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The Key Role of Hepcidin-25 in Anemia in Multiple Myeloma Patients with Renal Impairment.

Background and objectives: Anemia is common in multiple myeloma (MM) and is caused by a complex pathomechanism, including impaired iron homeostasis. Our aim is to evaluate the biomarkers of iron turnover: serum soluble transferrin receptor (sTfR) and hepcidin-25 in patients at various stages of MM in relation with markers of anemia, iron status, inflammation, renal impairment and burden of the disease and as predictors of mortality. Materials and methods: Seventy-three MM patients (six with smoldering and 67 with symptomatic disease) were recruited and observed for up to 27 months. Control gro

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… Approval by the Bioethics Committee of the Jagiellonian University was granted (approval number 1072.6120.248.2017). Written informed consent was obtained from all participants. All the patients with MM were treated at the Department of Hematology, University Hospital in Kraków, Poland. 2.3. … Institutional Review Board Statement The study was conducted according to the guidelines of the Declaration of Helsinki, and approved by the Institutional Ethics Committee: Bioethics Committee of the Jagiellonian University (protocol code 1072.6120.248.2017). …

Церковная боль и воздействие на качество жизни пациентов с множественным склерозом.

Основная цель этого исследования заключалась в оценке воздействия шейной боли на качество жизни пациентов с множественным склерозом по сравнению с группой здоровых людей (без болезней центральной нервной системы). Материалы и методы: В период с ноября 2023 года по август 2024 года данные были собраны в специализированном госпитале Сент-Лукаша в Коньском (Польша). Критерием включения в это исследование были следующие: возраст (20-50 лет), женщины и мужчины, здоровые люди (без болезней центральной нервной системы) и люди, страдающие множественным склерозом. Лицам из исследовательской группы был

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… Ethics Statement and Information About Project This study received positive consent from the Bioethics Committee of the Collegium Medicum of the Jan Kochanowski University (approval date: 30 June 2023, no. 32/2023). … Institutional Review Board Statement Consent was obtained by the Bioethics Committee at the Collegium Medicum of the Jan Kochanowski University (decision of 30 June 2023, No. 32/2023). …

Характеристики контроля за Pelvic во время статического равновесия у пациентов с множественным склерозом: исследование на основе новинок-сенсоров.

Фон/цели: Множественный склероз (MS) является воспалительным и нейродегенеративным заболеванием центральной нервной системы. Повреждения MS могут влиять на мотор, сенсорные и зрительные нервы, что приводит к нарушению равновесия, мышечному натяжению и боли. Вышеупомянутое может существенно повлиять на качество жизни. В этой связи необходимо использовать объективные методы функциональной оценки для установления баланса и выявления расстройств, связанных с походкой, у пациентов, имеющих MS. Цель исследования заключалась в оценке функционального состояния и качества жизни людей с множественным ск

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… Methodology This study was conducted after obtaining the consent of the Bioethics Committee of the Medical University of Białystok No. R-I-002/392/2019 at the Rehabilitation Clinic of the Medical University of Białystok. … Institutional Review Board Statement This study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of the Bioethical Commission (No. R-I-002/392/2019, 26 September 2019). …

IL1B Полиморфизм (rs1143634) и IL-1β Концентрация плазмы в качестве предсказателей расстройств питания и прогнозирующих факторов у многих пациентов с миеломой.

Множественная миелома (ММ) — гематологическая опухоль раннего прекурсора клеток В. Наиболее характерные симптомы, наблюдаемые во время MM, включают гипокалкемию, анемию, бактериальные инфекции и почечные повреждения. Отмечаются расстройства питания, особенно недоедание 35-71% Пациентов MM. Interleukin 1 бета (IL-1β) — цитокин, производящий мускулистую атрофию и липолиз во время недоедания и качексии. Цель этого исследования заключалась в оценке полезности полиморфизма однонуклеотида IL1B (SNP) (rs1143634) и плазменной концентрации IL-.1β при оценке риска нарушения питания и прогнозирования у п

Psychological empowerment and quality of life in haematopoietic stem cell transplantation patients: A quantitative study.

AimThis study aimed to evaluate the relationship between psychological empowerment, depression, anxiety, and quality of life in people with haematopoietic stem cell transplantation (HSCT).DesignA longitudinal prospective study.MethodsA sample of 150 people with haematological was recruited at Santaros Clinics in Lithuania between September 2020 and April 2022. Demographic characteristics, cancer-related characteristics, depression, anxiety, psychological empowerment and quality of life (QoL) were assessed using self-report questionnaires before and 10-12 weeks after HSCT. Descriptive statistic

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… Ethical consideration The study was approved by the Lithuanian Bioethics Committee (2020/3˗1217˗699), and Vilnius University Ethics Committee (2020‐06‐30, Nr.49). … ETHICS STATEMENT The study was approved by the Lithuanian Bioethics Committee (2020/3˗1217˗699) and Vilnius University Ethics Committee (2020‐06‐30, Nr.49). …

miRNAs as predictive biomarkers of response to treatment in pediatric patients with acute lymphoblastic leukemia.

MicroRNAs (miRNAs/miRs) are promising prognostic biomarkers in pediatric acute lymphoblastic leukemia (ALL). The present study aimed to identify miRNAs that could serve as prognostic biomarkers or as novel therapeutic targets in ALL. The expression levels of 84 miRNAs were assessed in the bone marrow aspirates of 10 pediatric patients with newly diagnosed ALL at diagnosis and on day 33 of induction of the ALL Intercontinental Berlin-Frankfurt-Münster 2009 protocol, and associations with established prognostic factors were evaluated. The levels at diagnosis of 25 miRNAs were associated with ≥2

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… The present study was approved by the Committee for Bioethics and Ethics of the School of Medicine of the Aristotle University of Thessaloniki (Thessaloniki, Greece; approval no. 1.463; 19/10/2021). … Ethics approval and consent to participate The present study was performed in accordance with the Declaration of Helsinki and approved by the Committee for Bioethics and Ethics of the School of Medicine of the Aristotle University of Thessaloniki (Thessaloniki, Greece; approval no. 1.463; 15/10/2021 …

Lung Cancer: Spectral and Numerical Differentiation among Benign and Malignant Pleural Effusions Based on the Surface-Enhanced Raman Spectroscopy.

We present here that the surface-enhanced Raman spectroscopy (SERS) technique in conjunction with the partial least squares analysis is as a potential tool for the differentiation of pleural effusion in the course of the cancerous disease and a tool for faster diagnosis of lung cancer. Pleural effusion occurs mainly in cancer patients due to the spread of the tumor, usually caused by lung cancer. Furthermore, it can also be initiated by non-neoplastic diseases, such as chronic inflammatory infection (the most common reason for histopathological examination of the exudate). The correlation betw

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… Six samples with non-cancerous lung effusion, considered the control, were collected according to standard best practice and ethics and bioethics guidelines. … Institutional Review Board Statement The study was in agreement with the institutional policies and relevant laws and approved by the Ethics and Bioethics Committee of Cardinal Stefan Wyszyński University (Warsaw, Poland) opinion number 13/2019. …

[The meaning and essence of donation. How much of "ourselves" do we give when we donate our organs?].

Our study endeavors to show, in the form of an empirical study, that the inadequate number of donations of human body parts in France can be explained by a fear of loss, in both an ontological and anthropological sense: to give is to renounce, to lose, to deprive oneself. This line of argument seeks, on one hand, to highlight how the common understanding of donation implicitly fuels this behaviour, and, on the other hand, to propose a relationship of oneself to oneself followed by oneself to others through various representations of the possession of one's body. Thus, a social practice with a

Death with dignity and euthanasia: comparative European approaches.

From 1800 to 1960, the average life expectancy doubled making medical activities a fight against death. In doing so, the dying process became medicalized. Some infectious diseases clearly disappeared while new surgical interventions, such as organ transplants, may be viewed as some kinds of human resuscitation. Sociologically, medicine has replaced religion and doctors are the new priests of our techno society. Paradoxically this has created a new fear The artificial process of dying is replacing death but it is transforming the individuals into artificially supported and suffering bodies rely

Профильы, связанные с питанием, в множестве склерозов: ассоциации с копингом, лечебный блок контроля и самоуправление.

Справочная информация/цели: Трудности, связанные с питанием людей с множественным склерозом (МС), могут отражать различные поведенческие и психологические процессы, включая эмоциональную реакцию на стресс, связанный с болезнью, обычное переедание, попытки контролировать потребление продуктов питания и более широкие процедуры самоуправления. Анализ, ориентированный на изменение направленности, может затушевывать эту неоднородность путем отдельного изучения тенденций, связанных с питанием. Цель этого исследования состояла в том, чтобы изучить вопрос о том, являются ли обычным перееданием, эмоцио

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… The Bioethics Committee at Poznan University of Medical Sciences confirmed that formal ethical approval was not required for this non-interventional questionnaire-based study. … The Bioethics Committee at Poznan University of Medical Sciences confirmed that formal ethical approval was not required for this non-interventional questionnaire-based study. Informed Consent Statement Informed consent was obtained from all subjects involved in this study. …

Knowledge about Ultraviolet Radiation Hazards and Tanning Behavior of Cosmetology and Medical Students.

Dear Editor, Ultraviolet (UV) radiation is a well-known physical hazard responsible for photoaging, photoallergic, and phototoxic reactions as well as carcinogenesis, including life-threatening melanomas (1,2). Overexposure to both natural and artificial UV radiation is a public health concern. 30% of cancers diagnosed worldwide are skin cancers. Approximately three million non-melanoma skin cancers and 132 000 new cases of melanomas are diagnosed globally each year (3). Sunburns, especially in childhood, are a very important risk factor for melanomas. Several studies demonstrated a positive a

Ethical considerations for hematologic precursor conditions.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… Couns 104 1 2021 3 11 32690398 10.1016/j.pec.2020.07.010 8 Sella T Fell GG Miller PG Patient perspectives on testing for clonal hematopoiesis of indeterminate potential Blood Adv 6 24 2022 6151 6161 36129839 10.1182/bloodadvances.2022008376 PMC9791300 9 Räikkä J Freedom and a right (not) to know Bioethics …

What Is Precision Psychotherapy?

Precision medicine impacts virtually all medical specializations, including psychiatry. Although precision psychiatry, in general, is a flourishing area of research and debate, psychotherapy as one pillar of psychiatry receives little attention. Theoretical discussions about precision psychotherapy are rare; research on precision in psychotherapy is just evolving. In this paper, we provide a conceptualization of precision psychotherapy providing a common idea of what should be understood as precision in the context of psychotherapy and what kind of psychotherapy research is considered to contr

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… The New Bioethics 23 ( 1 ): 1 – 12 . 28517985 10.1080/20502877.2017.1314895 Fernandes B. S. , Williams L. M. , Steiner J. , Leboyer M. , Carvalho A. F. , Berk M. 2017 . The new field of ‘precision psychiatry’ . …

Тенсорная диффузия МРТ и NODDI в классификации множественных склерозов.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Многокамерные модели диффузии и многокамерные приобретения все чаще используются для преодоления ограничений, связанных с обычной диффузионной тенсорной съемкой, но требуют более длительных сканирования и более сложной обработки. В то же время исследования по диффузионной классификации МРТ часто основываются на узком наборе тенсорных метрик, особенно на фракционной анизотропии. Мы изучили вопрос о том, может ли более широкое использование настольных элементов, включая дескрипторы формы, улучшить классификацию без повышения сложности приобретения.МЕТОДЫ: МРИ с несколькими

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… Materials and methods Participants This prospective, single-centre study was approved by the Bioethics Committee at the Regional Medical Chamber (No. 282/KBL/OIL/2020; 18 December 2020), and written informed consent was obtained from all participants. … Ethics approval The studies involving humans were approved by Bioethics Committee at the Regional Medical Chamber, No. 282/KBL/OIL/2020. The studies were conducted in accordance with the local legislation and institutional requirements. …

Conjoined twins: the ambiguity of double effect reasoning.

This essay explores the ethical debate that surrounds last year's case of conjoined ischiopagus tetrapus twins, Mary and Jodie. More precisely, it focuses on those arguments that involved double effect reasoning (DER). A classic model of DER is offered, followed by a summary of the opinions of theologians and philosophers in debating whether such reasoning could be used to justify the surgical separation of these babies. The purpose is to show the "give and take" of ethical discourse, how complex and demanding the application of DER often is, and how elusive finding a "right answer" can be.

20 Years of Legislation - How Australia Has Responded to the Challenge of Regulating Genetically Modified Organisms in the Clinic.

•In contrast to the prior voluntary system, since 2001, gene technology in Australia has been regulated under a legislated national Gene Technology Regulatory Scheme which is administered by the Gene Technology Regulator.•The Scheme provides science-based assessment of the potential risks of gene technology to the health and safety of people and the environment.•It complements the role of the Australian Therapeutic Goods Administration which regulates all therapeutic products in Australia to ensure they are safe and effective.•Recent reforms to the Scheme contribute to, and anticipate, the con

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… Nuffield Council on Bioethics. Joint Statement on the Ethics of Heritable Human Genome Editing. London : Nuffield Council on Bioethics ( 2020 ). 43. Andorno R Baylis F Darnovsky M Dickenson D Haker H Hasson K Geneva statement on heritable human genome editing: the need for course correction. …

Enhancing Immune Response in Non-Small-Cell Lung Cancer Patients: Impact of the 13-Valent Pneumococcal Conjugate Vaccine.

Background: Non-small-cell lung cancer (NSCLC) is one of the most frequently diagnosed diseases among all types of lung cancer. Infectious diseases contribute to morbidity and mortality by delaying appropriate anti-cancer therapy in patients with NSCLC. Methods: The study aimed to evaluate the effectiveness of vaccination with the 13-valent pneumococcal conjugate vaccine (PCV13) in 288 newly diagnosed NSCLC patients. The analysis of the post-vaccination response was performed after vaccination by assessing the frequency of plasmablasts via flow cytometry and by assessing the concentration of s

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… Institutional Review Board Statement The study was conducted by the Declaration of Helsinki and approved by the Bioethics Committee of the Regional Chamber of Physicians in Kielce (No. KB7/2012 approved on 18 December 2012). … The study protocol also received the necessary approval from the Bioethics Committee at the Medical University of Lublin under reference number KE-0254/283/2015 (approved on 15 January 2015). Informed Consent Statement Informed consent was obtained from all subjects involved in the study. …

Изучение роли позитивного образа тела, симптомов депрессии, инвалидности и возраста в принятии болезней у людей с множественным склерозом.

Фон: Множественный склероз (MS) является хроническим нейродегенеративным заболеванием, приводящим к постепенной инвалидности, которая может влиять не только на физическое, но и на психическое состояние пациентов. Психологическая адаптация к этому заболеванию играет важную роль в общей эффективности лечения. Цель этого исследования заключалась в определении изменяемых и немодифицированных корреляций принятия болезни. Методы: Включено в общей сложности 139 белых жителей, имеющих MS (PwMS) (106 женщин). Были использованы данные о принятии шкалы заболеваемости (АИС), шкалы оценки тела (БАС-2) и гр

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… Approval was granted by the Bioethics Committee of the Silesian Medical University (no. BNW/NWN/0052/KB/123/24 and date of approval: 11 June 2024). Patients were interviewed individually during a scheduled routine clinic visit or at support group meetings. …