Результаты поиска

Why Human Germline Editing is More Problematic than Selecting Between Embryos: Ethically Considering Intergenerational Relationships.

Do we have a moral obligation to genetically cure embryos rather than selecting between them? Such an obligation would be an ethical argument for human germline gene editing (hGGE) to avoid the inheritance of genetic conditions instead of using pre-implantation genetic diagnosis (PGD). In this article, the intuition that we do have such a moral obligation is critically evaluated. The article first develops a theoretical framework for discussing the ethical questions of hGGE. This framework is based on an exploration of the phenomenology of the germline, from both biological and philosophical p

Ethical Issues in Intrauterine Myelomeningocele Surgery.

Intrauterine surgery shows that the prognosis of neonates with myelomeningocele (MMC) has improved, both in survival and in quality of life. In order to study the current efficacy of intrauterine surgery for MMC and to make an ethical analysis of its proportionality, we conducted a PubMed search using the keywords "myelomeningocele", "intrauterine surgery", "MOMS", and "trial". Thirty-eight articles were found. The literature investigated the risks and benefits of intrauterine surgery based on the physiological parameters of MMC. Intrauterine surgery produces clear benefits. However, it also h

Sperm Donation and the Right to Privacy.

Sperm donation is an increasingly common method of assisted reproduction. In the debate on sperm donation, the right to privacy - construed as a right that refers to the limits of the realm of information to which others have access - plays a pivotal role with regard to two questions. The first question is whether the sperm donor's right to privacy implies his right to retain his anonymity, the second is whether the gamete recipients' right to privacy entitles them to withhold information about the circumstances of their conception from their donor-conceived offspring. In this contribution, I

Human organ markets and inherent human dignity.

It has been suggested that human organs should be bought and sold on a regulated market as any other material property belongingto an individual. This would have the advantage of both addressing the grave shortage of organs available for transplantation and respecting the freedom of individuals to choose to do whatever they want with their body parts. The old arguments against such a market in human organs are, therefore, being brought back into question. The article examines the different arguments both in favour and against the sale of human organs. It concludes that the body and any of its

Assisted reproduction--Islamic views on the science of procreation.

The field of assisted reproduction is one of the fastest growing areas in medicine. The development of new and sophisticated techniques all aim to give reproductive technologies and scientists a better understanding of reproductive biology. The development of new techniques may also be able to improve the chances of an infertile couple towards achieving a pregnancy. However the ethics and legality of assisted reproductive technology must not be brushed aside. Islamic scholars whose reference basis resides in the Holy Quran and the Hadith have addressed different issues relating to assisted rep

Приоритеты пациентов, врачей и исследователей в отношении важных результатов в множестве миеломы: исследование смешанных методов.

Исследования в области миеломы во все большей степени основываются на суррогатных конечных точках для ускорения утверждения, однако они могут не отражать приоритеты пациентов. Мы провели исследование по смешанным методам для определения результатов, оцениваемых пациентами и врачами, и их сопоставления с конечными точками, используемыми в выборочных контролируемых испытаниях (РСТ). Собеседования с 10 пациентов и пациентов 6 Клиники определили приоритеты в области лечения, которые вместе с конечными точками на основе систематического обзора миэломных РСТ, информированных специализированных обсле

Совпадение в полном тексте источника
… [Colour figure can be viewed at wileyonlinelibrary.com ] The study was approved by the Bioethics Committee of the Department of Medicine, Aristotle University of Thessaloniki. … ETHICS APPROVAL STATEMENT The study was approved by the Bioethics Committee of the Department of Medicine, Aristotle University of Thessaloniki (protocol No 6.247). PATIENT CONSENT STATEMENT Informed consent was obtained from all participants prior to inclusion in the study. …

Characteristics of patients with newly diagnosed hematological malignancies referred for echocardiography.

ObjectiveThe importance of cardio-hemato-oncology programs is increasing. The main aim of the study was to identify all coexisting cardiovascular disorders in patients with new hematological malignancies referred for echocardiography during baseline evaluation before anticancer therapy.Material and methodsThe study was based on 900 echocardiographic examinations performed within 12 months at the Institute of Hematology and Transfusion Medicine in Poland: 669 tests (74.3%) were dedicated to hemato-oncology patients at the different stages of cancer therapy, however almost a third of the tests (

Quality of life and its selected determinants in the group of patients with surgically treated spinal tumors.

INTRODUCTION: Spinal metastases are a common manifestation of advanced neoplastic disease. Destructive neoplastic lesions within the axial skeleton cause unrelieved pain and nervous system disorders involving spinal stenosis and other neural structures. The development of new systemic therapies, radiotherapy and minimally invasive spinal surgeries has increased patients' quality of life by minimising pain and neurological disorders due to vertebral neoplastic infiltration. The aim of the study was to assess the patients' quality of life before and after spine stabilisation surgery with spinal

Совпадение в полном тексте источника
… Materials and methods Ethics The study protocol was approved by the ethics committees of the involved institution (Bioethics Commission at the University of Rzeszow: Resolution no. 2016/12/7 on 01 December 2016). … Ethics statement The study was approved by the institutional Bioethics Committee at the University of Rzeszów (Resolution No. 2016/12/7; approved on 01-12-2016) and by all appropriate administrative bodies. …

Действенность и безопасность цифрового таперинга для пациентов, которым предписывается опиоид после хирургической операции: протокол для перспективного исследования кохарта.

Предыстория 300 million Каждый год во всем мире проводятся хирургические операции, и опиоиды по-прежнему являются одним из основных методов борьбы с острой послеоперационной болью. Исследования показали, что значительное число пациентов не прекращают опиоидное лечение и продолжают использовать опиоиды в течение месяцев или даже лет после операции. Известная практика применения опиоидов рецептурного отпуска и управления ими является частью нынешних клинических руководящих принципов безопасного прописывания. Каждый пациент должен получать тщательный контроль, образование и план скрининга, когда

Совпадение в полном тексте источника
… As this study is exploratory, requires handling of personal data, and seeks to improve existing practice, it requires the approval of a bioethics committee. The National Bioethics Committee of Iceland has given approval for a study using this protocol. …

Нет связи между когнитивным расстройством, физической инвалидностью и серумными биомаркерами в коорте прогрессивных пациентов с множественным склерозом.

Несмотря на значительные усилия, по-прежнему существует потребность в выявлении диагностических средств, которые позволили бы быстро и надежно обнаруживать прогрессирующую стадию множественного склероза (MS) и помогли бы в мониторинге курса заболевания и/или воздействия лечения. Цель этого перспективного исследования в группе людей с прогрессивным MS заключалась в том, чтобы определить, могут ли изменения в уровнях отдельных биомаркеров сыворотки и когнитивной функции предсказывать прогрессирование заболеваний и, следовательно, совершенствовать процесс принятия решений при оценке пациентов с M

Совпадение в полном тексте источника
… All study procedures were approved by the Bioethics Committee of the Medical University of Lodz (decision Nos. RNN/128/20/KE and KE/564/23). All subjects gave their informed consent before participating in this study. … Institutional Review Board Statement This study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Bioethics Committee of the Medical University of Lodz, Poland (decision Nos. RNN/128/20/KE and KE/564/23). …

Оценка воздействия таблеток для реконструкции и кладрибинных таблеток и алемтузузумаба на атрофию у пациентов с множественным склерозом, вызывающим рецидив.

ВВЕДЕНИЕ: Иммунная реконструктивная терапия (ИРТ) является высокоэффективной терапией для множественных склерозов (МС). Среди IRT можно выделить частично выборочную терапию, такую, как кладрибин в таблетках (CLAD) и неселективную терапию, которая включает алемтузумаб (ALEM). Сегодня известно, что эта терапия эффективна с точки зрения контроля за рецидивной активностью заболевания и развитием клинической инвалидности, что было доказано как в ходе клинических испытаний, так и в реальных данных (РВЭ). Вместе с тем отсутствуют данные об оценке воздействия IRT на нейродегенеративный процесс, которы

Совпадение в полном тексте источника
… However, the project application was sent to the MIM-NRI Bioethics Committee. Resolution No. 54/24 (dated October 16, 2024) was issued, according to which the study was not subject to review by the Bioethics Committee. …

Risk Factors for Catheter-Related Thrombosis in Multiple Myeloma Patients Undergoing Autologous Stem Cell Transplantation.

Background and Objectives: Cancer associated thrombosis (CAT) is a common complication of neoplasms. Multiple myeloma (MM) carries one of the highest risks of CAT, especially in the early phases of treatment. Autologous stem cell transplantation (ASCT) as the standard of care in transplant-eligible patients with MM carries a risk of catheter-related thrombosis (CRT). The aim of this study was identification of the risk factors of CRT in MM patients undergoing ASCT in 2009-2019. Materials and Methods: We retrospectively analyzed patients with MM undergoing ASCT. Each patient had central venous

Совпадение в полном тексте источника
… Institutional Review Board Statement Because our study involved a retrospective analysis of existing data with no patient intervention, and the patient data were de-identified, the Bioethics Committee of Poznan University of Medical Sciences determined that this study was not a medical experiment and … was exempt from the Bioethics Committee of Poznan University of Medical Sciences review. …

Incomplete systemic capillary leak syndrome after COVID-19 vaccination: a case-based review.

Although generalized edema is a rare adverse event after drugs or vaccinations, here we report a case of generalized edema with systemic inflammatory reaction clinically similar to incomplete systemic capillary leak syndrome (SCLS), potentially triggered by COVID-19 immunization. The patient presented with generalized subcutaneous edema, a drop in blood pressure, elevated inflammatory biomarkers, and hypoalbuminemia after receiving the vaccine, with no other apparent cause than vaccination. Comprehensive diagnostic evaluation revealed no specific underlying cause. She was treated with glucocor

Совпадение в полном тексте источника
… Disclosures Approval of the Bioethics Committee was not required. 1 Matheny M , Maleque N , Channell N , et al . ( 2021 ): Severe exacerbations of systemic capillary leak syndrome after covid-19 vaccination: A case series . …

Treatment of Medication-Related Osteonecrosis of the Jaw Without and With the Use of Advanced Platelet-Rich Fibrin: A Retrospective Clinical Study.

BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is drug-induced bone destruction that is exposed for a minimum of 6 to 8 weeks in patients who have not received head and neck radiotherapy and who have not been diagnosed with facial bone metastases. MRONJ treatment outcomes are unpredictable. Therefore, alternative treatment methods are being explored, such as blood-derived platelet-rich preparations enriched with growth factors, including advanced platelet-rich fibrin (A-PRF). The presence of growth factors may enhance healing and reduce post-procedure complications. There are

Совпадение в полном тексте источника
… Approval from the institutional ethics committee was obtained (Independent Bioethics Commission for Research, Medical University of Gdańsk, number of approval KB/510/2024). The patients signed an informed written consent to the surgical procedures. … Institutional Review Board Statement This study was conducted according to the guidelines of the Declaration of Helsinki and was approved by the Independent Bioethics Committee for Scientific Research at the Medical University of Gdańsk, Poland (protocol code KB/510/2024 and date of approval 12 December …

:: повышенный риск инфицирования в мягких миеломах: результаты проверочного исследования iStopM.

Инфекции являются одной из основных причин заболеваемости и смертности в миеломе (ММ). Хотя повышенный риск инфицирования был продемонстрирован в моноклональной гаммопатии неопределенного значения (MMUS), данные о запятнании множественных миеломы (SMM) ограничены. Мы использовали данные из исследования iStopMM, которые проверяли 75,422 Исландцы в возрасте ≥40 - годы для прекурсоров MM. Лица, диагностированные СММ, в разбивке по возрасту и полу сопоставляются с компараторами, не имеющими СМГС (см.1::5 (соотношение) и с лицами, имеющими MGUS1::1 соотношение). Результаты заражения были получены н

Совпадение в полном тексте источника
… Data may be shared on reasonable request pending the review of the investigators and the Icelandic National Bioethics Committee. Competing interests LSA has participated in a conference supported by Alexion. SR: Honoraria for scientific talks from Johnson & Johnson and Siemens Healthineers. … Ethics approval and consent to participate The iStopMM study protocol was approved by the Icelandic National Bioethics Committee (Number 16-022, date: 2016-04-06) with approval from the Icelandic Data Protection Agency. …