Результаты поиска

Clinically and histologically silent Q fever endocarditis accidentally diagnosed by PCR.

A case of Q fever endocarditis was diagnosed in a patient with no sign of active endocarditis by performing PCR targeting eubacterial 16S rDNA on the resected mitral valve. The diagnosis was confirmed by detection of high levels of anti-Coxiella burnetti antibodies, positive immunohistologic analysis of the valve tissue with specific antibodies and culture of C. burnetti from the valve tissue. As this patient had an unexplained aggravation of valve dysfunction, we recommended routine serologic testing for C. burnetti to allow the diagnosis of Q fever endocarditis at a very early stage.

Культуры крови Коксиеллы от острых и хронических пациентов.

Q лихорадка - всемирный зооноз, вызванный коксиеллой, может быть либо острым, либо хроническим заболеванием. Мы соотнесли результаты 844 C. seretii культуры крови с серологическими, клиническими и терапевтическими данными. С. Пёрнети был изолирован от 17% пациентов, не прошедших лечение с острой лихорадкой Q, и от 53% пациентов, не прошедших лечение с хронической лихорадкой Q. C. signetii не был изолирован от пациентов, которые получали антибиотики, активные против C. signetii. Для семи пациентов с положительной культурой, страдающих острой лихорадкой Q, серология была отрицательной, когда К.

Совпадение в аннотации оригинала
Q fever, a worldwide zoonosis caused by Coxiella burnetii, may present as either an acute or a chronic disease. We correlated the results of 844 C. burnetii blood cultures with serological, clinical, and therapeutic data. C. burnetii was isolated from 17% of untreated patients with acute Q fever and from 53% of untreated patients with chronic Q fever. C. bur…

Quiescent Q fever endocarditis exacerbated by cardiac surgery and corticosteroid therapy.

Q fever endocarditis occurs in up to 11% of patients infected by Coxiella burnetti. Major clues for the diagnosis are culture-negative endocarditis, hepatic involvement, rash, and thrombocytopenia. Characteristically, the diagnosis is delayed. In our patient, Q fever endocarditis occurred without previously recorded signs of infection. Fever, rash, and hepatic involvement all occurred following aortic valve replacement. The histologic picture of the excised valve was consistent with endocarditis, and serologic tests disclosed elevated IgA and IgG antiphase 1 antibody titers against C burnetti,…

Acute Q fever in Majorca island 2017-2022. An underestimated problem.

INTRODUCTION: Q fever (QF) is a zoonotic infection caused by Coxiella burnetii. Previous studies suggest that the incidence in the island of Majorca may be high. The objective was to know the epidemiological, clinical, diagnostic, and therapeutic characteristics of acute QF (AQF) on the island of Majorca during the years 2017-2022. METHODS: Retrospective analysis of a series of cases of AQF diagnosed in 3 out 4 hospitals of the Health Service of the island of Majorca. AQF was considered if a clinically compatible syndrome was present with one of the following serological criteria: confirmed A…

Q Fever-Related Community Infections: United States Exposure to Coxiella burnetii.

Coxiella burnetii is a significant infectious pathogen that causes Q fever. Q fever is thought to be uncommon in the US and most human cases are believed to occur in agricultural livestock workers. However, the extent of US community exposure to C. burnetii is not known with certainty. Using nationally representative 2003-2004 US National Health and Nutrition Examination Survey serologic, demographic, and occupational history data, the magnitude of US adult general population exposure to C. burnetii, excluding agricultural-sector workers, was estimated. Exposure was defined as positive serum I…

Toward assessing serodiagnosis of Q fever in high occupational-risk workers.

Q fever, a zoonotic disease caused by the bacterium Coxiella burnetii, occurs in acute or chronic forms in humans. Diagnosing acute and chronic Q fever relies mainly on detecting antibody titers against phase II and I antigens by indirect fluorescent antibody test (IFAT), the reference standard test. This study assessed the seroprevalence of anti-Coxiella burnetii antibodies by IFAT in 269 high occupational-risk workers along with the accuracy of an enzyme-linked immunosorbent assay (ELISA) and a chemiluminescent immunoassay (CLIA), routinely used in diagnostic laboratories, compared to IFAT, …

Delayed diagnosis of persistent Q fever: a case series from China.

BACKGROUND: Q fever, caused by the zoonotic pathogen Coxiella burnetii, exhibits a worldwide prevalence. In China, Q fever is not recognized as a notifiable disease, and the disease is overlooked and underestimated in clinical practice, leading to diagnostic challenges. CASE PRESENTATION: We present a case series of three patients diagnosed with persistent Q fever between 2022 and 2023. The average age of our three cases was 63.33 years old, consisting of two males and one female. The medical history of the individuals included previous valve replacement, aneurysm followed by aortic stent-gra…

Case report: membranoproliferative glomerulonephritis associated with Q fever causing chronic endocarditis.

BACKGROUND: Membranoproliferative glomerulonephritis is a rare entity which can be a result from autoimmune diseases, caused by various medications and infections. CASE PRESENTATION: We herein present the case of a 62-year-old male patient who presented with fatigue and was found to have severe anemia, impaired renal function, and nephrotic syndrome. A renal biopsy revealed membranoproliferative glomerulonephritis (MPGN) of the immune complex type with activation of the classical complement pathway. Further investigations led to the diagnosis of a chronic Coxiella burnetii-infection (Q fever)…

Giant cell arteritis associated with acute Q fever - A case report.

Q fever is a worldwide spread zoonotic disease, caused by the gram-negative intracellular bacillus Coxiella burnetii. Apart from its most common manifestations, Q fever has been reported to occasionally mimic autoimmune diseases. We herein present a case of acute Q fever in a 69-year-old man, manifesting as prolonged fever with pneumonitis, in whom biopsy of the temporal artery revealed giant cell arteritis. Moreover, PCR testing of the biopsy specimen was positive for Coxiella burnetii, thus further supporting the possibly infectious etiology of some cases of biopsy proven giant cell arteriti…

A Novel Marmoset (Callithrix jacchus) Model of Human Inhalational Q Fever.

Common marmosets (Callithrix jacchus) were shown to be susceptible to inhalational infection with Coxiella burnetii, in a dose-dependent manner, producing a disease similar to human Q fever, characterized by a resolving febrile response. Illness was also associated with weight loss, liver enzyme dysfunction, characteristic cellular activation, circulating INF-γ and bacteraemia. Viable C. burnetii was recovered from various tissues during disease and from 75% of the animal's lungs on 28 days post challenge, when there were no overt clinical features of disease but there was histological evidenc…

Acute and chronic Q fever national surveillance - United States, 2008-2017.

Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii and can manifest in an acute or chronic form. Many persons with acute Q fever are asymptomatic, but some develop a febrile illness, pneumonia or hepatitis. Chronic infections are rare and occur in less than 5% of persons exposed. Forms of chronic Q fever include endocarditis, infection of vascular grafts or aneurysms, osteomyelitis and osteoarthritis. Acute and chronic Q fever are nationally notifiable diseases, and presented here are the incidence, demographics and distribution of acute and chronic Q fever in the United S…

Polymicrobial Infections Among Patients with Vascular Q Fever, France, 2004-2020.

We report 5 cases of vascular Q fever complicated by polymicrobial superinfection in patients who had no risk factors for acute Q fever. Q fever was diagnosed by serologic and molecular assays for Coxiella burnetii. We confirmed additional infections using conventional graft cultures.

Frequency of Adverse Events Following Q Fever Immunisation in Young Adults.

Q fever is a zoonosis of concern in many countries. Vaccination is the most effective means of prevention, and since 1989, Australia has had a licensed Q fever vaccine, Q-VAX®. This vaccine was also used in the Netherlands in 2011 following the largest recorded Q fever outbreak globally. There is a paucity of available data regarding adverse events following immunisation (AEFI) for young adult females. Such data are important for informing future vaccination recommendations both within Australia and internationally. This study collected Q fever vaccine (Q-VAX®) AEFI data in veterinary and anim…