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Disordered inhibition in internuclear ophthalmoplegia: analysis of eye movement recordings with computer simulations.

High resolution infra-red oculographic recordings were obtained in 19 patients with clinically evident internuclear ophthalmoplegia. The major findings were attenuated phasic and tonic components of adducting saccades, fractionated phasic components of abducting saccades, equally long durations for phasic components of adducting and abducting saccades with refixation, and nasal drift of the abducting eye which initiated abducting nystagmus. Ipsilateral gaze paresis and abduction lag were occasionally associated with primarily unilateral cases of internuclear ophthalmoplegia. These findings wer

Evaluating upper limb movement smoothness metrics derived from markerless 3D motion tracking in children with neurological disorders.

BACKGROUND: Clinical assessment of movement smoothness during reaching in children is often based on subjective, ordinal-scaled therapist ratings. Markerless 3D motion tracking using an RGB-D camera offers a promising avenue for more objective and fine-grained smoothness evaluation. This study investigated the use of a new markerless RGB-D-based tracking method, SMPLify-KiDS, for the quantitative assessment of upper limb movement smoothness in a heterogeneous population of children with neurological impairments. METHODS: Thirty-eight children with neurological diagnoses performed three reachi

Antipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose.

The clinical evidence for antipsychotic (AP) therapeutic drug monitoring (TDM) in evaluating AP-related movement disorders and cardiometabolic side-effects remains inconsistent. This study evaluates how AP plasma concentrations associate with movement disorders and cardiometabolic side-effects over time, and compares its predictive value to prescription dose in first-episode psychosis (FEP) patients. We included 200 remitted FEP patients from the HAMLETT trial. AP plasma concentrations were standardized using robust z-scores to accommodate different AP types. The St. Hans Rating Scale and Barn…

Spectrum of Movement Disorders in Hematological Malignancies: A Comprehensive Systematic Review of Clinical Phenotypes, Mechanisms, and Outcomes.

BACKGROUND: Movement disorders associated with hematologic malignancies remain incompletely defined. This review synthesized published articles to clarify clinical patterns, mechanisms, and outcomes across hematologic malignancies. METHODS: A PRISMA-compliant systematic search of PubMed, Embase, Scopus, and Google Scholar was conducted to identify reports describing movement disorders associated with hematologic malignancies. Eligible reports were screened according to predefined criteria, and data were extracted on demographics, hematologic diagnosis, central nervous system (CNS) involvement…

Identifying rotator cuff disorders through shoulder movement quality: An exploratory study using a single inertial measurement unit.

BACKGROUND: To investigate differences in shoulder movement quality between rotator cuff disorders and other shoulder disorders (e.g., frozen shoulder and long head of the biceps tendinitis) by quantifying movement smoothness employing Spectral Arc Length (SPARC) derived from a single wrist-mounted Inertial Measurement Unit (IMU), exploring its potential for objective disorder identification. METHODS: In this exploratory cross-sectional study, thirty older adults with shoulder disorders were classified by physical therapists into rotator cuff disorder or other shoulder disorder groups. Angula

Impact of Hospital Volume Status on Postoperative Outcomes and Cost following Deep Brain Stimulation for Movement Disorders.

INTRODUCTION: Deep brain stimulation (DBS) has emerged as a transformative neurosurgical intervention for refractory movement disorders, including Parkinson's disease (PD), essential tremor (ET), and dystonia. While clinical efficacy is well established, significant variability exists in procedural outcomes across hospitals. This nationwide study investigated the impact of hospital procedural volume on short-term postoperative outcomes and cost following DBS across 234 US hospitals from 2015 to 2020. METHODS: We conducted a retrospective analysis of 6,964 DBS procedures (2015-2020) using the …

Deep Brain Stimulation for Movement Disorders in Spain: Temporal Trends, Complications, and Sex-Related Disparities (2002-2019).

Background/Objectives: This study aimed to describe temporal trends in deep brain stimulation (DBS) use for Parkinson's disease (PD), essential tremor (ET), and dystonia; characterize patient age and sex distribution and comorbidity; assess postoperative complications and in-hospital mortality (IHM) after implantation and explantation; and explore sex-specific differences in utilization and outcomes. Methods: We conducted a retrospective nationwide population-based study using the Spanish National Hospital Discharge Database (RAE-CMBD) from 2002 to 2019. All hospital admissions with DBS implan

Deep brain stimulation in the management of movement disorders in childhood: a UK-wide cross-sectional study.

INTRODUCTION: We aimed to establish the clinical characteristics of children and young people (CAYP) currently receiving deep brain stimulation (DBS) therapy for the management of movement disorders in the UK to better inform planning of future service provision. METHODS: Cross-sectional service evaluation of centres providing DBS for the management of movement disorders in childhood. RESULTS: A total of 139 CAYP were identified across three centres. Median age at surgery was 9.8 years (range 2.0-18.9 years), and median duration of DBS was 4.4 years (range from 1 week to 15.75 years). Modal …

Outcome measures for fear of movement in individuals with musculoskeletal disorders: a systematic review with meta- analysis.

INTRODUCTION: Fear of movement is a significant psychological factor in musculoskeletal disorders and can negatively affect clinical outcomes. Several assessment tools are currently available to measure fear of movement. This systematic review aimed to analyze and compare the psychometric properties of the main scales used in populations with musculoskeletal disorders. METHODS: A systematic literature review was conducted according to PRISMA guidelines. Studies were identified through MEDLINE (via PubMed), CINAHL (via EBSCO), Web of Science, and Scopus. Methodological quality was assessed usi

Исследования " горячих точек " и тенденций в области электрической стимуляции нарушений движения: библиометрический анализ на основе 2016 в адрес 2025.

Лечение электрической стимуляции стало важнейшим средством борьбы с нарушениями, связанными с движением. Однако быстро расширяющийся и фрагментированный объем литературы требует макроскопической оценки для выявления глобальных сетей сотрудничества и формирующихся научных границ. В связи с этим в рамках этого исследования был проведен всеобъемлющий визуализационный анализ исследовательских тенденций и " горячих точек " в этой области для определения эволюционной траектории и определения будущих терапевтических изменений. Публикации 2016 в адрес 2025 были найдены в Web of Science Core

Совпадение в аннотации оригинала
Electrical stimulation therapies have become pivotal interventions for managing refractory movement disorders. However, the rapidly expanding and fragmented body of literature necessitates a macroscopic evaluation to identify global collaborative networks and emerging scientific frontiers. Consequently, this study conducted a comprehensive visualization anal…

Robotic arm vs. stereotactic frame in deep brain stimulation surgery for movement disorders: a retrospective cohort study.

BACKGROUND: Recently, robotic arms have been incorporated into the implantation of electrodes for deep brain stimulation (DBS).This study aimed to determine the accuracy of brain electrode placement, initial clinical efficacy, and safety profile of the robotic arm Neuromate (Renishaw) compared to a stereotactic frame in movement disorders. METHODS: This study involved two retrospective cohorts: one cohort was operated on using a stereotactic frame and the other with a robotic arm. This study was conducted at Barcelona Hospital Clinic. RESULTS: Seventy-seven patients were included, of whom 30…

Practices, Resources and Challenges in Parkinson's Disease Management in Asia: Movement Disorders in Asia Study Group Report.

BACKGROUND: The prevalence of Parkinson's disease (PD) is increasing markedly in Asia, highlighting the urgent need to understand the current practices and challenges in delivering comprehensive PD care in this region. OBJECTIVES: We aimed to determine the resources and facilities for comprehensive management of PD in Asia focusing on regions (South East Asia, Middle East, Indian Subcontinent, East Asia, and Central Asia) and income levels (high-income countries-HIC, upper middle-income countries-UMIC, lower middle-income countries-LMIC). METHOD: A survey-based questionnaire was deployed to

Screening Tool Improves Recognition of Movement Disorders by Internists and Paediatricians in Patients With Inherited Metabolic Diseases.

Movement disorders are common in inherited metabolic diseases (IMDs) and significantly impact quality of life. Unfortunately, they are often underrecognised by metabolic physicians. This study investigated whether a new screening tool improves recognition of movement disorders in IMD patients by non-neurologists. Internists and paediatricians specialized in IMDs assessed videos of 44 IMD patients who perform four specific neurological tests, to evaluate the presence and phenotype of a movement disorder. Initially, baseline assessments were performed without the tool. Eight months later, the sa…

More than a symptom: qualitative exploration of embodied control and restlessness in compulsive movement in eating disorders.

BACKGROUND: Compulsive physical activity is a common but underexplored feature of eating disorders (ED). Beyond calorie expenditure, it often serves complex psychological, symbolic, and embodied functions. Understanding how these behaviors are experienced and change during treatment can guide more effective interventions. This study explored the lived experience of compulsive movement in individuals with anorexia nervosa (AN), bulimia nervosa (BN) and binge eating disorder (BED), and examined whether diagnosis or duration influenced narrative change during inpatient care. METHODS: Sixty-five

Spectrum of movement disorders in Malaria: a systematic review of case reports, case series, and cohort studies.

BACKGROUND: Movement disorders associated with malaria are often underrecognized. This review aimed to systematically assess their types, onset patterns, and clinical outcomes. METHODS: We systematically searched major databases for case reports, case series, and cohort studies describing movement disorders in malaria patients. Data were extracted on demographics, Plasmodium species, clinical presentation, imaging, treatment, and outcomes. PRISMA guidelines were followed throughout. RESULTS: A total of 86 individual cases were identified from 72 case reports/series, along with 12 cohort stud…

Movement disorders in relapsing and progressive MS: A comprehensive prospective evaluation of a large real-life cohort.

BACKGROUND: Recent studies suggest that movement disorders are common in early MS. However, the frequency and clinical characteristics of movement disorders at all stages of MS remain unknown. OBJECTIVES: To evaluate the frequency, clinical characteristics, and anatomical generators of movement disorders in relapsing and progressive MS. METHODS: We conducted a prospective study of adult MS patients from 2016 to 2022 at a neuroimmunology clinic. Patients were evaluated for demyelination-related movement disorders via a survey and focused examination. We classified movement disorders based on …

Efficacy and safety of multiple-target deep brain stimulation in non-parkinsonian movement disorders: a systematic review.

INTRODUCTION: To analyze studies employing multiple-target deep brain stimulation (DBS) for non-parkinsonian movement disorders and identify potential indications, therapeutic outcomes, and associated side effects. METHODS: We systematically screened PubMed and included studies involving patients treated with DBS targeting at least two brain regions, synchronous stimulation of ≥2 regions, patient data regarding symptoms/disease, and reported outcomes. Exclusion criteria included animal studies and reports lacking original data. RESULTS: Twenty-seven studies were identified, included and anal…

Focused Ultrasound for Treatment of Movement Disorders: A Review of Non-Food and Drug Administration Approved Indications.

INTRODUCTION: MRI-guided focused ultrasound (FUS) is an incisionless thermo-ablative procedure that may be used to treat medication-refractory movement disorders, with a growing number of potential anatomic targets and clinical applications. As of this article's publication, the only US Food and Drug Administration (FDA)-approved uses of FUS for movement disorders are thalamotomy for essential tremor (ET) and tremor-dominant Parkinson's Disease (PD), and pallidotomy for other cardinal symptoms of PD. We present a state-of-the-art review on all non-FDA approved indications of FUS for movement d…