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Herniation of the uterus, ovaries and fallopian tubes into the canal of Nuck in a 4-month-old child: A rare entity.

Partial or complete failure of obliteration of the processus vaginalis in the female results in the formation of a potential space known as the canal of Nuck, into which various organs and/or collections can herniate. A 4-month-old female presented with a left labial mass related to herniation of the uterus, ovaries and fallopian tubes through the canal of Nuck. Early diagnosis is important as there is a high risk of ovarian torsion and incarceration.

[Significance and expression of PAX8, PAX2, p53 and RAS in ovary and fallopian tubes to origin of ovarian high grade serous carcinoma].

Objective: To explore the origin of ovarian high grade serous carcinoma (HGSC) through analysing the expression and significance of PAX8, PA … tochemistry methods. (2) To compare the expression levels of PAX8, PAX2, p53 and RAS in ovarian and fallopian tubes of ovarian cancer patients with different pathological types. (3) To analyze the correlations of tubal and ovarian tissue in PAX8, PAX2, p53 and RAS expression of HGSC. (4) To analyze the factors of the prognosis of ovarian serous cancer in tissue m …

Detection of serous precursor lesions in resected fallopian tubes from patients with benign diseases and a relatively low risk for ovarian cancer.

The frequency of ovarian cancers in Japan has increased; however, doubts have been raised concerning the mechanism by which high-grade serous adenocarcinomas (HGSCs) arise. Conventionally, HGSC is thought to originate from the ovarian surface epithelium or epithelial inclusion cyst. However, recent data indicate that HGSCs may in fact develop from precursor lesions in the fallopian tube, including epithelia with a p53 signature, serous tubal intraepithelial carcinomas (STICs), secretory cell outgrowths (SCOUTs), and tubal intraepithelial lesions in transition (TILT). Here, we determined the fr

Ulipristal Acetate Antagonizes the Inhibitory Effect of Progesterone on Ciliary Beat Frequency and Upregulates Steroid Receptor Expression Levels in Human Fallopian Tubes.

Ulipristal acetate (UPA) is a new selective progesterone receptor (PR) modulator used for emergency contraception. However, our understanding of its mechanisms of action on oviductal cilia is limited. The present study focused on the in vitro effects of UPA (0.1, 1, and 10 μmol/L) on the cilia and steroid receptors of human fallopian tubes. The ciliary beat frequency (CBF), the ultrastructure of cilia, and the levels of steroid receptors were measured. The effects of UPA on the progesterone-induced CBF reduction were also studied. Our results show that UPA dose dependently antagonizes the prog…

Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice.

The anterior pituitary-derived hormone prolactin (PRL) signals through the PRL receptor (PRLR) and is important for female reproductive func … ice. Western blot analysis showed distinct molecular separation of PRLR isoforms in mouse and human fallopian tubes, and cellular localization was found in mouse and human tubal epithelia but not in mouse tubal smooth muscle cells. These data support the concept of an isoform- and cell type-specific expression of PRLR in human and mouse fallopian tubes. Moreover, …

Organic vs functional obstruction of the fallopian tubes: differentiation with prostaglandin antagonist- and beta 2-agonist-mediated hysterosalpingography and selective ostial salpingography.

In order to determine the prevalence and cause of functional vs organic obstruction of the fallopian tubes, hysterosalpingography was repeated after pharmacologic manipulation with a prostaglandin antagonist (aspirin) and/or a beta 2-agonist (terbutaline) in 100 patients in whom the fallopian tubes did not fill with contrast medium on the initial hysterosalpingogram. Selective ostial salpingography was performed in those in whom the fallopian tubes did not fill on the second hysterosalpingogram. Patients referred from three infertility clinics were included in the study if they could be resche…

[Transverse ectopia of the right testicle and tumor of the left testicle with immature uterus and fallopian tubes: report of a case].

A case of transverse ectopia of the right testicle and the left testicular tumor with the immature uterus and the fallopian tubes is reported. The patient, a 27-year-old married man, was admitted to our hospital with the suspicion of left testicular tumor and right undescended testicle. In his left scrotum, a double hen-egg-sized tumor was palpable and the right scrotum was empty. Exploration of the left inguinal canal disclosed double testicles with hernia uteri inguinalis. The right testicle showed transverse ectopia, and the histological finding of the left testicle was choriocarcinoma. In …

В ходе химиотерапии был обнаружен продвинутый первичный рак трубчатой трубки в множестве миеломы: отчет о деле и литература.

Множественная миелома (ММ) является общей злокачественной опухолью кровеносной системы, с другой стороны, заболеваемость раком фаллопийских трубок невелика, и на ее долю приходится лишь один случай: 0.1%~1.8% гинекологических злокачественных опухолей. Это крайне редкое явление. two Болезни, которые происходят вместе. В этой газете мы приводим случай первичного рака фаллопийских труб, который был обнаружен и метастазирован в яичник во время химиотерапии для MM, и мы анализируем литературу. ПРЕЗИДЕНТ: Пациент был 69 возраст и постменопаузальный период 19 Годы. Она была доставлена в больницу из-з

Совпадение в аннотации оригинала
BACKGROUND: Multiple myeloma (MM) is a common malignant tumor of the blood system, on the other hand, the incidence of fallopian tube cancer … thology confirmed the presence of malignant tumors originating from the right adnexa. The bilateral fallopian tubes and ovaries were removed. Postoperative paraffin pathology showed right fallopian tube cancer with ovarian metastasis. Following the surgery, the patient received three sessions of hyperthermic intraperitoneal therapy and one session of carboplatin …

Obesity-associated inflammation induces molecular stress responses in porcine fallopian tube and ovarian surface epithelium.

Chronic low-grade inflammation associated with obesity is increasingly recognized as a modifier of epithelial homeostasis within the female reproductive system. However, its early molecular consequences in physiologically relevant large-animal models remain insufficiently defined. To examine whether obesity-linked systemic inflammation is accompanied by alterations in epithelial stress markers in the Fallopian tube and ovarian surface epithelium of slaughterhouse-derived sows. Animals were retrospectively classified into lean (75-100 kg, n=3) and obese (200-250 kg, n=3) groups based on post-mo

Biopsychosocial Characteristics of Patients with Primary Fallopian Tube Carcinoma: Retrospective Single-Center Descriptive Pilot Study.

Background: Primary fallopian tube carcinoma (PFTC) is a rare gynecologic malignancy, and data describing its biopsychosocial characteristics remain limited. Understanding the biological, psychological, and social features of affected women may support patient-centered care and inform future research. Methods: This retrospective, single-center, descriptive pilot study included 20 patients with histopathologically confirmed PFTC treated in 2024-2025. Demographic, reproductive, clinical, preventive, and record-documented psychosocial variables were extracted from medical records. Categorical var

Leakage-Controlled Classification of Dataset-Derived Ordinal p53-Signature Size Categories in Fallopian-Tube Immunohistochemistry.

Background and Objectives: p53 signatures are segments of strongly p53-immunoreactive secretory epithelium in the fallopian tube. We tested whether fixed pathology-pretrained image representations could classify three ordered categories reconstructed from the public dataset's reported cell-count intervals. Methods: The primary cohort comprised 113 canonical p53 20× fields from 67 patients: 59 Small (12-20 cells), 24 Medium (21-80), and 30 Large (>80). A 141-field partial-label cohort retained boundary-spanning intervals for sensitivity analysis. Twenty-six eligible feature/head pipelines were

Application of paracrine effect of fallopian tube stem cells derived from Holstein cattle to bovine mastitis.

OBJECTIVE: Mastitis in dairy cows is a major cause of economic loss, and conventional antibiotic treatments often result in antimicrobial resistance and increased milk discard. This study aimed to evaluate bovine fallopian tube-derived stem cells as a novel source of mesenchymal stem cells (MSCs) and to investigate the therapeutic potential of their conditioned medium (C-DPBS) in mastitis treatment. MATERIALS AND METHODS: Bovine fallopian tubes, typically discarded after slaughter, were used as a source of stem cells. Isolated cells were characterized by analyzing cell surface markers and ass…

Incarcerated femoral hernia containing the ipsilateral fallopian tube without ovarian involvement: A rare case report.

INTRODUCTION: Femoral hernias, though less common than inguinal hernias, have a higher propensity for incarceration and strangulation, often leading to significant morbidity and mortality. They are more prevalent in women, and their clinical diagnosis remains challenging. PRESENTATION OF CASE: This case report describes a 35-year-old woman presenting with an incarcerated right femoral hernia containing the ipsilateral fallopian tube alone, without the ovary. Emergency surgery revealed the fallopian tube within the hernia sac without ischemic changes, and repair was successfully performed usin

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube.

The human Fallopian tube (FT) is an important organ in the female reproductive system and has been implicated as a site of origin for pelvic serous cancers, including high-grade serous tubo-ovarian carcinoma (HGSC). We have generated comprehensive whole-genome bisulfite sequencing, RNA-seq, and proteomic data of over 100 human FTs, with detailed clinical covariate annotations. Our results challenge existing paradigms that extensive epigenetic, transcriptomic and proteomic alterations exist in the FTs from women carrying heterozygous germline BRCA1/2 pathogenic variants. We find minimal differe

From Serous Tubal Intraepithelial Carcinoma to Neuroendocrine Carcinoma: Molecular Dissection of a Rare Fallopian Tube Carcinoma.

Primary neuroendocrine carcinoma (NEC) of the fallopian tube is exceptionally rare, with only a small number of cases reported. We report an unusual case in a 77-yr-old woman where a fallopian tube was involved by serous tubal intraepithelial carcinoma (STIC), a small component of high-grade serous carcinoma (HGSC), and a predominant component of small cell neuroendocrine carcinoma (SCNEC). Molecular analysis of microdissected different elements supported a clonal origin, with both tumor components (STIC/HGSC and SCNEC) displaying homologous recombination deficiency and a shared TP53 mutation,

Fallopian Tube Carcinosarcoma With Intrauterine Fluid Accumulation: MRI Findings, Diagnostic Challenges, and Long-Term Survival.

Fallopian tube carcinosarcomas are extremely rare biphasic malignancies with nonspecific clinical and imaging features, posing significant diagnostic challenges. We report a case of a heterologous carcinosarcoma originating from the fimbriated end of the fallopian tube, presenting as a right adnexal mass with intrauterine fluid accumulation in the absence of hydrosalpinx. Magnetic resonance imaging demonstrated heterogeneous high signal intensity on T2-weighted imaging, low signal intensity on T1-weighted imaging, and patchy enhancement on both early- and delayed-phase contrast-enhanced sequen

From Fallopian Tube to Ovarian Cancer: Understanding the Evaluation and Management of Serous Tubal Intraepithelial Carcinoma Lesions.

Ovarian cancer, particularly high-grade serous carcinoma (HGSC), remains a leading cause of mortality in gynecologic oncology. Emerging research identifies serous tubal intraepithelial carcinoma (STIC) as a precursor lesion in many HGSC cases, highlighting its role in ovarian cancer pathogenesis and prevention. Management of STIC is challenging, as there is only limited data available to guide clinical decision-making. For average-risk women, opportunistic salpingectomy is increasingly being adopted during routine procedures such as hysterectomy or cesarean section. This intervention has demon

Cumulative Live Birth Rate in Patients With Subtle Distal Fallopian Tube Abnormalities: A Retrospective Cohort Study.

PURPOSE: Compare reproductive outcomes between patients with subtle distal fallopian tube abnormalities (SDFTA) and unexplained infertility (UI) undergoing in vitro fertilization (IVF), exploring influencing factors. METHODS: This retrospective study analyzed 447 women undergoing their first IVF cycle after laparoscopic evaluation for UI between January 2019 and December 2021. Based on laparoscopic findings, 162 women were classified into the SDFTA group and 285 into the UI group. Propensity score matching (PSM) created 160 matched pairs. The primary outcome was the cumulative live birth rate

Mesonephric-like adenocarcinoma presenting with malignant peritonitis and suspected to originate from the fallopian tube: A case report.

BACKGROUND: Mesonephric-like adenocarcinoma (MLA) is a rare and highly malignant disease that occurs in the uterine body or ovaries. We report a case of a MLA that was considered to have originated in the fallopian tube and presented with malignant peritonitis. CASE SUMMARY: A 57-year-old female presented with a chief complaint of abdominal pain that began 2 months prior. Cancerous peritonitis was suspected. During exploratory laparoscopy, the right fallopian tube was found to be enlarged, with widespread disseminated lesions extending from the pelvic cavity to the upper abdomen. Histopatholo