caused by liver flukes of the genus Fasciola, poses significant health threats to both humans and livestock … teristic distribution patterns within the parasite depending on the fatty acid composition of their ceramides, notably including GSLs carrying very long-chain fatty acids. Additionally, GSL compositions within the tegument of immature versus adult parasites varied, suggestive of tissue remodeling upon maturation. AP-SMALDI MSI further enabled the identifica …

Divergent amino acid and sphingolipid metabolism in patients with inherited neuro-retinal disease.

OBJECTIVES: The non-essential amino acids serine, glycine, and alanine, as well as diverse sphingolipid species, are implicated in inherited … phingolipids. HSAN1 patients exhibited elevated serine, lower alanine, and a reduction in canonical ceramides and sphingomyelins compared to controls. Those patients diagnosed with both HSAN1 and MacTel showed the most significant decrease in circulating sphingomyelins. CONCLUSIONS: These results highlight metabolic distinctions between MacTel and HSAN1, e …

Dietary long-chain omega 3 fatty acids modify sphingolipid metabolism to facilitate airway hyperreactivity.

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients that can affect inflammatory responses. While n-3 PUFAs are generall … airway reactivity, that was not accompanied by inflammation. Lung and whole blood content of dihydroceramides, ceramides, sphingomyelins, and glucosylceramides were lower in mice fed the n-3 PUFA enriched diet consistent with lower sphingolipid synthesis. In contrast, phosphorylated long chain bases such as sphingosine 1-phosphate were increased. These find …

Applications of Lipidomics to Age-Related Musculoskeletal Disorders.

PURPOSE OF REVIEW: The goal of this review is to highlight the need for new biomarkers for the diagnosis and treatment of musculoskeletal di … icant dysregulation of lipids in aged muscle and bone, including alterations in diacylglycerols and ceramides. Studies have shown that alterations in some types of plasma lipids are associated with aging including reduced bone mineral density and the occurrence of osteoporosis. Musculoskeletal disorders are a major burden in our society, especially for olde …

Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer's Disease Transgenic Model.

PURPOSE: The induction of autophagy has recently been explored as a promising therapeutic strategy to combat Alzheimer's disease. Among many other factors, there is evidence that ceramides/dihydroceramides act as mediators of autophagy, although the exact mechanisms underlying such effects are poorly understood. Here, we describe how two dihydroceramide desaturase inhibitors (XM461 and XM462) trigger autophagy and reduce amyloid secretion by neurons. METHODS: Neurons isolated from wild-type and APP/PS1 transgenic mice were exposed to the two dihydroceramide desaturase inhibitors to assess the…

Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing.

Advancing age is associated with impairments in numerous physiological systems, leading to an increased risk of chronic disease and disabili … age and indicators of healthspan, including methionine and nitric oxide pathways, fatty acids, and ceramides. Overall, these results demonstrate that plasma metabolomics profiles in general, and amino acid and lipid metabolism in particular, are associated with ageing and indicators of healthspan in healthy adults.

Current and emerging concepts in atopic dermatitis pathogenesis.

Atopic dermatitis is a common skin disorder with a complex, evolving pathogenesis. Research on the pathogenesis has shifted from focusing pr … n ichthyosis vulgaris and atopic dermatitis, as well as reduced structural proteins and lipids (eg, ceramides), have been discovered as well. These alterations contribute to increased transepidermal water loss in addition to increased allergen exposure, resulting in debate over the "inside out" versus "outside in" theories-that is, the concept that immunity …

A Topographical Atlas of Shiga Toxin 2e Receptor Distribution in the Tissues of Weaned Piglets.

Shiga toxin (Stx) 2e of Stx-producing Escherichia coli (STEC) is the primary virulence factor in the development of pig edema disease shortl … gory III organs holding true for both genders. Dominant Gb3Cer and Gb4Cer lipoforms were those with ceramides carrying constant sphingosine (d18:1) and a variable C16:0, C22:0 or C24:1/C24:0 fatty acid. From the mapping data, we created a topographical atlas for Stx2e receptors in piglet tissues and organs, which might be helpful to further investigations o …