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Bilateral Atypical Optic Neuritis With Posterior Scleritis Secondary to Tuberculosis: Challenges in Management.

Atypical optic neuritis and posterior scleritis can indicate extrapulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis. We present a rare case of bilateral atypical optic neuritis accompanied by posterior scleritis secondary to TB. A 36-year-old gentleman presented with a four-day history of blurred vision in both eyes, along with pain during eye movements. His medical history included intermittent low-grade fever and a persistent cough lasting four months, accompanied by significant weight loss of 13 kg over two months. On examination, visual acuity in the right eye was 6/36, whil…

Rapidly Progressive Bilateral Syphilitic Optic Neuritis in an Elderly Patient: A Case Report.

Syphilitic optic neuritis (SON), caused by Treponema pallidum infection, typically demonstrates favorable visual outcomes when promptly diagnosed and appropriately treated with high-dose intravenous penicillin therapy. However, certain patient factors including advanced age, severe initial visual impairment, and rapid disease progression may influence treatment outcomes. This case report aims to highlight the clinical challenges and poor prognostic factors associated with SON in elderly patients by presenting a rare case of rapidly progressive bilateral visual dysfunction despite optimal medic…

MRI in detection of acute optic neuritis: A systematic review and meta-analysis.

BACKGROUND: MRI is frequently performed as part of the diagnostic workup in suspected acute optic neuritis (AON). Conflicting results exist regarding the overall diagnostic performance of MRI and different protocols in AON diagnosis. PURPOSE: This meta-analysis aims to evaluate a diagnostic performance of MRI for the detection of AON. DATA SOURCES: Search was performed on PubMed/MEDLINE, EMBASE and Cochrane databases until December 2024. STUDY SELECTION: Studies were assessed independently by two authors following PRISMA guidelines and were screened to exclude duplicates and review articles…

От диагностики к лечению: изучение механизмов, лежащих в основе оптического неврата в множестве склерозов.

Множественный склероз (MS) — хроническое аутоиммунное заболевание, воздействующее на центральную нервную систему, которое, как правило, вызывает сенсорные расстройства, моторную слабость, слабую походку, несогласованность и оптический неуриит (ON). Согласно статистическим данным, до 50% пациентов, страдающих синдромом MS, испытывают проблемы со зрением в период болезни, страдающие от нечеткого зрения, боли, недостатка зрения и даже слепоты. Лечение перешло от кортикостероидов к лечению, ориентированному на клетки В/Т. В рамках этого обзора проводится всеобъемлющая и систематическая оценка диаг

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system, commonly causing sensory disturbances, motor weakness, impaired gait, incoordination and optic neuritis (ON). According to the statistics, up to 50% of MS patients experience vision problems during the disease course, suffering from blurred vision, pain, color visio…

Болезни сна и риск оптового неврита при множественном склерозе: ретроспективное коортное исследование.

В этом ретроспективном когортном исследовании изучается взаимосвязь между расстройствами сна и риском развития оптического неврата у пациентов с множественным склерозом (МС). Используя данные Глобальной сети сотрудничества " Тринеткс " , мы проанализировали two Совпадающие группы: пациенты MS с документально подтвержденными нарушениями сна (n = 48,995) и без (n = 48,995). Сопоставимость показателей цен обеспечивает сбалансированность базовых характеристик, сводя к минимуму смешанные факторы. Наши выводы показали, что среди пациентов с расстройствами сна, страдающих оптическим неврато

Совпадение в аннотации оригинала
This retrospective cohort study investigates the relationship between sleep disorders and the risk of developing optic neuritis in patients with multiple sclerosis (MS). Utilizing data from the TriNetX Global Collaborative Network, we analyzed two matched cohorts as follows: MS patients with documented sleep disorders (n = 48,995) and those without (n = 48,9…

Успешное долговременное лечение педиатрического релапсирующего идиопатического оптического нерита с Mycofonate Mofetil.

Фон: Педиатрический оптический неуриит (НН) является редким, но тяжелым заболеванием, характеризующимся острыми нарушениями зрения, при этом 3-5% случаев повторного защелки не имеют идентифицируемых маркеров сопутствующих заболеваний, таких, как нервно-оптическое расстройство спектра (NMOSD) или множественный склероз (MS); таким образом, эти случаи классифицируются как повторный идиопатический оптический неуриит (RION). Кортикостероиды, как правило, используются для острого лечения; однако их продолжительное применение в отношении детей сопряжено с серьезными рисками, включая ожирение в центре

Совпадение в аннотации оригинала
Background: Pediatric optic neuritis (ON) is a rare but severe condition characterized by acute visual impairment, with 3-5% of relapsing cases lacking identifiable markers for associated conditions, such as neuromyelitis optica spectrum disorder (NMOSD) or multiple sclerosis (MS); these cases are thus classified as relapsing idiopathic optic neuritis (RION)…

Презентация и результаты оптического неврита: опыт одного центра из Северной Саудовской Аравии.

Цель этого исследования заключалась в анализе демографических характеристик, клинического представления и результатов лечения пациентов с оптическим неуритом (ОН) в больнице им. короля Халида, Хейла, Саудовская Аравия. Было проведено ретроспективное когортное исследование, в ходе которого были рассмотрены медицинские записи 40 пациенты, диагностированные в период с января 2021 и декабрь 2024. Собранные данные включали демографические данные, клинические представления, неврологические выводы, результаты съемки и результаты лечения. По данным исследования, в основном женщины (n = 32, 80%), гражд

Совпадение в аннотации оригинала
Objectives This study aimed to analyze the demographic characteristics, clinical presentation, and treatment outcomes of patients with optic neuritis (ON) at King Khalid Hospital, Hail, Saudi Arabia. Methods A retrospective cohort study was conducted reviewing medical records of 40 patients diagnosed with ON between January 2021 and December 2024. Data colle…

Optic neuritis following COVID-19 vaccination: Case series and review of the literature.

OBJECTIVE: To review cases of optic neuritis after COVID-19 vaccination and add similar cases to the literature. METHODS: Thorough PubMed and Scopus searches were conducted, and data from studies describing optic neuritis after COVID-19 vaccination were extracted, tabulated, pooled, and reviewed. RESULTS: We present 6 cases of optic neuritis following COVID-19 vaccination. Our literature search yielded 48 similar cases. All 54 cases were divided into 3 groups with respect to their serostatus: (1) double-seronegative or unknown serostatus optic neuritis cases, (2) myelin oligodendrocyte glyco…

Retinal Damage and Visual Network Reconfiguration Defines Visual Function Recovery in Optic Neuritis.

BACKGROUND AND OBJECTIVES: Recovery of vision after acute optic neuritis (AON) is critical to improving the quality of life of people with demyelinating diseases. The objective of the study was to prospectively assess the changes in visual acuity, retinal layer thickness, and cortical visual network in patients with AON to identify the predictors of permanent visual disability. METHODS: We studied a prospective cohort of 88 consecutive patients with AON with 6-month follow-up using high and low-contrast (2.5%) visual acuity, color vision, retinal thickness from optical coherence tomography, l…

Portable multi-focal visual evoked potential diagnostics for multiple sclerosis/optic neuritis patients.

PURPOSE: Multiple sclerosis (MS) is a neuro-inflammatory disease affecting the central nervous system (CNS), where the immune system targets and damages the protective myelin sheath surrounding nerve fibers, inhibiting axonal signal transmission. Demyelinating optic neuritis (ON), a common MS symptom, involves optic nerve damage. We've developed NeuroVEP, a portable, wireless diagnostic system that delivers visual stimuli through a smartphone in a headset and measures evoked potentials at the visual cortex from the scalp using custom electroencephalography electrodes. METHODS: Subject vision …

Trends in Plasma Exchange Use in Optic Neuritis Hospitalizations in the United States.

PURPOSE: To report use trends of plasma exchange (PLEX) as well as sociodemographic and medical comorbidities associated with PLEX in the United States. DESIGN: Retrospective cross-sectional study. PARTICIPANTS: Adult patients (≥ 18 years) admitted for inpatient hospitalization with a primary diagnosis of optic neuritis (ON). METHODS: Data from the National Inpatient Sample database was compiled to assess PLEX use rates between 2000 and 2020. The cohorts of patients receiving PLEX versus not receiving PLEX were analyzed between quarter 4 of 2015 through 2020 (International Classification of…

Predictive model for converting optic neuritis to multiple sclerosis; decision tree in focus.

BACKGROUND: Optic neuritis (ON) can be an initial clinical presentation of multiple sclerosis This study aims to provide a practical predictive model for identifying at-risk ON patients in developing MS. METHOD: We utilized data from the Optic Neuritis Treatment Trial study, which enrolled 457 patients aged from 18 to 46 years, all diagnosed with acute ON. These patients underwent up to 15 years of neurological and ophthalmologic examinations and imaging. The selection of variables for the developing model was based on clinical importance and statistical significance, and any missing values w…

Efficacy and safety of tocilizumab treatment in refractory MOG-IgG related optic neuritis.

BACKGROUND: Myelin oligodendrocyte glycoprotein (MOG) IgG related optic neuritis (ON) which manifests as recurrent episodes and severe visual impairment remains a challenging issue in relapse prevention. Tocilizumab (TCZ), a human monoclonal antibody against IL-6R, may be an alternative treatment for the prevention of relapse in refractory MOG-ON patients. OBJECTIVES: To investigate the efficacy and safety of Tocilizumab (TCZ) in patients with recurrent myelin oligodendrocyte glycoprotein IgG related optic neuritis (MOG-ON). DESIGN: We conducted an open-label, single-arm, nonrandomized, unco…

Isolated Optic Neuritis: Etiology, Characteristics, and Outcomes in a US Mountain West Cohort.

BACKGROUND: The diagnosis and treatment of autoimmune optic neuritis (ON) has improved with the accessibility and reliability of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) antibody testing, yet autoantibody-negative ON remains common. This study describes the demographic, clinical, and outcome data in patients with isolated ON across the pediatric and adult cohort. METHODS: A retrospective chart review of University of Utah Health patients with the International Classification of Diseases ( ICD ) code of ICD-9 377.30 (ON unspecified), ICD-9 377.39 (other ON), or ICD-10 H…

Clinical characteristics depending on magnetic resonance imaging patterns in idiopathic isolated optic neuritis.

To investigate differences in clinical features based on magnetic resonance imaging (MRI) in idiopathic isolated optic neuritis patients. We retrospectively analyzed 68 eyes of 59 patients diagnosed with optic neuritis and showed inflammatory findings indicative of optic neuritis on MRI. We investigated clinical features, such as the presence of accompanying pain, visual acuity, and optic disc swelling. Optic disc swelling was classified as normal, mild, or severe. The MRI results were divided into intraorbital, intracanalicular, and whole optic nerve according to the lesion, and these were co…

Genome-Wide Expression Profile in People with Optic Neuritis Associated with Multiple Sclerosis.

The aim of this study was to perform a genome-wide expression analysis of whole-blood samples from people with optic neuritis (ON) and to determine differentially expressed mRNAs compared to healthy control subjects. The study included eight people with acute ON and six healthy control subjects. Gene expression was analyzed using DNA microarrays for whole-human-genome analysis, which contain 54,675 25-base pairs. The additional biostatistical analysis included gene ontology analysis and gene set enrichment analysis (GSEA). Quantitative RT-PCR (qPCR) was used to confirm selected differentially …

When Sight and Cancer Collide: A Rare Case of Paraneoplastic Bilateral Optic Neuritis.

Bilateral acute optic neuritis is a rare and challenging clinical presentation, often associated with conditions like multiple sclerosis or neuromyelitis optica spectrum disorder. We present the case of a 40-year-old woman with a complex medical history, including poorly differentiated squamous cell carcinoma of the cervix (stage IIIC), who presented with a swift and profound bilateral vision loss. Despite initial treatment with high-dose methylprednisolone and therapeutic plasma exchange, her optic nerve enhancement on MRI and negative autoantibody results raised suspicion of paraneoplastic o…

Beyond Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies: Alternative Causes of Optic Neuritis.

Optic neuritis (ON) is the most common cause of vision loss in young adults. It manifests as acute or subacute vision loss, often accompanied by retrobulbar discomfort or pain during eye movements. Typical ON is associated with Multiple Sclerosis (MS) and is generally mild and steroid-responsive. Atypical forms are characterized by unusual features, such as prominent optic disc edema, poor treatment response, and bilateral involvement, and they are often associated with autoantibodies against aquaporin-4 (AQP4) or Myelin Oligodendrocyte Glycoprotein (MOG). However, in some cases, AQP4 and MOG …

Portable Multi-focal Visual Evoked Potential Diagnostics for Multiple Sclerosis/Optic Neuritis patients.

PURPOSE: Multiple Sclerosis (MS) is a neuro-inflammatory disease of the Central Nervous System (CNS) in which the body's immune system attacks and destroys myelin sheath that protects nerve fibers and causes disruption in axonal signal transmission. Demyelinating Optic Neuritis (ON) is often a manifestation of MS and involves inflammation of the optic nerve. ON can cause vision loss, pain and discomfort in the eyes, and difficulties in color perception.In this study, we developed NeuroVEP, a portable, wireless diagnostic system that delivers visual stimuli through a smartphone in a headset and…

Subclinical damage to the contralateral eye in unilateral optic neuritis: A longitudinal study.

BACKGROUND: Early detection of subclinical injuries can lead to a correct diagnosis and help control the advancement of the condition. This study aims to investigate the presence of subclinical damage and silent progression to the contralateral eye's visual function and structure in patients experiencing their first episode of unilateral optic neuritis (ON). METHODS: Fifty patients with first-onset unilateral ON were enrolled in this study. Based on etiology, they were classified as having neuromyelitis optica spectrum disorder-related ON (NMOSD-ON), myelin oligodendrocyte glycoprotein antibo…