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Расовые различия в выживании нескольких миелом: ассоциации с трансплантацией стволовых клеток, страхованием и расширением сети медицинских учреждений.

На уровне населения чернокожие пациенты с множественной миеломой (ММ) могут выжить хуже, чем белые. Авторы изучили вопрос о том, как автологическая трансплантация стволовых клеток (ASCT), страхование и расширение сети " Медикэйд " связаны с расовыми различиями в общем уровне выживания (rwOS) в реальном мире. МЕТОДЫ: Данные, полученные 4932 больные MM (MM)24% Блэк) в Флатиронской базе данных исследований в области здравоохранения анализировался с использованием моделей " Кокс регрессиал " (rwOS), " Файн энд срей " (ASCT) и " политомная регрессия " (страхо

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… Indiana, Kentucky, Louisiana, Massachusetts, Maryland, Maine, Michigan, Minnesota, Missouri, New Hampshire, New Jersey, New Mexico, New York, Ohio, Oklahoma, Oregon, Pennsylvania, Virginia, Washington, and West Virginia. b States in the study that did not expand Medicaid in the 2011–2021 study period: Alabama …

Взаимосвязь между БМИ и когнитивом, инвалидностью и качеством жизненных показателей при множественном склерозе: вторичный анализ DISCOMS.

СВЯЗЬ МЕЖДУ индексом массы тела (ИОВ) и когнитивированием, инвалидностью и качеством жизни (QOL) является спорной при множественном склерозе (MS). Мы изучили связь между BMI и когнитивной функцией, инвалидностью и QoL в MS. МЕТОДЫ: Был проведен перекрестный вторичный анализ процесса ДИСКОМС для изучения связи между БМИ и когнитивом, инвалидностью и QoL. Когнитивная функция измерялась по методу проверки символических цифр (ССРМ), а инвалидность измерялась на основе расширенной шкалы показателей инвалидности (СЭДСС) и установленных пациентом ступеней инвалидности (ПДДС). Кольные маркеры измеряли

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… Charity Morgan, Department of Biostatistics, The University of Alabama at Birmingham, Birmingham, AL, USA. Eric Engebretson, Department of Neurology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. …

Сочетание подтвержденной инвалидности - это полезный клинический конечный пункт для многоразовых склерозных клинических испытаний.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Чувствительные и значимые меры по ухудшению положения инвалидов по-прежнему остаются неудовлетворенной медицинской потребностью в множественных склерозах (МС). Совокупное подтвержденное ухудшение/прогрессирование инвалидности (CCDW/cCDP) сочетает расширенную шкалу взносов для инвалидов (EDSS) с испытаниями на аммуляцию и декстерность (время) 25-Foot ходовое испытание [T25FWT] и Nine- Тест на петлю [9HPT]. Мы провели оценку взаимосвязи между изменениями в этих мерах, с тем чтобы понять полезность КБРВ/КРХВ в качестве конечной точки для испытаний НР.МЕТОДЫ: Для анал

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… Solutions LLC, Genzyme, Genentech Inc., GW Pharmaceuticals, Immunic, Klein-Buendel Inc., Merck-Serono, Novartis, Osmotica Pharmaceuticals, Perception Neurosciences, Protalix Biotherapeutics, Recursion/Cerexis Pharmaceuticals, Regeneron, Roche, and SAB Biotherapeutics; is employed by the University of Alabama …

Клиническое и экономическое воздействие работников, обеспечивающих уход за пациентами, страдающими множественным склерозом, в зависимости от состояния болезни.

Справочная информация: Исследования по вопросу о партнерах по уходу за пациентами с множественным склерозом (МС) являются ограниченными. Цели: Клиническое и экономическое воздействие на партнеров по уходу за работниками оценивалось с точки зрения степени заболеваемости MS. Методы: работники с супругами/домашними партнерами с НР из базы данных о партнерах по работе (Jan. 1, 2010- Декабрь. 31, 2019) имеют право на получение пособия, если: супруг/партнер имел по крайней мере 3 Связанная с НРICD-9-CM/ICD-10-CM::340xx/G35) заявления пациентов/акушеров/болезней в рамках 1 год (последняя претензия =

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… digit representing certain US states: 0 = Connecticut, Massachusetts, Maine, New Hampshire, New Jersey, Puerto Rico, Rhode Island, Vermont, and Virgin Islands; 1 =Delaware, New York, and Pennsylvania; 2 = District of Columbia, Maryland, North Carolina, South Carolina, Virginia, and West Virginia; 3 = Alabama …

Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative.

PurposeTo provide real-world evidence on risks and outcomes of breakthrough COVID-19 infections in vaccinated patients with cancer using the largest national cohort of COVID-19 cases and controls.MethodsWe used the National COVID Cohort Collaborative (N3C) to identify breakthrough infections between December 1, 2020, and May 31, 2021. We included patients partially or fully vaccinated with mRNA COVID-19 vaccines with no prior SARS-CoV-2 infection record. Risks for breakthrough infection and severe outcomes were analyzed using logistic regression.ResultsA total of 6,860 breakthrough cases were

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… Medicine—UL1TR002736: University of Miami Clinical and Translational Science Institute • University of Virginia—UL1TR003015: iTHRIV Integrated Translational health Research Institute of Virginia • Carilion Clinic—UL1TR003015: iTHRIV Integrated Translational health Research Institute of Virginia • University of Alabama …

Рекомендации Международной группы по работе с миеломой по диагностике и лечению изолированных плазмоклеточных опухолей.

Одиночные плазмоклеточные опухоли (СП) — редкие локализованные опухоли клоновых плазмоклеток, либо в костной ткани (одиночная костная плазмоклеточная опухоль), либо в мягких тканях/экстраоссозных (экстромедуллярные) с отсутствием или минимальным проникновением в костный мозг (КМ) (<10% клоновых плазмоклеток по иммуногистохимии) и отсутствием признаков системного вовлечения или событий, определяющих миелому. Приблизительно 50% СП прогрессируют в симптоматическую миелому в течение 5 лет после начальной определенной локальной радиотерапии. Увеличение доступности улучшенных диагностических и монит

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… Susan Bal, University of Alabama at Birmingham, Birmingham, AL 21. Muahamed Baljevic, Vanderbilt University Medical Center, Nashville, TN 22. Rahul Banerjee, Fred Hutchinson Cancer Center, Seattle, WA 23. Linda Baughn, Mayo Clinic, Rochester, MN 24. Rachid Baz, H. … Luciano Costa, University of Alabama at Birmingham, Birmingham, AL 66. Caitlin Costello, University of California San Diego Health, La Jolla, CA 67. Andrew Cowan, Fred Hutchinson Cancer Center, Seattle, WA 68. Peter Croucher, Garvan Institute of Medical Research, Australia 69. …

TCF12 and LncRNA MALAT1 Cooperatively Harness High Cyclin D1 but Low β-Catenin Gene Expression to Exacerbate Colorectal Cancer Prognosis Independently of Metastasis.

Metastasis is a well-known factor worsening colorectal cancer (CRC) prognosis, but mortality mechanisms in non-metastatic patients with poor outcomes are less understood. TCF12 is a transcription factor that can be physically associated with the long non-coding RNA MALAT1, creating an alliance with correlated expression levels in CRC patients. This TCF12-MALAT1 alliance is linked to poorer prognosis independently of age and metastasis. To identify the downstream effects responsible for this outcome, we analyzed 2312 common target genes of TCF12 and MALAT1, finding involvement in pathways like

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… Gene Set Enrichment Analysis The downstream target genes of TCF12 were obtained from the ENCODE dataset, and the target genes of MALAT1, predicted by the LncRNA2Target database, were searched from the UALCAN website of the University of Alabama at Birmingham [ 45 ]. …

Current Advances in Multiple Myeloma: A Post International Myeloma Society (IMS 2022) Round Table Debate by the International Academy for Clinical Hematology (IACH).

This round table discussion organized by the International Academy for Clinical Hematology (IACH) was dedicated to the 19th annual meeting of the International Myeloma Society (IMS), which was held in Los Angeles between the 25th and 27th August 2022. After some key meetings of the discipline of the field of clinical hematology, the IACH organizes regular round table discussion in order to summarize the flow of information and get the opinion of a panel of experts and the key take-home messages. As part of this discussion, the panellists debated 6 key topics: disease monitoring, management of

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… This discussion was moderated by Mohamad Mohty (MMo) from the Sorbonne University Hospital in Paris (France), joined by experts in this field: Aurore Perrot (AP) from the university hospital of Toulouse (France); Luciano Costa (LC) from the University of Alabama (USA); Salomon Manier (SM) from the University …

Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… Science • Tufts Medical Center—UL1TR002544: Tufts Clinical and Translational Science Institute • Tulane University—UL1TR003096: Center for Clinical and Translational Science • University Medical Center New Orleans—U54GM104940: Louisiana Clinical and Translational Science (LA CaTS) Center • University of Alabama …

Amelioration of the cyclophosphamide induced genotoxic damage in mice by the ethanolic extract of Equisetum arvense.

In the present study, we evaluated the potential of the plant E. arvense against the cytotoxic and mutagenic effects induced by cyclophosphamide (chemotherapeutic agent) in the bone marrow cells of mice using the Chromosome assay (CA) and Mitotic index (MI) in vivo as the biomarkers. The study was performed following 3 protocols: pre-treatment, simultaneous treatment and post-treatment with the ethanolic extract of the plant. The results demonstrated that the plant extract was not cytotoxic and mutagenic and has a protective effect against the mutagenicity induced by cyclophosphamide in pre, s

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… It is distributed throughout Canada and the USA except the southeast (Florida, Georgia, Alabama, Louisiana, Mississippi, and Tennessee), throughout Europe and Asia south to Turkey, Iran, the Himalayas and across China (except the southeastern part), Korea and Japan [9] . …

Are you "tilting at windmills" or undertaking a valid clinical trial?

In this review, several aspects surrounding the choice of a therapeutic intervention and the conduct of clinical trials are discussed. Some of the background for why human studies have evolved to their current state is also included. Specifically, the following questions have been addressed: 1) What criteria should be used to determine whether a scientific discovery or invention is worthy of translation to human application? 2) What recent scientific advance warrants a deeper understanding of clinical trials by everyone? 3) What are the different types and phases of a clinical trial? 4) What c

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… to determine whether the study can be undertaken or continued. 18 Box 3- Tuskegee syphilis study: An unethical clinical trial that generated new regulations to protect human study participants The Tuskegee syphilis study was an infamous clinical study conducted between 1932 and 1972 in Tuskegee, Alabama …

Recognition and management of persistent chylomicronemia: A Joint Expert Clinical Consensus by the National Lipid Association and the American Society for Preventive Cardiology.

Extreme hypertriglyceridemia, defined as triglyceride (TG) levels ≥1000 mg/dL, is almost always indicative of chylomicronemia. The current diagnostic approach categorizes individuals with chylomicronemia into familial chylomicronemia syndrome (FCS; prevalence 1-10 per million), caused by the biallelic combination of pathogenic variants that impair the lipolytic action of lipoprotein lipase (LPL), or multifactorial chylomicronemia syndrome (MCS, 1 in 500). A pragmatic framework should emphasize the severity of the phenotype and the risk of complications. Therefore, we endorse the term "persiste

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… classification for treatment could include an estimation of risk of complications, particularly pancreatitis, noting that such risk increases markedly when severe PC is present. 25 In a recent study in 1,294,044 individuals from a large healthcare network across 3 US states (Minnesota, Florida, and Alabama …

Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a common type of kidney cancer and accounts for 2-3% of all cancer cases. Furthermore, a growing number of immunotherapy approaches are being used in antitumor treatment. Signaling lymphocyte activation molecule family (SLAMF) members have been well studied in several cancers, whereas their roles in ccRCC have not been investigated. The present study comprehensively assessed the molecular mechanisms of SLAMF members in ccRCC, performed using The Cancer Genome Atlas database, with analysis of gene transcription, prognosis, biological function, clinical

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… The University of Alabama at Birmingham Cancer data analysis Portal (UALCAN; http://ualcan.path.uab.edu/index.html ) is a dedicated portal for facilitating tumor subgroup gene expression and survival analyses ( 29 ). …

Burden of illness among patients with relapsed or refractory multiple myeloma, and eligible for B-cell maturation antigen-targeted therapies.

BACKGROUND: B-cell maturation antigen (BCMA)-targeted therapies were approved for triple-class exposed relapsed/refractory multiple myeloma (RRMM) after ≥4 lines of therapy. METHODS: This claims-based retrospective analysis examined clinical and economic burden among United States patients who met eligibility for BCMA-targeted therapies and started a new therapy between 1 January 2016 and 30 September 2022. RESULTS: Of 228 eligible patients (median age: 64, 52.6% male, 68.7% White), clinical burden was characterized by prevalent MM-related conditions and complications, and high treatment fai

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… SG is an employee of the University of Alabama at Birmingham, which receives research funding from CareVive Systems, PackHealth, Sanofi, and Janssen Oncology. SG also receives honoraria from CareVive, OncLive, and Sanofi. …

Increased Indoleamine 2, 3-Dioxygenase expression modulates Th1/Th17/Th22 and Treg pathway in humans with Helicobacter Pylori-Infected gastric mucosa.

Introduction and purposeIndoleamine 2, 3- dioxygenase (IDO) plays an importantrole in immunosuppressive pathway, as inhibits responsesof T cells and promotes immune tolerance. Host responsetoHelicobacter pylori (H. pylori) is involved in the infection persistenceand it is also associatedwith different clinical outcomes. The aim of this study was to investigate the role of IDO in H. pylori-infected patients with gastritis diseases and peptic ulcer diseases (PUD) through the assessment of the relationship among IDO protein expression and the numbers of T helper (Th)-1, Th17, Th22, and T regulato

"Они не хотят изучать его": доверие, раса и медицинское обслуживание среди пациентов-диадов с множественной миеломой.

БАКГРЕСС: Медицинское недоверие, лежащее в основе неэтичного исследования, является препятствием для лечения лиц из числа чернокожих/африканцев (АА) раком. Решающее значение имеет понимание доверия, недоверия и опыта в области здравоохранения, особенно в случае множественной миэломы (ММ), которая в непропорционально большой степени ложится тяжелым бременем на чернокожих/алкоголиков с точки зрения заболеваемости и выживания. ЦЕЛЬ ИССЛЕДОВАНИЯ: В этом исследовании качественно изучается опыт чернокожих/аАА и белых диад (больных с ММ и взрослых опекунов), с тем чтобы получить представление об этих

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… especially among Black/AA persons, have contributed to reduced health care system interactions and higher mortality rates, worsening racial health disparities. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 The Tuskegee study, which aimed to evaluate the natural progression of syphilis among Black men in Tuskegee, Alabama …

Stage-specific biomarkers in triple-negative breast cancer: Preliminary findings from bioinformatics approaches.

BackgroundIntegrated bioinformatics approaches were used to identify stage-specific candidate genes and potential drug targets in triple-negative breast cancer (TNBC).MethodsMicroarray (164 early-stage, 33 advanced-stage, and 53 normal samples) and RNA-seq (113 normal, 163 early-stage, and 30 advanced-stage TNBC samples) datasets were analyzed. Differentially expressed genes (DEGs) were identified, followed by co-expression analysis using Weighted Gene Co-expression Network Analysis (WGCNA) and protein-protein interaction analysis using the STRING database. miRNA co-regulation was evaluated us

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… Pan-cancer dysregulation patterns of these genes were then assessed using the University of Alabama at Birmingham Cancer Data Analysis portal (UALCAN), and the literature was curated to evaluate their associations with tumor aggressiveness. …

Launch and Post-Launch Prices of Injectable Cancer Drugs in the US: Clinical Benefit, Innovation, Epidemiology, and Competition.

BackgroundRising cancer drug prices adversely affect patients' adherence and survival.ObjectiveWe aimed to identify and quantify factors associated with launch prices and post-launch price changes of injectable cancer drugs in the US from 2005 to 2023.Data and methodsAll anticancer drugs with US FDA approval between 2000 and 2022 were identified in the Drugs@FDA database. The sample was then restricted to cancer drugs covered under Medicare Part B (injectable drugs). Data characterizing each drug's clinical benefits, disease epidemiology, approved indications, competition, and price were obtai

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… Second, the University of Alabama’s drug database, ‘Drug Bank’, was accessed to determine each drug’s product type. Drugs were categorized as small molecules and others, which entail biological agents, antibody-drug conjugates, gene therapies, cell therapies, enzymes, and radionuclides. …

Viewing the US presidential electoral map through the lens of public health.

Health, disease, and mortality vary greatly at the county level, and there are strong geographical trends of disease in the United States. Healthcare is and has been a top priority for voters in the U.S., and an important political issue. Consequently, it is important to determine what relationship voting patterns have with health, disease, and mortality, as doing so may help guide appropriate policy. We performed a comprehensive analysis of the relationship between voting patterns and over 150 different public health and wellbeing variables at the county level, comparing all states, including

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… The 14 states that have not expanded Medicaid (Alabama, Florida, Georgia, Kansas, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Wisconsin, Wyoming) have overall lower median insured rates among those making 138% below the federal poverty level compared …

Truthfulness in patient-reported outcomes: factors affecting patients' responses and impact on data quality.

The use of patient-reported outcome (PRO) measures in research and clinical care has expanded dramatically, reflective of an increasing recognition of patient-centeredness as an important aspect of high-quality health care. Given this rapid expansion, ensuring that data collected using PRO measures is of high quality is crucial for their continued successful application. Because of the subjective nature of the outcomes assessed, there are many factors that may influence patients' responses and thus challenge the overall quality of the data. In this review, we discuss the multiple factors that

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… cognitive burden placed on respondents, resulting in missing data or increased patient anxiety. 8 This may be pronounced when tools validated for research purposes are instituted in the clinic without evaluation in context, eg, in a case study of implementation of PRO collection at the University of Alabama …