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Epitranscriptomic regulation by m6A in immunity and autoimmune disorders: emerging mechanisms and clinical perspectives.

Immune-mediated diseases arise from intricate interactions among genetic, environmental, and epigenetic factors that disrupt immune homeosta … emic (systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis) and organ-specific (multiple sclerosis (MS), inflammatory bowel disease (IBD), type 1 diabetes mellitus (T1DM), and autoimmune thyroid disease (AITD) ADs, revealing disease-specific epitranscriptomic regulatory patterns. Critically, we highlight recent therapeutic breakthroughs targeting …

Кладрибинные таблетки в новую многократную эру склероза.

Множественный склероз (MS) — аутоиммунное состояние, характеризующееся воспалительным демиэлированием, которое приводит к необратимым неврологическим повреждениям в центральной нервной системе (КНС). В этом обзоре рассматриваются терапевтический потенциал и клиническая эффективность таблеток кладрипин (КладТ) для лечения MS с уделением особого внимания механизму восстановления иммунной системы и воздействию CNS. КлэдТ представляет собой заметный прогресс в лечении синдромов заболеваний, обусловленный избирательной ориентацией на лимфоциты, что приводит к устойчивой, но обратимой иммунной модул

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an autoimmune condition characterized by inflammatory demyelination that leads to irreversible neurological damage within the central nervous system (CNS). This review examines the therapeutic potential and clinical efficacy of cladribine tablets (CladT) for treating MS, focusing on the immune reconstitution mechanism and CNS effec…

Сочетание повреждений парамагнитного обода с зарегистрированными пациентами нейропсихиатрическими симптомами при множественном склерозе.

ОКРУЖАЮЩАЯ СРЕДА: Повреждения парамагнитного обода (ПВК) указывают на хронические активные повреждения при множественном склерозе (МС) и связаны с развитием инвалидности и объективным когнитивным упадком, однако их связь с такими невидимыми симптомами, как усталость, нарушение настроения и воспринимаемое когнитивное восприятие, остается неясной. Мы, вероятно, зачислили взрослых в MS, которые прошли 3T-показательную съемку. Были подсчитаны промежуточные ПНР, и участники были отнесены к 0, 1-3 или > 3 ПНР. Neuro-QoL T-показатели усталости, депрессии, беспокойства и восприятия были собраны в базо

Совпадение в аннотации оригинала
BACKGROUND: Paramagnetic rim lesions (PRLs) mark chronic active lesions in multiple sclerosis (MS) and have been linked to disability progression and objective cognitive decline, but their relationship with invisible symptoms such as fatigue, mood disturbance and perceived cognition remains unclear. METHODS: We prospectively enrolled adults with MS who unde…

Cost patterns of long-term prescribed medications in patients with multiple sclerosis in Germany.

Multiple sclerosis (MS) is a chronic neurological disease that affects people in their most productive years of life. A multimodal treatment approach is typically employed to slow the progression of disability and alleviate MS-related symptoms. This implies a high financial burden of MS on patients, healthcare systems and society. Our study focused on the costs that are attributable to long-term drug prescriptions in patients with MS. For this purpose, the medication plans of 728 MS patients from 3 medical centers in Germany were analyzed. Pharmaceutical pricing information was obtained from t…

Vortioxetine ameliorates experimental autoimmune encephalomyelitis model of multiple sclerosis in mice via activation of PI3K/Akt/CREB/BDNF cascade and modulation of serotonergic pathway signaling.

Multiple sclerosis (MS) is a chronic condition characterized by immune cell infiltration and cytokine overproduction that led to myelin sheath inflammatory assaults, thus causing axonal destruction. The former consequently provokes motor impairment and psychological disorders. Markedly, depression is one of the most prevalent lifelong comorbidities that negatively impacts the quality of life in MS patients. Vortioxetine (VTX), a multi-modal molecule prescribed to manage depression and anxiety disorder, additionally, it displays a promising neuroprotective properties against neurodegenerative d…

In vivo degradation forms, anti-degradation strategies, and clinical applications of therapeutic peptides in non-infectious chronic diseases.

Current medicinal treatments for diseases comprise largely of two categories: small molecular (chemical) (e.g., aspirin) and larger molecula … uccessfully used in clinical therapies for patients with non-infectious diseases, such as diabetes, multiple sclerosis, and cancer.

Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing-Remitting Multiple Sclerosis.

Palmitoylethanolamide (PEA) is an endogenous lipid mediator known to reduce pain and inflammation. However, only limited clinical studies have evaluated the effects of PEA in neuroinflammatory and neurodegenerative diseases. Multiple sclerosis (MS) is a chronic autoimmune and inflammatory disease of the central nervous system. Although subcutaneous administration of interferon (IFN)-β1a is approved as first-line therapy for the treatment of relapsing-remitting MS (RR-MS), its commonly reported adverse events (AEs) such as pain, myalgia, and erythema at the injection site, deeply affect the qua…

Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity.

Multiple sclerosis (MS) is an immune-mediated chronic central nervous system (CNS) disease affecting more than 400 000 people in the United States. Myelin-reactive CD4 T cells play critical roles in the formation of acute inflammatory lesions and disease progression in MS and experimental autoimmune encephalomyelitis (EAE), a well-defined mouse model for MS. Current MS therapies are only partially effective, making it necessary to develop more effective therapies that specifically target pathogenic myelin-specific CD4 T cells for MS treatment. While suppressing T-bet, the key transcription fac…

Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study.

AIM: Chronic cerebrospinal venous insufficiency (CCSVI) is a vascular phenomenon recently described in multiple sclerosis (MS) that is characterized by stenoses affecting the main extracranial venous outflow pathways and by a high rate of cerebral venous reflux that may lead to increased iron deposition in the brain. Aim of this study was to investigate the relationship between CCSVI and iron deposition in the brain of MS patients by correlating venous hemodynamic (VH) parameters and iron concentration in deep-gray matter structures and lesions, as measured by susceptibility-weighted imaging (…

Delivery of Chlamydia vaccines.

The plethora of ocular, genital and respiratory diseases of Chlamydia, including nongonococcal urethritis, cervicitis pelvic inflammatory disease, ectopic pregnancy, tubal factor infertility, conjunctivitis, blinding trachoma and interstitial pneumonia, and chronic diseases that may include atherosclerosis, multiple sclerosis, adult onset asthma and Alzheimer's disease, still pose a considerable public health challenge to many nations. Although antibiotics are effective against Chlamydia when effectively diagnosed, asymptomatic infections are rampart, making clinical presentation of complicati…

Contemporary approaches to designing and evaluating vaccines against Chlamydia.

The clinically relevant pathologic consequences of primary ocular, genital, or respiratory human infection by members of the genus Chlamydia are conjunctivitis, cervicitis, urethritis and sinusitis. The major complications and sometimes debilitating evolutionary outcomes of these infections include: trichiasis and cicatrizing trachoma, endometritis or pelvic inflammatory disease and involuntary tubal factor infertility and bronchopulmonary pneumonia. These diseases, in addition to other chlamydia-associated chronic syndromes (e.g., artherosclerosis, multiple sclerosis and Alzheimer's disease),…

Gastrointestinal hemorrhage in patients with systemic sclerosis and CREST syndrome.

OBJECTIVES: Systemic sclerosis (SSc) and calcinosis, Raynaud's phenomenon, esophageal disease, sclerodactyly, telangiectasia (CREST) syndrome present distinctive microvasculature lesions that are thought to be responsible for tissue damage and disease progression. Involvement of the gastrointestinal tract may lead to the occurrence of profuse hemorrhage. We performed a study to assess the incidence and characteristics of gastrointestinal hemorrhage in a large group of patients with SSc and CREST syndrome. METHODS: We reviewed the medical records of 144 patients with SSc/CREST seen at our inst

Toward Brain-Computer Interface motor rehabilitation for people with Multiple Sclerosis.

BACKGROUND: Multiple Sclerosis (MS) is a chronic neurodegenerative disease in which the immune system attacks the myelin sheaths around nerves. People with MS (pwMS) often experience pain, fatigue, cognitive dysfunction, and reduced mobility. Today, MS is incurable, and treatments can at best slow the progression of the disease and manage symptoms. We conducted a preliminary, single-arm study using a motor-imagery brain-computer interface (MI-BCI) with functional electrical stimulation (FES) and virtual reality avatar targeting gait in pwMS. METHODS: Twenty-six pwMS were enrolled; 24 complete…

Slower progression of amyotrophic lateral sclerosis with external application of a Chinese herbal plaster-The randomized, placebo-controlled triple-blinded ALS-CHEPLA trial.

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease characterized by gradually increasing damage to the upper and lower motor neurons. However, definitive and efficacious treatment for ALS is not available, and oral intake in ALS patients with bulbar involvement is complicated due to swallowing difficulties. HYPOTHESIS/PURPOSE: This study investigated whether the external plaster application of the herbal composition Ji-Wu-Li efficiently slows ALS progression because prior studies obtained promising evidence with oral herbal applications. STUDY DESIGN: The

The Prognostic Value of Paramagnetic Rim Lesions in People With Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: Paramagnetic rim lesions (PRLs) have been established as a radiologic surrogate for chronic active inflammation in multiple sclerosis (MS). Although associations between PRLs and disability have been observed, data on their prognostic value for long-term risk of clinical worsening, especially in the form of progression independent of relapse activity (PIRA), remain limited. In this study, we assessed the association of PRLs with future disability accumulation over a median follow-up of 5 years and their relation to other (para) clinical parameters. METHODS: From a l…

Long-term Effect of Permanent Demyelination on Axonal Survival in Multiple Sclerosis.

BACKGROUND AND OBJECTIVES: To investigate the long-term effect of permanent demyelination on axonal attrition by examining an association be … xamined twice with an average interval of 6.1 ± 1.4 years. RESULTS: From 85 examined patients with multiple sclerosis, 28 satisfied inclusion criteria. Latency of the mfVEP was delayed, and RNFL thickness was reduced in ON eyes compared with fellow eyes at both visits. There was significant correlation between latency asymmetry and baseline or follow-up intereye RN …

Дополнительные PET и MRI активности миэлопероксидаза в качестве неинвазивного суррогата для акролина тканей в экспериментальной нейроинфламмации.

Мьелопероксидаза (МПО), провоспалительный фермент и акролин, реактивный альдегид, присутствующий в окружающей среде и производимый в организме, играет ключевую роль в экспериментальном аутоиммунном энцефаломиелите (EAE) и множественном склерозе (MS). Вместе с тем не совсем ясно, какова связь между деятельностью МПО и уровнями распространения знаний. Цель этого исследования заключалась в изучении этой взаимосвязи в различных моделях мыши EAE с использованием молекулярных MRI (HEMAMP) и PET ([18F]MAPP), которые сообщают о деятельности MPO.МЕТОДЫ: Хроническая прогрессирующая C57BL/6-Myelin oligod

Совпадение в аннотации оригинала
BACKGROUND: Myeloperoxidase (MPO), a pro-inflammatory enzyme, and acrolein, a reactive aldehyde present in the environment and produced in the body, play pivotal roles in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS). However, the relationship between MPO activity and acrolein levels is not well understood. The purpose of this s…

The impact of social and environmental factors on triggering multiple sclerosis onset, before and during the COVID-19 pandemic: a retrospective study from Iran.

BACKGROUND: Multiple sclerosis (MS) is a chronic, inflammatory, and demyelinating disease of the central nervous system. The first presentation's possible triggers are still controversial among scientists. The objective of this study is to investigate and compare the potential social, environmental, and physical factors that may have contributed to the onset of MS before and during the Coronavirus Disease 2019 (COVID-19) pandemic. METHODS: A questionnaire was designed in the MS research center of Sina Hospital and also distributed as an online Google Form on social media among Iranian MS pati…

Cost-effectiveness of oral versus injectable disease modifying therapies in relapsing multiple sclerosis: a systematic review analysis.

BACKGROUND: Multiple sclerosis (MS) is a chronic and progressive neurological autoimmune disease that affects the central nervous system. There are two types of drugs used to treat this disease: injectable and oral drugs. The present study aimed at systematically reviewing the cost effectiveness of oral versus injectable drugs. METHODS: The researchers searched the PubMed, Scopus, and Web of Science databases to find relevant studies. After removing the duplicates, two authors independently assessed the records. The studies that had conducted full economic evaluations of oral versus injectabl…