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Prevention of Anthracycline-Induced Cardiotoxicity: The Good and Bad of Current and Alternative Therapies.

Doxorubicin (Dox)-induced cardiotoxicity (DIC) remains a serious health burden, especially in developing countries. Unfortunately, the high cost of current preventative strategies has marginalized numerous cancer patients because of socio-economic factors. In addition, the efficacy of these strategies, without reducing the chemotherapeutic properties of Dox, is frequently questioned. These limitations have widened the gap and necessity for alternative medicines, like flavonoids, to be investigated. However, new therapeutics may also present their own shortcomings, ruling out the idea of "natur

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… For instance, an in vitro experimental study revealed the inability of metoprolol to prevent cardiotoxicity in C57Bl6 mice treated with Dox and trastuzumab ( 70 ). … Doxorubicin-induced and trastuzumab-induced cardiotoxicity in mice is not prevented by metoprolol . ESC Heart Fail. ( 2021 ) 8 : 928 – 37 . 10.1002/ehf2.13198 33529501 PMC8006653 71. Guo L Zheng X Wang E Jia X Wang G Wen J . …

Cardio-oncology in Austria: cardiotoxicity and surveillance of anti-cancer therapies : Position paper of the Heart Failure Working Group of the Austrian Society of Cardiology.

Survival in cancer is continuously improving due to evolving oncological treatment. Therefore, cardiovascular short-term and long-term side effects gain crucial importance for overall outcome. Cardiotoxicity not only presents as heart failure, but also as treatment-resistant hypertension, acute coronary ischemia with plaque rupture or vasospasm, thromboembolism, arrhythmia, pulmonary hypertension, diastolic dysfunction, acute myocarditis and others. Recent recommendations have proposed baseline cardiac risk assessment and surveillance strategies. Major challenges are the availability of monito

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… Concomitant administration of metoprolol reversed the mortality increase, counteracting sorafenib-induced myocyte death [ 86 ]. In a direct assessment on human myocardium, sorafenib treatment affected contractility and decreased the concentration of systolic cytoplasmic calcium [ 87 ]. … Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): extended follow-up of a 2×2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol. Circulation. 2021;143(25):2431–2440. doi: 10.1161/CIRCULATIONAHA.121.054698. 55. …

Anticholinergic burden risk and prevalence of medications carrying anticholinergic properties in elderly cancer patients in Jordan.

BackgroundGeriatric cancer patients are susceptible to adverse drug events due to the complexity of their chemotherapy regimens and collateral treatments for their comorbid conditions. Prescribing medications with anticholinergic burden characteristics can complicate their condition, leading to negative impacts on their health outcomes and quality of life, including an increase in adverse drug event frequency, physical and cognitive impairments.ObjectiveThis study aims to examine the prevalence of anticholinergic prescribing and identify the cumulative anticholinergic load risk associated with

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… Drug | Total Anticholinergic Drug Users N = 354 (% of total N) | Anticholinergic Potency (Scale 1 – 3) Metoclopramide | 150 (42.4%) | 1 Furosemide | 129 (36.4%) | 1 Tramadol | 85 (24.0%) | 2 Bisacodyl | 60 (16.9%) | 1 Metoprolol | 55 (15.5%) | 1 Chlorpheniramine | 53 (15.0%) | 3 Metformin | 50 (14.1% …

Экономия и безопасность дотинурада в связи с кислотой и реанимацией у пациентов с гиперперурицемией и повышенными хроническими почечными заболеваниями: единый центр, ретроспективный анализ.

ЦЕЛЬ: мы изучили эффективность и безопасность дотинурада, селективного ингибитора реабсорбции у гиперурисемичных пациентов с продвинутой хронической болезнью почек (CKD) (стадия) G3-5). ВОЗМОЖНОСТИ И МЕТОДЫ: Мы ретроспективно проанализировали случаи 34 больные (средний возраст, 68.6 ± 13.3 годы; 17 мужчин и женщин 17 женщин) после 12 Количество месяцев дотинурадной обработки на основе изменений в мочеисперсной кислоте (UA) и соотношении белков и креатининов мочи (UPCR) плюс ежегодное изменение расчетной гермекулярной фильтрации (eGFR). Гиперурикемия (UA) ≥6.0 мг/дл) и усовершенствованная CKD (

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… Metoprolol increases uric acid and risk of gout in African Americans with chronic kidney disease attributed to hypertension. Am J Hypertens . 2017;30(9):871–875. doi: 10.1093/ajh/hpx113 22. Adverse reactions to bendrofluazide and propranolol for the treatment of mild hypertension. …

Recent Perspectives on Cardiovascular Toxicity Associated with Colorectal Cancer Drug Therapy.

Cardiotoxicity is a well-known adverse effect of cancer-related therapy that has a significant influence on patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) is associated with a number of undesirable side effects including cardiac complications. For both sexes, CRC ranks second and accounts for four out of every ten cancer deaths. According to the reports, almost 39% of patients with colorectal cancer who underwent first-line chemotherapy suffered cardiovascular impairment. Although 5-fluorouracil is still the backbone of chemotherapy reg

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… These patients were given a combination of the beta 1 selective adrenergic blocker (B) metoprolol succinate and the angiotensin receptor blocker (ARB) candesartan cilexetil. PRADA was a two-by-two factorial study (beta-blocker vs. … No significant adjunctive preventive effect of metoprolol on LVEF decrease was seen ( p = 0.77). There was no proof that the two drugs worked together more effectively [ 90 ]. 5.3. …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… pirbuterol”, “procarterol”, “albuterol”, “arformoterol”, “bambuterol”, “clenbuterol”, “formoterol”, “salmeterol”, “abediterol”, “carmoterol”, “indacaterol”, “olodaterol”, “vilanterol” | Beta blockers | “acebutolol”, “atenolol”, “betaxolol”, “bisoprolol”, “carteolol”, “carvedilol”, “esmolol”, “labetalol”, “metoprolol …

Cardiovascular and Oncologic Considerations in Adult Hodgkin Lymphoma: JACC: CardioOncology State-of the-Art Review.

Classic Hodgkin lymphoma is a highly curable lymphoma that affects primarily younger patients. The therapeutic landscape has evolved and generally consists of varying combinations of chemotherapy and immunotherapy as well as radiation in selected cases. Although most patients are cured of their lymphoma, there is a risk for late treatment-related cardiotoxicity that affects long-term survival and quality of life in this population. Careful consideration of baseline cardiac function and risk factors should be undertaken prior to proceeding with anthracycline-based therapies or thoracic radiatio

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… Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 × 2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol Eur Heart J 37 2016 1671 1680 26903532 10.1093/eurheartj/ehw022 PMC4887703 82 Bosch X. Rovira M. Sitges M. … Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): extended follow-up of a 2×2 factorial, randomized, placebo-controlled, double-blind clinical trial of candesartan and metoprolol Circulation 143 2021 2431 2440 33993702 10.1161/CIRCULATIONAHA.121.054698 PMC8212877 87 Heidenreich …

Inequity in Cardio-Oncology: Identifying Disparities in Cardiotoxicity and Links to Cardiac and Cancer Outcomes.

Minority and underresourced communities experience disproportionately high rates of fatal cancer and cardiovascular disease. The intersection of these disparities within the multidisciplinary field of cardio-oncology is in critical need of examination, given the risk of perpetuating health inequities in the growing vulnerable population of patients with cancer and cardiovascular disease. This review identifies 13 cohort studies and 2 meta-analyses investigating disparate outcomes in treatment-associated cardiotoxicity and situates these data within the context of oncologic disparities, preexis

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… Cardioprotective effect of metoprolol and enalapril in doxorubicin‐treated lymphoma patients: a prospective, parallel‐group, randomized, controlled study with 36‐month follow‐up . … Prevention of cardiac dysfunction during adjuvant breast cancer therapy (PRADA): a 2 x 2 factorial, randomized, placebo‐controlled, double‐blind clinical trial of candesartan and metoprolol . …

Orthostatic intolerance syndromes after hematopoietic cell transplantation: clinical characteristics and therapeutic interventions in a single-center experience.

BackgroundHematopoietic cell transplantation (HCT) is an established and potentially curative therapeutic option for hematologic cancers. HCT survivors are at risk of developing long-term complications impacting on morbidity and mortality. Orthostatic hypotension (OH) and postural tachycardia syndrome (POTS) have been anecdotally described after HCT. However, the incidence and clinical characteristics of patients with OH and POTS after HCT has not been well defined.MethodsThis retrospective study included 132 patients who had HCT between March 2011 and July 2018 and were referred to Cardio-onc

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… In the group of 12 patients with POTS, a b-adrenergic blocker was prescribed to 9 (75%) patients, metoprolol in 5 (42%) cases, carvedilol in 4 (33%) and propranolol in 1 (8%). …

Case Report: Endothelial-targeted bridging therapy for a TTP-like phenotype in fulminant iMCD-TAFRO.

BACKGROUND: iMCD-TAFRO (the TAFRO clinical subtype of idiopathic multicentric Castleman disease (iMCD)) is characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly. Diagnosis is challenging due to its rarity, non-specific early presentation, and overlap with sepsis, lymphoma, and thrombotic microangiopathy (TMA). Endothelial injury is increasingly recognized as a central driver of its severe complications. CASE PRESENTATION: A previously healthy 20-year-old woman presented with rapid progression of fever, anasarca, jaundice, and respiratory failure. Laboratory

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… During infusion, anticholinergic effects occurred (bilateral mydriasis, pupils 2.5 mm pre-treatment to 4–8 mm) with a modest increase in sinus tachycardia (~10–15 beats/min), managed with metoprolol (12.5 mg twice daily). …

Сердечные эффекты и коморбиды неврологических заболеваний.

Неврологические расстройства охватывают сложный и неоднородный спектр заболеваний, затрагивающих мозг, спинной мозг и периферийные нервные системы, каждая из которых сопряжена с уникальными проблемами, выходящими далеко за рамки первичных неврологических симптомов. Эти расстройства оказывают глубокое воздействие на сердечно-сосудистое здоровье, что приводит к интенсивному изучению сложных взаимосвязей между неврологическими и сердечно-сосудистыми системами. В этом обзоре обобщаются текущие сведения и исследования о сердечно-сосудистых коморбидах, связанных с основными неврологическими заболева

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… Beta-blockers, such as metoprolol and propranolol, are commonly used to regulate heart rate and blood pressure, particularly in patients at risk of arrhythmias and hypertension. …

Effectiveness of Convalescent Plasma Therapy in COVID-19 Patients with Hematological Malignancies: A Systematic Review.

Background: Immunocompromised patients, including those with hematological malignancies, are at a high risk of developing severe coronavirus disease 2019 (COVID-19) complications. Currently, there is a limited number of systematic reviews into the efficacy of convalescent plasma therapy (CPT) use in the treatment of COVID-19 patients with hematological malignancies. Therefore, the aim of this review was to systematically appraise the current evidence for the clinical benefits of this therapy in COVID-19 patients with hematological malignancies. Methods: A comprehensive search was conducted up

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… , tocilizumab, and HCQ Luetkens et al. [ 16 ] | 1/0 | NA | 1 (200 mL) | 6 days | Asymptomatic at approximately 6 days from onset | 0% | None | Oxygen therapy Moore et al. [ 17 ] | 1/0 | Day 88 post illness onset | 1 (200 mL) | 97 days | Asymptomatic at approximately 97 days from onset | 0% | None | Metoprolol …

Cardio-Oncology and Multi-Imaging Modalities.

Early detection and the rise of targeted cancer treatment have led to increased overall survival and decreased mortality among cancer patients. As the cancer survivor population ages, there is an increased risk for cardiovascular disease due to pre-existing comorbidities, deconditioning during therapy, or the natural progression of aging. Furthermore, with emerging oncologic therapies, there is an increased recognition of their potential cardiovascular toxicities. Indeed, heart disease is the leading cause of death in cancer survivors, which may reflect upon both the success of novel oncologic

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… Treatment is dependent on the symptoms and includes lifestyle modification, midodrine or pyridostigmine, rate control with metoprolol or ivabradine (for inappropriate sinus tachycardia), or fullerenol or dexrazoxane, which may prevent anthracycline-associated cardiotoxicity [ 15 ]. 2.5. …

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

Despite the various initiatives carried out in Brazil and in the world, the challenge of offering essential medicines in adequate presentations remains, especially to the public affected by diseases considered neglected and the pediatric population, for whom the therapeutic options remain limited. The main objective of this study was to evaluate the production of manipulated medicines as a strategy to mitigate therapeutic and access gaps to essential medicines within the Brazilian public health system, called the Unified Health System (SUS). The evaluation, carried out between 2020 and 2021, i

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… . | Infantile Metoprolol succinate | 25 mg/mL Oral solution | Hypertension; Cardiac insufficiency; Stable chronic angina; Acute myocardial infarction. | Infantile Sulfadiazine | 100 mg/5 mL Oral solution | Toxoplasmosis; Prevention of recurrence of rheumatic fever; Uncomplicated acute urinary tract infections …

Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.

Cancer progression is profoundly influenced by the complex interplay between the tumor microenvironment (TME), the immune system, and the patient's psychological state. This review delineates a critical pathway linking chronic stress to worsened cancer outcomes through inflammatory factors, anti-tumor immune suppression, and the induction of behavioral comorbidities. We postulate that sustained stress hormone signaling via the sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation orchestrates a systemic immunosuppressive cascade. A central mechanism is the stress-induce

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… Gandhi et al., 2021 Metastatic NSCLC (EGFR-mutant) Non-selective and Selective Beta-Blockers (Nebivolol, Metoprolol, Bisoprolol) Retrospective Cohort Analysis Erlotinib (Tyrosine Kinase Inhibitor) Concomitant beta-blocker use significantly improved both progression-free survival (PFS) and overall survival … Decrease in IL-6 and increase in IFN-ɣ. | Inhibits β-adrenergic receptor signaling to reverse the immunosuppressive tumor microenvironment, decreasing MDSCs and enhancing CD8 + T-cell activity. | Gandhi et al., 2021 Metastatic NSCLC (EGFR-mutant) | Non-selective and Selective Beta-Blockers (Nebivolol, Metoprolol …

Посттуральный ортостатический синдром тахикардии и ортостатическое гипотезирование после трансплантации стволовых клеток.

СПРАВОЧНИК: Посттуральная ортопедическая тахикардия (POTS) и ортостатическая гипотензия (OH), как правило, происходят после трансплантации стволовых клеток (HSCT). ЦЕЛИ: Данное исследование было направлено на определение распространенности ПОТС и ОЖ до ХОСТ и числа новых случаев после ХОСТ. МЕТОДЫ: В этом одном центре перспективного исследования была проведена оценка пациентов. 30 за несколько дней до 30 и 100 Через несколько дней после HSCT. Кровяное давление, сердечный ритм и уровень плазменного норепинефрина измерялись в суперном положении и после 10-minute испытание активного стенда для оц

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… Orthostatic plasma norepinephrine level as a predictor for therapeutic response to metoprolol in children with postural tachycardia syndrome. J Transl Med. 2014;12(1):249. doi: 10.1186/s12967-014-0249-3. 27. Abbate G., De Iulio B., Thomas G., et al. …

CSI position statement on management of heart failure in India.

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The Role of Drug Repurposing in the Development of Novel Antimicrobial Drugs: Non-Antibiotic Pharmacological Agents as Quorum Sensing-Inhibitors.

Background: The emergence of multidrug-resistant organisms (MDROs) is a global public health issue, severely hindering clinicians in administering appropriate antimicrobial therapy. Drug repurposing is a drug development strategy, during which new pharmacological applications are identified for already approved drugs. From the viewpoint of the development of virulence inhibitors, inhibition of quorum sensing (QS) is a promising route because various important features in bacterial physiology and virulence are mediated by QS-dependent gene expression. Methods: Forty-five pharmacological agents,

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… : mebendazole (Richter Pharmaceuticals; Budapest, Hungary; will be listed as RPh in the subsequent text), ivermectin (SA), 4. anti-allergy medications (H 1 -receptor antagonists and decongestants): cetirizine (SA), azelastine (SA), xylomethazoline (SA), 5. drugs targeting the cardiovascular system: metoprolol …

The emerging role of echocardiography-based techniques in cardio-onco-hematology.

In decades, the overall survival rate for cancer patients has improved significantly with continuous advances in cancer treatment technologies. However, cancer therapeutics-related cardiac dysfunction (CTRCD) has been one of the most worrying side effects, particularly in patients with hematological malignancies (HM), affecting the quality of life for cancer survivors. Early detection and prompt treatment are of vital importance. Echocardiography-based techniques can even identify subclinical myocardial damages, which is crucial for preventing irreversible myocardial damage. Conventional trans

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… Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up . …

Recent Advances in Serum Biomarkers for Risk Stratification and Patient Management in Cardio-Oncology.

PURPOSE OF REVIEW: Following significant advancements in cancer therapeutics and survival, the risk of cancer therapy-related cardiotoxicity (CTRC) is increasingly recognized. With ongoing efforts to reduce cardiovascular morbidity and mortality in cancer patients and survivors, cardiac biomarkers have been studied for both risk stratification and monitoring during and after therapy to detect subclinical disease. This article will review the utility for biomarker use throughout the cancer care continuum. RECENT FINDINGS: A recent meta-analysis shows utility for troponin in monitoring patients

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… Interestingly, metoprolol has generally failed to show a protective benefit during anthracycline treatment, while carvedilol has shown benefit, potentially due to its antioxidant properties [ 60 ]. …