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Retrobulbar chlorpromazine injections for the management of blind and seeing painful eyes.

PURPOSE: To report the efficacy of primary retrobulbar chlorpromazine injections for the management of blind and seeing painful eyes. PATIENTS AND METHODS: Retrospective case series from three university hospitals was done. Twenty eyes of 20 patients with at least 3 months of follow-up are reported. Ten of these 20 eyes did not receive any other ophthalmic medications either 2 weeks before chlorpromazine injection or at any time point after injection. Treatment was considered successful if pain control lasted for at least 3 months, without the need for reinjection or enucleation. RESULTS: Si

Acetaminophen and ibuprofen in the management of fever and mild to moderate pain in children.

Acetaminophen has become the non-narcotic of choice for children because of concerns regarding the connection between acetylsalicylic acid exposure and Reye's syndrome. Ibuprofen, recently granted over-the-counter status for children over two years of age, offers another choice for treatment. The efficacy and safety of both drugs have been studied in numerous clinical trials. This paper reviews the published evidence about the efficacy and safety of acetaminophen and ibuprofen with regard to treating fever and mild to moderate pain in children.

Medical management of pain for early motion in hand and wrist surgery.

Pain control is a prerequisite to early motion. It can best be accomplished with a combination of drugs given around the clock, rather than on an as-needed basis.

Vertebral compression fractures: how to manage pain, avoid disability.

About 25% of U.S. women over age 50 will suffer one or more vertebral compression fractures related to osteoporosis. Vertebral fractures may … ts include kyphosis, deconditioning, insomnia, and depression. Initial treatment includes bed rest, pain management with local and systemic analgesia, bracing to improve comfort, and patient reassurance. Long-term management includes spinal stretching exercises, walking, and treatment of underlying osteoporosis with calcitonin or estrogen in selected patients.

Concerning the management of pain associated with herpes zoster and of postherpetic neuralgia.

This simple method of achieving substantial pain control in patients with documented herpes zoster and postherpetic neuralgia has been effective in each of the patients in whom it has been used (the most recent 12 cases have been summarized for this report). It has been more effective than narcotic analgesics, oral anti-inflammatory analgesics, sedatives, tranquilizers, TENS, hypnosis and the wide variety of operative measures we have tried in the past. Although it was initially used pragmatically, there is now a reasonable rationale for its effectiveness that can be proposed based on more rec

Diagnosis, Pathology, and Management of Pain in the Ischemic Hand: A Comprehensive Review.

Chronic limb-threatening ischemia of the upper extremity, resulting from pathologies like vasospasm, occlusion, trauma, or end-stage renal disease, is challenging to manage because of severe pain and morbidity. This review seeks to summarize the vascular anatomy of the upper extremity at risk for chronic limb-threatening ischemia, explain the pathophysiology of ischemic pain signaling, review diagnostic testing, and explore medical and surgical pain management options, as well as introduce avenues for future research.

Paracetamol: A History of Assumptions, Errors, and Evidence Reversals in Pain Management.

PURPOSE OF REVIEW: Paracetamol (acetaminophen) is among the most widely used medications in the history of humanity for treatment of pain co … istory of paracetamol represents an instructive example of evidence reversal in modern medicine and pain management. Originally introduced as a safer successor to phenacetin, paracetamol benefited from a favorable safety reputation that often exceeded the available scientific evidence. Subsequent investigations have revealed a more complex reality. Hepatotoxicity …

[Pharmacological management of pain in chronic wounds and stomas in adult patients].

Pain associated with chronic wounds and stomas is a frequent and complex clinical problem that is often underestimated and undertreated. Its pathophysiology is multifactorial, since it combines nociceptive, inflammatory, and neuropathic mechanisms, which justifies the need for a comprehensive, multimodal pharmacological approach. This review critically analyzes recent evidence on systemic, topical, and adjuvant treatments used for the management of baseline pain, procedure-related pain, neuropathic pain, and breakthrough pain in patients with chronic wounds or stomas. Systematic reviews, clini

Nationwide Survey of Pharmacist Involvement in Managing Cancer Pain in Children.

BACKGROUND: Cancer pain distresses pediatric patients, affects quality of life, and is a psychological burden for families. The purpose of t … tients or their families" (68.3%), respectively. CONCLUSIONS: Pharmacists were actively engaged in pain management for children with cancer and their families. However, most reported difficulties, particularly in pain assessment and analgesic explanations. Therefore, educational programs should be developed to facilitate effective pain management.

Disparities associated with race and ethnicity in pain management: a scoping review.

INTRODUCTION: Health inequalities can occur where there are differences in how people are treated with respect to their race and ethnicity. Disparities and systemic inequities in healthcare have led to negative outcomes. Pain management is an area where there are perceived health inequalities. Medicines optimisation is a framework for healthcare provider interventions under four principles to ensure that medicines are used safely and effectively, producing the best possible outcomes for patients. Using this framework allows a systematic and theory-informed identification of areas of care at ri…

The Significance of Palliative Care in Managing Pain for Patients Undergoing Hemodialysis.

Background/Objectives: Pain is a common issue among patients undergoing hemodialysis (HD), and palliative care (PC) aims to improve their quality of life. This study investigates the incidence, nature, and treatment of pain in chronic HD patients in Hungary, along with factors influencing pain intensity and the benefits of PC. Methods: This study used a cross-sectional design involving 159 patients with chronic end-stage kidney disease (ESKD) receiving HD at the National Dialysis Center in Pécs, Hungary. Pain was assessed using a "PQRST" questionnaire, and statistical analyses were performed o

Targeted Interventional Therapies for the Management of Postamputation Pain: A Comprehensive Review.

Postamputation pain (PAP), including residual limb pain (RLP) and phantom limb pain (PLP), remains a significant and debilitating complication after limb loss. Despite advances in pharmacological management, many patients experience inadequate pain relief, underscoring the need for alternative therapeutic strategies. Objective: This narrative review critically synthesizes current interventional therapies for PAP, focusing on mechanisms, clinical efficacy and practical application. Methods: A literature search was conducted in PubMed, EMBASE, Scopus and Web of Science databases for studies publ

Is botulinum toxin the future of orofacial pain management? Evidence and perspectives.

Botulinum toxin (BTX) demonstrates potential as a complementary therapy in managing chronic orofacial pain (OFP), but challenges in the standardization of protocols and indications remain.

Нейрофизиологические подходы к борьбе с болью при множественном склерозе: мини-обзор.

Хроническая боль является распространенным, но зачастую недостаточно признанным симптомом у лиц с множественным склерозом (МС), который затрагивает 29-86% населения. Это положение может существенно повлиять на функциональность отдельных лиц, включая их способность заниматься профессиональной деятельностью. Патофизиология, лежащая в основе этого состояния, остается сложной и не вполне понятной, а неадекватные меры реагирования на фармакологические вмешательства или неблагоприятные последствия могут препятствовать его регулированию. В свете этих замечаний настоятельно необходимо определить новые

Совпадение в аннотации оригинала
Chronic pain is a prevalent yet often under-recognized symptom among individuals with multiple sclerosis (MS), affecting 29-86% of the popul … ial theta burst stimulation (rTMS variant). The results indicate the potential benefits of NIBS for pain management in MS. However, the study's limitations, including the scarcity of data, small sample size, the limited number of sessions, sham design, and brief follow-up, are also noted and discussed. Finally, directions for future research are suggested.

Pain management in primary care: A review of the updated CDC guideline.

In 2022, the CDC released an updated clinical practice guideline for prescribing opioids and managing pain in the outpatient setting. This article synthesizes the guideline recommendations and implementation considerations for clinical NP practice.

Management of Severe Pain in a Case of Sensory Guillain-Barre Syndrome.

Guillain-Barre syndrome (GBS) is an acute post-infectious polyradiculoneuropathy characterized by autoantibodies targeting host antigens, resulting in nerve fiber demyelination and axonal degeneration. While symmetric ascending weakness is typical, neuropathic pain is a common yet variable manifestation. We present a case of a 52-year-old man with progressive bilateral leg weakness and severe neuropathic pain following a flu-like illness. Despite conventional analgesics, his pain persisted, necessitating a unique pain management approach. The patient's examination revealed hyporeflexia and sen…