Результаты поиска

Progress in the application of 68Ga-Pentixafor PET/CT in lung cancer: a review.

68Ga-Pentixafor PET/CT, a molecular imaging technique targeting the C-X-C chemokine receptor 4 (CXCR4), has emerged as a promising tool in the diagnosis and therapeutic evaluation of lung cancer. Lung cancer remains a leading cause of cancer-related mortality worldwide, and accurate imaging modalities are critical for early detection, staging, and treatment monitoring. Current imaging approaches face challenges in differentiating tumor subtypes and assessing tumor biology, which limits personalized treatment strategies. This review systematically summarizes the application of 68Ga-Pentixafor P

Совпадение в полном тексте источника
… Watts A Singh B Singh H Bal A Kaur H Dhanota N [68Ga]Ga-Pentixafor PET/CT imaging for in vivo CXCR4 receptor mapping in different lung cancer histologic sub-types: correlation with quantitative receptors’ density by immunochemistry techniques . …

The Autologous Hematopoietic Stem Cells Transplantation Combination-Based Chimeric Antigen Receptor T-Cell Therapy Improves Outcomes of Relapsed/Refractory Central Nervous System B-Cell Lymphoma.

ObjectiveThe objective is to explore the effectiveness and safety of CAR T-cell therapy in advanced relapsed/refractory central nervous system B-cell lymphoma and compare the impact of autologous stem cell transplantation (ASCT) plus CAR T-cell therapy versus sequential CART therapy on the survival of patients.MethodsThe retrospective analysis was based on the data of 17 patients with advanced relapsed/refractory central nervous system B-cell lymphoma. Bridging chemotherapy was applied before CAR T-cell infusion to further reduce the tumor burden. For patients with autologous hematopoietic ste

Совпадение в полном тексте источника
… On the basis of the 2016 World Health Organization (WHO) guidelines and the diagnosed criteria of SCNSL [ 34 – 36 ], the diagnosis of CNS B-cell lymphoma by stereotactic biopsy and/or lumbar puncture for immunochemistry (IHC) ( Figure 1 ) and/or flow cytometry (FCM) has been confirmed. …

Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer.

ObjectivePatients with cancer pain are highly dependent on morphine analgesia, but studies have shown a negative correlation between morphine demand and patient outcomes. The long-term use of morphine may result in abnormally elevated serum morphine-3-glucuronide (M3G) levels. Hence, the effects of M3G on tumor progression are worth studying.MethodsThe effects of M3G on PD-L1 expressions in human non-small cell lung cancer (NSCLC) cell lines were first evaluated. Activation of TLR4 downstream pathways after M3G treatment was then determined by Western blot. The effects of M3G on human cytotoxi

Совпадение в полном тексте источника
… Immunochemistry staining For 3,3-diaminobenzidine (DAB) immunohistochemistry (IHC) staining of TLR4 and MOR, 60 paraffin-embedded human NSCLC samples were baked for 1 h at 70 °C and deparaffinized. …

Advanced Diagnostic Techniques

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Thyroid Thyroglobulin (follicular cells), calcitonin (medulla, C-cells), TTF1 (follicles and medulla) Urinary tumors Uroplakin III, cytokeratin 7, COX-2, COX-1 Vascular tumors (endothelium) Factor VIII–related antigen, CD31 FIGURE 17-3 Simplified algorithmic approach for canine tumor diagnosis using immunochemistry … | Thyroglobulin (follicular cells), calcitonin (medulla, C-cells), TTF1 (follicles and medulla) Urinary tumors | Uroplakin III, cytokeratin 7, COX-2, COX-1 Vascular tumors (endothelium) | Factor VIII–related antigen, CD31 FIGURE 17-3 Simplified algorithmic approach for canine tumor diagnosis using immunochemistry …

Network approach in liquidomics landscape.

Tissue-based biopsy is the present main tool to explore the molecular landscape of cancer, but it also has many limits to be frequently executed, being too invasive with the risk of side effects. These limits and the ability of cancer to constantly evolve its genomic profile, have recently led to the need of a less invasive and more accurate alternative, such as liquid biopsy. By searching Circulating Tumor Cells and residues of their nucleic acids or other tumor products in body fluids, especially in blood, but also in urine, stools and saliva, liquid biopsy is becoming the future of clinical

Unlocking the Microbial Symphony: The Interplay of Human Microbiota in Cancer Immunotherapy Response.

IntroductionThe emergence of cancer immunotherapy has revolutionized cancer treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to immunotherapy underscores the necessity of understanding additional factors influencing treatment efficacy. Among these factors, the human microbiota has garnered significant attention for its potential role in modulating immune response. Body: This review explores the intricate relationship between the human microbiota and cancer immunotherapy, highlighting recent advances and potential mechanisms u

Совпадение в полном тексте источника
… Discordance of microsatellite instability and mismatch repair immunochemistry occurs depending on the cancer type. Hum. Pathol. 2023;135:54–64. doi: 10.1016/j.humpath.2022.12.016. 17. …

The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.

Cardiac amyloidosis (CA) represents a growing etiology of heart failure (HF) and arrhythmogenesis, driven by the intramyocardial deposition of aberrantly folded proteins, notably immunoglobulin light chains (AL) and transthyretin (ATTR). This infiltrative process compromises myocardial compliance and disrupts the cardiac conduction system, leading to a diverse spectrum of dysrhythmias. The escalating prevalence of CA, particularly within geriatric demographics and individuals with plasma cell dyscrasias, underscores the imperative for refined diagnostic and therapeutic paradigms. The considera

Совпадение в полном тексте источника
… New insights into atrioventricular nodal anatomy, physiology, and immunochemistry: A comprehensive review and a proposed model of the slow-fast atrioventricular nodal reentrant tachycardia circuit in agreement with direct potential recordings in the Koch’s triangle area. …

Advanced Diagnostic Techniques

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… and medulla) Urinary tumors Uroplakin III, cytokeratin 7, COX-2, COX-1, p63 Vascular tumors (endothelium) Factor VIII–related antigen, CD31, CD34 (blood and lymphatic endothelium); LYVE-1 and Prox-1 (lymphatic endothelium) Figure 17-3 Simplified algorithmic approach for canine tumor diagnosis using immunochemistry … medulla) Urinary tumors | Uroplakin III, cytokeratin 7, COX-2, COX-1, p63 Vascular tumors (endothelium) | Factor VIII–related antigen, CD31, CD34 (blood and lymphatic endothelium); LYVE-1 and Prox-1 (lymphatic endothelium) Figure 17-3 Simplified algorithmic approach for canine tumor diagnosis using immunochemistry …

Understanding Mesangial Pathobiology in AL-Amyloidosis and Monoclonal Ig Light Chain Deposition Disease.

Patients with plasma cell dyscrasias produce free abnormal monoclonal Ig light chains that circulate in the blood stream. Some of them, termed glomerulopathic light chains, interact with the mesangial cells and trigger, in a manner dependent of their structural and physicochemical properties, a sequence of pathological events that results in either light chain-derived (AL) amyloidosis (AL-Am) or light chain deposition disease (LCDD). The mesangial cells play a key role in the pathogenesis of both diseases. The interaction with the pathogenic light chain elicits specific cellular processes, whi

Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this disease in the last years, there are still many unanswered questions. The objective of this article is to review recent knowledge and to increase understanding of the complex pathogenesis of FIP.

Совпадение в полном тексте источника
… Plaque assay, polypeptide composition and immunochemistry of feline infectious peritonitis virus and feline enteric coronavirus isolates Adv Exp Med Biol 173 1984 133 147 6331106 10.1007/978-1-4615-9373-7_12 15 Fiscus S.A. Teramoto Y.A. …

Protein-Based Adjuvants for Vaccines as Immunomodulators of the Innate and Adaptive Immune Response: Current Knowledge, Challenges, and Future Opportunities.

New-generation vaccines, formulated with subunits or nucleic acids, are less immunogenic than classical vaccines formulated with live-attenuated or inactivated pathogens. This difference has led to an intensified search for additional potent vaccine adjuvants that meet safety and efficacy criteria and confer long-term protection. This review provides an overview of protein-based adjuvants (PBAs) obtained from different organisms, including bacteria, mollusks, plants, and humans. Notably, despite structural differences, all PBAs show significant immunostimulatory properties, eliciting B-cell- a

Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value.

Lung cancer is the leading cause of cancer-related death worldwide. Bone metastasis, which usually accompanies severe skeletal-related events, is the most common site for tumor distant dissemination and detected in more than one-third of patients with advanced lung cancer. Biopsy and imaging play critical roles in the diagnosis of bone metastasis; however, these approaches are characterized by evident limitations. Recently, studies regarding potential biomarkers in the serum, urine, and tumor tissue, were performed to predict the bone metastases and prognosis in patients with lung cancer. In t

Совпадение в полном тексте источника
… Programmed cell death 1 ligand 1 (PD-L1) immunochemistry is commonly used as a prognostic biomarker of immune checkpoint inhibitor for clinical decision making. Nevertheless, some researchers suggest that the usefulness of PD-L1 expression is controversial ( 16 – 18 ). …

Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts.

The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play key roles in cancer cell dissemination to bone and subsequent metastasis. Our laboratory has evidenc

Совпадение в полном тексте источника
… Immunochemistry revealed that the osteoblast-derived cytokines VEGF and MCP-1 were specifically localized to bone ends composed of trabecular bone and not the bone shaft in non-cancer bearing mice [ 130 ]. IL-6 was found to be localized to the bone marrow [ 130 ]. …

Understanding DMG: current treatment options and prospective solutions using nanoparticles.

Diffuse Midline Gliomas (DMGs), which include the subset formerly known as Diffuse Intrinsic Pontine Glioma (DIPG), are associated with an extremely poor prognosis and a five-year survival rate below 2-3%. The devastating prognosis stems from an inherently invasive nature, a deep, anatomically restricted location, rapid cellular drug efflux mediated by transporters such as P-glycoprotein (ABCB1) and breast cancer resistance protein (BCRP/ABCG2), and an immunologically "cold" microenvironment. Coupled with limited Blood-Brain Barrier (BBB) permeability, these biological factors render conventio

Совпадение в полном тексте источника
… The results from this method compared favorably with established techniques like flow cytometry and immunochemistry. …

Резюме ЭСП 2013.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Обязательный экзамен по патологии: лишний или необходимый?

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Activation of PSC was confirmed by smooth muscle actin immunochemistry. Conclusion: Organotypic culture of normal human pancreas is possible with optimized cell viability at 72 h. Hypoxia-induced activation of PSC occurs very early. …

Экстракорпоральное обнаружение биомаркеров и патогенов в слюне: всеобъемлющий, панорамный обзор.

Человеческая слюна представляет собой разнородную жидкость с сложным составом, которая содержит антитела, белки и вирусы, что делает ее применимой в клинической диагностике. Анализ проб слюны имеет несколько преимуществ по сравнению с другими биофильтрами, включая неинвазивную и простую процедуру сбора для эксторального обнаружения. Диагностика биомаркеров или патогенов в слюне может осуществляться различными методами: масс-спектрометрией, ПЦР, ЭЛИСА, электрохимическими и оптическими методами, такими, как флуоресцентная, SPR и SERS. Раннее обнаружение раковых и других биомаркеров заболеваний,

Abstracts From the 42nd Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand held on June 16-18, 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Program-Abstracts

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Резюме: 32 Второй Конгресс ЭСП и Международный конгресс XXXIII МПД.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.