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Challenges of airway management in a patient with temporomandibular joint ankylosis complicating forceps delivery--a case report.

INTRODUCTION: These guidelines provide a comprehensive and practical framework for preventing osteoporosis. They are designed for use by healthcare professionals, including orthopaedic surgeons, primary care physicians, specialists, nurses, and allied health providers, as they work with patients at risk of or already diagnosed with osteoporosis. METHODOLOGY: This iterative process involved multiple questionnaires sent to a panel of 62 osteoporosis and bone health experts. Experts, including clinicians, researchers, and academicians, were selected based on their recognised expertise and contri

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… Its size is comparable to Nicaragua or the state of Alabama in the US. The state has both rural and urban populations of around 78 million people. It is one of India’s wealthiest states and has the second largest impact on India’s gross domestic product (Reserve Bank of India, 2021 ). …

Recognition and management of persistent chylomicronemia: A joint expert clinical consensus by the National Lipid Association and the American Society for Preventive Cardiology.

Extreme hypertriglyceridemia, defined as triglyceride (TG) levels ≥1000 mg/dL, is almost always indicative of chylomicronemia. The current diagnostic approach categorizes individuals with chylomicronemia into familial chylomicronemia syndrome (FCS; prevalence 1-10 per million), caused by the biallelic combination of pathogenic variants that impair the lipolytic action of lipoprotein lipase (LPL), or multifactorial chylomicronemia syndrome (MCS, 1 in 500). A pragmatic framework should emphasize the severity of the phenotype and the risk of complications. Therefore, we endorse the term "persiste

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… In a recent study in 1,294,044 individuals from a large healthcare network across three US states (Minnesota, Florida, and Alabama), 5618 (0.43 %) patients had at least one episode of chylomicronemia [ 11 ]. …

Effect of the BH3 Mimetic Polyphenol (-)-Gossypol (AT-101) on the in vitro and in vivo Growth of Malignant Mesothelioma.

Malignant mesothelioma (MM) is a primary tumor arising from mesothelial cells. The survival of MM patients following traditional chemotherapy is poor, thus innovative treatments for MM are needed. (-)-gossypol (AT-101) is a BH3 mimetic compound which possesses anti-tumoral activity by targeting multiple signaling transduction pathways. Several clinical trials employing AT-101 have been performed and some of them are still ongoing. Accordingly, we investigated the in vitro effects of AT-101 on cell proliferation, cell cycle regulation, pro-survival signaling pathways, apoptosis and autophagy of

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… Kraus (University of Alabama, Birmingham, AL, United States). Antibodies against Beclin-1 and p62/SQSTM1 were obtained from Abcam (Cambridge, United Kingdom) and the anti-LC3 antibody was purchased from Novus Biologicals (Littleton, CO, United States). …

Disparities in Palliative and Hospice Care and Completion of Advance Care Planning and Directives Among Non-Hispanic Blacks: A Scoping Review of Recent Literature.

ObjectivesPublished research in disparities in advance care planning, palliative, and end-of-life care is limited. However, available data points to significant barriers to palliative and end-of-life care among minority adults. The main objective of this scoping review was to summarize the current published research and literature on disparities in palliative and hospice care and completion of advance care planning and directives among non-Hispanc Blacks.MethodsThe scoping review method was used because currently published research in disparities in palliative and hospice cares as well as adva

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… A., et al. (2019). 36 | 60 caregivers and 60 African-American patients with advanced cancer | Single-site randomized trial at the Comprehensive Cancer Center of University of Alabama (Birmingham) | This is an on-going study assessing the acceptability, feasibility, and preliminary efficacy of a lay navigator-led … Noh, H., et al. (2018). 46 | 1,044 community-dwelling older adults in Alabama. | Cross-sectional study of data from a statewide survey | Black older adults were less likely to know about or document advance care planning and to have accurate knowledge of hospice care; however, despite their poorer perceived …

Patient Navigation in Cancer Treatment: A Systematic Review.

Purpose of reviewPatient navigation promotes access to timely treatment of chronic diseases by eliminating barriers to care. Patient navigation programs have been well-established in improving screening rates and diagnostic resolution. This systematic review aimed to characterize the multifaceted role of patient navigators within the realm of cancer treatment.Recent findingsA comprehensive electronic literature review of PubMed and Embase databases was conducted to identify relevant studies investigating the role of patient navigators in cancer treatment from August 1, 2009 to March 27, 2023.

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… breast (stage 0–III) or gynecologic FIGO 0-4B cancer | Y | Treatment adherence | Overall adherence rates were (87–94%) and there were no significant differences between the navigated and usual care groups Fouad et al. (2010) [ 37 ] | Breast | USA | Low income women, primarily African Americans, in 4 Alabama …

Best of JACC: Case Reports From ACC.23.

This dedicated issue of JACC: Case Reports highlights the top ranked Complex Clinical Cases from the ACC 2023 Scientific Sessions. These cases were reviewed and selected by a committee of peers in the months leading up to the annual meeting. These reviewers were ACC members with no affiliation to the JACC: Case Reports Editorial Board. While the cases were presented at the meeting and included in the formal Abstract Book from ACC, they have not been published elsewhere. These cases illustrate how the ACC can be a place for cardiovascular professionals to come together to learn, grow, and share

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… Omar, Department of Cardiology, University of South Alabama, Mobile, AL, USA Background Blunt chest trauma can present with variable intrathoracic organ involvement, including valvular dysfunction. …

PROMIS® Health Organization (PHO) 2021 Conference Abstracts.

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2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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… Clinical Characteristics of Kratom Exposures Reported to Georgia Poison Center: a Retrospective Review Pakhawadee Palungwachira 1 , Michael Yeh 1 , Ziad Kazzi 1 , William Rushton 2 , Brian Whitworth 2 1 Emory university, Atlanta, Georgia, USA. 2 Alabama poison center, Birmingham, Alabama, USA Background …

From bench to bedside: the application of cannabidiol in glioma.

Glioma is the most common malignant tumor in central nervous system, with significant health burdens to patients. Due to the intrinsic characteristics of glioma and the lack of breakthroughs in treatment modalities, the prognosis for most patients remains poor. This results in a heavy psychological and financial load worldwide. In recent years, cannabidiol (CBD) has garnered widespread attention and research due to its anti-tumoral, anti-inflammatory, and neuroprotective properties. This review comprehensively summarizes the preclinical and clinical research on the use of CBD in glioma therapy

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… Researchers from the University of Alabama at Birmingham have focused on exploring the safety and efficacy of prescription-level CBD (specifically Epidiolex ® ) in patients with tumor-related epilepsy enrolled in their Birmingham CBD program ( NCT02700412 for children and NCT02695537 for adults). …

Interventions to improve adherence to anti-osteoporosis medications: an updated systematic review.

An earlier systematic review on interventions to improve adherence and persistence was updated. Fifteen studies investigating the effectiveness of patient education, drug regimen, monitoring and supervision, and interdisciplinary collaboration as a single or multi-component intervention were appraised. Multicomponent interventions with active patient involvement were more effective.IntroductionThis study was conducted to update a systematic literature review on interventions to improve adherence to anti-osteoporosis medications.MethodsA systematic literature review was carried out in Medline (

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… . | Patients presenting themselves for a DXA at three health centers, the University of Iowa. the University of Alabama at Birmingham (UAB), and Kaiser Permanente of Georgia (KPGA) | Age ≥ 50. presenting for DXA | Age < 50, prisoners, overt cognitive disability, unable to speak or read English, deaf, …

Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence.

Mesenchymal stem cells form a population of self-renewing, multipotent cells that can be isolated from several tissues. Multiple preclinical studies have demonstrated that the administration of exogenous MSC could prevent renal injury and could promote renal recovery through a series of complex mechanisms, in particular via immunomodulation of the immune system and release of paracrine factors and microvesicles. Due to their therapeutic potentials, MSC are being evaluated as a possible player in treatment of human kidney disease, and an increasing number of clinical trials to assess the safety

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… mass formation in patients with PKD | Renal function (GFR) | 18 months | 6 | Autologous bmMSC | Experimental: single i.v. infusion 2 × 10 6 MSC/kg | Single group assignment | Mar 2014–Jan 2016; completed NCT02266394 | Hypoxia and inflammatory injury in human renovascular hypertension | Birmingham, Alabama …

A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview.

BackgroundComorbidity is an area of increasing interest in multiple sclerosis (MS).ObjectiveThe objective of this review is to estimate the incidence and prevalence of comorbidity in people with MS and assess the quality of included studies.MethodsWe searched the PubMed, SCOPUS, EMBASE and Web of Knowledge databases, conference proceedings, and reference lists of retrieved articles. Two reviewers independently screened abstracts. One reviewer abstracted data using a standardized form and the abstraction was verified by a second reviewer. We assessed study quality using a standardized approach.

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… Cutter, PhD (University of Alabama at Birmingham, Birmingham, AL, United States), Andrew D. …

Efficacy of bortezomib as first-line treatment for patients with multiple myeloma.

Recent years have seen a dramatic change in the approach towards diagnosing and treating Multiple Myeloma. Newer and more target specific approach to treatment has prolonged the survival for patients with multiple myeloma. The proteasome inhibitors make an important class of anti-myeloma drugs that disrupts the proteolytic machinery of the tumor cells preferentially, enhancing their susceptibility to apoptosis. Bortezomib, in particular has shown significant clinical efficacy in myeloma treatment. It is the most commonly used proteasome inhibitor and has been tested to be effective in prolongi

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… A present for Alabama. J Med Assoc State Ala. 1978;47(7):18–9. 12. Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. …

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

The Medicare experience with end-stage renal disease: trends in incidence, prevalence, and survival.

This article presents a detailed account of the incidence, prevalence, and survival experience of people with end-stage renal disease (ESRD) covered by Medicare. The number of new entrants into the ESRD program has risen since its inception. This increase is greatest for people whose cause of renal failure is primary hypertensive disease or diabetic nephropathy. The program incidence rates for black people is 2.8 times that of white people. Incidence is highest for persons 65 to 69 years of age. Total patient survival is 44 percent 5 years after renal failure onset. Total Medicare enrollment f

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… | | White persons under age 65 | | | | | State | 1978 population in thousands | Average annual ESRD incidence | ESRD incidence per million | 1978 population in thousands | Average annual ESRD incidence | ESRD Incidence per million U.S. total | 220,276 | 17,035.3 | 77 | 168,088 | 8,593.7 | 51 Alabama …

Proteasome inhibition by bortezomib parallels a reduction in head and neck cancer cells growth, and an increase in tumor-infiltrating immune cells.

Head and neck cancer (HNC) has frequently an aggressive course for the development of resistance to standard chemotherapy. Thus, the use of innovative therapeutic drugs is being assessed. Bortezomib is a proteasome inhibitor with anticancer effects. In vitro antitumoral activity of Bortezomib was investigated employing human tongue (SCC-15, CAL-27), pharynx (FaDu), salivary gland (A-253) cancer cell lines and a murine cell line (SALTO-5) originated from a salivary gland adenocarcinoma arising in BALB-neuT male mice transgenic for the oncogene neu. Bortezomib inhibited cell proliferation, trigg

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… Kraus (University of Alabama, Birmingham, AL, USA). Antibodies against Beclin-1 and p62/SQSTM1 were obtained from Abcam (Cambridge, United Kingdom) and the anti-LC3 antibody was purchased from Novus Biologicals (Littleton, CO, USA). …

Abstract Book for the 3rd European Myeloma Network Meeting

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… 11 Levine Cancer Institute-Atrium Health, Charlotte (USA); 12 University Medical Center Hamburg-Eppendorf, Hamburg (DE); 13 Janssen R&D, Raritan (USA); 14 Janssen Pharmaceutica NV, Beerse (BE); 15 Janssen Global Services, LLC, Raritan (USA); 16 Legend Biotech USA, Piscataway (USA); 17 University of Alabama …

Lipocalin 2-not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials.

Lipocalin 2 (Lcn2), also known as neutrophil gelatinase-associated lipocalin, is an innate immune protein encoded by the LCN2 gene. In this study, we investigated various roles and functions of Lcn2 characterized in a systems-based format and evaluated its therapeutic potentials and clinical relevance for diagnosis and prognosis. An additional systematic presentation was presented for 70 ongoing clinical trials utilizing Lcn2 in the diagnostic and prognostic setting as a key outcome measure. With trials being conducted through December 2030, Lcn2 will become all the more relevant given its ass

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… University, Nanchang, Jiangxi, China NCT05439538 | 60 | Other | Observational | Observational model: cohort; time perspective: prospective | 1 Jan 2025 | Not available NCT04354467 | 100 | Other | Observational | Observational model: cohort; time perspective: prospective | 30 Dec 2022 | Children's of Alabama …

Минимальная информация для исследований внеклеточной везиклетки (MISEV2023): от базовых до передовых подходов.

Внеклеточные везиклолы (ЭМ) с помощью своего сложного груза могут отражать состояние клетки их происхождения и изменять функции и фенотипы других ячеек. Эти особенности свидетельствуют о значительном биомаркировании и терапевтическом потенциале и вызывают широкий интерес, о чем свидетельствует постоянное увеличение числа научных публикаций об ЭМ за год. Значительные успехи были достигнуты в области ЭВМ, а также в понимании и применении биологии ЭМ. Вместе с тем сохраняются препятствия на пути реализации потенциала ЭМ в различных областях - от базовой биологии до клинического применения - в свя

Frailty as an Effect Modifier in Randomized Controlled Trials: A Systematic Review.

BackgroundThe effect of clinical interventions may vary by patients' frailty status. Understanding treatment effect heterogeneity by frailty could lead to frailty-guided treatment strategies and reduce overtreatment and undertreatment. This systematic review aimed to examine the effect modification by frailty in randomized controlled trials (RCTs) that evaluate pharmacological, non-pharmacological, and multicomponent interventions.MethodsWe searched PubMed, Web of Science, EMBASE, and ClinicalTrial.gov, from their inception to 8 December 2023. Two reviewers independently extracted trial data a

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… additional outpatient appointments (for example, dietician, continence clinic), occupational therapy, and community exercise programs offered as indicated e Mobility during the preceding month was quantified in terms of distance and frequency of travel and degree of independence using the University of Alabama …