Результаты поиска

Safety of ifosfamide during pregnancy: A comprehensive analysis.

OBJECTIVE: Little is known regarding the safety of ifosfamide in pregnant women and some case reports were associated with oligohydramnios. In the study, we performed a comprehensive analysis of the available data regarding the safety of ifosfamide in pregnant women. MATERIAL AND METHODS: First, we performed a case-by-case review of the cases related to ifosfamide use during pregnancy that were spontaneously reported in the French Pharmacovigilance Database. Second, we reviewed cases from the literature. Finally, we performed a disproportionality analysis on VigiBase, the WHO global safety da…

Safety of Hydroxyurea in Pregnancy: A Systematic Review of the Literature.

OBJECTIVE: Hydroxyurea (HU) is an antimetabolite drug used to manage several hematologic conditions, including chronic myeloid leukemia and sickle cell disease (SCD). Animal studies and limited human data have raised concern that HU exposures in pregnancy may increase the risk of congenital malformations or abnormal fetal growth. Although the quality of evidence is low, it has been recommended that HU is discontinued at least 3 months before conception. DATA SOURCES: We systematically reviewed all published studies up to July 2024 describing pregnancy and neonatal outcomes after HU exposure d

Pharmacokinetics and safety of eptinezumab in children and adolescents with migraine.

OBJECTIVE: The primary objective was to characterize the pharmacokinetics (PK) and safety of eptinezumab in children and adolescents with migraine. BACKGROUND: Migraine in children and adolescents is a prevalent and potentially debilitating disease, and few preventive therapies are approved for use in these populations. Eptinezumab, a calcitonin gene-related peptide monoclonal antibody approved for migraine prevention in adults, has demonstrated efficacy at doses of 100 mg or 300 mg administered intravenously every 12 weeks. Defining the appropriate dosing of eptinezumab in children and adole…

A pharmacovigilance analysis of post-marketing safety of durvalumab.

Durvalumab has demonstrated significant efficacy in several types of malignancies, while large-scale real-world safety studies remain limited. This study aimed to systematically evaluate the safety of durvalumab through data mining of the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS). We extracted reports of durvalumab as the primary suspected drug from the FAERS database (January 2017 to June 2024). Four disproportionality analysis algorithms were used to detect signals between durvalumab and adverse events (AEs). Durvalumab was recorded in 10,120 reports as the pri…

Phenol in dermatology: updated evidence on efficacy and safety.

Phenol, or carbolic acid, is an organic compound with caustic and antiseptic properties widely used in dermatology. Since its introduction a … formed by highly trained physicians, with constant monitoring and controlled application, to ensure safety and maximize the therapeutic benefits of this substance, whose efficacy is widely recognized.

Efficacy and safety of respiratory syncytial virus vaccines.

RATIONALE: Respiratory syncytial virus (RSV) is a highly transmissible pathogen that causes varying degrees of respiratory illness across all age groups. The safety and efficacy profiles of available RSV vaccines, a critical consideration for their integration into public health strategies and clinical practice, remain uncertain. OBJECTIVES: To assess the benefits and harms of RSV vaccines compared to placebo, no intervention, vaccines for other respiratory infections, other RSV vaccines, or monoclonal antibodies (mAbs) across all human populations. SEARCH METHODS: We conducted a comprehensi…

Safety, Efficacy, and Immunogenicity of a Salmonella Paratyphi A Vaccine.

BACKGROUND: Salmonella enterica serovar Paratyphi A (also known as S. Paratyphi A) is responsible for more than 2 million cases of enteric f … diagnosis of S. Paratyphi A infection within 14 days after challenge. Secondary end points included safety and immunogenicity. RESULTS: A total of 72 participants underwent randomization, of whom 34 in the CVD 1902 group and 36 in the placebo group were challenged with S. Paratyphi A. The median age of the participants was 32 years (range, 20 to 54), an …

Действенность и безопасность орлезумаба в педиатрическом многоклерозе.

ВВЕДЕНИЕ: Ocrelizumab, высокоэффективная антиCD20 моноклонная антитела, разрешена для использования взрослыми, однако педиатрические данные по-прежнему ограничены. Это ретроспективное когортное исследование позволяет оценить его безопасность и эффективность в отношении пациентов педиатрии с множественным склерозом (POMS) в двух третичных больницах в клинике ОАЕ-Кливленд Абу-Даби (ККАД) и медицинском центре Шейха Шахбута (SSMC). МЕТОДЫ: Были проанализированы электронные медицинские записи пациентов, проходящих лечение острелизумаба в возрасте до 18 лет. Собранные данные включали демографические

Совпадение в аннотации оригинала
INTRODUCTION: Ocrelizumab, a highly effective anti-CD20 monoclonal antibody, is approved for adult use, but pediatric data remain limited. This retrospective cohort study evaluates its safety and efficacy in pediatric-onset multiple sclerosis (POMS) patients at two tertiary hospitals in the UAE-Cleveland Clinic Abu Dhabi (CCAD) and Sheikh Shakhbout Medical C…

Exploring food safety knowledge and practices in Lebanon.

BACKGROUND: Lebanon's economic and financial crises have affected the quality-of-life, including food safety and food security. AIM: To assess food safety knowledge and practices among a sample Lebanese population and the association with the sociodemographic and economic characteristics of participants. METHODS: This cross-sectional study collected data online from 412 Lebanese adults aged ≥ 18 years [mostly female (77.7%)] between October and December 2021. The data included their sociodemographic characteristics, food safety knowledge and practices, experience of food insecurity, and fina…

Usefulness and Safety of Hybrid Uterine Septal Dissection.

OBJECTIVES: The objective of this study was to investigate the safety and utility of hybrid uterine septal resection. MATERIALS AND METHODS: This retrospective cohort trial included 16 patients who underwent hybrid uterine septal resection at Hyogo Medical University Hospital between January 2017 and September 2021. Hysteroscopic uterine septum resection was performed in 16 patients, whereas 5 patients with vaginal septal complications underwent an additional vaginal septectomy under supervision by thin laparoscopy and fluoroscopy. The main outcome measures were pregnancy success rate and pro…

[ICG angiography is a safety standard in bariatric surgery].

OBJECTIVE: To examine the specific characteristics of ICG-angiography during various bariatric interventions. MATERIAL AND METHODS: The study included 329 patients, with 105 (32%) undergoing sleeve gastrectomy (LSG), 98 (30%) undergoing mini-gastricbypass (MGB), 126 (38%) undergoing Roux-en-Y gastric bypass (RGB). Intraoperative ICG angiography was perfomed on all patients at 'control points', the perfusion of the gastric stump was qualitatively and quantitatively assessed. RESULTS: Intraoperative ICG angiography shows that during LSG the angioarchitectonics in the area of the His angle are

Sunscreen Safety and Efficacy for the Prevention of Cutaneous Neoplasm.

Sunscreen is widely used for ultraviolet radiation protection. Studies validate sun protection factors (SPFs) to prevent ultraviolet (UV)-induced skin changes such as melanoma and squamous cell carcinoma (SCC). Few studies examine sunscreen's impact on endocrine and immune system dysregulation, the production of radical oxygen species, and whether the ingredients deteriorate under prolonged exposure. We present an investigation of sunscreen labels and how ingredients impact sun safety and human health. A review of the literature was conducted using Embase and PubMed to examine sunscreen safety…

Efficacy and safety of microneedling radiofrequency in acne scars.

OBJECTIVES: To study the efficacy and safety of microneedling radiofrequency (MNRF) in the treatment of acne scars. MATERIAL AND METHODS: This is a hospital-based and prospective interventional study. A total of 44 patients (18- 55 years old), skin types III-V, with acne scars, were enrolled. Four sessions of MNRF (Lumenis legend PRO Machine, with non-insulated needle tips GEN6, GEN6L; Israel) were done with an interval of 3 weeks between each session and followed up 1 month after the last session. The outcome was assessed by Goodman and Baron's qualitative and quantitative acne scar grading,…

Safety of Prior Propranolol Therapy for Infantile Hemangioma.

Propranolol has been the primary treatment for infantile hemangioma (IH) since 2008. Prior studies have investigated the effects in late childhood of propranolol therapy given in infancy for IH, including neurocognitive dysfunction, sleep disorders, and hypoglycemia. However, few studies have determined the risk of these adverse effects later in life. Using the TrinetX database, we studied the risk of growth impairment, sleep disorders, learning disabilities, and diabetes mellitus in children aged 10-17 years who had received propranolol for IH in infancy. The maximum age of 17 years was chose

Safety and Effectiveness of Track Cauterization for Lung Cryoablation.

PURPOSE: To evaluate the safety and effectiveness of track cauterization for lung cryoablation through comparison of postprocedural adverse event (AE) rates. MATERIALS AND METHODS: Fifty-nine patients who underwent 164 percutaneous lung cryoablation procedures between 2013 and 2018 were included in this retrospective study. The study cohort was subdivided by whether track cauterization was conducted or not at the end of the procedure. The study cohort was also subdivided by the number of probes (1-2 probes vs 3-4 probes). Postablation AE rates were assessed by immediate and delayed (at 1 mont…

P-glycoproteins in anthelmintic safety, efficacy, and resistance.

P-glycoprotein (PGP) is a pivotal transmembrane transporter governing the cellular flux of diverse substances shielding mammals from toxics. It can thwart the effectiveness of medicines such as ivermectin (IVM) and other macrocyclic lactone (ML) anthelmintics, undermining therapeutic efforts. We analyze the role of PGPs in limiting the toxicity of these drugs in hosts, and their potential contribution to anthelmintic resistance in nematodes. Targeting nematode PGPs to increase drug sensitivity to MLs seems interesting, but is hampered by the lack of selective inhibitors. The nuclear hormone re

Updates on the MR safety guidelines - Essentials for radiologists.

Magnetic Resonance Imaging (MRI) is a sophisticated diagnostic tool that utilizes the magnetic properties of biological tissue to generate detailed images of internal structures without the use of ionizing radiation. Despite its benefits in providing high-contrast images of soft tissues, the strong magnetic fields used in MRI present a unique safety challenge. Increasing MRI-related accidents and the prevalence of patients with metallic implants in recent years underscore the critical need for stringent MR safety protocols. This article reviews the latest 2024 updates in the MRI safety manual …