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[Analysis of the current application status of blood purification therapy in critically ill children].

OBJECTIVE: To analyze the clinical features, treatment mode selection, factors influencing prognosis and current clinical application of con … non-survival group had higher proportions of primary diseases including necrotizing encephalopathy, hypernatremia, hemophagocytic syndrome, and post-congenital heart disease surgery (all P<0.05). Compared with the 2017-2020 group, the 2021-2024 group showed significantly increased age [months: 102.0 (28.0, 160.5) vs. 42.0 (17.0, 102.0)] and body weight [kg: 18. …

SIADH-related hyponatremia in hospital day care units: clinical experience and management with tolvaptan.

Hyponatremia (Na ˂ 135 mmol/l) is the most frequent electrolyte disorder in clinical practice, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the commonest cause of hyponatremia in cancer patients. Correcting hyponatremia in these patients can reduce morbidity and mortality, increase the response to anti-cancer agents, and help reduce hospital length of stay and costs. Tolvaptan is an oral medication used to treat SIADH-related hyponatremia patients that needs to be initiated at hospital so patients can have their serum sodium monitored. If tolvaptan could be initi

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… Patients must not present any contraindications for the use of tolvaptan like hypersensitivity to the active substance/excipients, anuria, volume depletion, hypovolemic hyponatremia, and hypernatremia, patients who cannot perceive thirst and pregnancy or breast feeding [ 9 ]. … If serum sodium increases ≥12 mmol/l within 24 h or ≥18 mmol/l within 48 h or there is a hypernatremia >145 mmol/l, tolvaptan treatment needs to be interrupted or discontinued followed by administration of hypotonic fluid [ 9 ]. …

High-Dose Vitamin C in Advanced-Stage Cancer Patients.

High-dose intravenously administered vitamin C (IVC) is widely used in cancer patients by complementary and alternative medicine practitioners. The most frequent indications for IVC therapy result from the belief in its effectiveness as a potent anti-cancer agent which additionally enhances chemosensitivity of cancer cells and reduces chemotherapy-related toxicities and fatigue intensity. In this narrative review, we decided to deal with this issue, trying to answer the question whether there is any scientific evidence supporting the rationale for application of high-dose IVC therapy in advanc

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… Moderate to severe laboratory abnormalities, such as hypernatremia, hypokalemia, hypercalcemia, and low hemoglobin count were also observed [ 27 , 28 , 58 ]. … High-dose vitamin C treatment seems to be safe in advanced cancer patients when appropriate precautions are taken with a risk of not serious side effects, such as transient headache, dizziness, nausea, flu-like symptoms, and abnormalities in the results of laboratory tests (anemia, hypernatremia, hypercalcemia …

Множественная миелома с психической нефропатией и негативом Бенса-Джонса Протеинурии: Редкое клиническое представление.

Множественная миелома (MM) — злокачественное расстройство плазменных клеток, которое обычно вызывает анемию, боль в костях, гиперкальцемию и почечную недостаточность. Мы сообщаем о случае 55-year-old Мужчина, у которого были в основном острые повреждения почек (АКИ), пинентопенция и системное воспаление без классических особенностей гиперкальцемии или литических повреждений костей. В частности, мочевые белки Бенса-Джонса были отрицательными, несмотря на заметно повышенную сыворотку каппа и аномальный белковый электрофорез (SPEP). Биопсия костного мозга выявила скромный плазмоцитоз, в то время

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… Interpretation Hemoglobin | 10.3 g/dL | 13–18 g/dL | Anemia WBC count | 2.45 ×10⁹/L | 4–11 ×10⁹/L | Leukopenia Platelets | 104 ×10⁹/L | 150–400 ×10⁹/L | Thrombocytopenia Urea | 171 mg/dL | 10–50 mg/dL | Elevated Creatinine | 9.34 mg/dL | 0.5–0.9 mg/dL | Markedly elevated Sodium | 150 mmol/L | 135–145 mmol/L | Hypernatremia …

Systematic Review of Intravenous Ascorbate in Cancer Clinical Trials.

BackgroundAscorbate (vitamin C) has been evaluated as a potential treatment for cancer as an independent agent and in combination with standard chemotherapies. This review assesses the evidence for safety and clinical effectiveness of intravenous (IV) ascorbate in treating various types of cancer.MethodsSingle arm and randomized Phase I/II trials were included in this review. The PubMed, MEDLINE, and Cochrane databases were searched. Results were screened by three of the authors (GN, RP, and CJP) to determine if they met inclusion criteria, and then summarized using a narrative approach.Result

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… Grade 3 and 4 metabolic toxicities (hypernatremia and hypokalemia) related to ascorbate was observed. … It is likely that hypernatremia and hyperkalemia, reported by Stephenson et al., was secondary to the approximately two-fold higher ascorbate dose that patients received in comparison to other trials. …

Neurology

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… phosphate-containing enemas, and iatrogenic causes related to thyroidectomy. 41 Hypercalcemia can cause disturbances of the CNS such as depression and seizures and is most often associated with hypercalcemia of malignancy or renal failure, although there are rare reports of primary hyperparathyroidism in cats. 41 Hypernatremia … , defined as a serum sodium concentration above 165 mEq/L in cats, results in clinical signs of weakness, ataxia, seizures, and coma. 86 The severity of clinical signs is related directly to the acuteness of onset and degree of hypernatremia 86 and is attributed to rapid shifts of water from the intracellular …

Гипервискозный синдром, гиперкальцемия и острая ренальная недостаточность в качестве первоначальных проявлений множественной миеломы в октогенариане.

Множественная миелома (ММ) — гематологическая порча, характеризующаяся распространением аномальных плазменных клеток, часто сопровождаемая чрезмерной секрецией моноклонных иммуноглобулинов. Синдром гипервискоза (HVS) является редким, но угрожающим жизни осложнением, которое ведет к расстройству микроциркуляции и дисфункции органов. Кроме того, гиперкальцемия, обычно связанная с остеолитическим разрушением костей, может также привести к острым повреждениям почек и изменению сознания. ПРЕДСТАВЛЕНИЕ СЛУЧАИ: Мы описываем 80-year-old Мужчина, у которого была путаница, общая слабость, снижение мочи

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… However, subsequent laboratory tests revealed severe anemia (Hemoglobin 2.1 g/dL), hypernatremia (147 mmol/L), and rapidly declining renal function (BUN 85.5 mg/dL, creatinine 3.3 mg/dL). …

Type-B lactic acidosis associated with progressive multiple myeloma.

We report a 64-year-old lady with stage II, Immunoglobulin-G lambda multiple myeloma (MM) (standard risk), who presented with type-B lactic acidosis (LA), and multi-organ dysfunction associating myeloma progression, and ending in imminent death. In the context of literature review of all previously reported similar cases, this report highlights and discusses the association of type-B LA and MM (especially progressive disease), and also emphasizes the poor outcome. Early recognition of this condition with intensive supportive care, and treatment of multiple myeloma may improve outcomes.

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… She was given one cycle of lenalidomide and dexamethasone, and was then admitted to the hospital in June 2013 with fatigue, decreased urine output, and sleepiness as a case of acute kidney injury, hypernatremia, sub-clinical disseminated intravascular coagulation, and progression of MM. …

Kidney care in patients with cancer: perspectives from the onconephrology committee of the Brazilian Society of Nephrology.

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… Decreased oral intake and gastrointestinal losses in those patients can also contribute to hyponatremia, hypernatremia, hypomagnesemia, hypokalemia, and hypophosphatemia 12 . Hypercalcemia is also a common electrolyte complication seen in cancer patients, occurring in up to 30% of cases. …

Emergency Care

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… Fluid therapy The diagnosis of intracellular fluid deficit is difficult and is based more on the presence of hypernatremia or hyperosmolality than on clinical signs. …

Management of Potential Organ Donor: Indian Society of Critical Care Medicine-Position Statement.

This position statement is documented based on the input from all contributing coauthors from the Indian Society of Critical Care Medicine (ISCCM), following a comprehensive literature review and summary of current scientific evidence. Its objective is to provide the standard perspective for the management of potential organ/tissue donors after brain death (BD) in adults only, regardless of the availability of technology. This document should only be used for guidance only and is not a substitute for proper clinical decision making in particular circumstances of any case. Endorsement by the IS

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… To avoid hypernatremia (concurrent DI) and hyperchloremic acidosis (increases renal vascular resistance, confounds base excess) 0.9% normal saline should be avoided. … Hypernatremia secondary to DI needs to be taken care of with water, 5% dextrose, and 0.45% normal saline. Serum sodium and potassium should be monitored every 2–4 hours. Sodium should be kept below 155 mEq/dL and potassium between 4–5 mEq/dL. …

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs.

ObjectiveThis study aims to examine the factors contributing to the increase in extracellular water to total body water ratio (ECW/TBW) among tumor patients without visible edema, and to offer insights into the diagnosis and prompt management of early water retention in such patients.MethodsA cohort of 274 tumor patients admitted to Anqing First People's Hospital, affiliated with Anhui Medical University between December 2020 and December 2022, were selected, excluding those with clinically observable edema. General clinical data, main laboratory test outcomes, and body composition indices wer

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… This underscores the need for vigilance in high-risk subgroups—particularly older males with anemia, hypernatremia, and/or hypokalemia—where body composition assessment can detect subclinical fluid shifts and associated abnormalities (e.g., low phase angle). …

Multicenter phase 2 study of romidepsin plus lenalidomide for previously untreated peripheral T-cell lymphoma.

Peripheral T-cell lymphomas (PTCLs) are associated with poor prognosis when treated with cytotoxic chemotherapy. We report the findings of a phase 2 study evaluating a chemotherapy-free combination of romidepsin plus lenalidomide as initial treatment for patients with PTCL who were aged >60 years or noncandidates for chemotherapy. Treatment was initiated with romidepsin 10 mg/m2 IV on days 1, 8, and 15 and lenalidomide 25 mg taken orally from days 1 to 21 of 28-day cycle for up to 1 year. The primary objective was overall response rate (ORR). Secondary objectives included safety and survival.

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… Hypoglycemia | 4 | 14 | 0 | 0 Mucositis | 4 | 14 | 0 | 0 Sinus bradycardia | 4 | 14 | 0 | 0 Colitis | 3 | 10 | 2 | 7 Arthralgia | 3 | 10 | 1 | 3 Atrial fibrillation | 3 | 10 | 1 | 3 Confusion | 3 | 10 | 1 | 3 Hypercalcemia | 3 | 10 | 0 | 0 Hyperkalemia | 3 | 10 | 0 | 0 Hypermagnesemia | 3 | 10 | 0 | 0 Hypernatremia …

Clinical practice guidelines on addressing cognitive impairment in treatable dementias.

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… disturbances • Dry skin • Tiredness • Muscle weakness • Abdominal pain • Mood symptoms- esp. depression Diabetes Mellitus • Hyperglycaemia • Hypoglycaemia | • • Hyperosmolar state with stupor: • Minor focal signs • Associated with excess hypoglycaemic agents or Insulinoma Dyselectrolytemia • Hyponatremia • Hypernatremia …

Воздействие кетогенного рациона питания на качество жизни взрослых людей с хроническими заболеваниями: систематический обзор случайных контролируемых испытаний.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Хронические заболевания отрицательно сказываются на качестве жизни (КОЛ). Кетогенное питание (КД) может улучшить КОЛ. ЦЕЛЬ: Цель этого систематического обзора заключалась в обобщении имеющихся данных о выборочных контролируемых испытаниях (РСТ) для определения воздействия KD на QOL у взрослых, страдающих хроническими заболеваниями. МЕТОДЫ: Представление докладов осуществлялось в соответствии с руководящими принципами ПРИСМА. Мы включали в себя выборочные контролируемые испытания (РСТ), проведенные на взрослых с хроническими заболеваниями, включая группу вмешательства, ко

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… assigned diet (5 frequent blood sampling; 1 surgery; 1 diabetes) Martin-McGill, 2020 [ 39 ] Assessment of diet adherence: food diaries Assessment of ketosis: urinary ketones and blood ketones (at home) Blood ketones: ≥4 mmol/L During the first 6 weeks: MCTKD: 79.7%; MKD: 79.3% Hypokalemia ( n = 2), hypernatremia …

POSTER PRESENTATIONS

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Phase 1/2 study of carfilzomib, pomalidomide, and dexamethasone with and without daratumumab in relapsed multiple myeloma.

We conducted a phase 1/2 study of carfilzomib, pomalidomide, and dexamethasone (KPd) and KPd with daratumumab (Dara-KPd) in relapsed/refractory multiple myeloma. The primary end points were identification of a maximum tolerated dose (MTD) of KPd for phase 1, and rates of overall response (ORR) and near complete response (nCR) after 4 cycles of KPd and Dara-KPd, respectively, for phase 2. The MTD for KPd was carfilzomib 20/27 mg/m2 on days 1, 2, 8, 9, 15, and 16 (cycles 1-8) and days 1, 2, 15, and 16 for cycles 9 and beyond; oral pomalidomide 4 mg on days 1 to 21; and oral dexamethasone 40 mg w

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… imbalances | | | | Hypokalemia | 11 (17) | 2 (3) | 7 (25) | 0 (0) Hypophosphatemia | 10 (15) | 4 (6) | 3 (11) | 2 (7) Hypercalcemia | 5 (8) | 1 (2) | 4 (14) | 0 (0) Hypocalcemia | 5 (8) | 1 (2) | 2 (7) | 0 (0) Hyponatremia | 4 (6) | 0 (0) | 2 (7) | 0 (0) Hyperkalemia | 3 (5) | 0 (0) | 3 (11) | 0 (0) Hypernatremia …

A randomized, placebo-controlled trial of the BTK inhibitor zanubrutinib in hospitalized patients with COVID-19 respiratory distress: immune biomarker and clinical findings.

BackgroundCytokine release triggered by a hyperactive immune response is thought to contribute to severe acute respiratory syndrome coronavirus 2019 (SARS-CoV-2)-related respiratory failure. Bruton tyrosine kinase (BTK) is involved in innate immunity, and BTK inhibitors block cytokine release. We assessed the next-generation BTK inhibitor zanubrutinib in SARS-CoV-2-infected patients with respiratory distress.MethodCohort 1 had a prospective, randomized, double-blind, placebo-controlled design; cohort 2 had a single-arm design. Adults with SARS-CoV-2 requiring hospitalization (without mechanica

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… 10.3) | 0 Hypoalbuminemia | 1 (3.3) | 2 (6.9) | 3 (75.0) Hypoxia | 1 (3.3) | 4 (13.8) | 0 Hypomagnesemia | 0 | 3 (10.3) | 0 Pain in extremity | 0 | 2 (6.9) | 0 COVID-19 pneumonia | 1 (3.3) | 0 | 1 (25.0) Acute respriatory distress syndrome | 0 | 0 | 1 (25.0) Hemorrhage intracranial | 0 | 0 | 1 (25.0) Hypernatremia …

Diabetic and Nondiabetic Endocrine Emergencies: Clinical Spectrum and Outcomes From a Tertiary Care Center in North India.

ObjectiveEndocrine emergencies, although uncommon, are potentially life-threatening and require prompt diagnosis and timely intervention. Although diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are well described, data on nondiabetic endocrine emergencies remain limited, particularly from low-resource settings. This study aimed to evaluate spectrum, clinical characteristics, and outcomes of endocrine emergencies presenting to a tertiary care hospital in North India.MethodsA prospective observational study was conducted over 18 months at a tertiary care academic hospital

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… The 2 cases of DI were due to postoperative pituitary injury and neurosarcoidosis, both of which resulted in symptomatic hypernatremia, effectively managed with oral desmopressin. …